LOCUS       NM_001405277            8155 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus supervillin (Svil), transcript variant 3, mRNA.
ACCESSION   NM_001405277 XM_006525794
VERSION     NM_001405277.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8155)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8155)
  AUTHORS   Smith,T.C., Vasilakos,G., Shaffer,S.A., Puglise,J.M., Chou,C.H.,
            Barton,E.R. and Luna,E.J.
  TITLE     Novel gamma-sarcoglycan interactors in murine muscle membranes
  JOURNAL   Skelet Muscle 12 (1), 2 (2022)
   PUBMED   35065666
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8155)
  AUTHORS   Gresakova,V., Novosadova,V., Prochazkova,M., Prochazka,J. and
            Sedlacek,R.
  TITLE     Dual role of Fam208a during zygotic cleavage and early embryonic
            development
  JOURNAL   Exp Cell Res 406 (2), 112723 (2021)
   PUBMED   34216590
REFERENCE   4  (bases 1 to 8155)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8155)
  AUTHORS   Pollock,L.M., Gupta,N., Chen,X., Luna,E.J. and McDermott,B.M. Jr.
  TITLE     Supervillin Is a Component of the Hair Cell's Cuticular Plate and
            the Head Plates of Organ of Corti Supporting Cells
  JOURNAL   PLoS One 11 (7), e0158349 (2016)
   PUBMED   27415442
  REMARK    GeneRIF: supervillin, an F-actin cross-linking protein, localizes
            to cuticular plates in hair cells of the mouse cochlea and
            vestibule. Supervillin localizes near the apicolateral margins
            within the head plates of Deiters' cells and outer pillar cells,
            and proximal to the apicolateral margins of inner phalangeal cells.
            Overall, supervillin localization suggests this protein may shape
            the surface structure of the organ of Corti.
            Erratum:[PLoS One. 2016 Aug 17;11(8):e0161638. doi:
            10.1371/journal.pone.0161638.. PMID: 27532603]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8155)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   7  (bases 1 to 8155)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 8155)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 8155)
  AUTHORS   Oh,S.W., Pope,R.K., Smith,K.P., Crowley,J.L., Nebl,T.,
            Lawrence,J.B. and Luna,E.J.
  TITLE     Archvillin, a muscle-specific isoform of supervillin, is an early
            expressed component of the costameric membrane skeleton
  JOURNAL   J Cell Sci 116 (Pt 11), 2261-2275 (2003)
   PUBMED   12711699
  REMARK    GeneRIF: archvillin is among the first costameric proteins to
            assemble during myogenesis and that it contributes to myogenic
            membrane structure and differentiation.
REFERENCE   10 (bases 1 to 8155)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124770.4 and AC115928.10.
            
            On Apr 21, 2022 this sequence version replaced XM_006525794.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.18246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               AC124770.4         133813-134345
            534-591             AC124770.4         176304-176361
            592-683             AC124770.4         179344-179435
            684-741             AC124770.4         185785-185842
            742-893             AC124770.4         185960-186111
            894-1503            AC124770.4         188081-188690
            1504-1587           AC124770.4         193211-193294
            1588-2457           AC124770.4         195176-196045
            2458-2622           AC124770.4         196471-196635
            2623-2657           AC124770.4         197321-197355
            2658-2719           AC124770.4         197909-197970
            2720-2859           AC124770.4         198426-198565
