LOCUS       NM_173733               2349 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus sulfite oxidase (Suox), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_173733
VERSION     NM_173733.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Hayman,D.J., Modebadze,T., Charlton,S., Cheung,K., Soul,J., Lin,H.,
            Hao,Y., Miles,C.G., Tsompani,D., Jackson,R.M., Briggs,M.D.,
            Pirog,K.A., Clark,I.M., Barter,M.J., Clowry,G.J., LeBeau,F.E.N. and
            Young,D.A.
  TITLE     Increased hippocampal excitability in miR-324-null mice
  JOURNAL   Sci Rep 11 (1), 10452 (2021)
   PUBMED   34001919
  REMARK    GeneRIF: Increased hippocampal excitability in miR-324-null mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Bender,D., Tobias Kaczmarek,A., Niks,D., Hille,R. and Schwarz,G.
  TITLE     Mechanism of nitrite-dependent NO synthesis by human sulfite
            oxidase
  JOURNAL   Biochem J 476 (12), 1805-1815 (2019)
   PUBMED   31167903
  REMARK    GeneRIF: Mechanism of nitrite-dependent NO synthesis by human
            sulfite oxidase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Belaidi,A.A., Roper,J., Arjune,S., Krizowski,S., Trifunovic,A. and
            Schwarz,G.
  TITLE     Oxygen reactivity of mammalian sulfite oxidase provides a concept
            for the treatment of sulfite oxidase deficiency
  JOURNAL   Biochem J 469 (2), 211-221 (2015)
   PUBMED   26171830
  REMARK    GeneRIF: This finding suggests the possibility to use
            oxygen-reactive SO variants in sulfite detoxification, as the loss
            of SO activity is causing severe neurodegeneration
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Klein,J.M. and Schwarz,G.
  TITLE     Cofactor-dependent maturation of mammalian sulfite oxidase links
            two mitochondrial import pathways
  JOURNAL   J Cell Sci 125 (Pt 20), 4876-4885 (2012)
   PUBMED   22854042
  REMARK    GeneRIF: the identified molecular hierarchy of SO maturation
            represents a novel link between the canonical presequence pathway
            and folding-trap mechanisms of mitochondrial import
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117232.3.
            
            On Nov 6, 2008 this sequence version replaced NM_173733.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ182547.1, SRR1660813.267365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC117232.3         159428-159494       c
            68-131              AC117232.3         158115-158178       c
            132-309             AC117232.3         157680-157857       c
            310-2349            AC117232.3         155463-157502       c
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.12 cM"
     gene            1..2349
                     /gene="Suox"
                     /gene_synonym="SO"
                     /note="sulfite oxidase"
                     /db_xref="GeneID:211389"
                     /db_xref="MGI:MGI:2446117"
     exon            1..67
                     /gene="Suox"
                     /gene_synonym="SO"
                     /inference="alignment:Splign:2.1.0"
     exon            68..131
                     /gene="Suox"
                     /gene_synonym="SO"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1719
                     /gene="Suox"
                     /gene_synonym="SO"
                     /EC_number="1.8.3.1"
                     /note="sulfite oxidase, mitochondrial"
                     /codon_start=1
                     /product="sulfite oxidase, mitochondrial precursor"
                     /protein_id="NP_776094.2"
                     /db_xref="CCDS:CCDS24285.1"
                     /db_xref="GeneID:211389"
                     /db_xref="MGI:MGI:2446117"
                     /translation="MLLQLYRSVVVRLPQAIRVKSTPLRLCIQACSTNDSLEPQHPSL
                     TFSDDNSRTRRWKVMGTLLGLGVVLVYHEHRCRASQESPRMYSKEDVRSHNNPKTGVW
                     VTLGSEVFDVTKFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQPHVRELLAEYKIGE
                     LNPEDSMSPSVEASDPYADDPIRHPALRINSQRPFNAEPPPELLTEGYITPNPIFFTR
