LOCUS       NM_001285840            3054 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus syntabulin (syntaxin-interacting) (Sybu), transcript
            variant d, mRNA.
ACCESSION   NM_001285840
VERSION     NM_001285840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Ragancokova,D., Rocca,E., Oonk,A.M., Schulz,H., Rohde,E.,
            Bednarsch,J., Feenstra,I., Pennings,R.J., Wende,H. and Garratt,A.N.
  TITLE     TSHZ1-dependent gene regulation is essential for olfactory bulb
            development and olfaction
  JOURNAL   J Clin Invest 124 (3), 1214-1227 (2014)
   PUBMED   24487590
  REMARK    Erratum:[J Clin Invest. 2022 Aug 15;132(16):e163087. doi:
            10.1172/JCI163087.. PMID: 35968788]
REFERENCE   5  (bases 1 to 3054)
  AUTHORS   Ying,Y., Li,L., Cao,W., Yan,D., Zeng,Q., Kong,X., Lu,L., Yan,M.,
            Xu,X., Qu,J., Su,Q. and Ma,X.
  TITLE     The microtubule associated protein syntabulin is required for
            glucose-stimulated and cAMP-potentiated insulin secretion
  JOURNAL   FEBS Lett 586 (20), 3674-3680 (2012)
   PUBMED   22975310
  REMARK    GeneRIF: syntabulin could be a novel effector of Epac2 and play a
            critical role in cAMP-enhanced insulin secretion
REFERENCE   6  (bases 1 to 3054)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   7  (bases 1 to 3054)
  AUTHORS   Funakoshi,E., Fukui,M., Hamano,A., Okamoto,H., Sugiyama,C.,
            Nishiyama,N., Ogita,K., Hori,T., Shimizu,N. and Ito,F.
  TITLE     Expression of m-Golsyn/Syntabulin gene during mouse brain
            development
  JOURNAL   Neurosci Lett 403 (3), 244-249 (2006)
   PUBMED   16750881
  REMARK    GeneRIF: results may indicate a significant role for this protein
            in neuronal cells and other types of cells such as those of the
            choroid plexus and ciliary body
REFERENCE   8  (bases 1 to 3054)
  AUTHORS   Funakoshi,E., Hamano,A., Fukui,M., Nishiyama,N., Ogita,K.,
            Shimizu,N. and Ito,F.
  TITLE     Molecular cloning of the m-Golsyn gene and its expression in the
            mouse brain
  JOURNAL   Gene Expr 13 (1), 27-40 (2006)
   PUBMED   16572588
REFERENCE   9  (bases 1 to 3054)
  AUTHORS   Funakoshi,E., Nakagawa,K.Y., Hamano,A., Hori,T., Shimizu,A.,
            Asakawa,S., Shimizu,N. and Ito,F.
  TITLE     Molecular cloning and characterization of gene for Golgi-localized
            syntaphilin-related protein on human chromosome 8q23
  JOURNAL   Gene 344, 259-271 (2005)
   PUBMED   15656992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK220268.1 and AB232447.1.
            
            Transcript Variant: This variant (d) lacks part of the 5' coding
            region, uses an alternate 5'-terminal exon, and initiates
            translation at a downstream start codon, compared to variant a. The
            encoded isoform (c) has a shorter N-terminus, compared to isoform
            a. Both variants 3 and 4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220268.1, SRR1660819.80180.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3026              AK220268.1         1-3026
            3027-3054           AB232447.1         3228-3255
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.91 cM"
     gene            1..3054
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="syntabulin (syntaxin-interacting)"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
     exon            1..364
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..2338
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="isoform c is encoded by transcript variant d;
                     syntaxin-1-binding protein; Golgi-localized
                     syntaphilin-related protein; Golsyn/Syntabulin"
                     /codon_start=1
                     /product="syntabulin isoform c"
                     /protein_id="NP_001272769.1"
                     /db_xref="CCDS:CCDS37071.1"
                     /db_xref="GeneID:319613"
                     /db_xref="MGI:MGI:2442392"
                     /translation="MGPLRESKKEQRVQHQEKEISRSRIPRLILRPHRPQQQQQQQNK
                     VSPASESPFSEEESREFNPSSSGRSARTISSNSFCSDDTGCPSSQSVSPVKTPSDTGH
                     SPIGFCPGSDEDFTRKKCRIGMVGEGSIQSARHKKEPKGGIIKPGSEADFSSSSSTGS
                     ISAPEVHMSTTGNKRASFSRNRGPHGRSNGASSHKSGSSPPSPREKDLVSMLCRNPLS
                     PSNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQ
                     QKEVTVRHLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEA
                     RKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDEL
                     CLDFSFDSPEKSLPLSSTFDKLPDGLSLEEQITEEGADSELLVGDSMAEGTDLLDEMV
                     TATTTESSGLEFVHSTPGPQALKALPLVSHEEGIAVMEQAVQTDVVPFSPAISELIQS
