LOCUS       NM_025932               2316 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus synapse associated protein 1 (Syap1), mRNA.
ACCESSION   NM_025932
VERSION     NM_025932.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2316)
  AUTHORS   Chen,X., Chen,X., Chao,R., Wang,Y., Mao,Y., Fan,B., Zhang,Y.,
            Xu,W., Qin,A. and Zhang,S.
  TITLE     Dlk2 interacts with Syap1 to activate Akt signaling pathway during
            osteoclast formation
  JOURNAL   Cell Death Dis 14 (9), 589 (2023)
   PUBMED   37669921
  REMARK    GeneRIF: Dlk2 interacts with Syap1 to activate Akt signaling
            pathway during osteoclast formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2316)
  AUTHORS   R von Collenberg,C., Schmitt,D., Rulicke,T., Sendtner,M., Blum,R.
            and Buchner,E.
  TITLE     An essential role of the mouse synapse-associated protein Syap1 in
            circuits for spontaneous motor activity and rotarod balance
  JOURNAL   Biol Open 8 (6) (2019)
   PUBMED   31118165
  REMARK    Erratum:[Biol Open. 2020 Feb 18;9(2):bio048942. doi:
            10.1242/bio.048942.. PMID: 32071078]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2316)
  AUTHORS   Schmitt,D., Funk,N., Blum,R., Asan,E., Andersen,L., Rulicke,T.,
            Sendtner,M. and Buchner,E.
  TITLE     Initial characterization of a Syap1 knock-out mouse and
            distribution of Syap1 in mouse brain and cultured motoneurons
  JOURNAL   Histochem Cell Biol 146 (4), 489-512 (2016)
   PUBMED   27344443
  REMARK    GeneRIF: findings demonstrate a widespread expression of Syap1 in
            the mouse central nervous system with regionally specific
            distribution patterns as illustrated in particular for olfactory
            bulb, hippocampus, and cerebellum; importantly, Syap1 knockout does
            not affect motoneuron survival or axon growth
REFERENCE   4  (bases 1 to 2316)
  AUTHORS   Yao,Y., Suraokar,M., Darnay,B.G., Hollier,B.G., Shaiken,T.E.,
            Asano,T., Chen,C.H., Chang,B.H., Lu,Y., Mills,G.B., Sarbassov,D.,
            Mani,S.A., Abbruzzese,J.L. and Reddy,S.A.
  TITLE     BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress
            expression of FoxC2 and stimulate adipocyte differentiation
  JOURNAL   Sci Signal 6 (257), ra2 (2013)
   PUBMED   23300339
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2316)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   6  (bases 1 to 2316)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011337.1, AK014893.1, AK051251.1 and AL807822.7.
            
            On Dec 4, 2009 this sequence version replaced NM_025932.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008390.1, AK147055.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK011337.1         1-15
            16-1925             AK014893.1         2-1911
            1926-2307           AK051251.1         1883-2264
            2308-2316           AL807822.7         23660-23668         c
FEATURES             Location/Qualifiers
     source          1..2316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 75.06 cM"
     gene            1..2316
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /note="synapse associated protein 1"
                     /db_xref="GeneID:67043"
                     /db_xref="MGI:MGI:1914293"
     exon            1..394
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1275
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /note="BSD domain-containing signal transducer and Akt
                     interactor protein"
                     /codon_start=1
                     /product="synapse-associated protein 1"
                     /protein_id="NP_080208.2"
                     /db_xref="CCDS:CCDS30511.1"
                     /db_xref="GeneID:67043"
                     /db_xref="MGI:MGI:1914293"
                     /translation="MFGGLSSWLGLKPPEGAAAEGEEPPSRDGDKLSAGAAPSEESPE
                     RPVEPTEEQQQQPPTEDPQFLHQAKGLGNYLYNFASAATKKITESVTETAQTIKKSVE
                     EGKIDDILDKTILGDFQKEQKKFVEEQNTKKSEAAVPPWVESHDEETIQQQILALSAD
