LOCUS       NM_033618               4491 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus SPT16, facilitates chromatin remodeling subunit
            (Supt16), mRNA.
ACCESSION   NM_033618
VERSION     NM_033618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4491)
  AUTHORS   Wang,J., Zhu,X., Dai,L., Wang,Z., Guan,X., Tan,X., Li,J., Zhang,M.,
            Bai,Y. and Guo,H.
  TITLE     Supt16 haploinsufficiency causes neurodevelopment disorder by
            disrupting MAPK pathway in neural stem cells
  JOURNAL   Hum Mol Genet 32 (5), 860-872 (2023)
   PUBMED   36226587
  REMARK    GeneRIF: Supt16 haploinsufficiency causes neurodevelopment disorder
            by disrupting MAPK pathway in neural stem cells.
REFERENCE   2  (bases 1 to 4491)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4491)
  AUTHORS   Chen,F., Zhang,W., Xie,D., Gao,T., Dong,Z. and Lu,X.
  TITLE     Histone chaperone FACT represses retrotransposon MERVL and
            MERVL-derived cryptic promoters
  JOURNAL   Nucleic Acids Res 48 (18), 10211-10225 (2020)
   PUBMED   32894293
  REMARK    GeneRIF: Histone chaperone FACT represses retrotransposon MERVL and
            MERVL-derived cryptic promoters.
REFERENCE   4  (bases 1 to 4491)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4491)
  AUTHORS   Husain,A., Begum,N.A., Taniguchi,T., Taniguchi,H., Kobayashi,M. and
            Honjo,T.
  TITLE     Chromatin remodeller SMARCA4 recruits topoisomerase 1 and
            suppresses transcription-associated genomic instability
  JOURNAL   Nat Commun 7, 10549 (2016)
   PUBMED   26842758
  REMARK    GeneRIF: FACT is required for TOP1 binding to H3K4me3 at non-B DNA
            containing chromatin for the site-specific cleavage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4491)
  AUTHORS   Tan,J.J., Ong,S.A. and Chen,K.S.
  TITLE     Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription
  JOURNAL   BMC Mol Biol 12, 4 (2011)
   PUBMED   21247419
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4491)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 4491)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 4491)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4491)
  AUTHORS   McGuire,M.V., Suthipinijtham,P. and Gascoigne,N.R.
  TITLE     The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin
            transcription complex, maps close to Tcra and is highly expressed
            in thymus
  JOURNAL   Mamm Genome 12 (8), 664-667 (2001)
   PUBMED   11471063
  REMARK    GeneRIF: The mouse Supt16h/Fact140 gene, encoding part of the FACT
            chromatin transcription complex, maps close to Tcra and is highly
            expressed in thymus
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI930189.1, AK148506.1, AF323667.1, AC159323.3 and CB202003.1.
            
            On Aug 1, 2007 this sequence version replaced NM_033618.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323667.1, SRR1660815.117488.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AI930189.1         1-48
            49-1999             AK148506.1         2-1952
            2000-2239           AF323667.1         1962-2201
            2240-2264           AC159323.3         167674-167698       c
            2265-2390           AC159323.3         166651-166776       c
            2391-2672           AF323667.1         2353-2634
            2673-3033           CB202003.1         111-471
            3034-3333           AF323667.1         2996-3295
            3334-4491           AC159323.3         154622-155779       c
FEATURES             Location/Qualifiers
     source          1..4491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.83 cM"
     gene            1..4491
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /note="SPT16, facilitates chromatin remodeling subunit"
                     /db_xref="GeneID:114741"
                     /db_xref="MGI:MGI:1890948"
     exon            1..155
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..3233
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /note="FACTp140; FACT 140 kDa subunit; facilitates
                     chromatin transcription complex subunit SPT16;
                     chromatin-specific transcription elongation factor 140 kDa
                     subunit; suppressor of Ty 16 homolog"
                     /codon_start=1
                     /product="FACT complex subunit SPT16"
                     /protein_id="NP_291096.2"
