LOCUS       NM_001407773            3065 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus SPT20 SAGA complex component (Supt20), transcript
            variant 17, mRNA.
ACCESSION   NM_001407773 XM_030252730
VERSION     NM_001407773.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Warrier,S., Nuwayhid,S., Sabatino,J.A., Sugrue,K.F. and Zohn,I.E.
  TITLE     Supt20 is required for development of the axial skeleton
  JOURNAL   Dev Biol 421 (2), 245-257 (2017)
   PUBMED   27894818
  REMARK    GeneRIF: Gcn5 and Supt20 hypomorphs show similar defects in
            rostral-caudal somite patterning potentially suggesting shared
            mechanisms.
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Liu,X., Xiao,W., Wang,X.D., Li,Y.F., Han,J. and Li,Y.
  TITLE     The p38-interacting protein (p38IP) regulates G2/M progression by
            promoting alpha-tubulin acetylation via inhibiting
            ubiquitination-induced degradation of the acetyltransferase GCN5
  JOURNAL   J Biol Chem 288 (51), 36648-36661 (2013)
   PUBMED   24220028
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Jin,J.Z. and Ding,J.
  TITLE     Cripto is required for mesoderm and endoderm cell allocation during
            mouse gastrulation
  JOURNAL   Dev Biol 381 (1), 170-178 (2013)
   PUBMED   23747598
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Clements,M., Pernaute,B., Vella,F. and Rodriguez,T.A.
  TITLE     Crosstalk between Nodal/activin and MAPK p38 signaling is essential
            for anterior-posterior axis specification
  JOURNAL   Curr Biol 21 (15), 1289-1295 (2011)
   PUBMED   21802298
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   7  (bases 1 to 3065)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   8  (bases 1 to 3065)
  AUTHORS   Zohn,I.E., Li,Y., Skolnik,E.Y., Anderson,K.V., Han,J. and
            Niswander,L.
  TITLE     p38 and a p38-interacting protein are critical for downregulation
            of E-cadherin during mouse gastrulation
  JOURNAL   Cell 125 (5), 957-969 (2006)
   PUBMED   16751104
  REMARK    GeneRIF: Both p38 and p38IP are required for E-cadherin
            downregulation during gastrulation. Also, p38 regulates E-cadherin
            protein expression downstream from NCK-interacting kinase.
REFERENCE   9  (bases 1 to 3065)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100927.11.
            
            On Jun 6, 2022 this sequence version replaced XM_030252730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.221210.1,
                                           SRR13422598.1176367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC100927.11        57589-57627
            40-145              AC100927.11        57871-57976
            146-230             AC100927.11        59891-59975
            231-266             AC100927.11        61252-61287
            267-325             AC100927.11        61719-61777
            326-392             AC100927.11        63361-63427
            393-519             AC100927.11        66258-66384
            520-623             AC100927.11        67839-67942
            624-740             AC100927.11        71628-71744
            741-794             AC100927.11        71856-71909
            795-934             AC100927.11        73025-73164
            935-1091            AC100927.11        73799-73955
            1092-1148           AC100927.11        74041-74097
            1149-1220           AC100927.11        75169-75240
            1221-1378           AC100927.11        76860-77017
            1379-1405           AC100927.11        77944-77970
            1406-1438           AC100927.11        78501-78533
            1439-1547           AC100927.11        79456-79564
            1548-1650           AC100927.11        79922-80024
            1651-1806           AC100927.11        80302-80457
            1807-2113           AC100927.11        82107-82413
            2114-2271           AC100927.11        83002-83159
            2272-2327           AC100927.11        85174-85229
