LOCUS       NM_026805               3186 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SV2 related protein (Svop), transcript variant 1,
            mRNA.
ACCESSION   NM_026805 XM_149659
VERSION     NM_026805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3186)
  AUTHORS   Yao,J., de la Iglesia,H.O. and Bajjalieh,S.M.
  TITLE     Loss of the SV2-like protein SVOP produces no apparent deficits in
            laboratory mice
  JOURNAL   PLoS One 8 (7), e68215 (2013)
   PUBMED   23894296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3186)
  AUTHORS   Cho,E.Y., Lee,C.J., Son,K.S., Kim,Y.J. and Kim,S.J.
  TITLE     Characterization of mouse synaptic vesicle-2-associated protein
            (Msvop) specifically expressed in the mouse central nervous system
  JOURNAL   Gene 429 (1-2), 44-48 (2009)
   PUBMED   19013223
  REMARK    GeneRIF: These results indicate that msvop is a central nervous
            system-specific gene and could be utilized for elucidating gene
            regulation in neuronal cells.
REFERENCE   5  (bases 1 to 3186)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
REFERENCE   6  (bases 1 to 3186)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   7  (bases 1 to 3186)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047764.1, AK053833.1 and AK082744.1.
            
            On Aug 14, 2005 this sequence version replaced XM_149659.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082744.1, AK053833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK047764.1         2-11
            11-3131             AK053833.1         2-3122
            3132-3186           AK082744.1         3144-3198
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.94 cM"
     gene            1..3186
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /note="SV2 related protein"
                     /db_xref="GeneID:68666"
                     /db_xref="MGI:MGI:1915916"
     exon            1..229
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1841
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptic vesicle 2-related protein"
                     /codon_start=1
                     /product="synaptic vesicle 2-related protein isoform 1"
                     /protein_id="NP_081081.1"
                     /db_xref="CCDS:CCDS39220.1"
                     /db_xref="GeneID:68666"
                     /db_xref="MGI:MGI:1915916"
                     /translation="MEEDLFQLRQLPVVKFRRTGESARSEDDAASGEHDIQIEGVRVG
                     LEAIELDDGAAVPKEFANPTDDTFMVEDAVEAIGFGRFQWKLSVLTGLAWMADAMEMM
                     ILSILAPQLHCEWRLPSWQVALLTSVVFIGMMSSSTLWGNISDQYGRKTGLKISVLWT
                     LYYGILSAFAPVYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWA
                     IGTVFEVLLAVFVMPSLGWRWLLLLSAAPLLLFAVLCFWLPESARYDVLSGNQEKAIA
                     TLKRIATENGAPMPLGKLIISRQEDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGL
                     VLLTTELFQAGDVCSISSRKKAVEAKCSLACEYLSKEDYMDLLWTTLSEFPGVLVTLW
                     VIDRLGRKKTMALCFIIFSLCSLLLFICIGRNVLTLLLFIARAFISGGFQAAYVYTPE
                     VYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAGVASCFL
                     PIETKGRALQESSHREWGQEMVGRGTNSAGVPRSDSGSQE"
     exon            230..390
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            391..476
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            477..575
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            576..647
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            648..772
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            773..836
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            837..962
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1091
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1165
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1242
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1350
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1462
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1544
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1634
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..3186
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1961
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