                     NHLPVPNLDPHTYRLHVVGAPGGQSLSLSLDDLHKFPKHEVTVTLQCAGNRRSEMSKV
                     KEVKGLEWRTGAISTARWAGARLCDVLAQAGHRLCDSEAHVCFEGLDSDPTGTAYGAS
                     IPLARAMDPEAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVESEES
                     YSHWQRRDYKGFSPSVDWDTVNFDLAPSIQELPIQSAITQPQDGAIVESGEVTIKGYA
                     WSGGGRAVIRVDVSVDGGLTWQEAELEGEEQCPRKAWAWRIWQLKAQVPAEQKELNII
                     CKAVDDSYNVQPDTVAPIWNLRGVLSNAWHRVHVQVVP"
     exon            132..309
                     /gene="Suox"
                     /gene_synonym="SO"
                     /inference="alignment:Splign:2.1.0"
     exon            310..2349
                     /gene="Suox"
                     /gene_synonym="SO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2320..2325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suox"
                     /gene_synonym="SO"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="Suox"
                     /gene_synonym="SO"
                     /note="major polyA site"
ORIGIN      
        1 tccgctctgg gccgctctag ccctgcacgg ggcgggtgaa attgttccgc tgccgacatc
       61 cagccgggtc ttgccacgat gctgctgcag ctatacagat ccgtggttgt gaggcttcca
      121 caggccatca gagtcaagtc aacccccttg aggctctgca ttcaagcatg ctccacaaat
      181 gattcacttg agccccagca tcccagcctt accttttctg atgataactc aaggactcgg
      241 agatggaaag tcatggggac cctgttaggc ctgggtgtgg tgctggtcta ccatgagcat
      301 cggtgtaggg cttctcagga gtcaccacgg atgtactcta aagaggatgt gcgttctcac
      361 aacaacccta aaactggagt ctgggtaact ctaggctctg aggtcttcga tgtcacaaaa
      421 tttgtggacc tgcatccagg aggaccatca aaactgatgc tagcagctgg aggtccccta
      481 gaacccttct gggccctcta tgctgtgcac aaccagcccc atgtacgtga gttactggcc
      541 gagtataaga ttggggaact gaaccccgaa gatagcatgt ccccctccgt ggaagcctct
      601 gacccttatg ctgatgatcc tattcgtcat ccagccctga ggattaatag ccagcgcccc
      661 tttaatgcag agcctcctcc tgaactgcta actgaaggct acatcacacc aaatcctatt
      721 ttcttcaccc gtaaccatct gcctgtacct aacctggacc cacacaccta tcgcttacat
      781 gtagtagggg cacctggagg tcagtcactg tctctgtcct tggatgattt gcataagttt
      841 cccaaacatg aggtcactgt cactctgcag tgtgctggta accggcgctc cgaaatgagt
      901 aaggtcaagg aagtgaaagg tctggaatgg agaacagggg ccatcagcac agcacgctgg
      961 gctggggccc ggctctgtga tgtgttagcc caggctggtc accgactctg tgactctgag
     1021 gcccatgtct gttttgaagg actggattca gaccccactg gaactgccta tggagcatcg
     1081 atccctctgg ctcgggccat ggatcctgaa gccgaggtcc tcctggctta tgaaatgaat
     1141 ggtcagcctc tacctcgtga ccatggcttc cctgtacggg tggtggttcc tggtgtagta
     1201 ggtgcccgtc atgtcaaatg gctcggcaga gtgagtgtgg aatcagagga gagttatagt
     1261 cactggcaga ggcgggatta caaaggcttt tctccatctg tggactggga cacggtaaac
     1321 tttgacctag ctccatcaat tcaggaacta cctatccagt cagctatcac acaacctcaa
     1381 gatggggcca ttgtagagtc aggcgaggtg actatcaagg gctatgcatg gagtggtggt
     1441 ggcagggctg tgattcgagt ggatgtgtct gtggatgggg gactaacctg gcaggaagct
     1501 gagctagagg gagaggaaca gtgtcccagg aaggcctggg cttggcgaat atggcagttg
     1561 aaagctcagg tgccggctga gcaaaaggaa ttgaacatca tttgcaaagc tgtagatgac
     1621 agttacaatg tgcagccaga cactgtagcc ccaatctgga accttcgggg cgtactcagc
     1681 aatgcctggc accgtgtcca tgttcaggtg gtcccatgaa agcatggaat ggcaccattt
     1741 gtacccaaag aaccacctag acctcttcac caacccagcc ttaatcctca ttgctgtaga
     1801 taaacatttc cttcctctcc ttgattcgta accttgtacg tactgtgtct taagctgtac
     1861 cccagcacac acatctcttc tggcccctga ccctgtgctt ggagagaggc tgctcgggtg
     1921 agagagcagc tcgaaagaca ctgctttctt accctatggt catctctact tctgatgccc
     1981 ccccatctgg gccttatttt gcattgctta gattcttcag atgtgtgtgt ggtgtgtgga
     2041 atgtgtaatt actgtacatt tttctttttc ttcttcatca tcttcttgtt attctttttt
     2101 tttccccctt tcaaaacagg gtttctctgt gtagccctgg ttgtccggga actcactctg
     2161 taccaggctg atctcaaact cagaggtttg cctgcctctg cctccagaat gctgggacta
     2221 aaggtttgca ccacctctgc ccagctacat aactattttc aattgcctct gggatgcaag
     2281 gggatttccc tcttagagtg ctacttttaa aactattcca ataaagtgtc tgtttaagat
     2341 tatgactgg
//