            2328-2411           AC100927.11        87325-87408
            2412-2517           AC100927.11        90738-90843
            2518-2645           AC100927.11        92337-92464
            2646-3065           AC100927.11        93112-93531
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.59 cM"
     gene            1..3065
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="SPT20 SAGA complex component"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
     exon            1..39
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            40..145
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            146..230
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2783
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="isoform 6 is encoded by transcript variant 17;
                     transcription factor (p38 interacting protein);
                     p38-interacting protein; protein FAM48A; family with
                     sequence similarity 48, member A; transcription factor
                     SPT20 homolog; suppressor of Ty 20"
                     /codon_start=1
                     /product="transcription factor SPT20 homolog isoform 6"
                     /protein_id="NP_001394702.1"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
                     /translation="MQQAVEQALDCAEYIVESAQQRPPKRKYLSSGRKSIFQKLYDLY
                     VEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETI
                     RLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQ
                     SRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSVAVACT
                     ANRLLYNRQKMNTRPMKRCWKRYSRSSLNRQQDLSHGPPPPQLRLLDFLQKRKERKAG
                     QHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEESIKSDDSQPTMWPAHDVK
                     DDYVFECEGGNQYQKTKLTILQSLGDPLYYGKIQPWKADEENDSQMSPSHSSADDHSN
                     WFVIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSAALSPGEEAEQAETSSIQSS
                     VLGKGVKHRPPPIKLPSGSGNSSSGNYFTAQQASSFLKSPTPPPSCKPSLSRKSSVDL
                     SQVSMLSPAALSPASSSQRSGTPKPSPPTPTPSSVPHPPDAQNSAPSTPSATPSPQES
                     GFTPQPTLLTQFAQQQRALSQAMPVTTIPLSTMVTSITTGSSLSPVMADSAGLTSVSV
                     LSSAGGAQALKSGSNSMLGCDTGAIPPAGKSLCSGLLPSGGLVANTLPSAVQAAPQAG
                     IPFGLQNTSSLRPLNLLQQQQQTQLPHFIQQPQQPAASGSQQPEEQGSEQGLTAQEQA
                     LTAQQAAVINLTGVGGFPQSQAAVLSQLGSAENRPEQSLPQQRLQLSSAFQQQQQQQQ
                     QQQQQQLQQLRFLQHQMAMAAAAAQTAQLHRHRHTGSQSKSKMKRGMPTTPKF"
     exon            231..266
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            267..325
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            326..392
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            393..519
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            520..623
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            624..740
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            741..794
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            795..934
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1091
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1148
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1220
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1378
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1405
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1438
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1547
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1650
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1806
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2113
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2271
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2327
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2411
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2517
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2645
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..3065
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3015..3020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="hexamer: TATAAA"
