LOCUS       NM_153579               5548 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus synaptic vesicle glycoprotein 2b (Sv2b), transcript
            variant 1, mRNA.
ACCESSION   NM_153579
VERSION     NM_153579.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5548)
  AUTHORS   Paulussen,I., Beckert,H., Musial,T.F., Gschossmann,L.J., Wolf,J.,
            Schmitt,M., Clasadonte,J., Mairet-Coello,G., Wolff,C., Schoch,S.
            and Dietrich,D.
  TITLE     SV2B defines a subpopulation of synaptic vesicles
  JOURNAL   J Mol Cell Biol 15 (9) (2024)
   PUBMED   37682518
  REMARK    GeneRIF: SV2B defines a subpopulation of synaptic vesicles.
REFERENCE   2  (bases 1 to 5548)
  AUTHORS   Bolz,S., Kaempf,N., Puchkov,D., Krauss,M., Russo,G., Soykan,T.,
            Schmied,C., Lehmann,M., Muller,R., Schultz,C., Perrais,D.,
            Maritzen,T. and Haucke,V.
  TITLE     Synaptotagmin 1-triggered lipid signaling facilitates coupling of
            exo- and endocytosis
  JOURNAL   Neuron 111 (23), 3765-3774 (2023)
   PUBMED   37738980
  REMARK    Erratum:[Neuron. 2023 Dec 6;111(23):3900. doi:
            10.1016/j.neuron.2023.11.003.. PMID: 38061332]
REFERENCE   3  (bases 1 to 5548)
  AUTHORS   Vana,N.S., van Loo,K.M.J., van Waardenberg,A.J., Tiessen,M.,
            Cases-Cunillera,S., Sun,W., Quatraccioni,A., Schoch,S. and
            Dietrich,D.
  TITLE     Early cortical oligodendrocyte precursor cells are
            transcriptionally distinct and lack synaptic connections
  JOURNAL   Glia 71 (9), 2210-2233 (2023)
   PUBMED   37226895
REFERENCE   4  (bases 1 to 5548)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5548)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5548)
  AUTHORS   Noakes,P.G., Chin,D., Kim,S.S., Liang,S. and Phillips,W.D.
  TITLE     Expression and localisation of dynamin and syntaxin during neural
            development and neuromuscular synapse formation
  JOURNAL   J Comp Neurol 410 (4), 531-540 (1999)
   PUBMED   10398046
REFERENCE   7  (bases 1 to 5548)
  AUTHORS   Serpinskaya,A.S., Feng,G., Sanes,J.R. and Craig,A.M.
  TITLE     Synapse formation by hippocampal neurons from agrin-deficient mice
  JOURNAL   Dev Biol 205 (1), 65-78 (1999)
   PUBMED   9882498
REFERENCE   8  (bases 1 to 5548)
  AUTHORS   Rich,K.A., Zhan,Y. and Blanks,J.C.
  TITLE     Migration and synaptogenesis of cone photoreceptors in the
            developing mouse retina
  JOURNAL   J Comp Neurol 388 (1), 47-63 (1997)
   PUBMED   9364238
REFERENCE   9  (bases 1 to 5548)
  AUTHORS   Gautam,M., Noakes,P.G., Moscoso,L., Rupp,F., Scheller,R.H.,
            Merlie,J.P. and Sanes,J.R.
  TITLE     Defective neuromuscular synaptogenesis in agrin-deficient mutant
            mice
  JOURNAL   Cell 85 (4), 525-535 (1996)
   PUBMED   8653788
REFERENCE   10 (bases 1 to 5548)
  AUTHORS   Ahnert-Hilger,G., Kutay,U., Chahoud,I., Rapoport,T. and
            Wiedenmann,B.
  TITLE     Synaptobrevin is essential for secretion but not for the
            development of synaptic processes
  JOURNAL   Eur J Cell Biol 70 (1), 1-11 (1996)
   PUBMED   8738414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079568.1 and BC060224.1.