            2860-2955           AC124770.4         199711-199806
            2956-3199           AC124770.4         201358-201601
            3200-3776           AC124770.4         202390-202966
            3777-3996           AC124770.4         203667-203886
            3997-4120           AC124770.4         213077-213200
            4121-4168           AC124770.4         216567-216614
            4169-4316           AC115928.10        106012-106159       c
            4317-4406           AC115928.10        102318-102407       c
            4407-4493           AC115928.10        102146-102232       c
            4494-4671           AC115928.10        100128-100305       c
            4672-4844           AC115928.10        97983-98155         c
            4845-5000           AC115928.10        95942-96097         c
            5001-5137           AC115928.10        94268-94404         c
            5138-5285           AC115928.10        93623-93770         c
            5286-5431           AC115928.10        93361-93506         c
            5432-5607           AC115928.10        91340-91515         c
            5608-5752           AC115928.10        89890-90034         c
            5753-6029           AC115928.10        89232-89508         c
            6030-6181           AC115928.10        85216-85367         c
            6182-6287           AC115928.10        83071-83176         c
            6288-6495           AC115928.10        82071-82278         c
            6496-6629           AC115928.10        80234-80367         c
            6630-6785           AC115928.10        74256-74411         c
            6786-6929           AC115928.10        72821-72964         c
            6930-7054           AC115928.10        71845-71969         c
            7055-7210           AC115928.10        70687-70842         c
            7211-8155           AC115928.10        69652-70596         c
FEATURES             Location/Qualifiers
     source          1..8155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 3.02 cM"
     gene            1..8155
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /note="supervillin"
                     /db_xref="GeneID:225115"
                     /db_xref="MGI:MGI:2147319"
     exon            1..533
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            534..591
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            592..683
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..741
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             734..7297
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /note="isoform c is encoded by transcript variant 3;
                     archvillin; p205/p250"
                     /codon_start=1
                     /product="supervillin isoform c"
                     /protein_id="NP_001392206.1"
                     /db_xref="GeneID:225115"
                     /db_xref="MGI:MGI:2147319"
                     /translation="MKRKERIARRLEGIENDSQPILLQSCTGLVTHRLLEEDTPRYMR
                     ATDPASPHIGRSKEEEDTPGSSLEKQTPSKYCIETSGIHSSGSMDTHSLESKAERIAR
                     YKAERRRQLAEKYGLTLDPEADSEYLSRYAKSRKDPDVTERRGKSDKQEEQSKDANSR
                     HSRTESGPRTSLVASQDCTPLGSNMSDQEQLLNVENQRRVQDPPLGEDGSSAFFSERS
                     ISFPEVPRSPKQIPSSPLQQPASPNHPGDSPLPTEARASSTGKPTHEWFLQRDSEGDT
                     PSLINWPSRVKVREKLVKEESARSSPELTSESLTQRRQQPAPAHFLPIQSESSTFDRV
                     TSKAVSSLQPSQSGVLPTDPVHAIKLVTMDTPESTSEFSWVGSATPKVIKSTTLKILE
                     GGSRDAPVLHICESKAEDWLSPEPLERSPKSLLTSEDDRLVRGHKDPSGNKDLDKAII
                     CSIDVESERERQVQHLPTQRTGRSEMLLYVQSGPVSQDATLTSHTKEASPKKRKVLAR
                     SLSDYTGPPQLQVPRHKDEAPSQELELQSSRAEGPGAEASVLDTRVSVAQLRNIFMES
                     TRASKKPELQSRVERSAEGIGLPMERERGSRKPRRYLSPGESRKTSERFRTQPITSAE
