LOCUS       NM_001416540            2849 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus syntabulin (syntaxin-interacting) (Sybu), transcript
            variant q, mRNA.
ACCESSION   NM_001416540
VERSION     NM_001416540.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2849)
  AUTHORS   Ragancokova,D., Rocca,E., Oonk,A.M., Schulz,H., Rohde,E.,
            Bednarsch,J., Feenstra,I., Pennings,R.J., Wende,H. and Garratt,A.N.
  TITLE     TSHZ1-dependent gene regulation is essential for olfactory bulb
            development and olfaction
  JOURNAL   J Clin Invest 124 (3), 1214-1227 (2014)
   PUBMED   24487590
  REMARK    Erratum:[J Clin Invest. 2022 Aug 15;132(16):e163087. doi:
            10.1172/JCI163087.. PMID: 35968788]
REFERENCE   5  (bases 1 to 2849)
  AUTHORS   Ying,Y., Li,L., Cao,W., Yan,D., Zeng,Q., Kong,X., Lu,L., Yan,M.,
            Xu,X., Qu,J., Su,Q. and Ma,X.
  TITLE     The microtubule associated protein syntabulin is required for
            glucose-stimulated and cAMP-potentiated insulin secretion
  JOURNAL   FEBS Lett 586 (20), 3674-3680 (2012)
   PUBMED   22975310
  REMARK    GeneRIF: syntabulin could be a novel effector of Epac2 and play a
            critical role in cAMP-enhanced insulin secretion
REFERENCE   6  (bases 1 to 2849)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   7  (bases 1 to 2849)
  AUTHORS   Funakoshi,E., Fukui,M., Hamano,A., Okamoto,H., Sugiyama,C.,
            Nishiyama,N., Ogita,K., Hori,T., Shimizu,N. and Ito,F.
  TITLE     Expression of m-Golsyn/Syntabulin gene during mouse brain
            development
  JOURNAL   Neurosci Lett 403 (3), 244-249 (2006)
   PUBMED   16750881
  REMARK    GeneRIF: results may indicate a significant role for this protein
            in neuronal cells and other types of cells such as those of the
            choroid plexus and ciliary body
REFERENCE   8  (bases 1 to 2849)
  AUTHORS   Funakoshi,E., Hamano,A., Fukui,M., Nishiyama,N., Ogita,K.,
            Shimizu,N. and Ito,F.
  TITLE     Molecular cloning of the m-Golsyn gene and its expression in the
            mouse brain
  JOURNAL   Gene Expr 13 (1), 27-40 (2006)
   PUBMED   16572588
REFERENCE   9  (bases 1 to 2849)
  AUTHORS   Funakoshi,E., Nakagawa,K.Y., Hamano,A., Hori,T., Shimizu,A.,
            Asakawa,S., Shimizu,N. and Ito,F.
  TITLE     Molecular cloning and characterization of gene for Golgi-localized
            syntaphilin-related protein on human chromosome 8q23
  JOURNAL   Gene 344, 259-271 (2005)
   PUBMED   15656992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100730.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.1007971.1,
                                           SRR10662773.2076664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC100730.8         135402-135504       c
            104-193             AC100730.8         131624-131713       c
            194-401             AC100730.8         129561-129768       c
            402-599             AC100730.8         102103-102300       c
            600-702             AC100730.8         66663-66765         c
            703-906             AC100730.8         60850-61053         c
            907-1056            AC100730.8         58681-58830         c
            1057-2849           AC100730.8         55171-56963         c
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.91 cM"
     gene            1..2849
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="syntabulin (syntaxin-interacting)"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
     exon            1..103
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            104..193
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2158
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="isoform n is encoded by transcript variant q;
                     syntaxin-1-binding protein; Golgi-localized
                     syntaphilin-related protein; Golsyn/Syntabulin"
                     /codon_start=1
                     /product="syntabulin isoform n"
                     /protein_id="NP_001403469.1"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
                     /translation="MGPLRESKRVQHQEKEISRSRIPRLILRPHRPQQQQQQQNKVSP
                     ASESPFSEEESREFNPSSSGRSARTISSNSFCSDDTGCPSSQSVSPVKTPSDTGHSPI
                     GFCPGSDEDFTRKKCRIGMVGEGSIQSARHKKEPKGGIIKPGSEADFSSSSSTGSISA
                     PEVHMSTTGNKRASFSRNRGPHGRSNGASSHKSGSSPPSPREKDLVSMLCRNPLSPSN
                     IHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKE
                     VTVRHLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEARKE
                     IKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDELCLD
