LOCUS       NM_181423               2592 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus suppressor of var1, 3-like 1 (S. cerevisiae)
            (Supv3l1), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_181423
VERSION     NM_181423.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2592)
  AUTHORS   Chen,P.L.
  TITLE     SUV3 Helicase and Mitochondrial Homeostasis
  JOURNAL   Int J Mol Sci 24 (11), 9233 (2023)
   PUBMED   37298184
  REMARK    GeneRIF: SUV3 Helicase and Mitochondrial Homeostasis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2592)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2592)
  AUTHORS   Fisher,C.L., Marks,H., Cho,L.T., Andrews,R., Wormald,S.,
            Carroll,T., Iyer,V., Tate,P., Rosen,B., Stunnenberg,H.G.,
            Fisher,A.G. and Skarnes,W.C.
  TITLE     An efficient method for generation of bi-allelic null mutant mouse
            embryonic stem cells and its application for investigating
            epigenetic modifiers
  JOURNAL   Nucleic Acids Res 45 (21), e174 (2017)
   PUBMED   28981838
REFERENCE   5  (bases 1 to 2592)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   6  (bases 1 to 2592)
  AUTHORS   Chen,P.L., Chen,C.F., Chen,Y., Guo,X.E., Huang,C.K., Shew,J.Y.,
            Reddick,R.L., Wallace,D.C. and Lee,W.H.
  TITLE     Mitochondrial genome instability resulting from SUV3
            haploinsufficiency leads to tumorigenesis and shortened lifespan
  JOURNAL   Oncogene 32 (9), 1193-1201 (2013)
   PUBMED   22562243
REFERENCE   7  (bases 1 to 2592)
  AUTHORS   Paul,E., Kielbasinski,M., Sedivy,J.M., Murga-Zamalloa,C., Khanna,H.
            and Klysik,J.E.
  TITLE     Widespread expression of the Supv3L1 mitochondrial RNA helicase in
            the mouse
  JOURNAL   Transgenic Res 19 (4), 691-701 (2010)
   PUBMED   19937380
  REMARK    GeneRIF: Spatial and temporal aspects of Supv3L1 promoter activity.
REFERENCE   8  (bases 1 to 2592)
  AUTHORS   Paul,E., Cronan,R., Weston,P.J., Boekelheide,K., Sedivy,J.M.,
            Lee,S.Y., Wiest,D.L., Resnick,M.B. and Klysik,J.E.
  TITLE     Disruption of Supv3L1 damages the skin and causes sarcopenia, loss
            of fat, and death
  JOURNAL   Mamm Genome 20 (2), 92-108 (2009)
   PUBMED   19145458
  REMARK    GeneRIF: Supv3L1 is important for the maintenance of the skin
            barrier. In addition, loss of Supv3L1 function leads to accelerated
            aging-like phenotypes.
REFERENCE   9  (bases 1 to 2592)
  AUTHORS   Pereira,M., Mason,P., Szczesny,R.J., Maddukuri,L., Dziwura,S.,
            Jedrzejczak,R., Paul,E., Wojcik,A., Dybczynska,L., Tudek,B.,
            Bartnik,E., Klysik,J., Bohr,V.A. and Stepien,P.P.
  TITLE     Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss
            of the SUV3 gene results in mouse embryonic lethality
  JOURNAL   Mech Ageing Dev 128 (11-12), 609-617 (2007)
   PUBMED   17961633
  REMARK    GeneRIF: Mice homozygous for Supv3L1 mutation die in utero before
            midgestation.
REFERENCE   10 (bases 1 to 2592)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB859685.1, BC049796.1, AW049139.1 and AK143755.1.
            
            On Jan 13, 2018 this sequence version replaced NM_181423.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143755.1, SRR1660817.2943.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BB859685.1         5-49
            46-2435             BC049796.1         1-2390
            2436-2461           AW049139.1         40-65               c
            2462-2592           AK143755.1         2443-2573
FEATURES             Location/Qualifiers
     source          1..2592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.4 cM"
     gene            1..2592
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /note="suppressor of var1, 3-like 1 (S. cerevisiae)"
                     /db_xref="GeneID:338359"
                     /db_xref="MGI:MGI:2441711"
     exon            1..324
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2393
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ATP-dependent RNA helicase SUPV3L1,
                     mitochondrial; SUV3-like protein 1; suppressor of var1
                     3-like protein 1"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase SUPV3L1,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_852088.1"
                     /db_xref="CCDS:CCDS35920.1"
                     /db_xref="GeneID:338359"
                     /db_xref="MGI:MGI:2441711"
                     /translation="MSLPRCTLLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVP
                     CLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYK
                     RQEIQKLSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFSAAHVDDLFP
                     FFLRHAKQIFPVLECKDDLRKISDLRIPPNWYPEARARQRKIIFHSGPTNSGKTYHAI
                     QRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERLTVEPEGKQATHVSCTV
                     EMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGESAAINLVSELLY
