LOCUS       NM_009299                651 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus seminal vesicle antigen (Sva), mRNA.
ACCESSION   NM_009299
VERSION     NM_009299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 651)
  AUTHORS   Lu SH, Yen YK, Ling TY, Cheng KT, Shu JA, Au HK and Huang YH.
  TITLE     Capacitation suppression by mouse seminal vesicle autoantigen
            involves a decrease in plasma membrane Ca2+-ATPase (PMCA)-mediated
            intracellular calcium
  JOURNAL   J Cell Biochem 111 (5), 1188-1198 (2010)
   PUBMED   20717922
  REMARK    GeneRIF: the decapacitation mechanism of the SVA might target
            membrane sphingolipid SPM and regulate PMCA activity to lower
            [Ca(2+)](i), thereby decreasing the [cAMP](i) level and preventing
            sperm pre-capacitation.
REFERENCE   2  (bases 1 to 651)
  AUTHORS   Huang YH, Kuo SP, Lin MH, Shih CM, Chu ST, Wei CC, Wu TJ and Chen
            YH.
  TITLE     Signals of seminal vesicle autoantigen suppresses bovine serum
            albumin-induced capacitation in mouse sperm
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1564-1571 (2005)
   PUBMED   16274671
REFERENCE   3  (bases 1 to 651)
  AUTHORS   Osawa M, Horiuchi H, Tian W and Kaneko M.
  TITLE     Divergent evolution of the prolactin-inducible protein gene and
            related genes in the mouse genome
  JOURNAL   Gene 325, 179-186 (2004)
   PUBMED   14697523
REFERENCE   4  (bases 1 to 651)
  AUTHORS   Lin HJ, Luo CW and Chen YH.
  TITLE     Localization of the transglutaminase cross-linking site in SVS III,
            a novel glycoprotein secreted from mouse seminal vesicle
  JOURNAL   J Biol Chem 277 (5), 3632-3639 (2002)
   PUBMED   11723121
REFERENCE   5  (bases 1 to 651)
  AUTHORS   Yu LC, Hsiao YL, Yang YH, Lin M and Chen YH.
  TITLE     The genomic structure of a mouse seminal vesicle autoantigen
  JOURNAL   Biochem Biophys Res Commun 231 (1), 106-110 (1997)
   PUBMED   9070229
REFERENCE   6  (bases 1 to 651)
  AUTHORS   Yu LC, Chen JL, Tsai WB and Chen YH.
  TITLE     Primary structure and characterization of an androgen-stimulated
            autoantigen purified from mouse seminal-vesicle secretion
  JOURNAL   Biochem J 296 (Pt 3) (Pt 3), 571-576 (1993)
   PUBMED   8280054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ055470.1 and AC155846.18.
            
            On Jun 17, 2009 this sequence version replaced NM_009299.1.
            
            Sequence Note: An in-frame AUG is located 7 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and is in a weak Kozak
            sequence context.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ055470.1, BC104305.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               CJ055470.1         1-613
            614-651             AC155846.18        164409-164446
FEATURES             Location/Qualifiers
     source          1..651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.28 cM"
     gene            1..651
                     /gene="Sva"
                     /note="seminal vesicle antigen"
                     /db_xref="GeneID:20939"
                     /db_xref="MGI:MGI:102785"
     exon            1..123
                     /gene="Sva"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..505
                     /gene="Sva"
                     /codon_start=1
                     /product="seminal vesicle antigen"
                     /protein_id="NP_033325.2"
                     /db_xref="CCDS:CCDS20060.1"
                     /db_xref="GeneID:20939"
                     /db_xref="MGI:MGI:102785"
                     /translation="MASLQKFYQPGAVIYLLIVFLLQETAGFWYHGLHNEPRNYTLTL
                     NMKITPSTSITNKKGNEFRVQLTVKNNVKQCQEVEINTEHERYIKFLSGPSTFETCIC
                     TISDFFWDIYVSESTYLTLSASILPYKNKCPDSDEPLLYGDSYQMYNITDKINVTP"
     exon            124..259
                     /gene="Sva"
                     /inference="alignment:Splign:2.1.0"
     exon            260..371
                     /gene="Sva"
                     /inference="alignment:Splign:2.1.0"
     exon            372..651
                     /gene="Sva"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggctcatg tatgccaacc catacagcat ggcttctctt caaaagttct atcaacctgg
       61 agcagtcata tatctcctta ttgtattctt acttcaggag actgctgggt tttggtacca
      121 tggcttacac aatgaacccc gtaactacac actcacactg aatatgaaaa tcactccaag
      181 tactagcatt actaacaaaa aagggaatga atttcgagta caactgacag ttaaaaacaa
      241 cgtgaagcaa tgccaggagg tagaaataaa tactgaacat gagagataca tcaagttcct
      301 ttctggtcca tcaacttttg aaacttgcat atgtaccatt agcgatttct tctgggatat
      361 atatgtctct gaaagcactt acctaacact atcagcctcc attctgccat ataagaacaa
      421 atgtcctgac tctgacgaac cactactata tggcgactct taccaaatgt acaatattac
      481 agataaaatc aatgtaacac cataaactgg aaggttgcaa tagaaccaca tcactaacgt
      541 actcttggag aggattgtgt gtgtgcgcat gtattttgca ataaaataaa atagtgttaa
      601 attaattctg tggtaaaatc tctgtatggt aaataaattt tttccacctc a
//