                     RKESDRYPSGSEIPVVEDEEKVDERAKLSVAAKRLLFREMEKSFDEHTVPKRHSRNAA
                     VEQRLRRLQDRSHTQPITTEEVVIAATEPIPASCSGVTHPVTARLPSPTVARSSVQPA
                     RLQASAHQKALARDQANEGRESAEPGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNR
                     IDVRQRRMNARYQTQPVTLGEVEQVQSGKLISFSPTVNTSVSIMASAVAPTYAGDLRK
                     LSVDNNTSATDYKSPPAENSDSPVRSILKPQAWRPLVEHSGSKGMPGESGKTESKNAL
                     TVAAEDSGVQTRGAFEEEEEPSYPILGRVREGDGQKEPKHVVLRRGSLELGNPSAAHL
                     GDELKEVSTAKSSLQENLDLKDKQASEENTDVETVMRKFSLKEFGETTSEQTEVAARK
                     ASVQMATPGAWKQQESSEQLAEKLFKNPCAMFASGEVKVPVGDSFLDSPSKTMSIKER
                     LALLKKSGEEDWKNRLIRKQEYGKATGGLHTQEVEQSLKKKEEGGLTDDNAISNVLWR
                     VTESRESQMTIEERKHLITVREEAWKTKGRGAANDSTQFTVAGRMVKKGLASPTSITP
                     ISSPLCSKSRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVAGIQETVL
                     TVTGKSVKEVMKLDDDETFAKFYRSVDHSIPRSPVELEEDFDVIFDPYAPKLTSSVAE
                     HKRQVRPKRRVQASKNPLKLLAARDDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFS
                     EVTLAGLASRENFSNINLRSVNLMEQNSNNSAMPYKKLMLLQIKGRRHVQTRLVEPRA
                     SSLNSGDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLIQTKRELGCRATYIQTIEE
                     GINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYETAIIETNCVYRLTDDKLVPDDDY
                     WGKIPKCSLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCD
                     INPLDPGECNPLIPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTELKRPTEKNSGE
                     VVQQKDDPRADVKPYDVTRMVATPQITAGTILDGVNVGRGYGLVEGDDRRQFEIATVS
                     VDVWHILEFDYSRLPRQSIGQFHEGDAYVVKWKYMASTAVGSRQKGEHLVRVAGKEKC
                     VYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGR
                     REEEEENVQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHG
                     CKAQGHTKEVGRTAANKIKEECPLEAGLHSSSNVTIHECDEGSEPLGFWDALGRRDRK
                     AYDCMLQDPGSFNFAPRLFILSSSSGDFSATEFVYPAQAPSAVSSMPFLQEDLYSAPQ
                     PALFLVDNHHEVYLWQGWWPTENKITGSARIRWASDRKSAMETVLQYCRGKNLKRPPP
                     KSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPL
                     ADLLARPLPEGVDPLKLEIYLTDEDFEFALDMSRDEFNALPTWKQVNLKKSKGLF"
     exon            742..893
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1503
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1587
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..2457
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2622
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2657
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2719
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2859
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2955
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3199
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3776
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3996
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4120
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4168
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4316
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4406
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4493
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4494..4671
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4672..4844
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4845..5000
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5137
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5138..5285
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5286..5431
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5432..5607
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5608..5752
