LOCUS       NM_001358015            3104 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus SPT20 SAGA complex component (Supt20), transcript
            variant 1, mRNA.
ACCESSION   NM_001358015 XM_006501801
VERSION     NM_001358015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3104)
  AUTHORS   Warrier,S., Nuwayhid,S., Sabatino,J.A., Sugrue,K.F. and Zohn,I.E.
  TITLE     Supt20 is required for development of the axial skeleton
  JOURNAL   Dev Biol 421 (2), 245-257 (2017)
   PUBMED   27894818
  REMARK    GeneRIF: Gcn5 and Supt20 hypomorphs show similar defects in
            rostral-caudal somite patterning potentially suggesting shared
            mechanisms.
REFERENCE   2  (bases 1 to 3104)
  AUTHORS   Liu,X., Xiao,W., Wang,X.D., Li,Y.F., Han,J. and Li,Y.
  TITLE     The p38-interacting protein (p38IP) regulates G2/M progression by
            promoting alpha-tubulin acetylation via inhibiting
            ubiquitination-induced degradation of the acetyltransferase GCN5
  JOURNAL   J Biol Chem 288 (51), 36648-36661 (2013)
   PUBMED   24220028
REFERENCE   3  (bases 1 to 3104)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   4  (bases 1 to 3104)
  AUTHORS   Jin,J.Z. and Ding,J.
  TITLE     Cripto is required for mesoderm and endoderm cell allocation during
            mouse gastrulation
  JOURNAL   Dev Biol 381 (1), 170-178 (2013)
   PUBMED   23747598
REFERENCE   5  (bases 1 to 3104)
  AUTHORS   Clements,M., Pernaute,B., Vella,F. and Rodriguez,T.A.
  TITLE     Crosstalk between Nodal/activin and MAPK p38 signaling is essential
            for anterior-posterior axis specification
  JOURNAL   Curr Biol 21 (15), 1289-1295 (2011)
   PUBMED   21802298
REFERENCE   6  (bases 1 to 3104)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   7  (bases 1 to 3104)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   8  (bases 1 to 3104)
  AUTHORS   Zohn,I.E., Li,Y., Skolnik,E.Y., Anderson,K.V., Han,J. and
            Niswander,L.
  TITLE     p38 and a p38-interacting protein are critical for downregulation
            of E-cadherin during mouse gastrulation
  JOURNAL   Cell 125 (5), 957-969 (2006)
   PUBMED   16751104
  REMARK    GeneRIF: Both p38 and p38IP are required for E-cadherin
            downregulation during gastrulation. Also, p38 regulates E-cadherin
            protein expression downstream from NCK-interacting kinase.
REFERENCE   9  (bases 1 to 3104)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100927.11.
            
            On or before Jun 6, 2022 this sequence version replaced
            XM_006501801.1, NM_001358015.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1581355.1,
                                           SRR13422600.1056795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC100927.11        57589-57627
            40-145              AC100927.11        57871-57976
            146-230             AC100927.11        59891-59975
            231-266             AC100927.11        61252-61287
            267-325             AC100927.11        61719-61777
            326-392             AC100927.11        63361-63427
            393-522             AC100927.11        66255-66384
            523-626             AC100927.11        67839-67942
            627-743             AC100927.11        71628-71744
            744-797             AC100927.11        71856-71909
            798-937             AC100927.11        73025-73164
            938-1094            AC100927.11        73799-73955
            1095-1151           AC100927.11        74041-74097
            1152-1223           AC100927.11        75169-75240
            1224-1381           AC100927.11        76860-77017
            1382-1408           AC100927.11        77944-77970
            1409-1441           AC100927.11        78501-78533
            1442-1550           AC100927.11        79456-79564
            1551-1653           AC100927.11        79922-80024
            1654-1809           AC100927.11        80302-80457
            1810-2116           AC100927.11        82107-82413
            2117-2274           AC100927.11        83002-83159
