LOCUS       NM_175190                780 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SWI5 recombination repair homolog (yeast) (Swi5),
            transcript variant 2, mRNA.
ACCESSION   NM_175190
VERSION     NM_175190.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Lu,C.H., Yeh,H.Y., Su,G.C., Ito,K., Kurokawa,Y., Iwasaki,H., Chi,P.
            and Li,H.W.
  TITLE     Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by
            modulating Rad51 dissociation
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10059-E10068 (2018)
   PUBMED   30297419
  REMARK    GeneRIF: Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous
            recombination.
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Su,G.C., Yeh,H.Y., Lin,S.W., Chung,C.I., Huang,Y.S., Liu,Y.C.,
            Lyu,P.C. and Chi,P.
  TITLE     Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination
  JOURNAL   Nucleic Acids Res 44 (13), 6242-6251 (2016)
   PUBMED   27131790
  REMARK    GeneRIF: Our results thus help establish the functional relevance
            of the trimeric RAD51-SWI5-SFR1 complex and provide insights into
            the mechanistic underpinnings of homology-directed DNA repair in
            mammalian cells.
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Tsai,S.P., Su,G.C., Lin,S.W., Chung,C.I., Xue,X., Dunlop,M.H.,
            Akamatsu,Y., Jasin,M., Sung,P. and Chi,P.
  TITLE     Rad51 presynaptic filament stabilization function of the mouse
            Swi5-Sfr1 heterodimeric complex
  JOURNAL   Nucleic Acids Res 40 (14), 6558-6569 (2012)
   PUBMED   22492707
  REMARK    GeneRIF: Biophysical evidence that the mouse Swi5-Sfr1 complex has
            a 1:1 stoichiometry.
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Akamatsu,Y. and Jasin,M.
  TITLE     Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair
            through homologous recombination
  JOURNAL   PLoS Genet 6 (10), e1001160 (2010)
   PUBMED   20976249
  REMARK    GeneRIF: Data show that Swi5-Sfr1 is a newly identified complex
            required for genomic integrity in mammalian cells with a specific
            role in the repair of DNA strand breaks.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 780)
  AUTHORS   Sakuraba,Y., Sezutsu,H., Takahasi,K.R., Tsuchihashi,K.,
            Ichikawa,R., Fujimoto,N., Kaneko,S., Nakai,Y., Uchiyama,M.,
            Goda,N., Motoi,R., Ikeda,A., Karashima,Y., Inoue,M., Kaneda,H.,
            Masuya,H., Minowa,O., Noguchi,H., Toyoda,A., Sakaki,Y., Wakana,S.,
            Noda,T., Shiroishi,T. and Gondo,Y.
  TITLE     Molecular characterization of ENU mouse mutagenesis and archives
  JOURNAL   Biochem Biophys Res Commun 336 (2), 609-616 (2005)
   PUBMED   16139793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808027.14, AK013517.1 and BY611716.1.
            
            [WARNING] On Jan 7, 2025 this sequence was replaced by NM_175190.6.
            
            On Mar 14, 2014 this sequence version replaced NM_175190.4.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in its 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (b) is shorter at the N-terminus,
            compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV058067.1, BC021748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL808027.14        141365-141420       c
            57-768              AK013517.1         17-728
            769-780             BY611716.1         436-447
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..780
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /note="SWI5 recombination repair homolog (yeast)"
                     /db_xref="GeneID:72931"
                     /db_xref="MGI:MGI:1920181"
     exon            1..184
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            185..233
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            234..358
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..518
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /note="isoform b is encoded by transcript variant 2; DNA
                     repair protein SWI5 homolog; protein SAE3 homolog"
                     /codon_start=1
                     /product="DNA repair protein SWI5 homolog isoform b"
                     /protein_id="NP_780399.1"
                     /db_xref="CCDS:CCDS50566.1"
                     /db_xref="GeneID:72931"
                     /db_xref="MGI:MGI:1920181"
                     /translation="MIDENNDVSEEALSSDIKKLKEKHDMLDKEISQLIAEGYRVIEL
                     EKHISLLHEYNDIKDVSQMLLGKLAVTRGVTTKELYPDFDLNLND"
     exon            359..453
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            454..780
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      751..756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      769
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggcctatg ggaagcaggg gcggaaccgc tttaacttgg tgcgtgcgca gcctgacgtg
       61 gggcggttgg tggtctccgt cgtcggtttc tagttccctg aagcagccgt ttaaccccaa
      121 ccctggaccc ttccgagttt aagcccaccc cactccgggt gccccggacc ttagggttca
      181 ggaggggtga gtcagaattc agccgacttt accatggcgg ctaccgatca ccgcaacggc
      241 cattccccat gattgatgag aataacgatg tcagcgagga ggccttgagc tctgacatta
      301 agaaactgaa ggagaagcat gacatgctgg acaaggagat ctcccagtta atagcagagg
      361 gctaccgtgt gattgagctg gagaagcata tctccctcct ccatgagtac aatgacatca
      421 aggatgtatc acagatgctg ctggggaagc tggctgtgac tcgaggcgtt accaccaagg
      481 agttatatcc agattttgat ctaaacctga atgactgagc agcttcttgg agattttcat
      541 ctacagccca cagggacagg aggatggggg cataaaaggc agagtctaga cagtatgttc
      601 atatggtttt cagattttaa aagatgctag aagccctcca aagtttgggg tgggttctag
      661 agaagaggag tattgggagg ggtgggtatt gtcaatgtta aggttcctaa acatacttgt
      721 gagtaggtgt gtgtggttgt cccttttgtt aataaacata tgagcagtct ctggttctga
//
