LOCUS       NM_022724               4282 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus suppressor of variegation 3-9 2 (Suv39h2), transcript
            variant 1, mRNA.
ACCESSION   NM_022724
VERSION     NM_022724.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4282)
  AUTHORS   Keenan,C.R., Coughlan,H.D., Iannarella,N., Tapia Del Fierro,A.,
            Keniry,A., Johanson,T.M., Chan,W.F., Garnham,A.L., Whitehead,L.W.,
            Blewitt,M.E., Smyth,G.K. and Allan,R.S.
  TITLE     Suv39h-catalyzed H3K9me3 is critical for euchromatic genome
            organization and the maintenance of gene transcription
  JOURNAL   Genome Res 34 (4), 556-571 (2024)
   PUBMED   38719473
  REMARK    GeneRIF: Suv39h-catalyzed H3K9me3 is critical for euchromatic
            genome organization and the maintenance of gene transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4282)
  AUTHORS   Balan,S., Iwayama,Y., Ohnishi,T., Fukuda,M., Shirai,A., Yamada,A.,
            Weirich,S., Schuhmacher,M.K., Dileep,K.V., Endo,T., Hisano,Y.,
            Kotoshiba,K., Toyota,T., Otowa,T., Kuwabara,H., Tochigi,M.,
            Watanabe,A., Ohba,H., Maekawa,M., Toyoshima,M., Sasaki,T.,
            Nakamura,K., Tsujii,M., Matsuzaki,H., Zhang,K.Y.J., Jeltsch,A.,
            Shinkai,Y. and Yoshikawa,T.
  TITLE     A loss-of-function variant in SUV39H2 identified in autism-spectrum
            disorder causes altered H3K9 trimethylation and dysregulation of
            protocadherin beta-cluster genes in the developing brain
  JOURNAL   Mol Psychiatry 26 (12), 7550-7559 (2021)
   PUBMED   34262135
  REMARK    GeneRIF: A loss-of-function variant in SUV39H2 identified in
            autism-spectrum disorder causes altered H3K9 trimethylation and
            dysregulation of protocadherin beta-cluster genes in the developing
            brain.
REFERENCE   3  (bases 1 to 4282)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4282)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4282)
  AUTHORS   Keenan,C.R., Iannarella,N., Naselli,G., Bediaga,N.G.,
            Johanson,T.M., Harrison,L.C. and Allan,R.S.
  TITLE     Extreme disruption of heterochromatin is required for accelerated
            hematopoietic aging
  JOURNAL   Blood 135 (23), 2049-2058 (2020)
   PUBMED   32305044
  REMARK    GeneRIF: Extreme disruption of heterochromatin is required for
            accelerated hematopoietic aging.
REFERENCE   6  (bases 1 to 4282)
  AUTHORS   Yang,L., Mei,Q., Zielinska-Kwiatkowska,A., Matsui,Y.,
            Blackburn,M.L., Benedetti,D., Krumm,A.A., Taborsky,G.J. Jr. and
            Chansky,H.A.
  TITLE     An ERG (ets-related gene)-associated histone methyltransferase
            interacts with histone deacetylases 1/2 and transcription
            co-repressors mSin3A/B
  JOURNAL   Biochem J 369 (Pt 3), 651-657 (2003)
   PUBMED   12398767
  REMARK    GeneRIF: ESET histone methyltransferase can form a large,
            multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2
            that participates in multiple pathways of transcriptional
            repression.
REFERENCE   7  (bases 1 to 4282)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4282)
  AUTHORS   Peters,A.H., O'Carroll,D., Scherthan,H., Mechtler,K., Sauer,S.,
            Schofer,C., Weipoltshammer,K., Pagani,M., Lachner,M., Kohlmaier,A.,
            Opravil,S., Doyle,M., Sibilia,M. and Jenuwein,T.