            2275-2330           AC100927.11        85174-85229
            2331-2450           AC100927.11        87289-87408
            2451-2556           AC100927.11        90738-90843
            2557-2684           AC100927.11        92337-92464
            2685-3104           AC100927.11        93112-93531
FEATURES             Location/Qualifiers
     source          1..3104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.59 cM"
     gene            1..3104
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="SPT20 SAGA complex component"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
     exon            1..39
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            40..145
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            146..230
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2822
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor (p38 interacting protein);
                     p38-interacting protein; protein FAM48A; family with
                     sequence similarity 48, member A; transcription factor
                     SPT20 homolog; suppressor of Ty 20"
                     /codon_start=1
                     /product="transcription factor SPT20 homolog isoform 1"
                     /protein_id="NP_001344944.1"
                     /db_xref="GeneID:56790"
                     /db_xref="MGI:MGI:1929651"
                     /translation="MQQAVEQALDCAEYIVESAQQRPPKRKYLSSGRKSIFQKLYDLY
                     VEECEKEPEVKQKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSET
                     IRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGY
                     QSRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSVAVAC
                     TANRLLYNRQKMNTRPMKRCWKRYSRSSLNRQQDLSHGPPPPQLRLLDFLQKRKERKA
                     GQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEESIKSDDSQPTMWPAHDV
                     KDDYVFECEGGNQYQKTKLTILQSLGDPLYYGKIQPWKADEENDSQMSPSHSSADDHS
                     NWFVIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSAALSPGEEAEQAETSSIQS
                     SVLGKGVKHRPPPIKLPSGSGNSSSGNYFTAQQASSFLKSPTPPPSCKPSLSRKSSVD
                     LSQVSMLSPAALSPASSSQRSGTPKPSPPTPTPSSVPHPPDAQNSAPSTPSATPSPQE
                     SGFTPQPTLLTQFAQQQRALSQAMPVTTIPLSTMVTSITTGSSLSPVMADSAGLTSVS
                     VLSSAGGAQALKSGSNSMLGCDTGAIPPAGKSLCSGLLPSGGLVANTLPSAVQAAPQA
                     GIPFGLQNTSSLRPLNLLQLPGGSLIFNTQQQQQQTQLPHFIQQPQQPAASGSQQPEE
                     QGSEQGLTAQEQALTAQQAAVINLTGVGGFPQSQAAVLSQLGSAENRPEQSLPQQRLQ
                     LSSAFQQQQQQQQQQQQQQLQQLRFLQHQMAMAAAAAQTAQLHRHRHTGSQSKSKMKR
                     GMPTTPKF"
     exon            231..266
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            267..325
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            326..392
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            393..522
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            523..626
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            627..743
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            744..797
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            798..937
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1094
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1151
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1223
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1381
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1408
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1441
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1550
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1653
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1809
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2116
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2274
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2330
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2450
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2556
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2684
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..3104
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="hexamer: TATAAA"
