LOCUS       NP_780399                 89 aa            linear   ROD 03-JUN-2024
DEFINITION  DNA repair protein SWI5 homolog isoform b [Mus musculus].
ACCESSION   NP_780399
VERSION     NP_780399.1
DBSOURCE    REFSEQ: accession NM_175190.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 89)
  AUTHORS   Lu,C.H., Yeh,H.Y., Su,G.C., Ito,K., Kurokawa,Y., Iwasaki,H., Chi,P.
            and Li,H.W.
  TITLE     Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by
            modulating Rad51 dissociation
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10059-E10068 (2018)
   PUBMED   30297419
  REMARK    GeneRIF: Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous
            recombination.
REFERENCE   2  (residues 1 to 89)
  AUTHORS   Su,G.C., Yeh,H.Y., Lin,S.W., Chung,C.I., Huang,Y.S., Liu,Y.C.,
            Lyu,P.C. and Chi,P.
  TITLE     Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination
  JOURNAL   Nucleic Acids Res 44 (13), 6242-6251 (2016)
   PUBMED   27131790
  REMARK    GeneRIF: Our results thus help establish the functional relevance
            of the trimeric RAD51-SWI5-SFR1 complex and provide insights into
            the mechanistic underpinnings of homology-directed DNA repair in
            mammalian cells.
REFERENCE   3  (residues 1 to 89)
  AUTHORS   Tsai,S.P., Su,G.C., Lin,S.W., Chung,C.I., Xue,X., Dunlop,M.H.,
            Akamatsu,Y., Jasin,M., Sung,P. and Chi,P.
  TITLE     Rad51 presynaptic filament stabilization function of the mouse
            Swi5-Sfr1 heterodimeric complex
  JOURNAL   Nucleic Acids Res 40 (14), 6558-6569 (2012)
   PUBMED   22492707
  REMARK    GeneRIF: Biophysical evidence that the mouse Swi5-Sfr1 complex has
            a 1:1 stoichiometry.
REFERENCE   4  (residues 1 to 89)
  AUTHORS   Akamatsu,Y. and Jasin,M.
  TITLE     Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair
            through homologous recombination
  JOURNAL   PLoS Genet 6 (10), e1001160 (2010)
   PUBMED   20976249
  REMARK    GeneRIF: Data show that Swi5-Sfr1 is a newly identified complex
            required for genomic integrity in mammalian cells with a specific
            role in the repair of DNA strand breaks.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 89)
  AUTHORS   Sakuraba,Y., Sezutsu,H., Takahasi,K.R., Tsuchihashi,K.,
            Ichikawa,R., Fujimoto,N., Kaneko,S., Nakai,Y., Uchiyama,M.,
            Goda,N., Motoi,R., Ikeda,A., Karashima,Y., Inoue,M., Kaneda,H.,
            Masuya,H., Minowa,O., Noguchi,H., Toyoda,A., Sakaki,Y., Wakana,S.,
            Noda,T., Shiroishi,T. and Gondo,Y.
  TITLE     Molecular characterization of ENU mouse mutagenesis and archives
  JOURNAL   Biochem Biophys Res Commun 336 (2), 609-616 (2005)
   PUBMED   16139793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808027.14, AK013517.1 and BY611716.1.
            
            [WARNING] On Jan 7, 2025 this sequence was replaced by NP_780399.2.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in its 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (b) is shorter at the N-terminus,
            compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV058067.1, BC021748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..89
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     Protein         1..89
                     /product="DNA repair protein SWI5 homolog isoform b"
                     /note="DNA repair protein SWI5 homolog; protein SAE3
                     homolog"
                     /calculated_mol_wt=10129
     Region          13..88
                     /region_name="Swi5"
                     /note="pfam07061"
                     /db_xref="CDD:462077"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K3D3.1)"
     CDS             1..89
                     /gene="Swi5"
                     /gene_synonym="1500019F05Rik; 2900010J23Rik"
                     /coded_by="NM_175190.5:249..518"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS50566.1"
                     /db_xref="GeneID:72931"
                     /db_xref="MGI:MGI:1920181"
ORIGIN      
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//