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..6029
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6030..6181
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6182..6287
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6288..6495
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6496..6629
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6630..6785
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6786..6929
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6930..7054
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7055..7210
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7211..8155
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8061..8066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8085
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
     regulatory      8132..8137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8155
                     /gene="Svil"
                     /gene_synonym="B430302E16Rik"
                     /note="major polyA site"
ORIGIN      
        1 acattgcctc cgattgtgtc ctccacggca gtgtcctcag gtttcatgtg gatttaccca
       61 gtaatggatg actctgccaa gaccagactg ggcaagcgca gcctcgaaga caccaggggc
      121 ctgggaactt caaaaagaag actcttttta ttaatatttt ggtgttcttc cttcagagaa
      181 actcttggga tatagccctc acctatttcc ggaatctggc atctcagcac cctctggaaa
      241 gcaccgatct aaatataccc tgctgtgaat cacccccctg ataaaggcct ttgccttgtt
      301 tgttgaccac tgatcttgtg cagtgctgct gatcttactt gggaaatgtt gttttttgtt
      361 tagtctttaa aggtagtatt catcaaagag actgtactca agaataccca aggctgaatt
      421 agaggacata gatggttttt gtttttgttt tttcttatta caacaataag gggagtgtac
      481 tatgttcctg gcccctctca cttagaggaa caaggattac acagaaattt gaaatttcaa
      541 caagaaaaac ttaggattcc agggattccc acatcaaaga aaagctgcaa gctttcagaa
      601 agagttttct tttgatgata aagaagagcc tgccaaccac aggagaggcc ttgatgtcaa
      661 gtgcttagct gtgctcccta aagttgcaga attaagaaaa atctttgaac caaagaggaa
      721 agacttttta gaaatgaaaa gaaaagaaag aattgctagg cgcttagaag gaatagaaaa
      781 tgactcccag cccatcctgt tgcagagctg cacagggcta gtgactcatc ggctgctaga
      841 agaagacaca cccagataca tgcgtgccac agaccctgca agccctcata ttgggcgatc
      901 caaagaagag gaagacactc ctgggtcctc cctagaaaag caaactcctt ctaaatactg
      961 catagaaacc tcaggcatcc atagttcggg ctccatggac acccacagtc tggagtccaa
     1021 agcggaaagg atcgcaagat acaaagcaga gaggaggcgg cagctggccg aaaagtacgg
     1081 gctgaccttg gacccagaag ctgactctga atacttgtct cgatatgcca agtctcggaa
     1141 ggacccagat gtgactgaga gacgaggaaa aagtgacaag caagaagaac agagcaagga
     1201 tgccaattcc cggcactcca ggacagagtc agggcccagg accagcttgg tggcgtccca
     1261 ggactgtacc ccgctgggaa gcaatatgtc tgaccaggag cagctgctca atgtggagaa
     1321 ccagagaaga gtccaagatc ccccactagg agaagatggc tcctctgcct tcttttctga
     1381 gcgaagcatt tccttccccg aagtgcccag gtctccaaag cagataccca gctcaccact
     1441 gcaacagcca gcctccccaa accaccccgg tgactcacca ctgcccacag aggcccgagc
     1501 cagtagtaca gggaagccca cacatgagtg gtttctgcag agagattctg aaggcgatac
     1561 accttcactt atcaactggc cttccagagt taaagttaga gaaaaattgg tgaaagagga
     1621 gagtgctcgc agcagccctg aactcacctc agagtcctta actcagagga gacagcagcc
     1681 ggcaccagca catttcctgc ctatccagtc agaaagttcc acctttgata gggtcaccag
     1741 caaagcagtg agctcattgc agccaagcca gagtggtgtt ctgccaactg accctgttca
     1801 tgccatcaag ctggtgacca tggatacccc agaaagcaca tctgaattca gctgggtggg
     1861 gtcagccacc ccaaaagtta taaaatctac caccttgaag attctagaag gtggttcaag
     1921 ggatgctcca gtactccata tttgtgagtc aaaagcagaa gattggctct ccccagaacc
     1981 tctggagagg agccccaagt cacttttgac ctcagaagat gacaggctcg tgagaggcca
     2041 caaagatccc tctggtaata aagacttgga caaggccatc atttgctcca tcgatgtaga
     2101 atctgagagg gagcggcaag ttcaacacct gcccactcag agaactggcc ggagtgaaat
