LOCUS       NM_001205345            3809 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Sad1 and UNC84 domain containing 2 (Sun2), transcript
            variant 1, mRNA.
ACCESSION   NM_001205345
VERSION     NM_001205345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3809)
  AUTHORS   Huang,Y., Peng,Q., Tian,X., Chen,C., Zhu,X., Huang,C., Huo,Z.,
            Liu,Y., Yang,C., Liu,C. and Zhang,P.
  TITLE     Nuclear membrane protein SUN2 promotes replication of flaviviruses
            through modulating cytoskeleton reorganization mediated by NS1
  JOURNAL   Nat Commun 15 (1), 296 (2024)
   PUBMED   38177122
  REMARK    GeneRIF: Nuclear membrane protein SUN2 promotes replication of
            flaviviruses through modulating cytoskeleton reorganization
            mediated by NS1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3809)
  AUTHORS   Jiao,S., Li,C., Guo,F., Zhang,J., Zhang,H., Cao,Z., Wang,W., Bu,W.,
            Lin,M., Lu,J. and Zhou,Z.
  TITLE     SUN1/2 controls macrophage polarization via modulating nuclear size
            and stiffness
  JOURNAL   Nat Commun 14 (1), 6416 (2023)
   PUBMED   37828059
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3809)
  AUTHORS   Ross,J.A., Arcos-Villacis,N., Battey,E., Boogerd,C., Orellana,C.A.,
            Marhuenda,E., Swiatlowska,P., Hodzic,D., Prin,F., Mohun,T.,
            Catibog,N., Tapia,O., Gerace,L., Iskratsch,T., Shah,A.M. and
            Stroud,M.J.
  TITLE     Lem2 is essential for cardiac development by maintaining nuclear
            integrity
  JOURNAL   Cardiovasc Res 119 (11), 2074-2088 (2023)
   PUBMED   37067297
REFERENCE   5  (bases 1 to 3809)
  AUTHORS   Sharma,R. and Hetzer,M.W.
  TITLE     Disulfide bond in SUN2 regulates dynamic remodeling of LINC
            complexes at the nuclear envelope
  JOURNAL   Life Sci Alliance 6 (8), e202302031 (2023)
   PUBMED   37188462
  REMARK    GeneRIF: Disulfide bond in SUN2 regulates dynamic remodeling of
            LINC complexes at the nuclear envelope.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3809)
  AUTHORS   Lei,K., Zhang,X., Ding,X., Guo,X., Chen,M., Zhu,B., Xu,T.,
            Zhuang,Y., Xu,R. and Han,M.
  TITLE     SUN1 and SUN2 play critical but partially redundant roles in
            anchoring nuclei in skeletal muscle cells in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (25), 10207-10212 (2009)
   PUBMED   19509342
  REMARK    GeneRIF: These results clearly indicate that SUN1 and SUN2 function
            critically in skeletal muscle cells for Syne-1 localization at the
            nuclear envelope, which is essential for proper myonuclear
            positioning.
REFERENCE   7  (bases 1 to 3809)
  AUTHORS   Schmitt,J., Benavente,R., Hodzic,D., Hoog,C., Stewart,C.L. and
            Alsheimer,M.
  TITLE     Transmembrane protein Sun2 is involved in tethering mammalian
            meiotic telomeres to the nuclear envelope
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7426-7431 (2007)
   PUBMED   17452644
  REMARK    GeneRIF: Sun2 is part of a membrane-spanning fibrillar complex that
            interconnects attached telomeres with cytoplasmic structures
REFERENCE   8  (bases 1 to 3809)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3809)
  AUTHORS   Wang,Q., Du,X., Cai,Z. and Greene,M.I.
  TITLE     Characterization of the structures involved in localization of the
            SUN proteins to the nuclear envelope and the centrosome
  JOURNAL   DNA Cell Biol 25 (10), 554-562 (2006)
   PUBMED   17132086
  REMARK    GeneRIF: SUN1 and SUN2 may form a physical interaction between the
            nuclear envelope and the centrosome
REFERENCE   10 (bases 1 to 3809)
  AUTHORS   Crisp,M., Liu,Q., Roux,K., Rattner,J.B., Shanahan,C., Burke,B.,
            Stahl,P.D. and Hodzic,D.
