LOCUS       NM_178652               1510 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SPT3, SAGA and STAGA complex component (Supt3),
            transcript variant 1, mRNA.
ACCESSION   NM_178652
VERSION     NM_178652.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Bardot,P., Vincent,S.D., Fournier,M., Hubaud,A., Joint,M., Tora,L.
            and Pourquie,O.
  TITLE     The TAF10-containing TFIID and SAGA transcriptional complexes are
            dispensable for early somitogenesis in the mouse embryo
  JOURNAL   Development 144 (20), 3808-3818 (2017)
   PUBMED   28893950
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   8  (bases 1 to 1510)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   9  (bases 1 to 1510)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   10 (bases 1 to 1510)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672242.12, AK075916.1 and CX210559.1.
            
            On Oct 25, 2017 this sequence version replaced NM_178652.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075916.1, AK050321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL672242.12        60186-60190         c
            6-1488              AK075916.1         1-1483
            1489-1510           CX210559.1         565-586
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 21.56 cM"
     gene            1..1510
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /note="SPT3, SAGA and STAGA complex component"
                     /db_xref="GeneID:109115"
                     /db_xref="MGI:MGI:1923723"
     exon            1..263
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1388
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /note="suppressor of Ty 3 homolog"
                     /codon_start=1
                     /product="transcription initiation protein SPT3 homolog"
                     /protein_id="NP_848767.1"
                     /db_xref="CCDS:CCDS37625.1"
                     /db_xref="GeneID:109115"
                     /db_xref="MGI:MGI:1923723"
                     /translation="MNNAAASPMSTTTSSSGRNAGKTISFAAELQSMMFSLGDARRPL
                     HETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMF
                     IRDYKSKIIKGIDEDDLLEEKLSGSSGTNKRQKIAQDLINSIDQTGELLAMFEDNELD
                     DVKQERMERAERQTRTMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVIAM
                     EILAYLAYETVAQLVDLALLVRQDMVSKAGDPFSHAISATFIQYHNSAEGSSCLKSSP
                     DSPENTPPPTPTAPSSGSQHSGRAASGSLGNGNTGQDTAKTKQRKRKKSTAACGVEAH
                     SDAIQPCHIREAIRRYGHKIGPLSPFTSAYRRSGMAFLAC"
     exon            264..364
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            365..449
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            450..536
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            537..627
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            628..767
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            768..843
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            844..956
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1064
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1235
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1346
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1494
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /note="hexamer: AATAAA"
     polyA_site      1494
                     /gene="Supt3"
                     /gene_synonym="2310066G22Rik; SPT3; SPT3L; Supt3h"
                     /note="major polyA site"
ORIGIN      
        1 ggcttggccc gtccctctag tcaccccagg ctccgctacc cccgccccgc ccctcatagt
       61 ggcgctctcg ccatcttacc cccaccccct ccagcctagc tcagtcacct tttccctttc
      121 tacaatctct ggttcccccc actccccgcc cccctgcccg tcgtgtcccg gggccgccgc
      181 cgccgcagac accgcgccat ctctgtcccc tctcattctc cacgcgggac gcgcagccgt
      241 gcctccacgt gtcttaagca gagatgaata atgctgcagc tagcccgatg tctactacca
      301 cttcaagtag tggaagaaat gcagggaaga ctataagctt tgcggccgag ttgcagagta
      361 tgatgttttc tctaggtgat gctaggaggc ctctccatga aactgcagtt ttggtggaag
      421 atgtggttca tacacaacta attaacctgt tacagcaagc tgcagaagtc tctcagcttc
      481 ggggagcaag agtgatctct gctgaagatc ttctgttctt gatgagaaaa gataagaaaa
      541 aacttagaag acttctaaag tacatgttta tccgagacta caagtcaaag atcatcaaag
      601 gcattgacga ggatgacctc ctggaagaaa aactgagtgg cagcagcggt acaaacaaga
      661 gacagaagat cgctcaggac ttgatcaact ctatcgacca gacaggagag ctgctggcaa
      721 tgtttgaaga caacgagctt gatgatgtca aacaggagag aatggagaga gcagaaagac
      781 agactcgtac tatggattca gctcaatatg cagaattctg tgaaagccga cagttaagtt
      841 tctccaaaaa agcttccaaa ttccgagact ggctggactg cagcagcatg gagataaaac
      901 ccaatgtcat agctatggaa atcctggcat atctggcata cgaaaccgtg gcccagctgg
      961 tggatctggc tcttctagtg aggcaagata tggtgtccaa ggcaggggac cccttcagcc
     1021 atgccatttc tgcaaccttc attcagtacc acaactctgc tgaggggtcc tcatgtttga
     1081 agtccagccc agactctcct gagaacacac ctcctcctac accaacagct ccctcttctg
     1141 gatcacagca ttcaggtaga gctgcatctg gttctttggg gaatgggaac acaggacaag
     1201 acactgccaa aaccaagcag cggaagagga aaaagagcac tgcggcctgt ggtgtcgagg
     1261 ctcacagcga tgccatccag ccctgccaca tcagagaggc cattcgacgc tacggccaca
     1321 agattggccc tctctcccca ttcacaagtg cctaccgaag gagtgggatg gctttcctgg
     1381 cctgctgagg ggaccatggc cgtgcctgcc gccacgaaga gggagtggtt caccgaggtc
     1441 attcttgcct gtcctgccgg aaaataaaat aggattttat gttctcctgc cctaaaaaaa
     1501 aaaaaaaaaa
//
