LOCUS       NM_009298               2996 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus surfeit gene 6 (Surf6), mRNA.
ACCESSION   NM_009298
VERSION     NM_009298.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Moraleva,A., Magoulas,C., Polzikov,M., Hacot,S., Mertani,H.C.,
            Diaz,J.J. and Zatsepina,O.
  TITLE     Involvement of the specific nucleolar protein SURF6 in regulation
            of proliferation and ribosome biogenesis in mouse NIH/3T3
            fibroblasts
  JOURNAL   Cell Cycle 16 (20), 1979-1991 (2017)
   PUBMED   28873013
  REMARK    GeneRIF: SURF6 is a novel positive regulator of proliferation and
            G1/S transition in mammals.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Moraleva,A.A., Malysheva,M.V., Magoulas,Ch., Polzikov,M.A. and
            Zatsepina,O.V.
  TITLE     Early expression of nucleolar SURF-6 protein in mouse spleen
            lymphocytes activated for proliferation in vitro
  JOURNAL   Bull Exp Biol Med 147 (5), 578-582 (2009)
   PUBMED   19907743
  REMARK    GeneRIF: The observations suggest that nucleolar protein SURF-6 can
            act as a marker of early T lymphocyte activation for proliferation
            and that it could participate in cell cycle regulation in mammals.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Polzikov,M., Magoulas,C. and Zatsepina,O.
  TITLE     The nucleolar protein SURF-6 is essential for viability in mouse
            NIH/3T3 cells
  JOURNAL   Mol Biol Rep 34 (3), 155-160 (2007)
   PUBMED   17086444
  REMARK    GeneRIF: Expression of SURF-6 is essential for mammalian cell
            viability and cell cycle progression.
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Romanova,L.G., Anger,M., Zatsepina,O.V. and Schultz,R.M.
  TITLE     Implication of nucleolar protein SURF6 in ribosome biogenesis and
            preimplantation mouse development
  JOURNAL   Biol Reprod 75 (5), 690-696 (2006)
   PUBMED   16855206
  REMARK    GeneRIF: Surf6 is essential for mouse preimplantation development,
            presumably by regulating ribosome biogenesis.
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Agostino,A., Invernizzi,F., Tiveron,C., Fagiolari,G., Prelle,A.,
            Lamantea,E., Giavazzi,A., Battaglia,G., Tatangelo,L., Tiranti,V.
            and Zeviani,M.
  TITLE     Constitutive knockout of Surf1 is associated with high embryonic
            lethality, mitochondrial disease and cytochrome c oxidase
            deficiency in mice
  JOURNAL   Hum Mol Genet 12 (4), 399-413 (2003)
   PUBMED   12566387
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Magoulas,C., Zatsepina,O.V., Jordan,P.W., Jordan,E.G. and Fried,M.
  TITLE     The SURF-6 protein is a component of the nucleolar matrix and has a
            high binding capacity for nucleic acids in vitro
  JOURNAL   Eur J Cell Biol 75 (2), 174-183 (1998)
   PUBMED   9548374
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Magoulas,C. and Fried,M.
  TITLE     The Surf-6 gene of the mouse surfeit locus encodes a novel
            nucleolar protein
  JOURNAL   DNA Cell Biol 15 (4), 305-316 (1996)
   PUBMED   8639267
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Garson,K., Duhig,T., Armes,N., Colombo,P. and Fried,M.
  TITLE     Surf5: a gene in the tightly clustered mouse surfeit locus is
            highly conserved and transcribed divergently from the rpL7A (Surf3)
            gene
  JOURNAL   Genomics 30 (2), 163-170 (1995)
   PUBMED   8586415
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Yu,L.C., Chen,J.L., Tsai,W.B. and Chen,Y.H.
  TITLE     Primary structure and characterization of an androgen-stimulated
            autoantigen purified from mouse seminal-vesicle secretion
  JOURNAL   Biochem J 296 (Pt 3) (Pt 3), 571-576 (1993)
   PUBMED   8280054
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Huxley,C. and Fried,M.
