LOCUS       NM_022030               3920 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus synaptic vesicle glycoprotein 2a (Sv2a), mRNA.
ACCESSION   NM_022030
VERSION     NM_022030.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3920)
  AUTHORS   Izquierdo-Villalba,I., Mirra,S., Manso,Y., Parcerisas,A., Rubio,J.,
            Del Valle,J., Gil-Bea,F.J., Ulloa,F., Herrero-Lorenzo,M.,
            Verdaguer,E., Beninca,C., Castro-Torres,R.D., Rebollo,E.,
            Marfany,G., Auladell,C., Navarro,X., Enriquez,J.A., Lopez de
            Munain,A., Soriano,E. and Aragay,A.M.
  TITLE     A mammalian-specific Alex3/Galphaq protein complex regulates
            mitochondrial trafficking, dendritic complexity, and neuronal
            survival
  JOURNAL   Sci Signal 17 (822), eabq1007 (2024)
   PUBMED   38320000
REFERENCE   2  (bases 1 to 3920)
  AUTHORS   Bolz,S., Kaempf,N., Puchkov,D., Krauss,M., Russo,G., Soykan,T.,
            Schmied,C., Lehmann,M., Muller,R., Schultz,C., Perrais,D.,
            Maritzen,T. and Haucke,V.
  TITLE     Synaptotagmin 1-triggered lipid signaling facilitates coupling of
            exo- and endocytosis
  JOURNAL   Neuron 111 (23), 3765-3774 (2023)
   PUBMED   37738980
  REMARK    Erratum:[Neuron. 2023 Dec 6;111(23):3900. doi:
            10.1016/j.neuron.2023.11.003.. PMID: 38061332]
REFERENCE   3  (bases 1 to 3920)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3920)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3920)
  AUTHORS   Leboeuf,M., Vargas-Abonce,S.E., Peze-Hedsieck,E., Dupont,E.,
            Jimenez-Alonso,L., Moya,K.L. and Prochiantz,A.
  TITLE     ENGRAILED-1 transcription factor has a paracrine neurotrophic
            activity on adult spinal alpha-motoneurons
  JOURNAL   EMBO Rep 24 (8), e56525 (2023)
   PUBMED   37534581
REFERENCE   6  (bases 1 to 3920)
  AUTHORS   Serpinskaya,A.S., Feng,G., Sanes,J.R. and Craig,A.M.
  TITLE     Synapse formation by hippocampal neurons from agrin-deficient mice
  JOURNAL   Dev Biol 205 (1), 65-78 (1999)
   PUBMED   9882498
REFERENCE   7  (bases 1 to 3920)
  AUTHORS   Rich,K.A., Zhan,Y. and Blanks,J.C.
  TITLE     Migration and synaptogenesis of cone photoreceptors in the
            developing mouse retina
  JOURNAL   J Comp Neurol 388 (1), 47-63 (1997)
   PUBMED   9364238
REFERENCE   8  (bases 1 to 3920)
  AUTHORS   Apel,E.D., Glass,D.J., Moscoso,L.M., Yancopoulos,G.D. and
            Sanes,J.R.
  TITLE     Rapsyn is required for MuSK signaling and recruits synaptic
            components to a MuSK-containing scaffold
  JOURNAL   Neuron 18 (4), 623-635 (1997)
   PUBMED   9136771
REFERENCE   9  (bases 1 to 3920)
  AUTHORS   Gautam,M., Noakes,P.G., Moscoso,L., Rupp,F., Scheller,R.H.,
            Merlie,J.P. and Sanes,J.R.
  TITLE     Defective neuromuscular synaptogenesis in agrin-deficient mutant
            mice
  JOURNAL   Cell 85 (4), 525-535 (1996)
   PUBMED   8653788
REFERENCE   10 (bases 1 to 3920)
  AUTHORS   Ahnert-Hilger,G., Kutay,U., Chahoud,I., Rapoport,T. and
            Wiedenmann,B.
  TITLE     Synaptobrevin is essential for secretion but not for the
            development of synaptic processes
  JOURNAL   Eur J Cell Biol 70 (1), 1-11 (1996)
   PUBMED   8738414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC125099.3.