                     /db_xref="CCDS:CCDS27051.1"
                     /db_xref="GeneID:114741"
                     /db_xref="MGI:MGI:1890948"
                     /translation="MAVTLDKDAYYRRVKRLYSNWRKGEDEYASIDAIVVSVGVDEEI
                     VYAKSTALQTWLFGYELTDTIMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPA
                     ITLLVREKNESNKSSFDKMIDAIKESKSGKKIGVFSKDKFPGEFMKSWSDCLNKEGFD
                     KVDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLA
                     ESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMG
                     IRFKSYCSNLVRTLMVDPTQEVQENYNFLLQLQEELLKELRHGVKICDVYNSVMDVVK
                     KQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGK
                     KPEEKTYALFIGDTVLVDEDGPATILTSVKKKVKNVGIFLKNEDDEEEEEEKDEAEDL
                     LGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKS
                     NVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYT
                     YLRINFYCPGSALGRNEGNIFPNPEATFVKEITYRASNMKAPGEQTVPALNLQNAFRI
                     IKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEA
                     HVNGFRFTSVRGDKVDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQF
                     YTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFE
                     VPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVELIHFERVQFHLKNFD
                     MVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPE
                     GFFEQGGWSFLEPEGEGSDAEDGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEE
                     SDYSKESLGSEEESGKDWDELEEEARKADRESRYEEEEEQSRSMSRKRKASVHSSGRG
                     SNRGSRHSSAPPKKKRK"
     exon            156..248
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            249..419
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            420..572
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            573..719
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            720..871
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1044
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1135
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1209
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1322
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1388
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1484
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1600
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1754
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1882
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2018
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2145
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2264
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2390
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2503
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2579
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2749
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2879
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3009
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3087
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..4491
                     /gene="Supt16"
                     /gene_synonym="Cdc68; Fact140; Spt16; Supt16h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagtgcgg gattccgggc cgagcgcggg tggcggagct gggacctcgc gtgattctcg
       61 gagcccgacg ggaagcggcg tccagggcaa tggctgtgac tctggacaaa gacgcgtact
      121 accggcgagt gaagagattg tacagtaact ggcggaaagg agaagatgag tatgccagta
      181 ttgatgccat tgttgtatcg gtgggtgttg atgaagaaat tgtgtatgcc aagtcaactg
      241 ccttacagac gtggctcttt ggttatgaac taactgatac aatcatggtc ttctgtgatg
      301 acaaaatcat cttcatggcc agcaaaaaga aggtggagtt tctgaaacag attgccaata
      361 ctaaaggcaa tgagaatgct aatggagccc ctgccatcac actgcttgtc agagagaaga
      421 atgaaagtaa caagagcagc tttgacaaaa tgattgacgc tatcaaagaa agcaagagcg
      481 gcaagaagat cggagtgttc agcaaagaca agttccctgg agagttcatg aagagctgga
      541 gtgattgtct caacaaggag ggctttgaca aagtagacat cagcgctgtt gtggcataca
      601 ccattgctgt gaaagaggac ggtgagctca acctgatgaa gaaagcagcc agcatcacct
      661 ctgaggtctt caacaagttc tttaaggaaa gagtcatgga aatagtggat gcagatgaga
      721 aagttcggca tagcaaattg gctgagtctg tggaaaaggc cattgaagaa aaaaaatacc
      781 tagctggggc agatccttct actgtggaaa tgtgttaccc tcctatcatt cagagtggtg
      841 gcaactataa tctcaagttc agtgtggtga gtgataagaa tcatatgcat tttggggcca
      901 ttacgtgtgc catgggcatt cgctttaaat cttactgctc caaccttgtt cgcactctga