  TITLE     The mouse surfeit locus contains a cluster of six genes associated
            with four CpG-rich islands in 32 kilobases of genomic DNA
  JOURNAL   Mol Cell Biol 10 (2), 605-614 (1990)
   PUBMED   2300057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773563.12, AK132194.1 and AK075636.2.
            
            On Sep 8, 2016 this sequence version replaced NM_009298.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132194.1, X92842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL773563.12        106379-106418       c
            41-2257             AK132194.1         3-2219
            2258-2639           AK132194.1         2221-2602
            2640-2996           AK075636.2         1671-2027
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.08 cM"
     gene            1..2996
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /note="surfeit gene 6"
                     /db_xref="GeneID:20935"
                     /db_xref="MGI:MGI:98447"
     exon            1..194
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1168
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /codon_start=1
                     /product="surfeit locus protein 6"
                     /protein_id="NP_033324.1"
                     /db_xref="CCDS:CCDS15812.1"
                     /db_xref="GeneID:20935"
                     /db_xref="MGI:MGI:98447"
                     /translation="MASLLAKDTYLQDLAKKICAQPGPERQRSTWGVRTKGSEAAGAP
                     KKKRKKTQKKSPEQEQKAMDHKTKALGKKPPTSSRPKNPMVSKQEKGLSSLGSPKDSQ
                     GTARESVFALDFLRQRLHEKIQLARGQGSTKELSAATLEKRQRRKQERERKKRKRKER
                     QAKQQVAEAEKKEEPVEVTPKMACKELQESGLIFNKVEVTEEEPASKAQRKKEKRQKV
                     KGNLTPLTGRNYRQLLDRLQARQGRLDELRDQDAAKAQELEAKMKWTNLLYKAEGVKI
                     RDDERLLQEALKRKEKRRAQRQRKWEKRSEHVVEKMQQRQDKRRQNLRKKKAARAERR
                     LQKAHKKGRVLPQDLERAGLS"
     exon            195..398
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /inference="alignment:Splign:2.1.0"
     exon            399..487
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /inference="alignment:Splign:2.1.0"
     exon            488..688
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /inference="alignment:Splign:2.1.0"
     exon            689..2996
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /note="hexamer: ATTACA"
     polyA_site      2642
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /note="major polyA site"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
                     /note="hexamer: AATAAT"
     polyA_site      2992
                     /gene="Surf6"
                     /gene_synonym="D2Wsu129e; Surf-6"
ORIGIN      
        1 ggggtcacgc cgctctactg gtggtacctg cgtgtacgga gcttccggcg gggctccacc
       61 gcgggagctt cctattctgg tcccagcctt ggttggcagc atggcttctc tcctggccaa
      121 ggatacctat cttcaggact tggccaagaa gatctgcgcg cagcctggcc ctgaacgaca
      181 gaggagcaca tggggtgtca gaacaaaagg ctcagaagct gctggcgccc ccaaaaagaa
      241 aaggaagaaa acacaaaaga agtctccgga gcaggaacag aaagctatgg atcacaagac
      301 taaagccctg ggcaagaagc ctcctacctc ttctaggccc aagaacccaa tggtatccaa
      361 acaagagaag ggcttgagct ccctggggtc ccctaaagat agccaaggca cagcacggga
