LOCUS       NM_027890               3255 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus sushi domain containing 2 (Susd2), transcript variant
            1, mRNA.
ACCESSION   NM_027890
VERSION     NM_027890.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Zhao,B., Gong,W., Ma,A., Chen,J., Velegraki,M., Dong,H., Liu,Z.,
            Wang,L., Okimoto,T., Jones,D.M., Lei,Y.L., Long,M., Oestreich,K.J.,
            Ma,Q., Xin,G., Carbone,D.P., He,K., Li,Z. and Wen,H.
  TITLE     SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2
            receptor signaling
  JOURNAL   Nat Immunol 23 (11), 1588-1599 (2022)
   PUBMED   36266363
  REMARK    GeneRIF: SUSD2 suppresses CD8<sup>+</sup> T cell antitumor immunity
            by targeting IL-2 receptor signaling.
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3255)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB632717.1, BC026837.1 and AC087540.34.
            
            On Jul 8, 2009 this sequence version replaced NM_027890.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128959.1, BC026837.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB632717.1         2-48
            48-3247             BC026837.1         1-3200
            3248-3255           AC087540.34        93951-93958         c
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.56 cM"
     gene            1..3255
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /note="sushi domain containing 2"
                     /db_xref="GeneID:71733"
                     /db_xref="MGI:MGI:1918983"
     exon            1..135
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2528
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sushi domain-containing protein 2"
                     /codon_start=1
                     /product="sushi domain-containing protein 2 isoform 1
                     precursor"
                     /protein_id="NP_082166.3"
                     /db_xref="CCDS:CCDS23929.1"
                     /db_xref="GeneID:71733"
                     /db_xref="MGI:MGI:1918983"
                     /translation="MKLALLPWILMLLSTIPGPGFTAGAQGSCSLRCGAQDGLCSCHP
                     TCSGLGTCCEDFLDYCLEILPSSGSMMGGKDFVVQHLKWTDPTDGVICRFKESIQTLG
                     YVDDFYQVHCISPLLYESGYIPFTISMDNGRSFPHAGTWLAAHPYKVSESEKSQLVNE
                     THWQYYGTSDTRGNLNLTWDTSALPTPAVTIELWGYEETGKPYSGNWTSKWSYLYPLA
                     TNIPNTGFFTFTPKPASPQYQRWKVGALRISSSRNYPGEKDVRALWTNDHALAWHLGD
                     DFRADSVAWARAQCLAWEALEDQLPNFLTELPDCPCTLAQARADSGRFFTDYGCDIEH
                     GSVCTYHPGAVHCVRSVQASPRYGSGQQCCYTAAGTQLLTSDSTSGSTPDRGHDWGAP
                     PYRTPPRVPGMSHWLYDVISFYYCCLWAPECPRYMKRRPSSDCRNYRPPRLASAFGDP
                     HFVTFDGTSFSFSGNGEYVLLETTLSDLRVQGRAQPGRMPNGTQARGTGLTAVAVQED
                     NSDVIEVRLAGGSRVLEVLLNQKVLSFTEQNWMDLKGMFLSVAAQDKVSIMLSSGAGL
                     EVGVQGPFLSVSILLPEKFLTHTRGLLGTLNNNPRDDFTLRNGQVLPLNASAQQVFQF
                     GADWAVSNTSSLFTYDSWLLVYQFVYGPKHNPNFKPLFPDETTLSPSQTEDVARLCEG
                     DRFCILDVMSTGSSSVGNATRIAHQLHQHRLKSLQPVVSCGWLPPPANGHKEGLRYLE
                     GSVVRFSCNNGYSLVGPESSTCQADGKWSMPTPECQPGRSYTVLLSIIFGGLAIVALI
                     SIIYMMLHRRRKSNMTMWSSQP"
     exon            136..343
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            344..495
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            496..663
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            664..838
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1040
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1126
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1395
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1539
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1698
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1947
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2220
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2397
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2503
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..3255
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3167
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
                     /note="major polyA site"
     polyA_site      3252