  TITLE     Loss of the Suv39h histone methyltransferases impairs mammalian
            heterochromatin and genome stability
  JOURNAL   Cell 107 (3), 323-337 (2001)
   PUBMED   11701123
REFERENCE   9  (bases 1 to 4282)
  AUTHORS   O'Carroll,D., Scherthan,H., Peters,A.H., Opravil,S., Haynes,A.R.,
            Laible,G., Rea,S., Schmid,M., Lebersorger,A., Jerratsch,M.,
            Sattler,L., Mattei,M.G., Denny,P., Brown,S.D., Schweizer,D. and
            Jenuwein,T.
  TITLE     Isolation and characterization of Suv39h2, a second histone H3
            methyltransferase gene that displays testis-specific expression
  JOURNAL   Mol Cell Biol 20 (24), 9423-9433 (2000)
   PUBMED   11094092
REFERENCE   10 (bases 1 to 4282)
  AUTHORS   Rea,S., Eisenhaber,F., O'Carroll,D., Strahl,B.D., Sun,Z.W.,
            Schmid,M., Opravil,S., Mechtler,K., Ponting,C.P., Allis,C.D. and
            Jenuwein,T.
  TITLE     Regulation of chromatin structure by site-specific histone H3
            methyltransferases
  JOURNAL   Nature 406 (6796), 593-599 (2000)
   PUBMED   10949293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX227854.1, AK083457.1 and AL732620.14.
            
            On Apr 23, 2009 this sequence version replaced NM_022724.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083457.1, AF149205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CX227854.1         1-23
            24-3869             AK083457.1         2-3847
            3870-4282           AL732620.14        166617-167029       c
FEATURES             Location/Qualifiers
     source          1..4282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 1.95 cM"
     gene            1..4282
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="suppressor of variegation 3-9 2"
                     /db_xref="GeneID:64707"
                     /db_xref="MGI:MGI:1890396"
     exon            1..284
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1474
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /EC_number="2.1.1.355"
                     /note="H3-K9-HMTase 2; su(var)3-9 homolog 2; histone H3-K9
                     methyltransferase 2; Suv39h histone methyltransferase;
                     suppressor of variegation 3-9 homolog 2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SUV39H2"
                     /protein_id="NP_073561.2"
                     /db_xref="CCDS:CCDS15652.1"
                     /db_xref="GeneID:64707"
                     /db_xref="MGI:MGI:1890396"
                     /translation="MAAARAKARGSEAGARCHRAPGPPPRPKARRTARRRRAETLTAR
                     RSRPSAGERRAGSQRAWSGAPRAAVFGDECARGALFKAWCVPCLVSLDTLQELCRKEK
                     LTCKSIGITKRNLNNYEVEYLCDYKVAKGVEYYLVKWKGWPDSTNTWEPLRNLRCPQL
                     LRQFSDDKKTYLAQERKCKAVNSKSLQPAIAEYIVQKAKQRIALQRWQDYLNRRKNHK
                     GMIFVENTVDLEGPPLDFYYINEYRPAPGISINSEATFGCSCTDCFFDKCCPAEAGVV
                     LAYNKKQQIKIQPGTPIYECNSRCRCGPECPNRIVQKGTQYSLCIFRTSNGCGWGVKT
                     LVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNV
                     SHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSD
                     SIDHSPAKKRVRTQCKCGAETCRGYLN"
     exon            285..430
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            431..1090