     2161 gctcctgtat gttcagagtg gtcctgtgtc ccaagatgcc acattgacca gtcacacaaa
     2221 ggaggcatct ccaaagaagc gcaaggttct ggcccgctct ctgtcagatt acacaggtcc
     2281 ccctcagctc caggtcccca gacacaagga tgaagcccca agccaggagc tggagctgca
     2341 gagttccagg gcagaagggc ctggtgcaga agccagcgtg ctggacacca gagtctccgt
     2401 cgcccagctc cgaaacatat ttatggagtc aacccgagcc agcaagaaac ctgaactcca
     2461 atcccgggtt gagaggtcag ctgaaggaat tggcttgccc atggaacgag agagagggtc
     2521 tcggaaacca agacgctatc tttctcctgg tgaaagtaga aaaacttctg agcgatttag
     2581 aactcaacct ataacctcag cagagcgaaa ggagtcggat aggtaccctt ctggttcaga
     2641 aataccagtg gtcgaggatg aagaaaaggt ggatgagcgg gccaagctga gcgtggctgc
     2701 caagaggctg cttttcaggg aaatggagaa atcctttgat gaacacactg tcccaaagag
     2761 acattcgaga aatgcagctg tggagcagag gctgcgtcgc ctgcaggacc gttcacacac
     2821 acagcccatc accacggagg aagtggtcat tgcagctact gaacctatcc ctgcttcgtg
     2881 ttctggggtc acccaccctg taacggcgag acttcctagc cccactgtag ctagaagcag
     2941 tgtgcagcct gccaggttac aagcatctgc tcaccaaaag gctttagcca gggaccaggc
     3001 aaatgagggc agagagtctg ccgaaccagg cgaacctgat tcctccactc tgagcttagc
     3061 agagaaattg gccttgttta acaaattgtc ccagccagtc tccaaagcca tttccacccg
     3121 aaacagaata gatgtgcggc agaggaggat gaacgcaagg taccagacgc agccggtcac
     3181 tcttggagaa gtggagcagg tgcagagtgg gaaactcatc tccttctccc ccactgtgaa
     3241 cacctctgtt tctattatgg cctctgcggt tgctcccaca tatgcagggg accttcggaa
     3301 gctatctgtt gacaacaaca caagtgccac tgactataag tctcctcctg cggaaaactc
     3361 agactctcca gtcagaagca ttctgaaacc acaagcttgg cggcctttgg tagagcacag
     3421 tgggagcaaa ggaatgccgg gggagtctgg aaagacagaa agcaagaatg ctctgactgt
     3481 ggctgcagaa gacagtggcg ttcaaacacg aggagccttc gaggaggaag aggagccctc
     3541 ctaccccatc cttggcagag tcagggaggg tgatggccag aaggagccta agcatgtcgt
     3601 cctaaggagg ggaagcttag agctaggcaa tccttctgct gcacaccttg gtgatgagct
     3661 gaaggaagtt tccactgcta aaagcagttt gcaagagaat ctagacctga aggataagca
     3721 ggcctcagag gagaacacag atgtggaaac tgtcatgagg aagttctcac tgaaagagtt
     3781 tggagaaacg acttctgagc agacagaggt ggctgccagg aaggcctcgg ttcagatggc
     3841 gaccccaggg gcctggaagc agcaggagtc ctctgagcaa ctagcagaga agctcttcaa
     3901 gaacccttgt gccatgtttg cttctggaga ggtcaaggtg ccagtaggcg acagtttcct
     3961 ggattcaccc agcaaaacca tgtcaatcaa agaaaggctg gcactgttaa agaagagtgg
     4021 cgaggaagac tggaagaaca ggctgattcg gaagcaggaa tatggcaaag ccactggcgg
     4081 cctgcacacg caggaggtgg agcagtccct gaagaaaaag gaagaaggag gacttacaga
     4141 tgataatgcc atttctaatg tgctttggag agtcacagaa agtcgagaga gccagatgac
     4201 gattgaagag aggaagcacc tcatcactgt gcgcgaggaa gcgtggaaga cgaagggcag
     4261 aggcgctgcc aatgactcca cacagttcac cgtggcagga agaatggtga agaaaggtct
     4321 ggcatcaccc acatccataa ctcccatctc atcccctctc tgcagtaaat caaggggcac
     4381 taccccggtt tccaaaccct tggaagatat tgaagccaga ccagatatgc agctggaatc
     4441 agacctgaag ttggacagac tggaaacctt cctaaggagg ctaaataaca aggttgctgg
     4501 gatacaggaa acggttctca cggtcactgg caaatctgtc aaggaggtga tgaagttgga
     4561 tgatgatgaa acatttgcca aattctaccg cagcgtggat cacagtatac ccagaagtcc
     4621 tgtggagctg gaggaggact tcgatgtcat tttcgaccct tatgctccca agttgacatc
     4681 ttctgtggca gagcataagc gccaggtcag gcccaagcgc cgggtccagg cttccaagaa
     4741 ccctctcaag ctgctggcag caagagacga cctccttcag gaatacacag agcaaaggct
     4801 aaatgtggcc ttcatggagt ccaagcggat gaaagtggaa aagatgtcat ccaactccaa
     4861 cttctcagaa gtgactctgg caggcctggc cagtagggag aacttcagca acatcaacct
     4921 gaggagtgtc aatctgatgg agcaaaactc caacaacagc gcgatgccct acaagaagct
     4981 catgctgttg cagattaaag gaagaagaca tgtgcagaca aggctggtgg agccccgagc
     5041 ctcatcactc aacagtgggg actgcttcct tctgctgtct cctcagtact gcttcctgtg
     5101 ggtgggagag ttctccaatg tcatcgagaa agcaaaggca tctgaacttg caacgttaat