                     /gene="Susd2"
                     /gene_synonym="1200011D11Rik"
ORIGIN      
        1 aagagcctgc cctgcaaatc tctgagccac tgtgctgcct gctggttgca gacacagggc
       61 acaccatgaa gctggccctc ctgccttgga ttttgatgct gctctcaaca ataccaggcc
      121 ccgggttcac agcaggtgcc cagggaagct gttccctgcg ctgcggggca caggatggac
      181 tctgttcctg tcacccaacc tgctcgggcc ttggcacctg ttgtgaagat tttctggact
      241 actgcctaga gattttaccc tcctcagggt ccatgatggg tggcaaagac ttcgtggtgc
      301 aacatttaaa gtggactgac cctactgatg gggtcatttg caggtttaag gagagtatcc
      361 aaacccttgg ctatgtcgac gacttctatc aagtgcactg catatcaccc ttgctctatg
      421 aaagcggcta tattcccttc accatatcaa tggacaatgg ccgctccttc cctcatgcag
      481 gcacttggct agctgcacat ccctacaaag tgtctgaatc cgagaagagc cagctggtga
      541 acgagaccca ttggcaatac tacggcactt cagacaccag gggaaacctc aacctcacct
      601 gggacacttc agcgctgccc acgccggccg tcaccattga gctgtggggc tatgaggaga
      661 caggaaaacc ctactctggg aactggacct cgaagtggtc ctatctgtac cctttggcta
      721 caaacatccc caataccggc ttcttcactt tcacccccaa acccgcatca cctcagtacc
      781 agaggtggaa agtgggtgct ctgaggatca gcagcagcag gaactaccca ggagagaagg
      841 atgtgcgggc gctctggacc aacgatcacg cactggcctg gcacctgggt gacgacttcc
      901 gggcagactc cgtagcctgg gcccgagcac agtgcctggc ctgggaggca ttggaagacc
      961 aactacccaa cttcctgacg gagctgccag actgcccctg caccctggcc caggccaggg
     1021 ctgattctgg ccgcttcttc actgactatg gttgtgacat tgaacatggc agcgtatgca
     1081 cctaccaccc aggggctgtg cactgtgtgc gctctgtgca agccagcccc aggtatggct
     1141 caggccagca atgctgctac acggcagcag ggacacagct cctgacttca gactcgacaa
     1201 gtggcagcac ccctgaccgt ggccacgact ggggtgcacc cccataccgg actcctcccc
     1261 gtgtgcccgg catgtctcat tggctctatg acgtcatcag cttctattac tgctgtcttt
     1321 gggctcctga gtgtccccgt tatatgaagc gccggccctc cagtgactgc cgcaactaca
     1381 gacccccacg cctggcctct gccttcgggg acccccattt tgtcaccttt gatggcacca
     1441 gcttctcgtt cagcggcaat ggcgaatatg tgctattgga gaccaccctg agtgatctga
     1501 gagtgcaggg ccgggcccag cctgggagaa tgcccaatgg cacccaggcc cgtggcacag
     1561 ggctgactgc agtggccgtc caagaagaca attcggatgt gatagaggtg cggttagctg
     1621 gcgggtctcg ggtcttggaa gtgttgctga atcagaaagt gctcagtttc actgaacaaa
     1681 attggatgga cctgaagggc atgttcctgt cagtggccgc tcaggataag gtgtcaatca
     1741 tgttgtcatc gggggctggc ctcgaggtcg gtgtacaagg tcctttcctg agtgtgagca
     1801 ttctgttgcc tgagaagttt ctgacccaca cccgtggtct cctggggaca ctcaacaata
     1861 accccaggga tgacttcacc ctgcgcaatg ggcaggtcct gcccctgaat gccagtgctc
     1921 agcaggtgtt ccagtttgga gccgactggg ctgtttccaa cacgtcttcc ctgtttactt
     1981 atgactcttg gcttctggtc taccaattcg tgtacggacc caagcacaac cccaacttca
     2041 aaccactctt ccctgatgag accacactca gccccagcca gacagaagat gtggccagac
     2101 tgtgtgaggg tgaccgtttc tgcatccttg atgtgatgag cacaggaagc tcgagcgtgg
     2161 gcaacgccac ccggattgcc caccaactgc accagcaccg tctgaagagc ctgcagcctg
     2221 tggtatcctg tggctggcta cccccacctg caaacgggca taaggaaggc ttgaggtacc
     2281 tggaaggatc cgttgtccga ttcagctgca acaatggcta cagcttggtg gggccggaga
     2341 gtagcacctg tcaggctgat ggaaagtggt ctatgcctac cccagagtgt cagccagggc
     2401 ggagctacac ggtgctactg agtatcatct tcggaggcct ggccatagtg gcactgatct
     2461 ctatcatcta tatgatgctg catcgccgca ggaagagcaa catgaccatg tggagctcac
     2521 agccctgaga ccagagcaca cttggctgac agcatcgggc cacgtgctca ccaagaccca
     2581 gtctccccgg gagaagcgca aagaacatgt accctagtcc tatgaatgcc acatctagta
     2641 tctgtgcctt gaacactatg gacccaatac ctgtcctagc ctgtccttct gactgagaca
     2701 tgataccgga tagtcttaac tccagaaccc cacccccaac acttctccat cagtaacctg
     2761 cacttccttt gtctattggt tatgactcta actcctcaga cttaagggat ggccttcttg
     2821 tcccgtccta gaactggagt acctatgtcc caagccctgc gttggaagct cccatttcag
     2881 ttcctcactc cccagagcct gataaactga gacctggtgc ctgccttcct gtgaggtccc
     2941 ccagagctaa actgccttga ttcctgcccc atggaacaac ttgagagctc gggttggctc
     3001 agtcccacaa tgaagagtgg ccccggagcc tgagcagtga gaaagagaac tgtccagcag
     3061 agaagagacc tcttttgtac cccaggcttc tactcttacc tcttctctag catactcagg
     3121 aacgcccttc catccccata caagaacaca agctcatgtt acatctttcc tggttcccgt
     3181 ctgtttgtgt ttccccacgg ttccataact gtccgtgagg tcacccacta atagcatcag
     3241 agtttgagcc ctgcc
//