      961 tggttgaccc cactcaggaa gttcaagaaa attacaactt tttacttcaa cttcaagagg
     1021 agttgctaaa ggaattaaga catggtgtga agatatgtga tgtgtataac tctgtcatgg
     1081 atgtggttaa gaagcagaaa ccagaattgc tgaacaaaat tacaaagaat ctaggatttg
     1141 ggatgggaat tgaattccgt gaaggctctc tagtaatcaa tagtaaaaat cagtacaagc
     1201 taaagaaagg gatggttttt agcatcaatc taggattttc agacctgact aacaaagaag
     1261 ggaaaaagcc agaagagaaa acctatgccc tgttcattgg tgacacggtg cttgtagatg
     1321 aggatggtcc agccactatt cttacttctg tgaaaaagaa agtaaagaat gtggggattt
     1381 tcctgaagaa tgaggatgat gaagaggagg aggaagagaa agatgaggca gaggaccttt
     1441 tgggaagagg ctctagggcg gcattactta ctgaaagaac aaggaatgag atgactgcag
     1501 aagagaagcg aagagcacat cagaaggaac tggcagcaca gctcaacgag gaagcgaaga
     1561 ggaggctgac agagcagaaa ggggaacagc agattcagaa agctcgaaaa tctaatgtgt
     1621 cctataaaaa cccatctctg atgcctaagg aaccacatat tcgggagatg aagatctata
     1681 ttgataagaa atatgagact gtgataatgc ctgtgtttgg cattgccaca cccttccata
     1741 ttgccacaat caagaacata agtatgtctg tcgaaggaga ctatacttac ttgcgaatca
     1801 acttctattg tccaggcagt gctctgggca ggaatgaggg caacatcttt cctaaccctg
     1861 aagccacttt tgtcaaggaa attacatacc gagcttcaaa tatgaaagca cctggagagc
     1921 agactgtacc cgccttaaat cttcagaatg cgttccgaat tataaaagaa gtacaaaaac
     1981 gttacaagac cagagaagct gaagagaaag aaaaagaggg cattgtaaaa caagactcgc
     2041 tggtgatcaa cctaaaccgg agtaatccaa aactgaaaga cctgtacatt cgtccaaaca
     2101 ttgcccagaa gagaatgcag ggctcactgg aggctcatgt caatggtttc cgattcacat
     2161 ctgttcgagg agacaaggtg gatattctgt acaataatat caagcatgcg ctgttccagc
     2221 cctgtgatgg cgagatgatt attgttttgc actttcacct caagaatgct atcatgtttg
     2281 ggaagaagcg acacacagat gtacagttct acacagaagt tggagagatc actacagatt
     2341 tggggaaaca tcaacacatg catgaccgag atgacctgta tgctgagcag atggaacgag
     2401 aaatgagaca caaactgaaa acggccttta aaaatttcat tgaaaaagta gaggccctaa
     2461 caaaggagga gctggagttt gaagtgccat ttagggacct ggggtttaat ggggctccct
     2521 acaggagtac ctgcctcctt cagcccacta gtagtgccct ggtaaatgct acagagtggc
     2581 caccctttgt ggtgacactg gatgaagtgg agctgatcca ttttgagagg gtccagtttc
     2641 acctgaagaa ctttgatatg gtcattgtct acaaggatta cagcaagaaa gtcacgatga
     2701 tcaatgctat tcctgttgcc tctctagacc ccatcaagga gtggctgaat tcctgtgacc
     2761 taaagtacac agaaggagtt cagtctctca actggactaa aatcatgaag accattgttg
     2821 atgaccccga gggcttcttt gaacaaggtg gctggtcctt cctggaacct gagggtgagg
     2881 ggagtgacgc tgaggacgga gactcggagt ctgaaattga agatgagact ttcaatcctt
     2941 ctgaagatga ctatgaagag gaagaagagg acagcgatga agattactca tcagaagctg
     3001 aagaatcaga ctattctaag gaatctctgg gaagtgaaga agaaagcggg aaggactggg
     3061 atgagctaga agaagaagca cgaaaagcgg accgggaaag ccgttatgag gaggaagaag
     3121 aacagagccg aagtatgagc cggaagagga aggcatctgt acatagttca ggccgtggct
     3181 ctaaccgtgg ttccagacac agctctgcac ccccgaagaa aaagagaaag taatatgaac
     3241 cttgggtcct atgctccatt ctttatgcag acaactccta aaatgacatg acatagaaac
     3301 tgtttttcct tttggtttcg ttgaagtttt gccatttgtg tttatgggtt taggggccat
     3361 ttgtgcggac caagctactc ggggaattcc aggcccacca ggacatgtgc cagtggcccc
     3421 gatcagatgg ctggcaaggg aggcggtgtt gaagggcagg aggctcctcc cactgttgat
     3481 cccattgcct cttttcttct gacaacttac ctttggtgtc tgaaagctga attcccaaga
     3541 cagtgagaga ctctgaccac taaccatttc taggattctt ttttctttac ttttttattt
     3601 ttcctgtttt gagacagtct tgctatgcag ccatggctta ccttgaagtc actgtaagcc
     3661 aggctagcct caaatgtatg atcctctcgc tctgcctccc aagtgctaag gctacaggct
     3721 tgagtcactg tacttagacg aagcatagtt ctggcccaga gtcagtcctc cgtccgtccc
     3781 tttatcagtt ccagatctgc agttctcaag aacgtccttg ggctctgctg atgactgtga
     3841 cttggctgag ctgggctggt gtctggtctt cagtggttct ggtttcttgc ctcatgcaca
     3901 ttctggggtt gtttttgctg catcagaaga caaacactgg cactcgtggc tgtttttttt
     3961 tttttttttt tttttttttt cctccttaca agtccatatg tggtgcagtg ctcaaacaca
     4021 aattaccatt gtctcttctg atacatctaa ggaagaatgg tcatgcttcg tatactacag
     4081 gtgaaatcta gagggaggct taaaggagtc aacatggatc tcaaagagta agtcgtgtct
     4141 tggcctagaa tatcttgaca agaagagaag cgggaagaag gccacaccca caaggctggg
     4201 cactgctgct cttcccttta ctttctctgc agtgtcctgt gttggttgct tccgatgatc
     4261 agctttgaaa tactgggggg ctctatcttg ccatcctccc ctgcaggttc tctgcatcca
     4321 cctgtcccac ttcgccgcct ctgttctgtg actttatgag aaggggcttc tcagatttta
     4381 tgtttgtttg tttgttttct ccccttagca gtaggacttg atattttgaa ttttggaaga
     4441 actaaaagat aaataaactg ggattttttt ttgttttgtt ttgttttttt t
//