      421 gtctgtcttt gcactggatt ttctgcgaca gcggctgcat gaaaagatcc agctggcccg
      481 gggccagggt agcaccaagg agttgtctgc tgccactctc gagaaaagac agcggagaaa
      541 gcaggagagg gaacggaaga agaggaagag gaaggagcgc caagcaaagc agcaggttgc
      601 agaggctgag aaaaaggagg agccagtaga ggtgaccccc aaaatggcct gcaaggagct
      661 gcaggaatca gggctgatct ttaacaaggt ggaagtgact gaagaggagc cagccagcaa
      721 ggcccagcgc aagaaggaga agaggcagaa agtgaaaggg aacctgacac cgctcacagg
      781 caggaactac aggcagctgt tggaccgtct gcaggcacgg cagggccgcc tggacgagct
      841 tcgtgatcag gatgcagcca aggcccagga gctggaggcc aagatgaagt ggaccaactt
      901 gctgtacaag gctgagggtg tgaagatcag ggatgacgaa cgcctgctgc aggaagccct
      961 gaagcgcaaa gagaagcgcc gggcacagcg gcagcgcaag tgggagaagc gttcagagca
     1021 tgtggtggag aagatgcagc agcgacagga caagcggcgc cagaacctgc gcaagaagaa
     1081 ggcagctcgg gctgagcgac ggctacagaa ggcccacaag aagggccggg tgcttcccca
     1141 ggacctggag cgtgcaggcc tctcctgagc agtttgcacc tgccaagttc ctggctcagc
     1201 cccttccctc catctccatc cttgagggtt gggatggtat gtggtgctag tgcaggtcta
     1261 ggcaacagac tgggtctcct gtgtgaggtc aacacagttc ttgcacccca caaccatagt
     1321 gagatctctg actgtgtgcc tggttgtttc atcagcatct ttaagaagga ccgtgtcctc
     1381 caggccctga gagggataga ggggatctcc catgtttgga gaggtgtgtc tacgtgtctg
     1441 taagtctgcg tgttctgaac tctctggagt caggatagag gttacagtga ggcaccctca
     1501 ccgactcttt cctgcccacc tgcattccca gtggccgtga gcgcacaaag ccttggctac
     1561 ctgttctgta tttattagtc cctggggaca gagagagccc agggagttag tgggagaatc
     1621 tgatccagtc gggtatgtct ctgtgccaga gctccggggc tgtctttgtg ttggcatcca
     1681 gctcaaaacc tggagtcctt cctgagtcca caggatatgc ttgctcacct gtgagccaat
     1741 tggtggctga gacttggggt tgtatgttgc ctagttttat gtcagtttga cacaagctgg
     1801 acttgtcaga gaagagaggc ctcagctgtg agctccacta ccttgttctg tgggcaagcc
     1861 tgttgtgcgc ttattaaaga tgtggtaggg agcagttcat tttggacagt gctacccctg
     1921 gactggtggt cctgggttgt ttaagaaagt agggcaagct agctgtgggg agtgagccct
     1981 taagtagcac tcctctggct tttgctttac ttcctgcctc taggttcctg tcctggttcc
     2041 cttggtgacg taacccttct ctccctcaag ctgcttttgg tcatgttgtt ttgttttatc
     2101 acagcaatag aaacccaaag ataagtctgt gcttttggag gaaaggaggc agggcagggt
     2161 ggctcctggg atgctggcta ggctgaggtt gtgagtggag atagggctac ttttaactag
     2221 gtgacaggaa tggccagaca taggtgcaga gccaccctcc cgggtcagag cttgggtgca
     2281 ggggtgggct ggtagggctg gggtcatttg taattactaa aggctgaaca gaattaagaa
     2341 gtgcttgttg tgtgtggtgg cacacaccgt tagtcccatt actcaggagg cataggcagg
     2401 tggatctctt cagtttgagg ccagccaggg ctacgtagag acctgtgtaa gaaaacaaca
     2461 ataacaaaac acagatctag atagaagtgt tggcacattg ctgtaatccc agcactggag
     2521 taagagtcat taagcttcca ggtaacctca ttgtaccttg ctgatgtgtc acctaacttc
     2581 cctattttct tctgtattaa aagtttgatg ctcgatttga caaattacat tcagatacca
     2641 cactcccatg tgttcgtatt tgtttgtcat ctgtgccaac tcctttccac ctgtaaccgg
     2701 ttttgcccgt tgatcgagga cccaggtgag gtcctcctgc ggcacccagg tctacactgt
     2761 gcctgttttc tctgtcccat agcctggcca aaaggccctt tctcaatctc ctctcctcct
     2821 ctttctcctg ggacccagaa aaccagcctc tatatctttg cccagtgatt ggcttgtgcc
     2881 atctttattt acccaatcaa ataattaggg aatctctccc tacaactatg ccttcttaaa
     2941 cctggaaata atgccctccc atagttactc ttttaaaaat attttgtttt tatttg
//
