LOCUS       NM_199196               4449 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus SUZ12 polycomb repressive complex 2 subunit (Suz12),
            transcript variant 1, mRNA.
ACCESSION   NM_199196 XM_109999
VERSION     NM_199196.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4449)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4449)
  AUTHORS   Tangeman,J.A., Rebull,S.M., Grajales-Esquivel,E., Weaver,J.M.,
            Bendezu-Sayas,S., Robinson,M.L., Lachke,S.A. and Del Rio-Tsonis,K.
  TITLE     Integrated single-cell multiomics uncovers foundational regulatory
            mechanisms of lens development and pathology
  JOURNAL   Development 151 (1) (2024)
   PUBMED   38180241
REFERENCE   3  (bases 1 to 4449)
  AUTHORS   Matsui,Y., Djekidel,M.N., Lindsay,K., Samir,P., Connolly,N., Wu,G.,
            Yang,X., Fan,Y., Xu,B. and Peng,J.C.
  TITLE     SNIP1 and PRC2 coordinate cell fates of neural progenitors during
            brain development
  JOURNAL   Nat Commun 14 (1), 4754 (2023)
   PUBMED   37553330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4449)
  AUTHORS   Guo,L. and Zhang,C.
  TITLE     SUZ12 promotes the malignant behavior of gastric cancer cells by
            CDKs
  JOURNAL   J Biochem Mol Toxicol 37 (7), e23365 (2023)
   PUBMED   36994588
  REMARK    GeneRIF: SUZ12 promotes the malignant behavior of gastric cancer
            cells by CDKs.
REFERENCE   5  (bases 1 to 4449)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   6  (bases 1 to 4449)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4449)
  AUTHORS   de Napoles,M., Mermoud,J.E., Wakao,R., Tang,Y.A., Endoh,M.,
            Appanah,R., Nesterova,T.B., Silva,J., Otte,A.P., Vidal,M.,
            Koseki,H. and Brockdorff,N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
REFERENCE   8  (bases 1 to 4449)
  AUTHORS   Pasini,D., Bracken,A.P., Jensen,M.R., Lazzerini Denchi,E. and
            Helin,K.
  TITLE     Suz12 is essential for mouse development and for EZH2 histone
            methyltransferase activity
  JOURNAL   EMBO J 23 (20), 4061-4071 (2004)
   PUBMED   15385962
  REMARK    GeneRIF: Here we show that mice lacking Suz12, like Ezh2 and Eed
            mutant mice, are not viable and die during early postimplantation
            stages displaying severe developmental and proliferative defects.
REFERENCE   9  (bases 1 to 4449)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4449)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC064461.1 and AK076010.1.
            
            On Jul 9, 2009 this sequence version replaced NM_199196.1.
            
            Summary: This gene encodes a core component of the polycomb
            repressive complex 2 (PRC2) that also includes, at least, embryonic
            ectoderm development protein (EED) and enhancer of zeste homolog 1
            or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1
            or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3
            and Lys26 of histone 1, leading to recruitment of the PRC1 complex,
            histone 2A ubiquitylation and transcriptional repression of the
            target genes. This gene product is essential for the activity and
            integrity of the PRC2 complex, and is required for X chromosome
            inactivation, stem cell maintenance and differentiation. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064461.1, AK122213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4063              BC064461.1         1-4063
            4064-4064           AK076010.1         1337-1337
            4065-4449           BC064461.1         4064-4448
FEATURES             Location/Qualifiers
