LOCUS       NM_009302               3993 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus SWA-70 protein (Swap70), transcript variant 1, mRNA.
ACCESSION   NM_009302
VERSION     NM_009302.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3993)
  AUTHORS   Chang,C.Y., Pearce,G., Betaneli,V., Kapustsenka,T., Hosseini,K.,
            Fischer-Friedrich,E., Corbeil,D., Karbanova,J., Taubenberger,A.,
            Dahncke,B., Rauner,M., Furesi,G., Perner,S., Rost,F. and
            Jessberger,R.
  TITLE     The F-actin bundler SWAP-70 promotes tumor metastasis
  JOURNAL   Life Sci Alliance 7 (8), e202302307 (2024)
   PUBMED   38760173
  REMARK    GeneRIF: The F-actin bundler SWAP-70 promotes tumor metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3993)
  AUTHORS   Qian,Q., Hu,F., Yu,W., Leng,D., Li,Y., Shi,H., Deng,D., Ding,K.,
            Liang,C. and Liu,J.
  TITLE     SWAP70 Overexpression Protects Against Pathological Cardiac
            Hypertrophy in a TAK1-Dependent Manner
  JOURNAL   J Am Heart Assoc 12 (7), e028628 (2023)
   PUBMED   36974751
  REMARK    GeneRIF: SWAP70 Overexpression Protects Against Pathological
            Cardiac Hypertrophy in a TAK1-Dependent Manner.
REFERENCE   3  (bases 1 to 3993)
  AUTHORS   Chen,Z., Flores Castro,D., Gupta,S., Phalke,S., Manni,M.,
            Rivera-Correa,J., Jessberger,R., Zaghouani,H., Giannopoulou,E.,
            Pannellini,T. and Pernis,A.B.
  TITLE     Interleukin-13 Receptor alpha1-Mediated Signaling Regulates
            Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis
  JOURNAL   Arthritis Rheumatol 74 (9), 1544-1555 (2022)
   PUBMED   35438841
REFERENCE   4  (bases 1 to 3993)
  AUTHORS   Dohnke,S., Moehser,S., Surnov,A., Kurth,T., Jessberger,R.,
            Kretschmer,K. and Garbe,A.I.
  TITLE     Role of Dynamic Actin Cytoskeleton Remodeling in Foxp3+ Regulatory
            T Cell Development and Function: Implications for
            Osteoclastogenesis
  JOURNAL   Front Immunol 13, 836646 (2022)
   PUBMED   35359955
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3993)
  AUTHORS   Ricker,E., Manni,M., Flores-Castro,D., Jenkins,D., Gupta,S.,
            Rivera-Correa,J., Meng,W., Rosenfeld,A.M., Pannellini,T., Bachu,M.,
            Chinenov,Y., Sculco,P.K., Jessberger,R., Prak,E.T.L. and
            Pernis,A.B.
  TITLE     Altered function and differentiation of age-associated B cells
            contribute to the female bias in lupus mice
  JOURNAL   Nat Commun 12 (1), 4813 (2021)
   PUBMED   34376664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3993)
  AUTHORS   Gross,B., Borggrefe,T., Wabl,M., Sivalenka,R.R., Bennett,M.,
            Rossi,A.B. and Jessberger,R.
  TITLE     SWAP-70-deficient mast cells are impaired in development and
            IgE-mediated degranulation
  JOURNAL   Eur J Immunol 32 (4), 1121-1128 (2002)
   PUBMED   11920580
  REMARK    GeneRIF: In mast cells SWAP-70 plays a role both in establishing
            the initial competence to degranulate and to develop into mature
            mast cells.
REFERENCE   7  (bases 1 to 3993)
  AUTHORS   Borggrefe,T., Keshavarzi,S., Gross,B., Wabl,M. and Jessberger,R.