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1237
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1367
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..4282
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="hexamer: AATAAA"
     polyA_site      2517
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="major polyA site"
     regulatory      2579..2584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="hexamer: AATAAA"
     polyA_site      2604
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="hexamer: ATTAAA"
     polyA_site      3052
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="hexamer: AATAAA"
     polyA_site      3178
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
     regulatory      4262..4267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
                     /note="hexamer: AATAAA"
     polyA_site      4282
                     /gene="Suv39h2"
                     /gene_synonym="4930507K23Rik; D030054H19Rik; D2Ertd544e;
                     KMT1B"
ORIGIN      
        1 ttcgggctga ccgcgccagt ttgaatgaaa gctccgcaag atggcggcgg ccagggccaa
       61 ggcacggggc agtgaggcag gagcgcggtg tcaccgggct ccaggtccgc ccccgaggcc
      121 caaggccagg cgaacggcga gacgccgccg cgcggagacc ctgacggcgc gacgctcgcg
      181 gccgtctgcg ggcgagaggc gcgccggctc ccagcgagcg tggtccggag ctccgcgggc
      241 cgcggtcttt ggcgacgagt gtgcacgagg tgccttattc aaggcctggt gtgtgccttg
      301 cctagtttca cttgatactc tccaggaatt atgtagaaaa gaaaagctca catgtaaatc
      361 gattggaatc accaaaagga atctaaacaa ttatgaggtg gagtacttgt gtgactacaa
      421 ggtagcaaag ggtgtggaat attatcttgt aaaatggaaa ggatggccag attctacaaa
      481 cacctgggag cccttgagaa acctcaggtg tccacagctc ctgcggcagt tctctgatga
      541 caagaagact tacttagctc aggaaaggaa atgcaaggct gtcaattcaa aatccttgca
      601 acctgcaatt gctgagtata ttgtacagaa agctaagcaa agaatagctc tgcagagatg
      661 gcaagattac ctcaacagaa gaaagaacca taaggggatg atatttgttg aaaacactgt
      721 tgacttggag ggcccacctt tagacttcta ctacattaac gagtacaggc cagctcccgg
      781 gatcagcata aacagtgaag ccacctttgg atgttcatgt acagactgct tctttgacaa
      841 gtgttgtcct gctgaagctg gagttgtgtt ggcttataat aagaagcaac aaattaaaat
      901 ccaaccaggc actcccatct acgaatgcaa ctcaaggtgt cgatgtggac ctgaatgtcc
      961 caataggatt gtacaaaaag gcacacaata ttcactgtgc atctttagaa ctagcaatgg
     1021 ctgtggttgg ggtgtaaaaa cccttgtgaa gattaaaaga atgagttttg tcatggaata
     1081 tgttggagag gtgatcacaa gtgaagaggc cgagagacgg ggacagttct atgacaacaa
     1141 agggatcacc tacctctttg acctggacta cgagtctgat gagttcacag tggatgcagc
     1201 tcgatatgga aacgtatccc attttgtgaa tcatagttgt gacccaaatc ttcaggtgtt
     1261 tagtgttttc atcgataacc ttgatactcg gctgcccagg atagcattgt tctctacaag
     1321 aaccataaac gctggagaag agctgacttt tgactatcaa atgaaaggtt ctggagaagc
     1381 atcttcagac tccattgacc acagccctgc caaaaaaagg gtcagaaccc aatgtaaatg
     1441 tggagccgag acttgcagag gttacctcaa ctgaagtgtc aggaaacgga gctcatgaag
     1501 aaaaagctca ttagaagaaa aacaaaacaa aaactaacaa ttgaaaaagt atttgggact
     1561 cctttctatt acctacatat tgtattatat gatgttaata tacagttcat ggctcaagtc
     1621 attgccaagt atattactgt ttattctgaa aaggactgcg gggcacataa acggtagata
     1681 tttggtggtt aaatggaaag tgaactatgt ataaatcact gtttgcttac ttgagaagtc
