LOCUS       NM_024462                748 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus small vasohibin binding protein (Svbp), transcript
            variant 2, mRNA.
ACCESSION   NM_024462
VERSION     NM_024462.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 748)
  AUTHORS   Landskron,L., Bak,J., Adamopoulos,A., Kaplani,K., Moraiti,M., van
            den Hengel,L.G., Song,J.Y., Bleijerveld,O.B., Nieuwenhuis,J.,
            Heidebrecht,T., Henneman,L., Moutin,M.J., Barisic,M., Taraviras,S.,
            Perrakis,A. and Brummelkamp,T.R.
  TITLE     Posttranslational modification of microtubules by the MATCAP
            detyrosinase
  JOURNAL   Science 376 (6595), eabn6020 (2022)
   PUBMED   35482892
REFERENCE   2  (bases 1 to 748)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 748)
  AUTHORS   Pagnamenta,A.T., Heemeryck,P., Martin,H.C., Bosc,C., Peris,L.,
            Uszynski,I., Gory-Faure,S., Couly,S., Deshpande,C., Siddiqui,A.,
            Elmonairy,A.A., Jayawant,S., Murthy,S., Walker,I., Loong,L.,
            Bauer,P., Vossier,F., Denarier,E., Maurice,T., Barbier,E.L.,
            Deloulme,J.C., Taylor,J.C., Blair,E.M., Andrieux,A. and Moutin,M.J.
  CONSRTM   WGS500 Consortium; Genomics England Research Consortium
  TITLE     Defective tubulin detyrosination causes structural brain
            abnormalities with cognitive deficiency in humans and mice
  JOURNAL   Hum Mol Genet 28 (20), 3391-3405 (2019)
   PUBMED   31363758
REFERENCE   4  (bases 1 to 748)
  AUTHORS   Zhou,C., Yan,L., Zhang,W.H. and Liu,Z.
  TITLE     Structural basis of tubulin detyrosination by VASH2/SVBP
            heterodimer
  JOURNAL   Nat Commun 10 (1), 3212 (2019)
   PUBMED   31324789
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 748)
  AUTHORS   Aillaud,C., Bosc,C., Peris,L., Bosson,A., Heemeryck,P., Van
            Dijk,J., Le Friec,J., Boulan,B., Vossier,F., Sanman,L.E., Syed,S.,
            Amara,N., Coute,Y., Lafanechere,L., Denarier,E., Delphin,C.,
            Pelletier,L., Humbert,S., Bogyo,M., Andrieux,A., Rogowski,K. and
            Moutin,M.J.
  TITLE     Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate
            neuron differentiation
  JOURNAL   Science 358 (6369), 1448-1453 (2017)
   PUBMED   29146868
REFERENCE   6  (bases 1 to 748)
  AUTHORS   Suzuki,Y., Kobayashi,M., Miyashita,H., Ohta,H., Sonoda,H. and
            Sato,Y.
  TITLE     Isolation of a small vasohibin-binding protein (SVBP) and its role
            in vasohibin secretion
  JOURNAL   J Cell Sci 123 (Pt 18), 3094-3101 (2010)
   PUBMED   20736312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF012097.1, AK010418.1 and BQ044357.1.
            
            On Aug 15, 2009 this sequence version replaced NM_024462.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR and uses a downstream start codon, compared to
            variant 1. The resulting isoform (b) has a shorter N-terminus,
            compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF551079.1, AK010418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BF012097.1         5-75
            72-727              AK010418.1         2-657
            728-748             BQ044357.1         494-514
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.34 cM"
     gene            1..748
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /note="small vasohibin binding protein"
                     /db_xref="GeneID:69216"
                     /db_xref="MGI:MGI:1916466"
     exon            1..177
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /inference="alignment:Splign:2.1.0"
     exon            178..327
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..414
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /note="isoform b is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 23; coiled-coil
                     domain containing 23"
                     /codon_start=1
                     /product="small vasohibin-binding protein isoform b"
                     /protein_id="NP_077782.1"
                     /db_xref="CCDS:CCDS38858.1"
                     /db_xref="GeneID:69216"
                     /db_xref="MGI:MGI:1916466"
                     /translation="MDPPARKEKSKVKEPAFRVEKAKQKSAQQELKQRQRAEIYALNR
                     VMTELEQQQFDEFCKQMQPPGE"
     exon            328..729
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      711..716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /note="hexamer: AATAAA"
     polyA_site      729
                     /gene="Svbp"
                     /gene_synonym="2410005K17Rik; Ccdc23"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagtggc tcctgcggga ggggcacctc aggccgcggc cccgccctcc ccggcgcgcc
       61 ccgcccagtc caagggcagc gggctgggcg ctgcggtccc gcggaagggg ggagctaggg
      121 tgaaccccgc gtgggggctt gtctacgacg tggcggaggc cgtgagcccg aggccgggtc
      181 agagctaacc aagaagcatt cagaagccaa accatggatc cacctgcccg gaaagaaaaa
      241 tccaaagtta aagaaccagc cttcagagtg gagaaggcta agcagaaatc tgcccagcag
      301 gagctgaagc aaagacagag agcagagatc tatgctctca acagagtcat gacggagctg
      361 gagcagcagc agtttgatga gttctgtaag cagatgcagc cgcctgggga gtgagccagc
      421 ctgcatcccc ggcagaggaa ctggtgcctg cctttgtctg tgagctcatt cccactgtta
      481 ccctgagctg gcccaatgga gccttacaga actaatcagg acttgtggag acctctgcac
      541 tgaacttcct ataagtaact tccaccacac tggtttctac tctcagaact gccccagtgc
      601 ttgctgggta gacttttcat ctaagacagt ggatttttca aaaagacctt ttttctattg
      661 tttgagaaaa atcattgttt cttgtgaaac tgcgtgtctt ccctaaaaat aataaaattc
      721 agaaatgtta aaaaaaaaaa aaaaaaaa
//