                     FSFDSPEKSLPLSSTFDKLPDGLSLEEQITEEGADSELLVGDSMAEGTDLLDEMVTAT
                     TTESSGLEFVHSTPGPQALKALPLVSHEEGIAVMEQAVQTDVVPFSPAISELIQSVLK
                     LQDYCPTSSASPDESGADSMESFSESISALMLDLTPRSPNSAILLSPVEIPFSKGAME
                     AHANRLMRELDFAAYTEERLDSVLSLSQGSVVRQYWSSNFLVDLLAVAAPVVPTVLWA
                     FSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT"
     exon            194..401
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            402..599
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            600..702
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            703..906
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1056
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..2849
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2824..2829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="hexamer: AATAAA"
     polyA_site      2849
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="major polyA site"
ORIGIN      
        1 actgagagac ggcagcgctt gctcgcacag ctgataggat taggagctcg actgctttgt
       61 cagccctgat tgagtccaag acagccccgg caggcacacg caggtgcctc ctcctggacg
      121 gcggcggcgg cggcagcggc ggcgtgggga gccggcaggc agcagcgaaa tggggcccct
      181 ccgagagagc aagagagtgc agcatcagga gaaagagatt tccaggagcc ggattccccg
      241 gttgattctg cggccccatc ggcctcagca gcagcaacag cagcagaaca aggtttcccc
      301 agcctccgag tctccctttt cggaggaaga aagtagagag ttcaacccca gcagctctgg
      361 acgctcagca aggacgatta gcagcaacag cttctgctca gatgacacag gttgtcccag
      421 cagccagtcg gtatcgcctg tgaagactcc ttcagacaca gggcacagtc ccattggctt
      481 ttgccctgga agcgatgaag actttaccag gaagaaatgc aggattggaa tggttggtga
      541 gggaagtatt cagtcagctc gtcataaaaa agaacccaag ggaggcatca taaagccagg
      601 cagtgaagca gattttagct cctcgagcag cacaggcagc atctcggctc ctgaggtcca
      661 catgtccacg acaggaaaca agagagcctc tttctcacgc aaccgaggcc ctcatgggcg
      721 gagcaatgga gcatcatccc acaagtctgg cagcagccca ccatccccaa gggaaaaaga
      781 ccttgtgtct atgctgtgca ggaatccact gagccccagt aacatccacc ctagttacgc
      841 cccttcttct ccaagtagca gcaactccgg ctcctacaaa ggaagtgatt gtagtccagt
      901 catgagaagg tctggaagat acatgtcttg tggcgaaaat cacggtgtca aacccccaaa
      961 tccagaacag tatttgactc ctctgcagca gaaggaggtc acagtgaggc acctgaggac
     1021 caagctgaag gagtctgagc gccgactcca tgagagggaa tctgaaatca tggagctcaa
     1081 gtctcagctg gctcgaatga gggaggactg gattgaggaa gagtgccaca gagtggaggc
     1141 tcagttggca ctcaaagaag ccagaaaaga gattaaacag ctcaaacagg tcatcgagac
     1201 tatgaggagc agcttggctg ataaagataa aggcattcag aagtactttg tggacataaa
     1261 catccaaaac aagaaactgg agtctctgct tcaaagcatg gagatggcac acaatagttc
     1321 cctgagggat gaactgtgtc ttgacttttc ctttgattcc ccagagaaaa gtttacccct
     1381 gagcagcaca tttgacaagt tgccagatgg gttatctctg gaagaacaga taacagagga
     1441 aggtgctgac agtgagcttc tggtgggaga cagcatggct gaaggcacag atctgttaga
     1501 tgagatggtg actgccacca ccacagaatc cagtggcctg gagtttgttc attccactcc
     1561 agggccacaa gccctcaagg ctctcccctt ggtgagccac gaagagggca ttgcggtgat
     1621 ggagcaagcc gtgcagaccg acgtggtgcc gttcagccct gccatctcag agctcattca
     1681 gagtgtgcta aagctgcagg actactgtcc cacaagctca gcatctccag atgaatctgg
     1741 agctgactcg atggaaagct tctcagaatc tatctctgcc ttaatgcttg atttaactcc
     1801 aagaagtcct aactcggcca tccttctgtc tcctgtggag atcccattca gcaagggggc
     1861 tatggaagcc catgcaaatc gcctcatgag agagctagat tttgcagcct acacagaaga
     1921 aagattggac agtgtcctct cactgtccca gggcagtgtt gtgaggcagt actggagcag
     1981 caatttcttg gtggatctac tggctgtggc tgcccctgtg gtacccactg ttctgtgggc
     2041 attcagtact cagagagggg gtacagatcc tgtctacaac atcggagctt tgctccgagg
     2101 ttgctgtgtg gtggccctac actcactacg ccgcaccgct ttccacatga aaacctaatt
     2161 agttgttact gtgtgccaat gtatctgtgt ggcctgatgc caggtagagc aacagcaggt
     2221 gatcagtgga agtctctatt ctgtcagttt tgcttctcgc tatttgattt gcactatagt
     2281 cagttgaagc ctgttcactg tttaaaccag aggtattttc caaggcatgg aaacctggtt
     2341 ctggtagctg tcccaccaga gtggtgtaga aagcatgctt atgcccctgc cgtgttgtct
     2401 gaggtgcccg ttcttatact aatggttcag gaagagaaaa tgccgtttgc actttcacca
     2461 cagcctttct aaggctggca tgttatctcc ttgctttgct ttgtgccgtt tgaaaatgtg
     2521 taattgttcc agcattccaa tgctcttgtg catagcaggg gactgtaacc aaaaataaaa
     2581 atgtacttgt gtaattggtt caaagacttg aatagctctt tatcgtcttg aggttgataa
     2641 agtttgagtg tttagatttt tgttttttaa cttaatgtag ctccaaagtc ttataagact
     2701 catttgctct taaacctgtc agttagtgat actatgtaaa tttacaatgt actaacttat
     2761 tttttgctta ttatatatag tgttttttgg aaattgtttg tacccacata cttaaagcat
     2821 gaaaataaag gttagtggtt ccatttaaa
//
