LOCUS       NM_021363               1200 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus seminal vesicle secretory protein 3A (Svs3a),
            transcript variant 1, mRNA.
ACCESSION   NM_021363
VERSION     NM_021363.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Lin,H.J., Lee,C.M., Luo,C.W. and Chen,Y.H.
  TITLE     Functional preservation of duplicated pair for RSVS III gene in the
            REST locus of rat 3q42
  JOURNAL   Biochem Biophys Res Commun 326 (2), 355-363 (2005)
   PUBMED   15582586
  REMARK    GeneRIF: Report the gene duplication of SVS III in both mouse and
            rat.
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Lin,H.J., Luo,C.W. and Chen,Y.H.
  TITLE     Localization of the transglutaminase cross-linking site in SVS III,
            a novel glycoprotein secreted from mouse seminal vesicle
  JOURNAL   J Biol Chem 277 (5), 3632-3639 (2002)
   PUBMED   11723121
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Ulvsback,M., Lazure,C., Lilja,H., Spurr,N.K., Rao,V.V., Loffler,C.,
            Hansmann,I. and Lundwall,A.
  TITLE     Gene structure of semenogelin I and II. The predominant proteins in
            human semen are encoded by two homologous genes on chromosome 20
  JOURNAL   J Biol Chem 267 (25), 18080-18084 (1992)
   PUBMED   1517240
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Moutier,R. and Bertrand,M.F.
  TITLE     Syp-3, a third polymorphic locus for mouse seminal vesicle proteins
  JOURNAL   Biochem Genet 21 (7-8), 797-800 (1983)
   PUBMED   6626148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC131996.1, BY722061.1, DV048837.1 and AK020575.1.
            
            On Sep 17, 2009 this sequence version replaced NM_021363.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131996.1, AF242220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               BC131996.1         1-232
            233-573             BY722061.1         229-569
            574-1095            DV048837.1         142-663
            1096-1200           AK020575.1         1093-1197
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.07 cM"
     gene            1..1200
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /note="seminal vesicle secretory protein 3A"
                     /db_xref="GeneID:64335"
                     /db_xref="MGI:MGI:1927635"
     exon            1..94
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..819
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; semenogelin II; seminal vesicle secretion 3A;
                     seminal vesicle protein 3; SVS III; seminal vesicle
                     secretory protein III; seminal vesicle secretion 3 alpha"
                     /codon_start=1
                     /product="seminal vesicle secretory protein 3A isoform 1
                     precursor"
                     /protein_id="NP_067338.2"
                     /db_xref="CCDS:CCDS17030.1"
                     /db_xref="GeneID:64335"
                     /db_xref="MGI:MGI:1927635"
                     /translation="MKSIFFSLSLLLLLEKKAAGIELYAGGTKGHFLVKTSPLMFIGK
                     NQFLYGHKEEQEEAPEESIFVQTKHHEYGQDADADMGGALSSQELTSLKEDIVCEEED
                     ELAQQKSQLPSQSQIKSQTQVKSYAAQLKSQPGQLKTIGQVKSQTMLKSHGAPLKSFK
                     ARLNLREDIPQQVKGRGYGLAEDLAQVRQQPAKVHRLKGKHRQSRKTAAFYPQFRRRS
                     RPYPRYFVQFQEQLQGSVHHTKSFYPGPGMCYCPRGGVILYQDAFTD"
     exon            95..859
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1200
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1167..1172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /note="hexamer: AATAAA"
     polyA_site      1191
                     /gene="Svs3a"
                     /gene_synonym="9530026M05Rik; Semg2; Svp-3; Svp3; Svs3"
                     /note="major polyA site"
ORIGIN      
        1 gtggaggccc ttcctggtaa gatgaagtcc atcttcttca gcctttctct gctcctcctt
       61 ctggagaaga aagcagctgg gatagaactc tatgcaggtg gaacaaaagg acacttccta
      121 gtaaaaacct ccccactcat gtttattggg aaaaaccagt tcctctatgg gcacaaagaa
      181 gaacaggaag aggcacctga agaaagcatc tttgtgcaaa ctaagcacca tgaatatggc
      241 caggatgctg atgctgacat gggaggggca ctcagttcac aggaactgac aagtttaaag
      301 gaagacatag tttgtgaaga agaagatgag cttgcccaac aaaaatccca gctgccatcc
      361 cagtcacaaa taaaatccca aactcaagta aaatcctacg cagcccaact gaagtcccaa
      421 ccaggccagc taaagaccat agggcaggtg aagtcacaaa ccatgctgaa atcccacgga
      481 gcccctctga agtccttcaa agcacgcctt aatctgcgag aagacattcc tcagcaagtc
      541 aagggcagag gatatggcct ggctgaagac ctggcccaag tgcgtcaaca gccagcaaag
      601 gttcacaggc tcaaaggaaa gcacaggcag tccaggaaaa cagcagcatt ctacccacag
      661 ttcagacgcc gctctcggcc ctaccctcgg tactttgtgc aatttcaaga gcagctacag
      721 ggcagtgttc atcacacaaa atctttctac ccaggtcctg ggatgtgcta ctgtccaaga
      781 ggaggggtga ttctatacca agatgccttc actgattaag gcattcatta acctctcaag
      841 aattaagaca catttagagg agtcacctga cctgtgtgga ctgtgatgtc ctgaagatgc
      901 tgaccactct ctagtcctca acaccttgca cggatgccat gacccactca cacattcctt
      961 cctgagactt tctaatgttg gagcaacctc acacaggtgc tctctaataa gcagagcctt
     1021 gctgacatca tttgcttttg actgttgaaa tctccaagtt cctagtggtt tcggtgcttg
     1081 ggtggcacat tttcaaatga tcaactcaca ctgaaacatc cgtacactct tgtagtgtta
     1141 cacatactag aaaacaagtg tttcccaata aagatattgc tttggcatca attgcttttt
//