                     VLKLQDYCPTSSASPDESGADSMESFSESISALMLDLTPRSPNSAILLSPVEIPFSKG
                     AMEAHANRLMRELDFAAYTEERLDSVLSLSQGSVVRQYWSSNFLVDLLAVAAPVVPTV
                     LWAFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT"
     exon            365..581
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            582..779
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            780..882
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1086
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1236
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..3029
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="Sybu"
                     /gene_synonym="Golsyn"
                     /note="major polyA site"
ORIGIN      
        1 gggaggggcg ctgaaagcgg gacgtggcga gtgacctggt gggtgctgcg ctccgaggtg
       61 ctaggcagct gttccgggcc gcaggtgaag gcggcgacca ggaggcgcct ccggagccgc
      121 cacggaaggt ggcaccacgt gcccggcggg gcggggcggc gggcgcgccc tcggagccga
      181 gcgcgaccgc tggcggggac gcggcgagcc cgctgctgct gccgcacgca gcctcggact
      241 cagtgctgtc tcctcccttg ctcggtgctc acaggtgcct cctcctggac ggcggcggcg
      301 gcggcagcgg cggcgtgggg agccggcagg cagcagcgaa atggggcccc tccgagagag
      361 caagaaggag cagagagtgc agcatcagga gaaagagatt tccaggagcc ggattccccg
      421 gttgattctg cggccccatc ggcctcagca gcagcaacag cagcagaaca aggtttcccc
      481 agcctccgag tctccctttt cggaggaaga aagtagagag ttcaacccca gcagctctgg
      541 acgctcagca aggacgatta gcagcaacag cttctgctca gatgacacag gttgtcccag
      601 cagccagtcg gtatcgcctg tgaagactcc ttcagacaca gggcacagtc ccattggctt
      661 ttgccctgga agcgatgaag actttaccag gaagaaatgc aggattggaa tggttggtga
      721 gggaagtatt cagtcagctc gtcataaaaa agaacccaag ggaggcatca taaagccagg
      781 cagtgaagca gattttagct cctcgagcag cacaggcagc atctcggctc ctgaggtcca
      841 catgtccacg acaggaaaca agagagcctc tttctcacgc aaccgaggcc ctcatgggcg
      901 gagcaatgga gcatcatccc acaagtctgg cagcagccca ccatccccaa gggaaaaaga
      961 ccttgtgtct atgctgtgca ggaatccact gagccccagt aacatccacc ctagttacgc
     1021 cccttcttct ccaagtagca gcaactccgg ctcctacaaa ggaagtgatt gtagtccagt
     1081 catgagaagg tctggaagat acatgtcttg tggcgaaaat cacggtgtca aacccccaaa
     1141 tccagaacag tatttgactc ctctgcagca gaaggaggtc acagtgaggc acctgaggac
     1201 caagctgaag gagtctgagc gccgactcca tgagagggaa tctgaaatca tggagctcaa
     1261 gtctcagctg gctcgaatga gggaggactg gattgaggaa gagtgccaca gagtggaggc
     1321 tcagttggca ctcaaagaag ccagaaaaga gattaaacag ctcaaacagg tcatcgagac
     1381 tatgaggagc agcttggctg ataaagataa aggcattcag aagtactttg tggacataaa
     1441 catccaaaac aagaaactgg agtctctgct tcaaagcatg gagatggcac acaatagttc
     1501 cctgagggat gaactgtgtc ttgacttttc ctttgattcc ccagagaaaa gtttacccct
     1561 gagcagcaca tttgacaagt tgccagatgg gttatctctg gaagaacaga taacagagga
     1621 aggtgctgac agtgagcttc tggtgggaga cagcatggct gaaggcacag atctgttaga
     1681 tgagatggtg actgccacca ccacagaatc cagtggcctg gagtttgttc attccactcc
     1741 agggccacaa gccctcaagg ctctcccctt ggtgagccac gaagagggca ttgcggtgat
     1801 ggagcaagcc gtgcagaccg acgtggtgcc gttcagccct gccatctcag agctcattca
     1861 gagtgtgcta aagctgcagg actactgtcc cacaagctca gcatctccag atgaatctgg
     1921 agctgactcg atggaaagct tctcagaatc tatctctgcc ttaatgcttg atttaactcc
     1981 aagaagtcct aactcggcca tccttctgtc tcctgtggag atcccattca gcaagggggc
     2041 tatggaagcc catgcaaatc gcctcatgag agagctagat tttgcagcct acacagaaga
     2101 aagattggac agtgtcctct cactgtccca gggcagtgtt gtgaggcagt actggagcag
     2161 caatttcttg gtggatctac tggctgtggc tgcccctgtg gtacccactg ttctgtgggc
     2221 attcagtact cagagagggg gtacagatcc tgtctacaac atcggagctt tgctccgagg
     2281 ttgctgtgtg gtggccctac actcactacg ccgcaccgct ttccacatga aaacctaatt
     2341 agttgttact gtgtgccaat gtatctgtgt ggcctgatgc caggtagagc aacagcaggt
     2401 gatcagtgga agtctctatt ctgtcagttt tgcttctcgc tatttgattt gcactatagt
     2461 cagttgaagc ctgttcactg tttaaaccag aggtattttc caaggcatgg aaacctggtt
     2521 ctggtagctg tcccaccaga gtggtgtaga aagcatgctt atgcccctgc cgtgttgtct
     2581 gaggtgcccg ttcttatact aatggttcag gaagagaaaa tgccgtttgc actttcacca
     2641 cagcctttct aaggctggca tgttatctcc ttgctttgct ttgtgccgtt tgaaaatgtg
     2701 taattgttcc agcattccaa tgctcttgtg catagcaggg gactgtaacc aaaaataaaa
     2761 atgtacttgt gtaattggtt caaagacttg aatagctctt tatcgtcttg aggttgataa
     2821 agtttgagtg tttagatttt tgttttttaa cttaatgtag ctccaaagtc ttataagact
     2881 catttgctct taaacctgtc agttagtgat actatgtaaa tttacaatgt actaacttat
     2941 tttttgctta ttatatatag tgttttttgg aaattgtttg tacccacata cttaaagcat
     3001 gaaaataaag gttagtggtt ccatttaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
