LOCUS       NM_001407764            3309 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus SPT20 SAGA complex component (Supt20), transcript
            variant 8, mRNA.
ACCESSION   NM_001407764 XM_006501804
VERSION     NM_001407764.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3309)
  AUTHORS   Warrier,S., Nuwayhid,S., Sabatino,J.A., Sugrue,K.F. and Zohn,I.E.
  TITLE     Supt20 is required for development of the axial skeleton
  JOURNAL   Dev Biol 421 (2), 245-257 (2017)
   PUBMED   27894818
  REMARK    GeneRIF: Gcn5 and Supt20 hypomorphs show similar defects in
            rostral-caudal somite patterning potentially suggesting shared
            mechanisms.
REFERENCE   2  (bases 1 to 3309)
  AUTHORS   Liu,X., Xiao,W., Wang,X.D., Li,Y.F., Han,J. and Li,Y.
  TITLE     The p38-interacting protein (p38IP) regulates G2/M progression by
            promoting alpha-tubulin acetylation via inhibiting
            ubiquitination-induced degradation of the acetyltransferase GCN5
  JOURNAL   J Biol Chem 288 (51), 36648-36661 (2013)
   PUBMED   24220028
REFERENCE   3  (bases 1 to 3309)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   4  (bases 1 to 3309)
  AUTHORS   Jin,J.Z. and Ding,J.
  TITLE     Cripto is required for mesoderm and endoderm cell allocation during
            mouse gastrulation
  JOURNAL   Dev Biol 381 (1), 170-178 (2013)
   PUBMED   23747598
REFERENCE   5  (bases 1 to 3309)
  AUTHORS   Clements,M., Pernaute,B., Vella,F. and Rodriguez,T.A.
  TITLE     Crosstalk between Nodal/activin and MAPK p38 signaling is essential
            for anterior-posterior axis specification
  JOURNAL   Curr Biol 21 (15), 1289-1295 (2011)
   PUBMED   21802298
REFERENCE   6  (bases 1 to 3309)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   7  (bases 1 to 3309)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   8  (bases 1 to 3309)
  AUTHORS   Zohn,I.E., Li,Y., Skolnik,E.Y., Anderson,K.V., Han,J. and
            Niswander,L.
  TITLE     p38 and a p38-interacting protein are critical for downregulation
            of E-cadherin during mouse gastrulation
  JOURNAL   Cell 125 (5), 957-969 (2006)
   PUBMED   16751104
  REMARK    GeneRIF: Both p38 and p38IP are required for E-cadherin
            downregulation during gastrulation. Also, p38 regulates E-cadherin
            protein expression downstream from NCK-interacting kinase.
REFERENCE   9  (bases 1 to 3309)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100927.11.
            
            On Jun 6, 2022 this sequence version replaced XM_006501804.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC100927.11        57589-57627
            40-350              AC100927.11        57871-58181
            351-435             AC100927.11        59891-59975
            436-471             AC100927.11        61252-61287
            472-530             AC100927.11        61719-61777
            531-597             AC100927.11        63361-63427
            598-727             AC100927.11        66255-66384
            728-831             AC100927.11        67839-67942
            832-948             AC100927.11        71628-71744
            949-1002            AC100927.11        71856-71909
            1003-1142           AC100927.11        73025-73164
            1143-1299           AC100927.11        73799-73955
            1300-1356           AC100927.11        74041-74097
            1357-1428           AC100927.11        75169-75240
            1429-1586           AC100927.11        76860-77017
            1587-1613           AC100927.11        77944-77970
            1614-1646           AC100927.11        78501-78533
            1647-1755           AC100927.11        79456-79564
            1756-1858           AC100927.11        79922-80024
            1859-2014           AC100927.11        80302-80457
            2015-2321           AC100927.11        82107-82413
            2322-2479           AC100927.11        83002-83159
            2480-2535           AC100927.11        85174-85229
            2536-2655           AC100927.11        87289-87408
            2656-2761           AC100927.11        90738-90843
            2762-2889           AC100927.11        92337-92464
