LOCUS       NP_001394693             864 aa            linear   ROD 13-JUN-2024
DEFINITION  transcription factor SPT20 homolog isoform 1 [Mus musculus].
ACCESSION   NP_001394693 XP_006501867
VERSION     NP_001394693.1
DBSOURCE    REFSEQ: accession NM_001407764.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 864)
  AUTHORS   Warrier,S., Nuwayhid,S., Sabatino,J.A., Sugrue,K.F. and Zohn,I.E.
  TITLE     Supt20 is required for development of the axial skeleton
  JOURNAL   Dev Biol 421 (2), 245-257 (2017)
   PUBMED   27894818
  REMARK    GeneRIF: Gcn5 and Supt20 hypomorphs show similar defects in
            rostral-caudal somite patterning potentially suggesting shared
            mechanisms.
REFERENCE   2  (residues 1 to 864)
  AUTHORS   Liu,X., Xiao,W., Wang,X.D., Li,Y.F., Han,J. and Li,Y.
  TITLE     The p38-interacting protein (p38IP) regulates G2/M progression by
            promoting alpha-tubulin acetylation via inhibiting
            ubiquitination-induced degradation of the acetyltransferase GCN5
  JOURNAL   J Biol Chem 288 (51), 36648-36661 (2013)
   PUBMED   24220028
REFERENCE   3  (residues 1 to 864)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   4  (residues 1 to 864)
  AUTHORS   Jin,J.Z. and Ding,J.
  TITLE     Cripto is required for mesoderm and endoderm cell allocation during
            mouse gastrulation
  JOURNAL   Dev Biol 381 (1), 170-178 (2013)
   PUBMED   23747598
REFERENCE   5  (residues 1 to 864)
  AUTHORS   Clements,M., Pernaute,B., Vella,F. and Rodriguez,T.A.
  TITLE     Crosstalk between Nodal/activin and MAPK p38 signaling is essential
            for anterior-posterior axis specification
  JOURNAL   Curr Biol 21 (15), 1289-1295 (2011)
   PUBMED   21802298
REFERENCE   6  (residues 1 to 864)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   7  (residues 1 to 864)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   8  (residues 1 to 864)
  AUTHORS   Zohn,I.E., Li,Y., Skolnik,E.Y., Anderson,K.V., Han,J. and
            Niswander,L.
  TITLE     p38 and a p38-interacting protein are critical for downregulation
            of E-cadherin during mouse gastrulation
  JOURNAL   Cell 125 (5), 957-969 (2006)
   PUBMED   16751104
  REMARK    GeneRIF: Both p38 and p38IP are required for E-cadherin
            downregulation during gastrulation. Also, p38 regulates E-cadherin
            protein expression downstream from NCK-interacting kinase.
REFERENCE   9  (residues 1 to 864)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100927.11.
            
            On Jun 6, 2022 this sequence version replaced XP_006501867.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.59 cM"
     Protein         1..864
                     /product="transcription factor SPT20 homolog isoform 1"
                     /note="transcription factor (p38 interacting protein);
                     p38-interacting protein; protein FAM48A; family with
                     sequence similarity 48, member A; transcription factor
                     SPT20 homolog; suppressor of Ty 20"
                     /calculated_mol_wt=94121
     Region          77..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     Site            297
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TT00.1)"
     Region          <480..769
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8NEM7; propagated from
                     UniProtKB/Swiss-Prot (Q7TT00.1)"
     Site            516
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NEM7; propagated from
                     UniProtKB/Swiss-Prot (Q7TT00.1)"
     Site            521
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TT00.1)"
     CDS             1..864
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /coded_by="NM_001407764.1:433..3027"
                     /note="isoform 1 is encoded by transcript variant 8"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
ORIGIN      
        1 mqqaveqald caeyivesaq qrppkrkyls sgrksifqkl ydlyveecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlvcdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsvavacta nrllynrqkm ntrpmkrcwk
      241 rysrsslnrq qdlshgpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 lavpsevdve kyakveesik sddsqptmwp ahdvkddyvf eceggnqyqk tkltilqslg
      361 dplyygkiqp wkadeendsq mspshssadd hsnwfvigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saalspgeea eqaetssiqs svlgkgvkhr pppiklpsgs gnsssgnyft
      481 aqqassflks ptpppsckps lsrkssvdls qvsmlspaal spasssqrsg tpkpspptpt
      541 pssvphppda qnsapstpsa tpspqesgft pqptlltqfa qqqralsqam pvttiplstm
      601 vtsittgssl spvmadsagl tsvsvlssag gaqalksgsn smlgcdtgai ppagkslcsg
      661 llpsgglvan tlpsavqaap qagipfglqn tsslrplnll qlpggslifn tqqqqqqtql
      721 phfiqqpqqp aasgsqqpee qgseqgltaq eqaltaqqaa vinltgvggf pqsqaavlsq
      781 lgsaenrpeq slpqqrlqls safqqqqqqq qqqqqqqlqq lrflqhqmam aaaaaqtaql
      841 hrhrhtgsqs kskmkrgmpt tpkf
//