     5161 tcagacaaag agggagcttg gttgtagagc tacatacatc cagaccatcg aagaaggaat
     5221 taacacacat actcacgcag ccaaagactt ctggaagctc ttgggtggcc agaccagtta
     5281 ccagtctgcc ggagacccaa aggaagatga gctgtacgag acagccatca tagagacgaa
     5341 ctgtgtctac cgcctgacag atgacaaact cgttcctgat gatgactact gggggaagat
     5401 tcccaagtgt tcccttctgc agtccaaaga ggtcctggtg tttgactttg gtagtgaagt
     5461 ttacgtgtgg catgggaagg aagtcacgtt agcacaacgg aaaatagcat tccagctggc
     5521 taagcactta tggaacggaa cctttgacta tgagaactgt gacatcaacc ccctggaccc
     5581 cggagagtgc aacccgctca ttcccaggaa aggacaagga cggcctgact gggcaatatt
     5641 tggaagagtt acggagcaca atgagactat tctgttcaaa gagaaattcc ttgactggac
     5701 agagctgaag agacccacag agaagaattc tggagaagtt gtccagcaga aggatgaccc
     5761 gagggccgac gtcaagcctt atgatgtgac acggatggtg gcgacgcccc agattacagc
     5821 tggcaccatc ttagatgggg tgaacgttgg ccgtggctat ggcctggtgg aaggagatga
     5881 cagaagacag tttgagattg ccactgtctc tgtggatgtg tggcacattc tggaatttga
     5941 ctacagcagg ctccccaggc agagcatcgg gcagttccac gagggggacg cctatgtggt
     6001 caagtggaag tacatggcaa gtacagcagt gggaagccga caaaagggag agcacctggt
     6061 gagagtggct ggcaaagaga agtgtgtcta tttcttctgg caaggccggc actcgaccgt
     6121 gagtgagaag ggaacgtcag ctctcatgac agtagaactg gatgaagaga ggggggccca
     6181 ggtccaggtc ctgcagggaa aggagccacc ctgcttcctt cagtgtttcc aagggggtat
     6241 ggtggtgcac tccggacgga gggaagagga agaagaaaat gtgcaaagtg aatggagact
     6301 gtattgtgtg cgaggagagg tgcccatgga agggaacttg ctagaagtgg cctgtcattg
     6361 cagcagtctg aggtccagga cttccatggt cgttctgaat ataaacaagg ccctcatcta
     6421 cttgtggcat ggatgcaaag ctcaaggtca tacgaaggag gttggaagga ctgcagcaaa
     6481 taagatcaag gaagaatgtc ccctggaagc aggtttgcac agcagcagca acgtgacaat
     6541 acatgagtgt gacgaaggat ccgagcccct gggattctgg gacgctctgg ggaggaggga
     6601 cagaaaggcc tatgactgca tgcttcaaga tcctggaagt tttaacttcg cgccccgcct
     6661 gttcatcctc agcagctcct ccggagactt ctctgcgaca gagtttgtgt accccgcaca
     6721 agcgccctct gccgtcagct ccatgccttt cctgcaggag gacctgtaca gcgcgccgca
     6781 gccagctctc ttccttgttg acaaccatca cgaggtgtac ctctggcaag gctggtggcc
     6841 cactgaaaac aagataaccg gctctgcccg cattcgctgg gcctcagacc ggaagagtgc
     6901 catggagacg gtcctgcagt actgccgagg aaagaatctc aaaaggccac cccccaagtc
     6961 ttaccttatt catgctgggc tagagcccct gacattcacc aacatgtttc ccagctggga
     7021 acacagagaa gacattgctg aaatcacaga aatggatact gaagtttcca accagatcac
     7081 cttggtggaa gatgtattag ccaagctctg taaaaccatc tatccactgg cagatctgct
     7141 tgccaggcca ctcccagagg gggtcgaccc tctaaagctt gagatttatc tcacagatga
     7201 agactttgag tttgcactcg acatgtccag agatgaattc aatgcactgc ccacctggaa
     7261 gcaagtgaac ctgaagaagt caaagggcct attctgaggg tgagatgaca gggccacaga
     7321 gaagtcgctg ccgctagacc cgaaaatgaa tggagataca tatttggact agtagttttt
     7381 tctgtcaaag aagaaagtat ttttgaatca gagtttttca aaacctacag cttgttctag
     7441 agttgagcat tctgtaaatg tataagagaa ctcttctgat tgttcttttc cacagttcag
     7501 gtgaactgaa aagaaaagtg tcttttccgt tcccctcagc caagtgctgc ctcagtggcc
     7561 gctgcagccc tacccttctg gtctggctca gcactgcctt ttttaaagca attctcttta
     7621 taaagtgtta ttttgatagt ttgtgaattc taaatatata tatatatatt tatataaaca
     7681 catataaatc aagtatgtat ttaacaaagc aatatgtatt cattcacttg caactgtttt
     7741 ctttggtgtc aaaacaatat tagaggactg tgttgcttct gttgagttaa gcctaccacc
     7801 agtctgtccc gtgctcagga gtgcctcctt cagccttagg tctggcttgt gctaagttct
     7861 gcttccggtg ctaaagcaaa caaagacttt gtattcttag tgtgaactct gaagaatcta
     7921 tttgaatcaa cctttctacc ttaatatctc cccccagaaa tgtatagtgc cttgtttatg
     7981 tacagtttat atacagaaaa gtttgctctg cttttttgat gctggtttgg aatattatct
     8041 acagctttat tctcagtaga aataaaaaca tctcaatttc tcatacccat tgtaaacatt
     8101 acacatgtca ttttgtggca caggatccca aaataaaata tcaaagtaat cccaa
//