     1741 ggaatagaca attattccct ttagtgtttg aaaagtgagg ctaccacagt tactatgaaa
     1801 ccttttatct tgactcaaac agataatcca atttaggcaa atgtataaat tttatttttt
     1861 tactatatta tttctgttta atactcactg atcagagaca aataagtgct gaatttttta
     1921 ctatattttc tacttttaca taaaaacatt ggcatcttaa tgatatattt caggtgtaaa
     1981 aatgtgaaag acttacttct agcttgatct tattttgaag caatagatac cattacaaag
     2041 gttgtatatc tgaacctgaa attcttaaaa gatttttttt agttgcacag aagaaaagcc
     2101 cctaatcacc ttctctagaa gtctatagtg gctggccatt gtgcttcttt gaacacacag
     2161 aacagtgact aggagggccc attggagtgc caggcagagt gagccactca gcgagtggga
     2221 ggtccgcact gagtatctca tctgagcagg agtgagatcc gtgagggaca caagccccga
     2281 tgacagtgta attcaggtca cttgcaggca cttttaatta ctatccacta catttaaata
     2341 attttgtatt ttgtgcatgc ccttttgaac agatacttgt tttatacaag aattttttta
     2401 taagataaaa cttagcttgg ccagagttat gtctgattga atttttatta acttctgggg
     2461 attagatgcg gtttttccct gtgtagtaaa acccaataaa gaaaaaactt actttcatct
     2521 ttctgggtct gggagttcta atcatggtgt ccactgtgaa gacaaaacaa atgcagcaaa
     2581 taaagcaagc ttttggtttc ctaagagttc ccccggctca ctgctccagg ctttaataga
     2641 ctatgataag cgtcagtaaa atgaactgaa ttcaggagct cagcatttcc tttatcttcc
     2701 taactcttgg cctggtttga gagaagctac agtattactc aaaatcacct tcatggggct
     2761 gctgttcaca acagtacatg cagaatatcg ccttcatggg gctgctgttc acagtacata
     2821 gtattcagtg tgcatatttg aggccttgta gtatgtctgc tacccaaaga tttccgaatt
     2881 tgtcaagaaa aaagtataat tttaaatggc atttcttttg ttttgagaat cttaaaagca
     2941 acacgggtat cccgtcccat ccccccgtcc caccccctaa caaccccttg gccaagctca
     3001 ccttgaatta ttctcaggtt taaagattaa aaaaagacag acaaaaccaa aacccagtgt
     3061 ttgactgtct agatatttgg tcttatttac tgttaaggtt aaaaggaaac ttaggagggc
     3121 aagaaggaaa atactgttta ataaatatgt ggctttgttt tgtccttact aatagaaatt
     3181 taatgtgccc ttaagatttt gtggggagtg ggtaggcctt tggacagagt atctgtagcc
     3241 aggttagcct tgaatttact gtgtagctga gtattatcgt gaactcctca gctctgcccc
     3301 cctacggccc agcgctggga ttgcagacac gtgccaccat gccagcctgg agatttttac
     3361 ctttaaacac aaacagactt cactctgagt gccacacatg taatggtcat tgcttccctt
     3421 cactattcca ttactctttc ctgcctctca acattccccc attacatccc tctcagactg
     3481 tcacctcatg ttagctattt atacagggta tgtgtatgtg tgtgcacatt gttgtgataa
     3541 aagtgatcaa ttcagctgga gcctgattcc tcacgtcaca cgtcccaagt atgtagtgtc
     3601 ttcagcaaca tgtccttgga aataatcatg acaggaactt gagcagaggc tggaaccatg
     3661 taggaaagct aacgctgctt cttggcttac tctcagccag actcatgctc agctaggttt
     3721 cttagatagc ccaggcccct ctgcctagga atggtactgc ccacagtgag ctagaccccg
     3781 ctacatcaat tacaattaag gaaatcccca cagacatgcc acaggccaat tttgatggag
     3841 ccagtttctc aaatgaggtt actttttccc aggtgaccct aggcttgtca agttgtatga
     3901 gaaggtatat acaatcagtt tgcatttgat tcttctctga agtaaaagtg gctagccttt
     3961 aggattttgt gatgtatctt ggcattttga aatgttttta actttgctaa tttagaactc
     4021 ttgaagaatg atgtagccac tacaatcaat gctgcccgtt ttaatgcttt atgtaaagag
     4081 ctttcctcat acagcagagt gctcgagcat ggactctaaa agcttcgggg tgtgtgtgtc
     4141 tgtgtgtgtg tgttgcttac tagctatgtg aactaacctt tgtgccttag tttcatgcct
     4201 acctcaaagt atggtttcat agattaaagc tttataaagt gggctttttt tttaataaca
     4261 gaataaacac catatgtaaa ga
//