  TITLE     Coupling of the nucleus and cytoplasm: role of the LINC complex
  JOURNAL   J Cell Biol 172 (1), 41-53 (2006)
   PUBMED   16380439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118227.12.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156246.1, AK172398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC118227.12        130558-130755       c
            199-359             AC118227.12        127940-128100       c
            360-550             AC118227.12        127039-127229       c
            551-691             AC118227.12        126739-126879       c
            692-787             AC118227.12        125692-125787       c
            788-881             AC118227.12        125285-125378       c
            882-961             AC118227.12        124065-124144       c
            962-1089            AC118227.12        122327-122454       c
            1090-1344           AC118227.12        118309-118563       c
            1345-1422           AC118227.12        117700-117777       c
            1423-1466           AC118227.12        117252-117295       c
            1467-1632           AC118227.12        116635-116800       c
            1633-1854           AC118227.12        116082-116303       c
            1855-1939           AC118227.12        115735-115819       c
            1940-2055           AC118227.12        115270-115385       c
            2056-2223           AC118227.12        115010-115177       c
            2224-2316           AC118227.12        114761-114853       c
            2317-3809           AC118227.12        112287-113779       c
FEATURES             Location/Qualifiers
     source          1..3809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..3809
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /note="Sad1 and UNC84 domain containing 2"
                     /db_xref="GeneID:223697"
                     /db_xref="MGI:MGI:2443011"
     exon            1..198
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            199..359
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2430
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein unc-84 homolog B; SUN domain-containing protein 2;
                     sad1/unc-84 protein-like 2"
                     /codon_start=1
                     /product="SUN domain-containing protein 2 isoform 1"
                     /protein_id="NP_001192274.1"
                     /db_xref="CCDS:CCDS56993.1"
                     /db_xref="GeneID:223697"
                     /db_xref="MGI:MGI:2443011"
                     /translation="MSRRSQRLTRYSQDDNDGGSSSSGASSVAGSQGTVFKDSPLRTL
                     KRKSSNMKHLSPAPQLGPSSDSHTSYYSESVVRESYIGSPRAVSLARSALLDDHLHSE
                     PYWSGDLRGRRRRGTGGSESSKANGLTAESKASEDFFGSSSGYSSEDDLAGYTDSDQH
                     SSGSRLRSAASRAGSFVWTLVTFPGRLFGLLYWWIGTTWYRLTTAASLLDVFVLTRSR
                     HFSLNLKSFLWFLLLLLLLTGLTYGAWHFYPLGLQTLQPAVVSWWAAKESRKQPEVWE
                     SRDASQHFQAEQRVLSRVHSLERRLEALAADFSSNWQKEAIRLERLELRQGAAGHGGG
                     SSLSHEDALSLLEGLVSRREATLKEDLRRDTVAHIQEELATLRAEHHQDSEDLFKKIV
                     QASQESEARVQQLKTEWKSMTQEAFQESSVKELGRLEAQLASLRQELAALTLKQNSVA
                     DEVGLLPQKIQAARADVESQFPDWIRQFLLGDRGARSGLLQRDEMHAQLQELENKILT
                     KMAEMQGKSAREAAASLGQILQKEGIVGVTEEQVHRIVKQALQRYSEDRIGMVDYALE
                     SGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGF
                     AVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGTFAYD
                     QDGEPIQTFYFQASKMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH"
     exon            360..550
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            551..691
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            692..787
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            788..881
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            882..961
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1089
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1344
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1422
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1466