  TITLE     Impaired IgE response in SWAP-70-deficient mice
  JOURNAL   Eur J Immunol 31 (8), 2467-2475 (2001)
   PUBMED   11500831
  REMARK    GeneRIF: SWAP-70 deficient mice exhibit B cell anomalies including
            increased autoantibody production and impaired isotype switching.
REFERENCE   8  (bases 1 to 3993)
  AUTHORS   Masat,L., Liddell,R.A., Mock,B.A., Kuo,W.L., Jessberger,R., Wabl,M.
            and Morse,H.C. 3rd.
  TITLE     Mapping of the SWAP70 gene to mouse chromosome 7 and human
            chromosome 11p15
  JOURNAL   Immunogenetics 51 (1), 16-19 (2000)
   PUBMED   10663557
REFERENCE   9  (bases 1 to 3993)
  AUTHORS   Borggrefe,T., Masat,L., Wabl,M., Riwar,B., Cattoretti,G. and
            Jessberger,R.
  TITLE     Cellular, intracellular, and developmental expression patterns of
            murine SWAP-70
  JOURNAL   Eur J Immunol 29 (6), 1812-1822 (1999)
   PUBMED   10382743
REFERENCE   10 (bases 1 to 3993)
  AUTHORS   Borggrefe,T., Wabl,M., Akhmedov,A.T. and Jessberger,R.
  TITLE     A B-cell-specific DNA recombination complex
  JOURNAL   J Biol Chem 273 (27), 17025-17035 (1998)
   PUBMED   9642267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147244.2 and AC124472.4.
            
            On Mar 2, 2023 this sequence version replaced NM_009302.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065136.1, AK146773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC147244.2         851-1008            c
            159-299             AC124472.4         151256-151396       c
            300-473             AC124472.4         138872-139045       c
            474-701             AC124472.4         130673-130900       c
            702-848             AC124472.4         128798-128944       c
            849-957             AC124472.4         126890-126998       c
            958-1139            AC124472.4         124699-124880       c
            1140-1247           AC124472.4         121413-121520       c
            1248-1414           AC124472.4         119979-120145       c
            1415-1613           AC124472.4         115402-115600       c
            1614-1710           AC124472.4         114117-114213       c
            1711-3993           AC124472.4         111267-113549       c
FEATURES             Location/Qualifiers
     source          1..3993
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.7 cM"
     gene            1..3993
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /note="SWA-70 protein"
                     /db_xref="GeneID:20947"
                     /db_xref="MGI:MGI:1298390"
     exon            1..158
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1817
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /note="isoform 1 is encoded by transcript variant 1;
                     switch-associated protein 70; SWAP-70; SWAP complex
                     protein, 70 kDa"
                     /codon_start=1
                     /product="switch-associated protein 70 isoform 1"
                     /protein_id="NP_033328.3"
                     /db_xref="CCDS:CCDS21744.1"
                     /db_xref="GeneID:20947"
                     /db_xref="MGI:MGI:1298390"
                     /translation="MRGLKDELLKAIWHAFTALDLDRSGKVSKSQLKVLSHNLCTVLK
                     VPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKN
                     LTKSPLLITEDDAFKVWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGGGWQQEQFE
                     HYKINFDDNKDGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMM
                     KKGHKRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFL
                     IKCFDKTFEISASDKKKKQEWIQAIYSTIHLLKLGSPPPHKEARQRRKELRRKLLAEQ
                     EELERQMKELQAANENKQQELESVRKKLEEAASRAADEEKKRLQTQVELQTRFSTELE
                     REKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQ
                     ARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEQQRVMKEQALQEAMAQLEQLEL
                     ERKQALEQYEGVKKKLEMATHMTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAF
                     TQAELEEREKSWKEKKTTE"
     exon            159..299
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            300..473
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            474..701
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            702..848
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            849..957
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1139
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1247
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1414
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1613
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1710
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..3993
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /note="hexamer: AATAAA"
     polyA_site      2979
                     /gene="Swap70"
                     /gene_synonym="70kDa"
     regulatory      3898..3903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /note="hexamer: ATTAAA"
     polyA_site      3918
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /note="major polyA site"
     regulatory      3962..3967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Swap70"
                     /gene_synonym="70kDa"
                     /note="hexamer: ATTAAA"
     polyA_site      3993
                     /gene="Swap70"
                     /gene_synonym="70kDa"
ORIGIN      
        1 agaggcgctg agttgccgac tgggctgacc aggtctgtta gggcagcgcg gccgcggcca
       61 tgaggggctt gaaagacgaa ctgctcaaag ccatttggca cgccttcacc gcgctcgacc
      121 tggaccgcag cggcaaggtc tccaagtcgc aactcaaggt cctttcccat aacctgtgca
      181 cggtgctgaa ggttccacat gacccggttg cccttgagga gcactttagg gatgacgatg
      241 aggggcctgt ctccaatcag ggctacatgc catatttaaa caagttcatt ttggaaaagg
      301 tccaagacaa ctttgacaag attgaattca atagaatgtg ttggacactt tgtgtcaaga
      361 aaaacctcac aaagagtcct ctactcatta cagaagatga tgcatttaaa gtgtgggtca
      421 ttttcaactt tttgtcagag gacaagtatc cactaattat tgtgccagaa gagattgaat
      481 acctgcttaa gaagcttaca gaagctatgg gaggaggttg gcaacaagaa caatttgaac
      541 attacaaaat aaactttgat gacaataaag atggcctttc tgcatgggaa cttattgagc
      601 taattgggaa tggacagttt agcaagggca tggaccgtca gaccgtatct atggccatta
      661 acgaagtctt caatgagctt attttagatg tattgaagca gggttacatg atgaagaaag
      721 gtcacaaacg gaaaaactgg actgagcgct ggtttgtatt aaaacccaac ataatttcct
      781 actatgtgag cgaggatctg aaagataaga aaggagacat cctgctggat gaaaactgct
      841 gtgtggagtc tctgcctgac aaagatggaa agaaatgtct ttttctaata aaatgctttg
      901 ataagacctt tgaaatcagt gcctcagata agaagaagaa acaagaatgg attcaggcca
      961 tttactccac catccatctg ttgaagctgg gcagcccccc accacacaag gaagcccgcc
     1021 agcgtcggaa agagctccga aggaagctgc tagccgagca ggaggagctg gagcggcaga
     1081 tgaaggaact ccaagccgcc aatgaaaaca agcaacagga gctggaaagc gtgaggaaga
     1141 aactggagga agcagcctct cgtgcggcag acgaggaaaa gaaacgcttg cagactcagg
