LOCUS       NM_001358237            3414 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus suppressor of variegation 3-9 1 (Suv39h1), transcript
            variant 3, mRNA.
ACCESSION   NM_001358237 XM_011247453
VERSION     NM_001358237.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3414)
  AUTHORS   Keenan,C.R., Coughlan,H.D., Iannarella,N., Tapia Del Fierro,A.,
            Keniry,A., Johanson,T.M., Chan,W.F., Garnham,A.L., Whitehead,L.W.,
            Blewitt,M.E., Smyth,G.K. and Allan,R.S.
  TITLE     Suv39h-catalyzed H3K9me3 is critical for euchromatic genome
            organization and the maintenance of gene transcription
  JOURNAL   Genome Res 34 (4), 556-571 (2024)
   PUBMED   38719473
  REMARK    GeneRIF: Suv39h-catalyzed H3K9me3 is critical for euchromatic
            genome organization and the maintenance of gene transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3414)
  AUTHORS   Hou,L., Zhao,J., Cai,L., Jin,L., Liu,B., Li,S., Yang,J., Ji,T.,
            Li,S., Shi,L., Shen,B., Yu,H., Wang,Y. and Cai,X.
  TITLE     HBV PreC interacts with SUV39H1 to induce viral replication by
            blocking the proteasomal degradation of viral polymerase
  JOURNAL   J Med Virol 96 (4), e29607 (2024)
   PUBMED   38628076
  REMARK    GeneRIF: HBV PreC interacts with SUV39H1 to induce viral
            replication by blocking the proteasomal degradation of viral
            polymerase.
REFERENCE   3  (bases 1 to 3414)
  AUTHORS   Wu,X., Shen,Y., Meng,Y., Chen,J., Zhang,Y., Zeng,S. and Xu,H.
  TITLE     Suv39h1 contributes to activation of hepatic stellate cells in
            non-alcoholic fatty liver disease by enabling anaerobic glycolysis
  JOURNAL   Life Sci 341, 122498 (2024)
   PUBMED   38340980
  REMARK    GeneRIF: Suv39h1 contributes to activation of hepatic stellate
            cells in non-alcoholic fatty liver disease by enabling anaerobic
            glycolysis.
REFERENCE   4  (bases 1 to 3414)
  AUTHORS   Rao,V.K., Pal,A. and Taneja,R.
  TITLE     A drive in SUVs: From development to disease
  JOURNAL   Epigenetics 12 (3), 177-186 (2017)
   PUBMED   28106510
  REMARK    Review article
REFERENCE   5  (bases 1 to 3414)
  AUTHORS   Krauss,V.
  TITLE     Glimpses of evolution: heterochromatic histone H3K9
            methyltransferases left its marks behind
  JOURNAL   Genetica 133 (1), 93-106 (2008)
   PUBMED   17710556
  REMARK    Review article
REFERENCE   6  (bases 1 to 3414)
  AUTHORS   Czvitkovich,S., Sauer,S., Peters,A.H., Deiner,E., Wolf,A.,
            Laible,G., Opravil,S., Beug,H. and Jenuwein,T.
  TITLE     Over-expression of the SUV39H1 histone methyltransferase induces
            altered proliferation and differentiation in transgenic mice
  JOURNAL   Mech Dev 107 (1-2), 141-153 (2001)
   PUBMED   11520670
  REMARK    GeneRIF: role in co-regulating growth control and differentiation
            during mammalian development
REFERENCE   7  (bases 1 to 3414)
  AUTHORS   O'Carroll,D., Scherthan,H., Peters,A.H., Opravil,S., Haynes,A.R.,
            Laible,G., Rea,S., Schmid,M., Lebersorger,A., Jerratsch,M.,
            Sattler,L., Mattei,M.G., Denny,P., Brown,S.D., Schweizer,D. and
            Jenuwein,T.
  TITLE     Isolation and characterization of Suv39h2, a second histone H3
            methyltransferase gene that displays testis-specific expression
  JOURNAL   Mol Cell Biol 20 (24), 9423-9433 (2000)
   PUBMED   11094092
REFERENCE   8  (bases 1 to 3414)
  AUTHORS   Rea,S., Eisenhaber,F., O'Carroll,D., Strahl,B.D., Sun,Z.W.,
            Schmid,M., Opravil,S., Mechtler,K., Ponting,C.P., Allis,C.D. and
            Jenuwein,T.
  TITLE     Regulation of chromatin structure by site-specific histone H3
            methyltransferases
  JOURNAL   Nature 406 (6796), 593-599 (2000)
   PUBMED   10949293
REFERENCE   9  (bases 1 to 3414)
  AUTHORS   Bultman,S. and Magnuson,T.