     source          1..4449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.36 cM"
     gene            1..4449
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /note="SUZ12 polycomb repressive complex 2 subunit"
                     /db_xref="GeneID:52615"
                     /db_xref="MGI:MGI:1261758"
     exon            1..494
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            495..541
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            542..606
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            607..675
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            676..725
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            726..811
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1043
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1137
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1243
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1421
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1513
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1657
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1815
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2014
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2094
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..4373
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /note="hexamer: ATTAAA"
     polyA_site      4321
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
     regulatory      4347..4352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /note="hexamer: TATAAA"
     polyA_site      4373
                     /gene="Suz12"
                     /gene_synonym="2610028O16Rik; D11Ertd530e; mKIAA0160"
                     /note="major polyA site"
ORIGIN      
        1 ccgaagcgga gcggggctcg gaggagacac tttttttttt tcctccctcc ttccctcctc
       61 tcctcctccc ttcccttccc ctctcctccc ctctctcctc cttcccccct cggtccgctg
      121 gagcctgctg gggcgagcgg ttggtgtagc aggcgcgctc actctccggg gccgcccggc
      181 gggtagctgg cggggggagg aggcaggaac cgcgatggcg cctcagaagc acggcggtgg
      241 gggagggggc ggctcggggc ccagcgcggg gtccggggga ggcggcttcg ggggttcggc
      301 ggcggcggtg gcggcggcgg cttcgggcgg caaatccggc ggcgggggct gtggaggcgg
      361 cggcagttac tcggcctcct cctcctcggc ggcggccgcg gcggcggcgg cgggggccgc
      421 ggtgttgccg gtgaagaagc cgaaaatgga gcacgtccag gctgaccacg agcttttcct
      481 ccaggccttt gagaaaccaa cacagatata tagatttctt cgaactcgaa atcttatcgc
      541 accaatattt ttgcacagaa ctcttactta catgtctcat cgaaattcca gaacaagcat
      601 caaaaggaaa acatttaaag ttgatgatat gttatcaaaa gtagagaaaa tgaaaggaga
      661 gcaagaatct catagcttgt ctgcacattt gcaacttaca tttaccggtt tcttccacaa
      721 aaatgataag ccatcacaaa actcagaaaa tgaacaaaat tctgttaccc tggaagtcct
      781 gcttgtgaaa gtttgccaca aaaaaaggaa ggatgtaagt tgtccaataa gacaagtccc
      841 tactggtaaa aagcaggtgc ctttgaatcc tgacctcaat caaacaaaac caggaaattt
      901 tccatccctg gcagtttcca gtaatgaatt tgaacctagt aacagccata tggtgaagtc
      961 ctactcgttg ctgtttagag taactcgtcc aggaagaaga gaatttaatg gaatgattaa
     1021 tggagaaacc aatgaaaata ttgatgtcag tgaagaactt ccagccagaa gaaaacgaaa
     1081 tcgcgaagat ggagaaaaga catttgttgc acaaatgaca gtttttgaca aaaacaggcg
     1141 tttacagctt ttagatgggg aatatgaagt ggccatgcag gaaatggaag aatgtccaat
     1201 aagtaagaaa agagcaacat gggagacaat tcttgatggg aagaggctgc ctccatttga
     1261 gacattttct cagggaccta cattacaatt tactcttcga tggacaggag aaaccaacga
     1321 taagtctaca gctcctgttg ccaagcctct tgccactaga aattcagaga gccttcatca
     1381 ggaaaataag cctggttctg ttaaacctgc acaaactatt gctgttaagg agacgctgac
     1441 tacagagctg caaacaagaa aagaaaagga taattcaaat gaaagtcgcc agaagttaag