     1201 tggagctaca gaccaggttc agcacggagc tggagcggga gaagctgatc agacagcaga
     1261 tggaggagca ggttgcccag aagtcctccg aactggagca gtatctgcag cgagttcggg
     1321 agctggaaga catgtaccta aagctgcagg aggctcttga ggacgagagg caggcccggc
     1381 aggatgaaga gactgtgcgc aagcttcagg ccaggttgct ggaggaagag tcttctaaga
     1441 gggcagagct ggaaaagtgg cacctggagc agcagcaggc cattcagaca acagaggcgg
     1501 agaagcagga gctggaacag cagcgtgtca tgaaggagca ggcattgcag gaggccatgg
     1561 cacagctgga acagttggag ttggagcgga agcaggccct ggagcagtat gagggagtta
     1621 aaaagaagct agagatggca acacatatga ccaagagctg gaaggacaaa gtggcccatc
     1681 atgagggatt aatacgattg atagaaccag gttccaagaa ccctcatctg atcaccaact
     1741 ggggacccgc agcgttcacc caggcagagc tcgaggagag agagaagagc tggaaagaga
     1801 agaagaccac agagtgacgg ccgtcccagc ggtcacccag tcagtcacat cagtgaggag
     1861 tcaagagctt catacctggg acaagaacat tggctttgct gcttctaagt ctcccctcag
     1921 ggctccagca gggtcctgtg ctgaggacgc catgtttacc ttctagagat gtctcagctc
     1981 tcctggcgag aacataggca caggtgtggc tggagccacc tcactgttgt cttctgcagc
     2041 ccttgcagcc cctggtctca gccccgcctt ggatgggagg tcagctgtct cctcccctcc
     2101 ggcagcgcat tcccttggcc gattgcctgg tctgttggcc tctttgagtc aggtgtcatg
     2161 gcaagcctcc gctgttggtg ctctgatgga caagtcacta gtcactgccc ttgtggatgg
     2221 aatctggttg gtgactcttc ccagcttcag ctaagatact tccctccctg accaccacac
     2281 acatggcatg cttcgtttgc attttctttc tcctcacctc aaagcaagac ttatcctggc
     2341 ccagcggctc aacttagttc tttgggtgtt ctgtccccag ctgctagtct gttgaaatca
     2401 atggtgattg gatagtttgg ggggttacat gggcacagtg gaagctgaca gaatgtggac
     2461 tggtaagatg taaagtgtca caggatgatg gccagccttg tggctttcac tagaactatg
     2521 tctctctgct tttccctccg aggatgacac agattgtggt ttgtatgctt cttgtttgag
     2581 gaatgatttc agccctaatc tggtctgaga cggagatgag tggttggaaa gtaagcctta
     2641 ccacactagt tggaatctgt aaccagcagt aactccatgc acagccaaga agctttacat
     2701 tataaacagg aaggtgaccc atgtggcaca gaagaggtgg gactcagtag agagcaggga
     2761 cccccacggg cctggtccag ccttgcctca gagcaggaag gaggccattc cagacatgtg
     2821 caagtctaca gatagatccc agcagtcctg gcatctacat aaggactgga tagagttcca
     2881 ttaatctctg ccttttatga ctggaaaaca tttgccaatg gaagtcttac caatttttct
     2941 taagattttg ggctgcttaa taaaagtaat tttatttaat gtttatagtt gccttcatac
     3001 agtttagatt tgtgtgcaaa gtatcactgt gtcacgaacc ttcttagtgg ataacttggg
     3061 tgtaggtttg gacctggcca ttcactcacc atgtttcctt gtcagtgcag ccgggaatca
     3121 gaccaagggg accagggtct cccctgtgtc ttgatgatgt ctcctagaga cctcagtgtc
     3181 cttggagaga aaagaaaaag aaactccaag aaggtactgg ccggtgtgaa atgtctggac
     3241 ggaagcaagg gcctgggggt ccaggggaga ctggggtaaa gggatcgccc gggccgggct
     3301 gacagaacct ccctccttaa acctggactg tcttacagca cagccagagg catggcccgc
     3361 agctgccacg gccctccttg tctggtctca agcctgaata ctgcatgctc cctttgtatg
     3421 ggctgtgcag aaggcgtctg cagtctgtag tgtttgtttc tgcttgcctc accggcttca
     3481 gtagcactgt ggctgggaag tgaaagtcct ttgtagacag tggatgagaa gaccgcacag
     3541 atgtgaactg tgtgactccc ctttaggcca atgcgctgat acttgtgggt ctctcctgat
     3601 actcaaggtg gtttcagcta agtgtctata gaccgtgcct catctctgta ataactacag
     3661 gaaacgttgg gagtgtctgt ctgtgtgttc actgtaatca gccctttcct ccaacgagag
     3721 atgagattat ttgcaggaat tatgaatgaa aagcatttga aaatgttttg ggatctacta
     3781 tattgagaat gaacaaaata tttataattt taaaacattt ttatctacac atacaatgta
     3841 atatgctcta cttcttgttt tttttttgtt ttgttttttt gctaattttt ctaaggtatt
     3901 aaaatgtttt ctatgggatt tttggtttct atttttttag taaagtggac tcaataacaa
     3961 aattaaacat accagaattt catacatttt aaa
//