  TITLE     Molecular and genetic analysis of the mouse homolog of the
            Drosophila suppressor of position-effect variegation 3-9 gene
  JOURNAL   Mamm Genome 11 (4), 251-254 (2000)
   PUBMED   10754099
REFERENCE   10 (bases 1 to 3414)
  AUTHORS   Aagaard,L., Laible,G., Selenko,P., Schmid,M., Dorn,R., Schotta,G.,
            Kuhfittig,S., Wolf,A., Lebersorger,A., Singh,P.B., Reuter,G. and
            Jenuwein,T.
  TITLE     Functional mammalian homologues of the Drosophila PEV-modifier
            Su(var)3-9 encode centromere-associated proteins which complex with
            the heterochromatin component M31
  JOURNAL   EMBO J 18 (7), 1923-1938 (1999)
   PUBMED   10202156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663032.9.
            
            On Nov 22, 2022 this sequence version replaced NM_001358237.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.25920.1,
                                           SRR7345562.1453296.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-497               AL663032.9         26488-26984         c
            498-643             AL663032.9         24695-24840         c
            644-1306            AL663032.9         22960-23622         c
            1307-1453           AL663032.9         16283-16429         c
            1454-1592           AL663032.9         16059-16197         c
            1593-3414           AL663032.9         13534-15355         c
FEATURES             Location/Qualifiers
     source          1..3414
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.64 cM"
     gene            1..3414
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /note="suppressor of variegation 3-9 1"
                     /db_xref="GeneID:20937"
                     /db_xref="MGI:MGI:1099440"
     exon            1..497
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..1726
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /EC_number="2.1.1.355"
                     /note="isoform 3 is encoded by transcript variant 3;
                     histone-lysine N-methyltransferase SUV39H1; su(var)3-9
                     homolog 1; histone H3-K9 methyltransferase 1;
                     position-effect variegation 3-9 homolog; Suv39h histone
                     methyltransferase; suppressor of variegation 3-9 homolog
                     1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SUV39H1
                     isoform 3"
                     /protein_id="NP_001345166.1"
                     /db_xref="GeneID:20937"
                     /db_xref="MGI:MGI:1099440"
                     /translation="MGEPATLGCSVCCKSSWNQLQDLCRLAKLSCPALGVSKKNLYDF
                     EVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHKDLERELVRRH
                     RRSKPPRHLDPNLANYLVQKAKQRRALQRWEQELNAKRSHLGRITVENEVDLDGPPRS
                     FVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQ
                     PIYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVG
                     EIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVY
                     NVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQGGGVDPVDMESTRMDSNFGLAGL
                     PGSPKKRVRIECKCGTTACRKYLF"
     exon            498..643
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1306
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1453
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1592
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..3414
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /note="hexamer: AATAAA"
     polyA_site      3142
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /note="major polyA site"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
                     /note="hexamer: AATACA"
     polyA_site      3414
                     /gene="Suv39h1"
                     /gene_synonym="DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6"
ORIGIN      
        1 ctcttctcgc gaggccggtt aggcccgaat gttgttagct gtggagaaag atggcggaaa
       61 atttaaaagg tgaagctgtg gtgctagaga cgcgagctac tggcccggcc gagtagaatg
      121 gagggaaggt ggccggggct ccaggccagg cgtccggagc tacggagcct ggagctggaa