            
            On Oct 5, 2007 this sequence version replaced NM_153579.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All seven variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079568.1, SRR1660815.93058.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2886              BC079568.1         1-2886
            2887-2974           BC060224.1         2271-2358
            2975-4084           BC079568.1         2974-4083
            4085-5548           BC060224.1         3466-4929
FEATURES             Location/Qualifiers
     source          1..5548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 43.62 cM"
     gene            1..5548
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /note="synaptic vesicle glycoprotein 2b"
                     /db_xref="GeneID:64176"
                     /db_xref="MGI:MGI:1927338"
     exon            1..389
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1222
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     CDS             772..2823
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /note="synaptic vesicle protein 2B; synaptic vesicle
                     glycoprotein 2 b"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2B"
                     /protein_id="NP_705807.2"
                     /db_xref="CCDS:CCDS21368.1"
                     /db_xref="GeneID:64176"
                     /db_xref="MGI:MGI:1927338"
                     /translation="MDDYRYRDNYEGYAPSDGYYRSNEQNQEEDAQSDVTEGHDEEDE
                     IYEGEYQGIPHPDDVKSKQTKMAPSRADGLGGQADLMAERMEDEEELAHQYETIIDEC
                     GHGRFQWTLFFVLGLALMADGVEIFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMA
                     GAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPI
                     VFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSW
                     RVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV
                     FTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLI
                     LAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQ
                     HGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHK
                     FINCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRL
                     KMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRA
                     TAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL
                     M"
     exon            1223..1403
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1555
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1689
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1779
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1890
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1979
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2144
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2278
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2479
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2639
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..5524
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5505..5510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /note="hexamer: ATTAAA"
     polyA_site      5524
                     /gene="Sv2b"
                     /gene_synonym="A830038F04Rik; mKIAA0735"
                     /note="major polyA site"
ORIGIN      
        1 gttcatccgc aaatccagaa agggcgggtc cggggagtgg gctctggctc ccctccaacc
       61 tatccggaac tcctctcctt ggatctgaaa gggagttaga agcaaagagc tttccgcagt