            2890-3309           AC100927.11        93112-93531
FEATURES             Location/Qualifiers
     source          1..3309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.59 cM"
     gene            1..3309
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="SPT20 SAGA complex component"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
     exon            1..39
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            40..350
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            351..435
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..3027
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="isoform 1 is encoded by transcript variant 8;
                     transcription factor (p38 interacting protein);
                     p38-interacting protein; protein FAM48A; family with
                     sequence similarity 48, member A; transcription factor
                     SPT20 homolog; suppressor of Ty 20"
                     /codon_start=1
                     /product="transcription factor SPT20 homolog isoform 1"
                     /protein_id="NP_001394693.1"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
                     /translation="MQQAVEQALDCAEYIVESAQQRPPKRKYLSSGRKSIFQKLYDLY
                     VEECEKEPEVKQKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSET
                     IRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGY
                     QSRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSVAVAC
                     TANRLLYNRQKMNTRPMKRCWKRYSRSSLNRQQDLSHGPPPPQLRLLDFLQKRKERKA
                     GQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEESIKSDDSQPTMWPAHDV
                     KDDYVFECEGGNQYQKTKLTILQSLGDPLYYGKIQPWKADEENDSQMSPSHSSADDHS
                     NWFVIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSAALSPGEEAEQAETSSIQS
                     SVLGKGVKHRPPPIKLPSGSGNSSSGNYFTAQQASSFLKSPTPPPSCKPSLSRKSSVD
                     LSQVSMLSPAALSPASSSQRSGTPKPSPPTPTPSSVPHPPDAQNSAPSTPSATPSPQE
                     SGFTPQPTLLTQFAQQQRALSQAMPVTTIPLSTMVTSITTGSSLSPVMADSAGLTSVS
                     VLSSAGGAQALKSGSNSMLGCDTGAIPPAGKSLCSGLLPSGGLVANTLPSAVQAAPQA
                     GIPFGLQNTSSLRPLNLLQLPGGSLIFNTQQQQQQTQLPHFIQQPQQPAASGSQQPEE
                     QGSEQGLTAQEQALTAQQAAVINLTGVGGFPQSQAAVLSQLGSAENRPEQSLPQQRLQ
                     LSSAFQQQQQQQQQQQQQQLQQLRFLQHQMAMAAAAAQTAQLHRHRHTGSQSKSKMKR
                     GMPTTPKF"
     exon            436..471
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            472..530
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            531..597
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            598..727
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            728..831
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            832..948
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1002
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1142
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1299
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1356
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1428
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1586
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1613
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1646
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1755
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1858
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2014
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2321
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2479
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2535
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2655
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2761
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2889
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3309
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3259..3264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="hexamer: TATAAA"
     polyA_site      3309
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="major polyA site"
ORIGIN      