            
            On Nov 17, 2006 this sequence version replaced NM_022030.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046587.1, AK028318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC125099.3         94751-94827         c
            78-1046             AC125099.3         90447-91415         c
            1047-1227           AC125099.3         88901-89081         c
            1228-1379           AC125099.3         87807-87958         c
            1380-1513           AC125099.3         87596-87729         c
            1514-1603           AC125099.3         86903-86992         c
            1604-1714           AC125099.3         86577-86687         c
            1715-1803           AC125099.3         86315-86403         c
            1804-1968           AC125099.3         85607-85771         c
            1969-2102           AC125099.3         85294-85427         c
            2103-2309           AC125099.3         83434-83640         c
            2310-2469           AC125099.3         82706-82865         c
            2470-3920           AC125099.3         80871-82321         c
FEATURES             Location/Qualifiers
     source          1..3920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.65 cM"
     gene            1..3920
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /note="synaptic vesicle glycoprotein 2a"
                     /db_xref="GeneID:64051"
                     /db_xref="MGI:MGI:1927139"
     exon            1..77
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            78..1046
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..2653
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /note="calcium regulator SV2A; synaptic vesicle protein 2;
                     synaptic vesicle protein 2A; synaptic vesicle glycoprotein
                     2 a"
                     /codon_start=1
                     /product="synaptic vesicle glycoprotein 2A"
                     /protein_id="NP_071313.1"
                     /db_xref="CCDS:CCDS17631.1"
                     /db_xref="GeneID:64051"
                     /db_xref="MGI:MGI:1927139"
                     /translation="MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRR
                     SYSRFEEEDDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIP
                     RAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECG
                     HGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVG
                     AFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV
                     FSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR
                     VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVF
                     SVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMM
                     MGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRG
                     GQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKF
                     VNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR
                     LRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKR
                     TTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQV
                     LQ"
     exon            1047..1227
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1379
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1513
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1603
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1714
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1803
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1968
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2102
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2309
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2469
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..3920
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3873
                     /gene="Sv2a"
                     /gene_synonym="mKIAA0736"
                     /note="major polyA site"
ORIGIN      
        1 cgccgctgcc gcctcagccc tgtggctgga ccccctccct cacccgggga ctccctgacc
       61 cggggaacca agctcaggtc ttcagagcct ctcagaagaa aaataggcag ccctccctga
      121 aatatcttgg atcctcagtt tagcctctcc aacctggctc cccattccca atccctctcc
      181 ctccccctcc ccctccccca ctactcaccc tactgaactg ggtgcagaac aaagctcctt
      241 tcttcctttt tccccatctg gacctcactg tccaggccct agttcctctc agtctgagcc
      301 caaagatatt ggaacacagt tcatctggag agagggtctt cttgacccct ccgattcact