     polyA_site      3104
                     /gene="Supt20"
                     /gene_synonym="D3Ertd300e; Fam48a; p38IP; Supt20h"
                     /note="major polyA site"
ORIGIN      
        1 gcggttggag gtgtgggtgg gcgttacagc aggccttagg tatttctgga aaatcgctgc
       61 aaggttggca gaatgcttct tcagggcgga gtgcggtgtg actgttgagt agaggttgct
      121 tctctgtgga gttggcgttc tgaggtatag aagaagacat ggtttccacc ccacttccac
      181 agcacgtcta agttttatct tttttggggt ccttatctgt tgccacaatg caacaagctg
      241 tagaacaagc tttggattgc gcagagtaca tcgtggaaag tgctcagcag agacctccta
      301 aaaggaaata cctgtctagt ggaagaaagt ctatatttca aaaactttat gacttatatg
      361 ttgaagaatg tgaaaaagaa cccgaggtta agcagaaatt aagaagaaat gtgaacttgt
      421 tagagaagct tgttatgcag gagactttgt cgtgtttagt agtcaatctg tacccaggaa
      481 atgaaggcta ttctctgatg ctcaggggga aaaatggatc agattctgag accatccgat
      541 tgccttatga agaaggagaa ttgcttgaat acttagatgc agaagaatta cctcctattt
      601 tggtggatct ccttgaaaaa tcacaggtta atatttttca ttgtggatgt gtgatagcag
      661 aaatacgtga ctataggcag tccagtaata tgaagtctcc tggttaccaa agtaggcaca
      721 ttctcttacg tccaacaatg cagactttag tctgtgatgt ccattctata acaagtgaca
      781 accataagtg gacccaggaa gacaaacttt tgcttgagag ccagctgatt ctagctacag
      841 cagagccact gtgtcttgac ccatcggtgg cagtagcgtg cactgccaat aggctgctct
      901 ataaccggca gaagatgaac actcgcccaa tgaaacggtg ttggaagagg tactccaggt
      961 cctccctgaa ccgccagcag gacctctctc acggccctcc tccccctcag ctgagactac
     1021 ttgatttctt acaaaagcgg aaggaaagga aagcaggcca gcattatgac ctcaaaattt
     1081 ccaaagcagg aaattgtgta gacatgtgga aacggagccc ctgtaacttg gctgtgcctt
     1141 ctgaagtaga tgtggaaaaa tatgctaaag tggaggaatc catcaaatct gacgactcac
     1201 agccaacaat gtggccagct catgatgtaa aagacgatta tgtatttgaa tgtgaaggtg
     1261 gtaatcagta tcagaaaaca aagctgacca tcttgcagtc tcttggggat ccactttact
     1321 atggtaaaat acagccgtgg aaagcagatg aagaaaatga cagccaaatg tctccatccc
     1381 actcctctgc tgatgaccat tcaaactggt ttgtcattgg gtcaaagact gacgcagaga
     1441 gggtagttaa tcaataccag gagttggtcc agaatgaagc caaatgccca gtgaagatgt
     1501 cacacagcag tagtggttca gccgctctca gtccagggga ggaggcagaa caggcggaga
     1561 cctcgtccat tcagtcttca gttttgggaa agggagtaaa acaccgaccc ccacccatca
     1621 aacttccctc aggctcagga aatagttcct caggtaacta tttcacagca cagcaggcca
     1681 gcagcttcct taaatctcca actcctcctc catcgtgtaa gccaagcctt tctcggaagt
     1741 cttctgtgga cctcagtcaa gttagcatgc tttctcctgc cgccctgtcc cctgccagct
     1801 catcccagag atctggaact cctaagccat ctcctcctac accaacccct tcatcggtcc
     1861 cacaccctcc tgacgctcag aactcagctc ctagtacccc ttcagccacc ccatctcccc
     1921 aagaatcagg cttcacccct cagcccactt tgttaactca gtttgctcag cagcaaaggg
     1981 ctctgagcca ggcaatgcct gtgacaacca ttcctctttc taccatggta acgtccataa
     2041 caacaggaag ctcgctctcc ccggtcatgg cagactctgc tgggctaacc tccgtcagtg
     2101 tactgagctc tgctggtgga gcccaggctc tgaagagtgg ctcaaactcc atgctgggct
     2161 gtgacactgg ggccatacct cctgcaggaa aaagcctgtg cagcggcctt ctgccatcag
     2221 gaggtctcgt agcaaacaca ctgcccagtg ccgtgcaggc ggctcctcaa gcaggtatcc
     2281 catttggttt acaaaatact tcaagtctca gacctttaaa tctactccag cttcctggtg
     2341 gttcactcat ttttaacacc cagcagcaac agcagcagac gcagctccct cactttatac
     2401 aacaacctca gcagcctgca gcttccggtt cccaacagcc agaggagcag ggttctgaac
     2461 aagggttaac tgcgcaggaa caggccttaa ctgctcagca agctgccgtt attaacctta
     2521 ctggagtagg aggctttccc cagtcacagg cagccgtgtt gtctcagctt ggctctgctg
     2581 agaacagacc tgagcaaagc cttcctcagc agagactcca gctctcctct gcctttcagc
     2641 agcagcagca gcagcagcaa caacaacaac aacagcaact acaacagttg cgattcttgc
     2701 agcaccaaat ggctatggca gcagcagccg cacaaacagc ccagctacat cgtcaccggc
     2761 acacaggcag ccagtcaaag agtaaaatga agagaggcat gccaactact ccaaaattct
     2821 gagcaatttt ttttttcttt tttacaaaca cgaccattga atgaattgta tttctactgt
     2881 tttcccgaga tgtcagtatt ttgcattgct gtgtgtgcac actttacaca gaagcacagc
     2941 cctgtgattc ttacatggaa acatggtgaa atgttttcct gtacatacca atcgcagaaa
     3001 caacgtaagg actagaaata tctttcaaag aatggaatta ggtatttatt tagtataaaa
     3061 agcctgtgca gtgtaacaaa tacaattttt acagctgttt tgca
//