      121 gaacacagtg cctggactag gctctggctg atccttctaa atagactcag gagccccggg
      181 agggctgggg tgctgcaggg tgctgggagc gcgctgcaca gaggctctgc acagcggagg
      241 cagcagcgaa ggcgacgagg gcgcggcgat gcaggtgtgc cctagggaga gcctgcctcg
      301 gttgggatta ccaaccgcgt tagcctgagc tgccgcccag acttacggtg ttcggctgct
      361 gaccggctcg ctgcggattt tccacccagg ctataacctt caggagaagg acaaacatca
      421 cagccagtga gctgccaagc actgctccga ccttgtcaaa gagagcagct ggacccattt
      481 ttagttactc ccagcacaag cctctgggtc atataaggag aacagaccag aatttgatac
      541 tttccgaaga cgtttaacac acaccagcac aaaaggctac ttaggttgtc tttgtatgaa
      601 tttggttgat ttgagaaaca aattgaaaag gtgattttat tgaaaaagtc tcatgagcat
      661 gctcaccatt tcaatgatat aatagatgat ggttattgga acagcccaaa tatttaccac
      721 agagcaagag atatagcttg agcggctacc agacaatccc agaaccaagg aatggatgac
      781 tacaggtatc gggacaacta tgagggctat gcccctagtg atggctacta ccgtagcaat
      841 gagcagaatc aggaagaaga tgcacagagc gatgttacag aaggccatga cgaggaagat
      901 gagatctatg aaggcgagta ccaaggcatc cctcatccag atgatgtcaa gtctaagcag
      961 accaagatgg cgccctccag agcagatggt cttgggggcc aggcagactt gatggctgag
     1021 aggatggaag atgaggagga gctggctcac caatatgaga ccatcattga tgagtgtggc
     1081 catgggcgct tccagtggac cctcttcttc gtcttgggtt tggccttgat ggctgatgga
     1141 gtggaaatat ttgtagtgag ctttgctctg ccaagtgcag agaaagacat gtgtctgtcc
     1201 agttccaaga aaggaatgct tgggctgata gtctacctag gaatgatggc aggggccttc
     1261 atcttgggcg gcctggctga taaactggga aggaagaagg tcctcagcat gtcactggcc
     1321 atcaatgcct cctttgcttc actctcctcc ttcgtgcagg gatatggagc cttcctcttc
     1381 tgcagactca tctcaggcat agggattggg ggctccctgc caattgtttt tgcctacttt
     1441 tctgagttct tatcacgaga gaaacgcggt gagcatctta gctggctggg catcttctgg
     1501 atgactggag gcatctatgc atctgccatg gcctggagca tcattccaca ctatggctgg
     1561 ggcttcagca tggggactaa ttaccacttc cacagctgga gagtgtttgt catcgtctgt
     1621 gctctgcccg ccactgtgtc catggtggct ctgaagttca tgccagaaag ccccaggttc
     1681 ctgctggaga tgggcaaaca tgatgaagcc tggatgattc tcaaacaagt ccatgataca
     1741 aacatgagag ctaaggggac cccggaaaag gtgttcacgg tttcccacat caaaactccc
     1801 aagcaaatgg atgaattcat tgagatacag agctcaaccg gaacttggta ccagcgctgg
     1861 ctggtcaggt tcatgaccat tttcaaacag gtctgggata acgccttgta ctgtgtgatg
     1921 gggccctaca gaatgaacac cctgattctg gctgtggtct ggttcaccat ggccttaagt
     1981 tactacggcc tgacggtgtg gttccccgac atgatccgct atttccagga tgaagaatat
     2041 aagtctaaaa tgaaggtgtt ttttggtgag cacgtgcatg gcgccacgat caactttacc
     2101 atggaaaacc agatccacca acatgggaag cttgtgaacg ataagttcat aaagatgtat
     2161 tttaaacatg tcctctttga ggacacattc tttgacaaat gctattttga agatgtgaca
     2221 tccacagata cgtatttcaa gaactgcacc atcgaatcga ccaccttcta caacacagac
     2281 ctctacaaac acaagttcat caactgtcgg tttatcaatt ccacctttct ggagcagaag
     2341 gagggctgcc acatggactt tgaagaggac aatgattttc tgatttacct cgtcagcttc
     2401 ctcggcagcc tctctgtctt gcctgggaac ataatttctg ccctgctcat ggacagaatt
     2461 ggaagactca agatgattgg cggctccatg ctcatctctg cagtctgctg cttcttcctg
     2521 ttttttggca acagcgagtc tgcgatgatc ggctggcaat gcctgttctg tgggaccagc
     2581 attgcagcct ggaatgctct ggatgtgatc acagttgagc tgtatcccac caaccagagg
     2641 gccacggcct tcggcatcct caacggactg tgcaagtttg gggccatcct gggaaacact
     2701 atctttgctt cttttgttgg gataaccaaa gtggtcccca tccttctggc tgctgcttct
     2761 ctggttggag gtggcctgat tgcccttcga ttgccagaga ctcgagagca agtcctgatg