     polyA_site      3065
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="major polyA site"
ORIGIN      
        1 gcggttggag gtgtgggtgg gcgttacagc aggccttagg tatttctgga aaatcgctgc
       61 aaggttggca gaatgcttct tcagggcgga gtgcggtgtg actgttgagt agaggttgct
      121 tctctgtgga gttggcgttc tgaggtatag aagaagacat ggtttccacc ccacttccac
      181 agcacgtcta agttttatct tttttggggt ccttatctgt tgccacaatg caacaagctg
      241 tagaacaagc tttggattgc gcagagtaca tcgtggaaag tgctcagcag agacctccta
      301 aaaggaaata cctgtctagt ggaagaaagt ctatatttca aaaactttat gacttatatg
      361 ttgaagaatg tgaaaaagaa cccgaggtta agaaattaag aagaaatgtg aacttgttag
      421 agaagcttgt tatgcaggag actttgtcgt gtttagtagt caatctgtac ccaggaaatg
      481 aaggctattc tctgatgctc agggggaaaa atggatcaga ttctgagacc atccgattgc
      541 cttatgaaga aggagaattg cttgaatact tagatgcaga agaattacct cctattttgg
      601 tggatctcct tgaaaaatca caggttaata tttttcattg tggatgtgtg atagcagaaa
      661 tacgtgacta taggcagtcc agtaatatga agtctcctgg ttaccaaagt aggcacattc
      721 tcttacgtcc aacaatgcag actttagtct gtgatgtcca ttctataaca agtgacaacc
      781 ataagtggac ccaggaagac aaacttttgc ttgagagcca gctgattcta gctacagcag
      841 agccactgtg tcttgaccca tcggtggcag tagcgtgcac tgccaatagg ctgctctata
      901 accggcagaa gatgaacact cgcccaatga aacggtgttg gaagaggtac tccaggtcct
      961 ccctgaaccg ccagcaggac ctctctcacg gccctcctcc ccctcagctg agactacttg
     1021 atttcttaca aaagcggaag gaaaggaaag caggccagca ttatgacctc aaaatttcca
     1081 aagcaggaaa ttgtgtagac atgtggaaac ggagcccctg taacttggct gtgccttctg
     1141 aagtagatgt ggaaaaatat gctaaagtgg aggaatccat caaatctgac gactcacagc
     1201 caacaatgtg gccagctcat gatgtaaaag acgattatgt atttgaatgt gaaggtggta
     1261 atcagtatca gaaaacaaag ctgaccatct tgcagtctct tggggatcca ctttactatg
     1321 gtaaaataca gccgtggaaa gcagatgaag aaaatgacag ccaaatgtct ccatcccact
     1381 cctctgctga tgaccattca aactggtttg tcattgggtc aaagactgac gcagagaggg
     1441 tagttaatca ataccaggag ttggtccaga atgaagccaa atgcccagtg aagatgtcac
     1501 acagcagtag tggttcagcc gctctcagtc caggggagga ggcagaacag gcggagacct
     1561 cgtccattca gtcttcagtt ttgggaaagg gagtaaaaca ccgaccccca cccatcaaac
     1621 ttccctcagg ctcaggaaat agttcctcag gtaactattt cacagcacag caggccagca
     1681 gcttccttaa atctccaact cctcctccat cgtgtaagcc aagcctttct cggaagtctt
     1741 ctgtggacct cagtcaagtt agcatgcttt ctcctgccgc cctgtcccct gccagctcat
     1801 cccagagatc tggaactcct aagccatctc ctcctacacc aaccccttca tcggtcccac
     1861 accctcctga cgctcagaac tcagctccta gtaccccttc agccacccca tctccccaag
     1921 aatcaggctt cacccctcag cccactttgt taactcagtt tgctcagcag caaagggctc
     1981 tgagccaggc aatgcctgtg acaaccattc ctctttctac catggtaacg tccataacaa
     2041 caggaagctc gctctccccg gtcatggcag actctgctgg gctaacctcc gtcagtgtac
     2101 tgagctctgc tggtggagcc caggctctga agagtggctc aaactccatg ctgggctgtg
     2161 acactggggc catacctcct gcaggaaaaa gcctgtgcag cggccttctg ccatcaggag
     2221 gtctcgtagc aaacacactg cccagtgccg tgcaggcggc tcctcaagca ggtatcccat
     2281 ttggtttaca aaatacttca agtctcagac ctttaaatct actccagcaa cagcagcaga
     2341 cgcagctccc tcactttata caacaacctc agcagcctgc agcttccggt tcccaacagc
     2401 cagaggagca gggttctgaa caagggttaa ctgcgcagga acaggcctta actgctcagc
     2461 aagctgccgt tattaacctt actggagtag gaggctttcc ccagtcacag gcagccgtgt
     2521 tgtctcagct tggctctgct gagaacagac ctgagcaaag ccttcctcag cagagactcc
     2581 agctctcctc tgcctttcag cagcagcagc agcagcagca acaacaacaa caacagcaac
     2641 tacaacagtt gcgattcttg cagcaccaaa tggctatggc agcagcagcc gcacaaacag
     2701 cccagctaca tcgtcaccgg cacacaggca gccagtcaaa gagtaaaatg aagagaggca
     2761 tgccaactac tccaaaattc tgagcaattt tttttttctt ttttacaaac acgaccattg
     2821 aatgaattgt atttctactg ttttcccgag atgtcagtat tttgcattgc tgtgtgtgca
     2881 cactttacac agaagcacag ccctgtgatt cttacatgga aacatggtga aatgttttcc
     2941 tgtacatacc aatcgcagaa acaacgtaag gactagaaat atctttcaaa gaatggaatt
     3001 aggtatttat ttagtataaa aagcctgtgc agtgtaacaa atacaatttt tacagctgtt
     3061 ttgca
//