     1501 aatattttat cagttccttt ataacaataa tacaagacaa cagacagaag ccagagacga
     1561 cctgcactgc ccgtggtgca ctctgaactg ccgtaaactg tatagcttac tcaaacatct
     1621 aaagctctgc cacagcaggt tcatcttcaa ttacgtatat catccaaaag gtgctaggat
     1681 agatgtttca atcaatgagt gttatgatgg ctcctatgca ggaaatcctc aggatataca
     1741 tcgccaacct ggatttgctt ttagtcgaaa tggaccggta aagagaacac ctatcacaca
     1801 tattcttgtt tgcaggccaa aaagaacaaa agcaagcatg tcggagtttc ttgaatctga
     1861 agatggagaa gtggagcagc agagaacata cagcagtggc cacaatcgtc tctatttcca
     1921 cagtgatacc tgcttacctc ttcggccaca agaaatggaa gtagatagtg aagatgagaa
     1981 agatccagaa tggctgagag aaaaaaccat tactcaaatt gaagaatttt ctgatgtgaa
     2041 tgaaggagag aaagaagtga tgaagctgtg gaacctccat gtcatgaagc atggatttat
     2101 tgctgacaat caaatgaatc atgcctgtat gctgtttgta gaaaattatg gacagaaaat
     2161 aattaagaag aatttatgtc gaaacttcat gcttcatcta gtcagcatgc atgactttaa
     2221 tcttattagc ataatgtcaa tagataaagc tgttaccaag ctccgagaaa tgcagcaaaa
     2281 actagaaaaa ggagaatctg cgaccccttc aaatgaagaa atagctgagg aacaaaatgg
     2341 aacagcaaat ggattcagtg aaactaactc aaaagagaaa gctttggaaa ctgacggtgt
     2401 ctcaggggtt ccaaaacaga gcaagaaaca aaaactctga gaacttgccc catgttttga
     2461 acagacactg aagttgcttc tagggaattc agcctctagg aagagttttg gttttaggtt
     2521 gtttggcttt taatcatgga ttgggaacag gcagtgttcg atgatgtcat tgatttcagc
     2581 acggaggttc tgtgggtctg cttggctgct tctcctcacg tgcttatcaa ctttagtgat
     2641 gtcctcaatt tggttttagc ctgaaaagca gtttttcaaa tagttaattt tttcttagct
     2701 atgacacaca tcttattaaa tatattgggt taatctagaa atttcacacc taaattttaa
     2761 tgcttatttc atttgtgact ttttctgctt tgtaattatg agacattttc tgggaaaggg
     2821 atgttgggat gttatgctgt cttagagatg gagaattttt gtgaaattgt tacttacatt
     2881 gccactttcc cccaaacgtt gacccttgat tcagaaatca tgcatctggg atgagaagtt
     2941 acaaagcaag ttctgcatca gttgtgttac aagttcaaaa cagcaccagt tggtctcctg
     3001 tcggaggcag tgtgactgcc ttccatgcag ccatgcagtg ccgtcccgtg cgcactgagg
     3061 gagctcgctg ttccttttca agtgaatggt tttagtgctt gttttcccag tttaggtttt
     3121 tacttgaaca tgtttttagt ttttcctttt aattaggtaa ccccatggga aattgttctg
     3181 tgcacgtctt ttgcactagg atggtaaagc aagagaaaca gttggagatt cagaagatgc
     3241 cactgtgggg agggtgtctc tgagtgtaaa ccagaagatg tcacaccttg tttcctttgt
     3301 gacatccttc ttgattagaa tatccataca gataagctga cttgaattgt tgtgagcaat
     3361 tttccctgtg ttctgtgttt tatgcacata ttcgtggttg ggttttctcc aacagaaagt
     3421 ggtttcacta ctggcacgga tagcttttta ttccagctcc aagcactgtg gttgaataac
     3481 atcacctcaa ttttttatta tcctttaaag atattgcatt ttcatattct ttatttataa
     3541 aggatcaatg ctgctgtaaa tactggtatt tttaatgttt taatttcatt ccaccaccat
     3601 cagatgcagt tccctgtttt gtttggttaa gggacataag ctttctcatg gtgtcttcag
     3661 agatttataa gtgtaaatac tgatttggct ggtctttatg atgtgtttaa ctgtgaggct
     3721 atttaaatag tgtggatgtg acttgtcatc cagtattaag ttcttagtta ctggtttttg
     3781 tgttaaaaaa aaataagaaa gagggaagct gcagttttcg ttgtaggctc cctagctggt
     3841 aaactctcct cacgagttca ctgaactctg atttttgcct ctgggtagtg ggttctgagc
     3901 atttctcctg ggctttaatt tgctaaagct gtgcacatat gtaaaaatca aaaaaataga
     3961 ttattttagg gaagatgtag gtgtagaatt attgcttatg tcatttctta aagcagttat
     4021 gctcttaatg cttaaaagaa ggctagcatt gtttgcacaa aaaattggtg atttccctcc
     4081 cctgaacagt aatgaaatta cttctgttga gtaaactttt tatgtcatct tataataaaa
     4141 gctaaaaatg ccctttggtt ctatttataa aaaaaaaaaa gcttttctat atgtaccctt
     4201 gaaaacagat tttgaagaaa tcatgtaaga tgataaagca tttgaatggt acaatagatg
     4261 taaaaaaatt cagtttaaaa gaaacgtttg tttttacatt aaatgtttat ttgaaatcaa
     4321 atgattttgt acataaagtt caataatata aagctgtctt ctgcttttct tcaaaaaaaa
     4381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4441 aaaaaaaaa
//