      361 gagcaaaggg ctgaaaaaga agcagagagt aaggtagatc cagtgaagtg ccccaagccc
      421 catcatggaa gaaggctttc gagaccgagc agcgttcatc cgtggggcca aagacattgc
      481 caaggaagtg aagaagcatg cggccaagaa ggtggtgaag ggccttgaca gagtccagga
      541 tgagtattcc cgaaggtcct actcccgctt tgaggaggag gacgacgacg atgacttccc
      601 tgcccctgcg gacggctatt accgcggaga aggggcccag gatgaggagg aaggtggcgc
      661 ttctagtgat gccaccgagg gccacgatga agatgatgag atctatgagg gagaatatca
      721 gggcatcccc cgggcagagt ctgggggcaa aggcgaacgc atggcagatg gggcacccct
      781 ggctggagtg agagggggct tgagtgatgg ggagggtccc cctgggggtc ggggggaggc
      841 gcagcggcgt aaagatcggg aagaattggc tcagcagtat gaaaccatcc tccgggagtg
      901 tggccatggc cgcttccagt ggacactcta cttcgtgctg ggtctggcgc tgatggcaga
      961 tggtgtagag gtctttgtgg tgggctttgt gctgcccagt gctgagaaag acatgtgcct
     1021 gtcggactcc aacaaaggca tgctaggcct cattgtgtac ctgggcatga tggtgggggc
     1081 cttcctctgg ggaggcctgg ctgatcggct gggtcggaga cagtgtctgc tcatctcact
     1141 ctcagtcaac agcgtcttcg ccttcttctc gtccttcgtc cagggttatg gaacctttct
     1201 cttctgccgc ctcctttccg gggtcgggat tggcggttcc atccccatag tcttctccta
     1261 tttttcggag tttctggcgc aggagaaacg tggggagcat ttgagctggc tctgtatgtt
     1321 ctggatgatc ggtggagtgt atgcagctgc aatggcctgg gccatcatcc ctcactatgg
     1381 gtggagtttc cagatgggct ctgcttacca gttccacagc tggagggtgt ttgtcctcgt
     1441 gtgtgccttt ccctctgtgt ttgccatcgg ggctctgact acgcagccag agagtccccg
     1501 cttcttccta gagaatggga agcatgacga agcctggatg gtactgaagc aggttcacga
     1561 caccaacatg cgagccaagg gccaccctga gcgcgtcttc tcagtgaccc acattaaaac
     1621 gattcatcaa gaggatgaat tgattgagat ccagtctgac acaggaacct ggtaccagcg
     1681 ctggggagta cgggctttga gccttggggg tcaggtttgg gggaatttcc tctcctgctt
     1741 cagtccagag tatcggcgca tcacgctgat gatgatgggt gtgtggttca ccatgtcttt
     1801 cagctactat ggtttgactg tctggtttcc cgacatgatc cgccatctcc aggctgtgga
     1861 ctatgcagcc cgaaccaaag tgttcccagg ggagcgcgtg gagcatgtga cgtttaactt
     1921 cacactggag aatcagatcc accgaggggg acagtacttc aatgacaagt tcatcgggct
     1981 gcgtctgaag tcagtgtcct ttgaggattc cctgtttgag gagtgttact ttgaagatgt
     2041 tacatccagc aacacattct tccgcaactg cacgttcatc aacactgtgt tctataacac
     2101 tgacctattt gagtacaagt tcgtgaacag ccggctggtg aacagcacgt tcctgcacaa
     2161 taaggaaggc tgcccgctag acgtgacggg gacaggcgaa ggtgcctaca tggtgtactt
     2221 tgtcagcttc ttggggacac tggctgtgct tcctggaaac attgtgtctg ctctgctcat
     2281 ggacaagatt ggcaggctca gaatgcttgc tggttccagt gtgttgtcct gtgtgtcctg
     2341 cttcttcctg tcttttggga acagcgagtc agccatgatc gctctgctct gcctttttgg
     2401 gggagttagc atcgcatcct ggaacgcgct ggacgtgctg accgttgagc tctacccttc
     2461 cgacaagagg actactgcct ttggcttcct gaatgccctg tgtaagctgg cagctgtgct
     2521 ggggatcagc atcttcacat cctttgtggg catcaccaag gctgctccca ttctctttgc
     2581 ctcggctgct cttgcccttg gtagctctct ggctctgaag ctgcctgaga cccggggaca
     2641 ggtgctgcag tgagggatgg gggctgtctc aggggcttta gggatggcag gcacactgtg
     2701 agaccaataa ttccttttat ccctaccctg ccctgctgtc ctggtcctca ctcctgtgtt
     2761 tggtgtctta gctgtgtgtg cctgtgtgca tgtgtgtgac cctgatgggc agggactaca
     2821 gggacggtcc cttcgttcca cttttgggat gaggtactcc ttacctgctg ccaccctcaa
     2881 ctttgcacaa ggagaaggct gcgctgcatc cttctctccc ccagtgttag caggggggct
     2941 gtttccctgc tccgagggtt ccggaacttc tgccttcccc ttctttccct ccgcctaggc
     3001 cctggtgaac cacaggtatg gagttataat gggggctgag gcttggacca aaagaacttc
     3061 ttgagtggga aggccttggg tgccctctag cctcccaagg atgctgggga gtagcaataa
     3121 acctcagccc tctggccacc attttcacct caattcaggc tacaagtgtg aagcctggat
     3181 ttaatttatg gaattagttt tctgagtttt atttatatgt aagttctgag gcagcttagc
     3241 tggactgtgt gtggatgtat acatacactc gtgtgtgtgc gtgcgcatgt gtgtgtgtgt
     3301 gtaccatggg gtaggggtac cactctactg tctaatataa gccaagagta gtagtttcag
     3361 tgaacacaca caacactgtt tttctatagt acctcccaga atcttgtatc tgtgctgggg
     3421 ctggaggcag aacccctagg ccaggctggg atgagtcctg caatcttggg ggacctgagg
     3481 gcacctgaca aggactcact ctctccttgc tctagagagg ttctacccac tagccacagc
     3541 cctccatctg acctgttcac acaggcagtg gaccagagga aagaaaggga gaataaccag
     3601 gcacgtatgg tcaaaccagc aggtccgaaa gcacaaggag ctggggcagg aagcaggggt
     3661 ccgtccctaa cccttctcaa aaaggctggg tcgtgaggga cccctaatgc agggaccaga
     3721 agcctcagtt tccccgtttt gcccttccac agaacagcct tgtaggtaga gctgcccccg
     3781 tcctacccta ctctgtgtgg ctgctttctt tggtactctc tctccactcc caacgtagct
     3841 gtgacgtgtt gtagttttta gctgtttgta aaatgttaaa aaaaaaaaaa gttaaaagga
     3901 agttaaacta accacaaaaa
//