     2821 tgaccaaccc accgggaaaa gacagatggg aagatctttt tcaggacact ccagcacagc
     2881 cacgcctcct gcctctcact gtctacagga taccgcggac agcacggaag gagaaatgga
     2941 ctttgtgatc cctagtttag gacccactgc agttgttaat acatttttaa ctcaggtgat
     3001 tgactagggg tgcccagaac catccttggg atcccagagc tgtgtgctta gcttcaggtc
     3061 tcttcatccc aggcagggag aggacactcc agtaaacaca cacagtaagc aaggagtata
     3121 tgctcctcta aatgaggtgc aaaaaactat ttgcatttcg gactgaagtt gaggactaga
     3181 accacttaag ctcctccatg cagcttctgg gagcccagtg acctagcaga ttgtcatagt
     3241 ggggagtggg gtcaacacat actgggctca gagagcagac tacgtatttg catttgaaag
     3301 tatcacctat catattttcc ttttgaaaac tggcacagta gccttgagga tactctgata
     3361 tagaaaaacc caacctttaa gcaaaatgta tatagacgga cttttcttcc caagcatcct
     3421 gaactttgca taacgaagag gtgatacact aagaactata tttattatgg ttttgctctt
     3481 gtcagagcaa cgtgaggatg ggtattatgt aaactaagtt tgtatataag agttttgagg
     3541 ttttattccc acaaatggtg gctgctaagg ttgccaacat tttagccata tttggggagg
     3601 actctccatt caaggtcgca ggaaacttgg tgcgaatggg tagcatcttg cttgctgtcc
     3661 ggaggatgta cttggcaagc cacgtgccat ttcctttacc tgggaacttt tcttcaaatt
     3721 ggtagggcag gtacttctct ctcctgtgtt gctcatttgt gaaactcagg accataggtt
     3781 gtttgatgct gtttacccag agagaacagg aagaaatgaa atgaaaatgt ttttattttt
     3841 attattggct gcttgcactc cttttcttta gagagaaccc cctcacagat aactgactaa
     3901 ggatggggaa aggtaaccac agttcttcaa aatgtgagtt cttcctgttt gatttcaaag
     3961 aaaaacacaa tgtacattta ttatagtgtt taggacctat gagaaattta tgctctgtgt
     4021 gttggctcgg ggcgttcgaa acaggccatt agcatgcaca ttaggaaata aaaggcatga
     4081 gatacattcg tttcttcatt gctccaagga agctttttct gagatccagg ttggaacttg
     4141 aatgtggaaa ggggagaggg ggtcagggct gctctggcag gtgccagcag tctggaggct
     4201 aggctgaggg agtggctttt gttcatcagt accctctgca atggtagaga cagagctagg
     4261 agttcctgcc acctgagctg ctcttacctg ggccagcaga acgactgact gactgactgt
     4321 aagaactagt ttgctcacgt tatttgcagc acacacacaa gctgtgatgt gctaatctct
     4381 acctattaga aatcttccca aatctaaacc aaactaatga ctacattgag tgttttctca
     4441 gttctgtgga aatacttaga tgccaggcca gttcaagcca tctttgccta gtcctctgga
     4501 atataagttg gcagtgggaa agagtgaaat ctttgagaac ttcccatttt caagtgtggc
     4561 taacatgttt actctgcttc tctggtcccc acctctttat ttacaccacc attactttct
     4621 gtccagggaa ggaagatgca tcaggtctga tgtgataacc cccattactc caaatataaa
     4681 tatatataaa tatacagaat gtattaatgc ttctctcggt gttttatagg aattaactga
     4741 taacgctctg ttgataacga gaaactttct gtaatatagc tgtgatgtcc ttttccattt
     4801 tcttgtgata tggaatgcat tgcttaggat catgagagaa ttgtataaat ctgtggttat
     4861 gtatccctca taacagtgtt ctttaatggg ataatagacc tcagtgctca gctaccactc
     4921 aagaaatgta cgagacagtt agaatccaca tttacagtca gatatatctt gtaaacttta
     4981 aatctgacta atttttaaag cacaggagtg gctgcagtta ttttaggcta actgttcttg
     5041 gtttctaagc tctgtcttct acattacatt tatggctcct taacctgttt gcctaaccaa
     5101 ccaagggcaa ttcccgtcca tccatcacac gggatgtgag aaggatgcag ccatggtctg
     5161 cagcctctct catgaagggt tatctggcca tggtacttgg ctgcttcata acttgctgtc
     5221 actcctgatg agataagtgt gtctttaaaa atagtccccg tgtcaggtca ctggggtgta
     5281 atgtacaaca tccttagcca tccatttttt cttttctttt tttttgccct gagagactcc
     5341 caatggcatc tatagaggac taaagaagag agccgttccc tcactgagtc agactgttca
     5401 cagttcatta tgtattttat gatggcttgt ttgggagccg atactttcag cagtctcaac
     5461 tgtgttgtgg gatctcctga tgctggtttc tgagcttttg ttttattaaa actgattagt
     5521 gaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