                     KRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFY
                     RISLIKQSAQLTALAAQQQASGKEEKSSNRDDNLPLTEAVRPKTPPVVIKSQLKSQED
                     EEEISTSPGVSEFVSDAFDTCSLNQEDLRKEMEQLVLDKKQEEATALEEDSTDWEKEL
                     QQELQEYEVVAESEKRDENWDKEIEKMLQES"
     exon            395..513
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            514..580
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            581..654
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            655..794
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            795..943
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1002
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1150
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..2316
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /note="hexamer: AATAAA"
     polyA_site      1935
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /note="hexamer: AATAAA"
     polyA_site      2316
                     /gene="Syap1"
                     /gene_synonym="2010110O17Rik; BSTA"
                     /note="major polyA site"
ORIGIN      
        1 gacgcatgcg cggccagctg agccgccgtc agagagggtg ggccaagctt cgggaggtct
       61 ccggttccgg tcagtctccc tcgaagacca gcggagtcgg atcagccagt ggttaagggt
      121 gccagggctc ttgggcgagg ggaccgcggc agaggcggcg gtgaccccgc gggcgggatg
      181 ttcggagggt tgagcagttg gctgggcttg aagccgcccg agggggcggc ggcggaggga
      241 gaagagcctc ccagccggga cggggacaag ctgtccgcgg gagccgcgcc ttctgaggag
      301 agccccgagc ggcccgtgga gcccactgag gagcagcagc agcagccgcc gacggaggac
      361 ccacagttcc tccaccaggc caaaggcctt ggcaattatt tgtataactt tgcaagtgct
      421 gcaacaaaga agataactga atctgttaca gaaacagctc agacaatcaa gaaatccgtg
      481 gaagaaggaa aaatagatga tatccttgac aagactattt taggagattt tcaaaaagaa
      541 cagaaaaaat ttgttgagga acagaataca aaaaagtcag aagcagctgt gcctccgtgg
      601 gttgagagtc atgatgaaga gacaattcaa cagcagattt tggctttatc agctgacaag
      661 aggaatttcc tccgtgaccc accagctggt gtgcagttta actttgactt tgatcagatg
      721 taccctgttg ccctggtcat gctccaagag gatgagctac taagcaagat gagatttgcc
      781 cttgttccta aacttgtgaa ggaagaagta ttctggagga actacttcta ccgaatctcc
      841 ctgattaagc agtcggccca actcactgca ctggccgctc agcagcaagc ctctggaaag
      901 gaggaaaaaa gcagcaacag agatgataac ttgcctctga cagaggcagt acggcccaaa
      961 acaccacctg tcgtaatcaa atctcagctt aaaagtcaag aggatgaaga ggaaatctct
     1021 actagcccag gagtttctga gtttgttagt gatgccttcg atacgtgcag cttaaatcag
     1081 gaggatttaa gaaaggaaat ggaacaactt gtgcttgata agaagcaaga ggaagcaact
     1141 gcactagaag aagattctac tgattgggaa aaggagctac aacaggagct tcaggaatat
     1201 gaagtggtag cagagtctga gaagcgagat gaaaactggg ataaagaaat tgagaagatg
     1261 cttcaggaga gttaataatt gtctccgcaa accagttctt aacattgtgt gacatgaaat
     1321 tctcatgatc gctgagtcag aaggcacaaa aaaagggtgt aactttatgc aatttgaaat
     1381 gattcttttt ctagctaaaa cttgcctctt aaatgaacag ctattgtaat aatcagaaac
     1441 aacaggatat tgtatgtaac atttcataca tataaaatta gcattcttat aagcagcaga
     1501 actatctgtg ccacagaaac acaggtaaat actagagtct tttttctaga aggttggcaa
     1561 cataatttat tctttagtta tgtttttcta tatatgcctt tttgttgata aatggttaaa
     1621 gtacttacta tcagaaagta atatcttact atcaaaatga ccaaattata ccaaagaaat
     1681 caaaagaaag cactttcaaa atattttctt gccggatatt ttctaaaatt ctatctgaaa
     1741 gacaaaagct gagatatttc tgttcacttg aatgacataa atatcaccca gtttgacatg
     1801 ctgaaacact ttctgtgcag gactagggag ggatgtggtg aacacttgtt gttcacagtg
     1861 ctccaggttc catttccact atctcagcta aaagtgcaag ccagatttgt ttaaataaag
     1921 ttgaacttct ccctagagcc ttctcatttt gctttgttaa gtataccaca aattcaacgt
     1981 tgtgcttttt gtaggaactg aggtcttcag tcctttttgt attaataact gtcaagaagc
     2041 ctgtttaccg taaggtttgt tctcctggta atagtcacta tgtataaatg tcttaaataa
     2101 ttatccttta tagaatggtc ttccttgatc tagaacctac taattaatac ttcttgtatt
     2161 ctgctatgcc atcaggcaac tgttcataga atgtgatgat tttaaaagag caaggtgatt
     2221 taatgttaga aaactaacta ccattcacct ttcaagtttt cacagcactt ttatttcata
     2281 agggaaataa aatcaagaca tttctttata agagaa
//