     regulatory      3113..3118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /note="hexamer: ATTAAA"
     polyA_site      3137
                     /gene="Svop"
                     /gene_synonym="1110030H18Rik; msvop"
                     /note="major polyA site"
ORIGIN      
        1 gcccactcct gtcggtctcc cggcggtggc agcggctggc tttgtctccc gggcagggct
       61 ccctccccca gcagctagct gcccagcgag gaagcggtag agctgtccag catcccggtg
      121 ctgaaagccg gagcaccggc ccttgctcca ccatgtaagg gtcatgccca ggctcgccct
      181 ggcgcaccgc ggacatggag gaggatctgt tccagctcag gcagttgccg gtggtgaaat
      241 tccgacgcac aggggagagt gctcggtcag aggacgatgc ggcttccggg gagcatgaca
      301 tccagattga gggggtccga gtgggcctag aagccatcga gctggatgat ggagccgctg
      361 tccccaagga gtttgccaat cccactgatg acactttcat ggtggaagat gcggtggaag
      421 ccattgggtt tggaagattt cagtggaagc tctctgttct cacaggcttg gcttggatgg
      481 cagatgccat ggagatgatg attctgagca tcctggctcc tcagctgcat tgcgagtggc
      541 gactccccag ctggcaggtg gcgctgctca cttcggtggt cttcatcggc atgatgtcca
      601 gttccacgct ctggggaaac atctcggacc agtatggcag gaaaactggg ctgaagatca
      661 gtgtgctctg gaccctgtac tatggcatcc tcagcgcctt cgcgcccgtg tatagctgga
      721 tcctggtgct ccgaggcctg gtgggctttg ggattggagg ggtgccccag tcggtgacgc
      781 tgtacgccga gttccttccc atgaaggcca gagccaagtg cattttgctg attgaggtct
      841 tctgggccat agggaccgtg ttcgaggtgc ttctggctgt gtttgtgatg cccagcctgg
      901 gctggcgctg gctgctcctg ctctcggccg ctccactact actcttcgct gttctgtgct
      961 tctggctgcc agagagtgct aggtacgatg tgctgtccgg gaaccaggaa aaggcaatcg
     1021 ctactttaaa gcggattgca acggaaaatg gagcccccat gcctctggga aagcttatca
     1081 tctccagaca ggaagaccga ggcaaaatga gggacctttt cacaccccac tttcgttgga
     1141 caactctgct gctgtggttt atatggttct ccaatgcctt ctcttactac ggcttggttc
     1201 tgctcaccac ggaactcttc caggcaggag acgtctgcag catctccagc cggaagaagg
     1261 cagtggaagc caaatgcagc ttggcctgtg agtacctgag caaagaggat tacatggacc
     1321 tgctgtggac caccctgtcc gagttcccag gtgtccttgt gactctgtgg gtcatcgacc
     1381 gcctgggccg caagaagacc atggctctgt gtttcatcat cttctccctc tgcagcctcc
     1441 tgctgttcat ctgcattgga agaaatgtgc taaccctctt actgttcatc gccagagcgt
     1501 ttatttctgg aggcttccaa gcagcctatg tttacacgcc tgaggtgtat cccacggcga
     1561 cgagggcgct gggtttgggc acctgcagcg gcatggcgag agtgggcgct ctcattactc
     1621 cgttcatagc tcaggtgatg ctggaatctt ccgtgtacct gaccctggct gtctacagtg
     1681 gctgctgcct cctggctggc gtggcctcct gctttctgcc catagagacc aaaggccgag
     1741 cactgcagga gtccagccac cgggagtggg gccaagagat ggttggccga gggacaaaca
     1801 gcgcaggtgt ccccaggtcg gactctggct ctcaggagta gtgacccctg ggagttgagc
     1861 ttggagccta gagagctggc agagcccagc tgggccactt atggtcactg ccgacatcaa
     1921 gaacttcccc cccacccccg agagggcgat gtggaccgac agggttttgt gtcttcactg
     1981 tgtttgacca tgttcatcat cgagggtcat gcgccccagg aagatggggc agcattcact
     2041 ccagggggtt ctctgtggtg ggggatgggc tgcacatcac cgtggatctg catggggaag
     2101 ctgctagtga gggagggtcc cagggtgctc agagccagct gagcagatgt cacattgcta
     2161 cccagtcata cccttggaga gccactgccc aaaggtctcc atagatagtc tccgcccaga
     2221 cccctgggac gcccgccatt ttgtccagtt atgtttctcc tgcaccctgg cctcaggaat
     2281 tctttggaat taaggcaagc tagctagtgt ctggctggag cagctcttct ggagcctgag
     2341 actccctcac ccccaccccc tgctgctacc ttggctgggc ccctctagat gcctctccac
     2401 aacctgcggg ggtagaaact ggccaatgaa agtgctttgg aatttgagcc aagtagcccc
     2461 tgttggcccc ttgtggagtc tctgtttctg gctgcagagg gtccagtgat atttctgggg
     2521 agagctacat acccgccagg cagcagacgc agaaagttgt taacccattc cctgacttgg
     2581 agactgaggc ctggcgatgg ggaggctgaa gccagagtcg ctcctggagc agttaaggcc
     2641 tttctgggct ccccgctcag ccctactaga cggcgagtcc cagtttactc aggcttccag
     2701 actttgccct gtgtgggtgg cagcatgggt tgaggaggga tctctagggc aaagcatcac
     2761 taagtcctgg gaccaggaac ctgttgcccc ctctgggtct gcctctgctt tctttctgtc
     2821 gagggcaatg ctggccctac agaggcaggc cctgggagtc tgtcctggca caaggatctc
     2881 cctttcagag agagaggagg aggaaggata agatgtaggt aggtctgtct tggggctgtc
     2941 cacgcatcct cccagattcc ggaacacatg agccgccttc tgaaattcag gaaggaaact
     3001 cgcagtggga ggaaggagac cgccaggccc cattaaaggc cggaggaaac tggtcactgc
     3061 tcaatggaca cattgcaagg aagccaaatg tgcgctgcgc tgttcatctc ttattaaaac
     3121 gttggtgacg gacattacta tgggatttaa atctggtcac tggccacggt gcactagtga
     3181 cagttt
//