        1 gcggttggag gtgtgggtgg gcgttacagc aggccttagg tatttctgga aaatcgctgc
       61 aaggttggca gaatgcttct tcagggcgga gtgcggtgtg actgttgagt agaggttgct
      121 tctctgtgga gttggcgttc tgagggtaaa gcctgggtta aaaaaaaaaa atctgcagtt
      181 gggacccaag ttcaccaggg aaattagttt agctgatgtc tactctggga gccatctttt
      241 atcgccatca gagtacctag ttaggacgcc aagtgcaaaa gcgatgtgca tagactggag
      301 acagattatg attgatataa acttaacatc aaaattaaga aaaaaaatag tatagaagaa
      361 gacatggttt ccaccccact tccacagcac gtctaagttt tatctttttt ggggtcctta
      421 tctgttgcca caatgcaaca agctgtagaa caagctttgg attgcgcaga gtacatcgtg
      481 gaaagtgctc agcagagacc tcctaaaagg aaatacctgt ctagtggaag aaagtctata
      541 tttcaaaaac tttatgactt atatgttgaa gaatgtgaaa aagaacccga ggttaagcag
      601 aaattaagaa gaaatgtgaa cttgttagag aagcttgtta tgcaggagac tttgtcgtgt
      661 ttagtagtca atctgtaccc aggaaatgaa ggctattctc tgatgctcag ggggaaaaat
      721 ggatcagatt ctgagaccat ccgattgcct tatgaagaag gagaattgct tgaatactta
      781 gatgcagaag aattacctcc tattttggtg gatctccttg aaaaatcaca ggttaatatt
      841 tttcattgtg gatgtgtgat agcagaaata cgtgactata ggcagtccag taatatgaag
      901 tctcctggtt accaaagtag gcacattctc ttacgtccaa caatgcagac tttagtctgt
      961 gatgtccatt ctataacaag tgacaaccat aagtggaccc aggaagacaa acttttgctt
     1021 gagagccagc tgattctagc tacagcagag ccactgtgtc ttgacccatc ggtggcagta
     1081 gcgtgcactg ccaataggct gctctataac cggcagaaga tgaacactcg cccaatgaaa
     1141 cggtgttgga agaggtactc caggtcctcc ctgaaccgcc agcaggacct ctctcacggc
     1201 cctcctcccc ctcagctgag actacttgat ttcttacaaa agcggaagga aaggaaagca
     1261 ggccagcatt atgacctcaa aatttccaaa gcaggaaatt gtgtagacat gtggaaacgg
     1321 agcccctgta acttggctgt gccttctgaa gtagatgtgg aaaaatatgc taaagtggag
     1381 gaatccatca aatctgacga ctcacagcca acaatgtggc cagctcatga tgtaaaagac
     1441 gattatgtat ttgaatgtga aggtggtaat cagtatcaga aaacaaagct gaccatcttg
     1501 cagtctcttg gggatccact ttactatggt aaaatacagc cgtggaaagc agatgaagaa
     1561 aatgacagcc aaatgtctcc atcccactcc tctgctgatg accattcaaa ctggtttgtc
     1621 attgggtcaa agactgacgc agagagggta gttaatcaat accaggagtt ggtccagaat
     1681 gaagccaaat gcccagtgaa gatgtcacac agcagtagtg gttcagccgc tctcagtcca
     1741 ggggaggagg cagaacaggc ggagacctcg tccattcagt cttcagtttt gggaaaggga
     1801 gtaaaacacc gacccccacc catcaaactt ccctcaggct caggaaatag ttcctcaggt
     1861 aactatttca cagcacagca ggccagcagc ttccttaaat ctccaactcc tcctccatcg
     1921 tgtaagccaa gcctttctcg gaagtcttct gtggacctca gtcaagttag catgctttct
     1981 cctgccgccc tgtcccctgc cagctcatcc cagagatctg gaactcctaa gccatctcct
     2041 cctacaccaa ccccttcatc ggtcccacac cctcctgacg ctcagaactc agctcctagt
     2101 accccttcag ccaccccatc tccccaagaa tcaggcttca cccctcagcc cactttgtta
     2161 actcagtttg ctcagcagca aagggctctg agccaggcaa tgcctgtgac aaccattcct
     2221 ctttctacca tggtaacgtc cataacaaca ggaagctcgc tctccccggt catggcagac
     2281 tctgctgggc taacctccgt cagtgtactg agctctgctg gtggagccca ggctctgaag
     2341 agtggctcaa actccatgct gggctgtgac actggggcca tacctcctgc aggaaaaagc
     2401 ctgtgcagcg gccttctgcc atcaggaggt ctcgtagcaa acacactgcc cagtgccgtg
     2461 caggcggctc ctcaagcagg tatcccattt ggtttacaaa atacttcaag tctcagacct
     2521 ttaaatctac tccagcttcc tggtggttca ctcattttta acacccagca gcaacagcag
     2581 cagacgcagc tccctcactt tatacaacaa cctcagcagc ctgcagcttc cggttcccaa
     2641 cagccagagg agcagggttc tgaacaaggg ttaactgcgc aggaacaggc cttaactgct
     2701 cagcaagctg ccgttattaa ccttactgga gtaggaggct ttccccagtc acaggcagcc
     2761 gtgttgtctc agcttggctc tgctgagaac agacctgagc aaagccttcc tcagcagaga
     2821 ctccagctct cctctgcctt tcagcagcag cagcagcagc agcaacaaca acaacaacag
     2881 caactacaac agttgcgatt cttgcagcac caaatggcta tggcagcagc agccgcacaa
     2941 acagcccagc tacatcgtca ccggcacaca ggcagccagt caaagagtaa aatgaagaga
     3001 ggcatgccaa ctactccaaa attctgagca attttttttt tcttttttac aaacacgacc
     3061 attgaatgaa ttgtatttct actgttttcc cgagatgtca gtattttgca ttgctgtgtg
     3121 tgcacacttt acacagaagc acagccctgt gattcttaca tggaaacatg gtgaaatgtt
     3181 ttcctgtaca taccaatcgc agaaacaacg taaggactag aaatatcttt caaagaatgg
     3241 aattaggtat ttatttagta taaaaagcct gtgcagtgta acaaatacaa tttttacagc
     3301 tgttttgca
//