      181 ggccggcgcg gcaaacgtgg gggccgagag cgcgggcccg gcgcgcgggc agggcggggc
      241 tgaggggagg gggcgcgtgc ttcggccgcg gggggcgcgg ggctgcgcag gccgcgcgcg
      301 gggtttctcg gccgcgcgcg gctggccggc gcgcctacgc gcgtgagaga gagtcctgaa
      361 ggagaaggtt gcggccacgc gcgggaaaag gcggctctca gtgaccgtta ccctttcggt
      421 ttccacggga gacgccggaa ggggaggaag aagtggaacg gacccccttc tcaaaatggg
      481 ggagccggcg actctaggtt gcagtgtgtg ctgtaaatct tcttggaatc aactgcagga
      541 cctgtgccga ctagccaagc tttcttgtcc tgcccttggt gtttctaaga agaatctgta
      601 tgactttgaa gttgaatacc tgtgtgatta taagaagatc cgtgagcagg agtattacct
      661 ggttaagtgg cgtgggtatc ccgactcaga aaacacctgg gagccacggc agaatctaaa
      721 atgtatacga gttcttaagc agttccacaa ggacttagaa agagagcttg tccgacgaca
      781 ccgccggtca aagccaccca ggcatctgga cccaaaccta gccaattacc tggtgcagaa
      841 ggccaagcag aggcgggcac ttcagcgttg ggaacaagag ctcaatgcca agcgcagcca
      901 cctggggcgg atcaccgtgg agaatgaggt agacctggat ggccctccaa ggtcctttgt
      961 ctatatcaat gagtatcgag ttggtgaggg catcaccctc aaccaggtag ctgttggctg
     1021 tgagtgccag gactgtctgt tggcacccac tggaggctgt tgccctggag catccctgca
     1081 caagtttgcc tacaatgacc aaggccaggt gcgactgaaa gctgggcagc ccatctacga
     1141 gtgcaactcc cgctgttgct gtggctatga ctgcccaaac cgtgtagtcc agaaaggcat
     1201 ccgctacgat ctctgcatct tccgcactaa tgatggccga ggctggggtg tccgcacgct
     1261 ggaaaagatc cgaaaaaata gctttgttat ggagtatgtg ggagagatta ttacctcaga
     1321 ggaggcagag cggaggggcc agatctacga ccgccagggc gccacctacc tctttgacct
     1381 ggactacgtg gaagacgtat ataccgtgga tgccgcttat tatggcaaca tctctcattt
     1441 tgtcaaccat agttgtgatc ccaacctgca ggtgtacaac gtattcatag acaaccttga
     1501 tgagcgacta ccccgcatcg cattctttgc cacaagaacc atctgggcgg gcgaggagct
     1561 cacctttgat tacaacatgc aaggtggggg tgtggacccc gtggacatgg agagtacccg
     1621 aatggactcc aactttggcc tggctgggct ccccggctcc cccaagaaac gagtccgtat
     1681 tgaatgcaaa tgtgggacaa cggcttgccg aaaatacctc ttctagccct gagaagtctg
     1741 aggccagact aactgaaggg gcctgaagcc accttcctct cctacagcta ccctcttgtc
     1801 aaggatgacc atcaatcaga gccttgtctg cctccacttg tcctcaccta ccctaacctg
     1861 ctctagggtc agggctgttg tgaggactaa ctccgggtac ccttttcctg ttcctttccc
     1921 cctgttccag gcccatcagg cattgcactt aaaactccca gccccatttt cagaaacata
     1981 tttttcacat catgattccc tagagttgga attcatgtca tataatggag gtccagattg
     2041 aggaactcgg ctgtaaaaca gattctttgt tttggacagc atctctgcag ctctatgtag
     2101 taagtctggt gtttggaccg ttaatcttcc tgtctcagcc ttcctcatga tgagattgta
     2161 ggtgtaaacc cagctaagat ttttgttcta attgcatctg cttctgcttg gagcttgtgt
     2221 gtgacctgtt gcaggcctct tcattactct aatggtatga ggaagcaacc ccctggcaga
     2281 cagacatcag agctgagata ccagcctaac atcaagctgg atcagcaacc ccagagcctt
     2341 tgtactcagg aaagaaaagg caatcttcag agctgggaga taaggctggt tccgctcttt
     2401 gtgcttttga tgctggctgg tattaacctt aagacctata gggtctcaac agttgcaagt
     2461 ctgaaaagta gttgcccaaa tgccatcaga atggggatgg agtaaatacc tctttgaaag
     2521 ccccacagaa aggttagaac taagttttac catcaggaag tacagtgctg gacttgctgg
     2581 aaacccagcc ttggcatttg atggccacta gaactactag aagctggaac caagatctag
     2641 gtattcttta gatagcactt aagacagtaa tgtgcatcga ctagaaggcg atgtgatgcc
     2701 aggcacttgg tagagcacct ggtccataca gattgtctca gggaagcctt gaaaaccaca
     2761 aaggtggagc ccagaaaaaa gcccatgtga cagaaggcaa tgtctaggcc aaaaatactt
     2821 gtcagctcca agtattcacc tgggtccact tgtctcagtt aactgcctag aaatgtacaa
     2881 aaggcaaaga ttctgatggc tgccttgccc cctgcttccc cacctccagg aagcctttcc
     2941 tgacttcctg tgcccagagt gccctatgtg aaactctgta ccctgctacc agatgccagg
     3001 tctgtgtgtg tattttgtat atatgtttcc tgcccatact tcccaggctg accttcaggc
     3061 atggactgaa tctggttctc tctgtacccc tcagccctcc ctagcctgga gtgcacacca
     3121 ataaactgtg ttgttgagtt aataagcttg agatttggga gattgaggtc ttgatgataa
     3181 ctgggaaatg agaggttaga agctggggtt gagttgctct agaatgcggt cagaaaggct
     3241 tgagtcatct caccgtgatc ttcctatttg gggcccctta taaagtggtc taaagccatt
     3301 ttaaaaacac acttgaacaa atagtccagc tttttctaaa ttgatttgtt gctacaaaca
     3361 aaaataacta cctgaagaaa taaatacaat ggaagtcaat gtgctaaaat tcaa
//