                     TTGEEVEVQKYERLTPISVLDHALESLDNLQPGDCIVCFSKNDIYSVSRQIEIRGLES
                     AVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINE
                     KGEKELEPITTSQALQIAGRAGRFSSHFKEGQVTTMHRDDLALLKDILNRPVDPIQAA
                     GLHPTAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPL
                     SLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKD
                     LMDLEAVHDVFDLYLWLSYRFIDMFPDSSLVRSLQKELDAIIQEGVHNITKLIKISES
                     RKLLNLESLPSGDQSRLSGASKSPARRTRGTKSAGNKATEPLSPSDKELPLASRLVQQ
                     GLLTADMLRQLQKEWLTQQPEHSREKVGTRRKKKDPDSD"
     exon            325..402
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            403..510
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..625
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..794
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..906
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            907..984
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1076
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1257
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1351
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1571
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1652
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1829
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1978
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2592
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /note="major polyA site"
     polyA_site      2481
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
     regulatory      2538..2543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2583
                     /gene="Supv3l1"
                     /gene_synonym="6330443E10Rik"
ORIGIN      
        1 gagcggcgcc agtggtccgg attttccccg gctccattcg agccgcggcc tcaatgtcct
       61 tgcctcggtg taccttgctg tgggctcggc tcccggcggg gcgcggggct gggccccggg
      121 cggccccttg ctccgccctt cgcgctctcg tggggtcgtt cccgggggct tcaggacgcg
      181 ttccctgctt ggccgcctcc tcctctgcct ctggtggctc caaagccccg aacacgtcct
      241 tgttcgtgcc gctgacggtg aagcctcagg gtcccagcgc cgatggcgac gtgggcgcgg
      301 agctcactcg gcctctagac aagaatgaag taaagaagat cttagacaag ttttataaga
      361 ggcaagaaat tcaaaagctg agtgctgact atggacttga tgctcgtctc ttccaccagg
      421 ctttcataag cttcaggaat tacattatgc aatcccattc tctggacgtg gacattcaca
      481 ttgtcctgaa tgatatctgc ttcagtgcag ctcatgtgga cgatttattt ccatttttct
      541 tgagacatgc caaacaaata tttcctgtat tggaatgcaa ggatgatcta cgtaaaatca
      601 gtgacttgag gataccaccc aactggtacc cagaagccag agcgagacag cggaagataa
      661 tattccactc aggccctacc aacagtggga agacttacca tgccatccag agatacctgt
      721 cagcgacctc tggcgtgtac tgcggtcctc taaaactgct ggcgcacgag atctttgaga
      781 agagcaatgc tgctggtgtg ccgtgtgact tggtgacagg tgaagagcgg ctgacagtgg
      841 agcctgaggg gaaacaagcc acccatgtct cttgcactgt ggagatgtgc aatgttgcaa
      901 ctccttatga agtggcagtg atagatgaaa tccagatgat tcgagaccca gccagaggat
      961 gggcttggac cagagcactg ctagggctct gtgccgagga agtccattta tgtggagagt
     1021 ctgctgctat taacctggtc tctgagctcc tgtacaccac tggggaggaa gtagaggttc
     1081 agaagtatga gaggcttacc cccatttctg tgctggatca tgcgctggag tctttggaca
     1141 accttcagcc tggggactgc attgtctgct ttagcaagaa tgacatttat tctgtgagcc
     1201 gacagattga aattcgggga ctggaatccg cggtgatata cggcagcttg ccacctggga
     1261 ccaaacttgc tcaagcaaga aagtttaatg accccaatga tccatgcaag atcctggtag
     1321 ccacagatgc aattggcatg ggacttaatt tgagcataag gagaattatt ttttactccc
     1381 ttataaagcc cagcatcaat gaaaagggag agaaggagct ggagcccatc accacctccc
     1441 aagccctgca gattgcaggc agagctggca gattcagctc acactttaaa gaggggcagg
     1501 ttaccacaat gcaccgagac gacctggctt tattgaagga cattttgaat agacctgtgg
     1561 atcctataca ggccgccggt ctccacccga ctgccgagca gattgagatg tttgcctacc
     1621 acctccccga gacaacgctg tccaatctca ttgatatttt tgtagacttt gcacaagttg
     1681 atgggcagta ctttgtctgc aatatggatg attttaagtt ctctgcagag ctgatccagc
     1741 atatcccact aagtctccgg gtgaggtatg tgttctgcac agcccccatc aataagaagc
     1801 agccttttgt ctgctcgtcg ttgttacagt ttgccaggca gtacagcagg aatgagcccc
     1861 tgacctttgc atggctacgc cggtacatca agtggcctct gcttccgcct aagaatatta
     1921 aagacctcat ggatcttgaa gctgtccatg acgtctttga tctttacctg tggctaagct
     1981 accgatttat tgatatgttt ccagactcta gccttgttcg aagtctccag aaagagctgg
     2041 atgccattat ccaagaaggc gtgcacaaca tcaccaagct gattaaaatc tctgagtcac
     2101 gcaagctttt gaatctggag agcttaccat cgggggacca gtcacggttg tcaggagcct
     2161 ccaagagccc agcgagaagg acacgtggca ccaaaagtgc agggaataag gccacagagc
     2221 cactcagccc cagtgacaag gagctgcccc ttgcctctag gttggtgcag caaggactcc
     2281 tcactgcaga catgctcagg cagctccaga aggagtggct gacacagcag ccagaacaca
     2341 gcagagagaa agtggggaca cggagaaaga agaaggaccc cgactccgat taggtttttt
     2401 taattttgca aataaaaatc aattttaaat ccttatgcac acggcattct ctgcctgagg
     2461 caggattgtg gccaacttgt actatctggt ttgtttgttt gtttgtttgt ttgtttgttt
     2521 ttttaattgc acaaaaaagt aaattcctaa agctacttaa attacttatt atagccttta
     2581 aaatagagtg tc
//