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1632
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1854
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1939
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2055
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2223
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2316
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..3809
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /note="hexamer: AATAAA"
     polyA_site      3807
                     /gene="Sun2"
                     /gene_synonym="B230369L08Rik; C030011B15; Unc84b"
                     /note="major polyA site"
ORIGIN      
        1 acatacacac tcggccacgc gcgcaccgcc ctgccccact cgcgcagcgc ggtcctctgc
       61 cggccgcatt gtccgctcac cgaccccgcg ccgtcccgcg tctccgctcc gcgcgcgttt
      121 cagccccagc cccgggcccg gcccggccca gtgcgcggcg ccgcccgggg gactccgacg
      181 cgggaagaac cacgcaagtc tttctttagg agagtgtccc taccctgccc catcatgtcg
      241 agacgaagcc agcgcctcac tcgctactct caggatgata acgatggcgg cagcagcagc
      301 agtggtgcga gctccgtggc aggaagccag ggcaccgtgt ttaaagacag tcctctcagg
      361 actttgaaga ggaaatccag caacatgaag cacctgtccc cagctccaca gctgggcccc
      421 tcctctgact cccacacctc ctactacagc gagtctgtgg ttcgagagtc ctacatcggc
      481 agcccccggg ctgtgtccct cgccaggagt gccctcctgg atgaccacct acacagtgag
      541 ccctactgga gcggggacct tcgggggagg aggaggagag gaacaggtgg ttctgagagc
      601 agcaaggcca atgggctcac cgcggagagc aaggcctcag aagacttttt cggatcttcc
      661 tcaggctatt cttcagagga tgaccttgca ggctacacgg actcagacca gcacagctcg
      721 gggtccaggt taaggagtgc agcatctcgg gccggctcct ttgtctggac tctggtcact
      781 tttccaggcc gcctctttgg tcttctctac tggtggattg gcaccacctg gtaccgcctg
      841 acaactgctg cctccctcct ggatgtcttc gtcctaacca ggtccaggca cttctcgctg
      901 aacctgaaga gttttctgtg gttccttctg ctcttgctac tcctgactgg tctgacctac
      961 ggtgcttggc atttttaccc cttagggctg cagacattgc aacccgctgt ggtctcctgg
     1021 tgggcagcaa aagagagcag gaagcagcca gaggtgtggg aatccagaga cgcctcccag
     1081 cacttccagg ctgagcagcg cgttctctcc cgggttcact ctctggagcg gcgtctggaa
     1141 gcccttgctg cagacttttc ctccaactgg cagaaggagg ccatacggct ggaacgcctg
     1201 gagctgcggc agggggctgc tggccatgga ggaggcagta gcctgagcca tgaagatgcc
     1261 ctgtctctcc tagaagggtt ggtgagccgc cgcgaggcta ccctgaagga ggacttgcgc
     1321 agggacacag tggctcatat ccaggaagaa ttggctaccc tgagggcaga gcatcaccaa
     1381 gactcggaag atctcttcaa gaagatcgtc caggcctctc aggagtccga agcccgagtc
     1441 cagcagctga agacagaatg gaaaagcatg acccaggagg ccttccagga gagctctgtg
     1501 aaggagctgg gacggctgga agcccagctg gccagcctgc ggcaggagct ggctgccctg
     1561 actctgaagc agaactcggt ggcagatgaa gtgggcctgc tgccacagaa gatccaggct
     1621 gccagggctg atgtggaatc ccagttccct gactggatca ggcagttcct tcttggagac
     1681 aggggtgcgc gcagcgggct cctgcagaga gatgagatgc acgctcagct gcaggagctg
     1741 gagaacaaga tccttaccaa gatggctgag atgcagggca agtcagccag ggaggccgca
     1801 gcgtccctgg gacagatact gcagaaagaa ggcatagttg gggtgacaga ggagcaggtg
     1861 caccggatcg tcaagcaggc cctgcagcgc tacagtgagg acaggattgg aatggtggat
     1921 tacgccctgg aatcaggagg agccagtgtt atcagcaccc gctgctctga gacttatgag
     1981 accaagacgg cactcctcag cctctttggc atccccctgt ggtaccactc ccagtcacct
     2041 cgggtcattc tgcagccaga tgtgcaccca ggcaactgct gggccttcca ggggccccag
     2101 ggctttgcag tggtccgcct ctctgctcga atccgaccta cagccgttac cttagagcac
     2161 gtgcccaagg ccttgtcacc caacagcact atctccagtg ctcccaagga cttcgccatc
     2221 tttggcttcg atgaagacct gcagcaggaa gggacacttc ttggcacgtt tgcctacgac
     2281 caggatgggg agcccatcca gaccttctat ttccaggcct ctaagatggc cacataccaa
     2341 gttgtggagc ttcggatcct gaccaactgg ggccaccctg agtacacgtg tatctaccgc
     2401 ttccgggtgc acggagagcc tgcccactag tcttctgaga tcttgggcct gttgctagcc
     2461 acgtgggaag ctcatctttc ccagcatcta ccctgctctg aaaataggtg cccagcaccc
     2521 caccgctgcc tgcacatgct tcttagcgct gacttccagg agcaagagtg aagaggcagc
     2581 acgtagaact ccctgcataa gccaagccac caggctccta tgcctctctt agtcttcccc
     2641 ctagagctag gcgcctacca ggtgtatata tgtagcatac tttgggggac tgcgatcaga
     2701 agtgaggtgg agggactggc accggttaac tcctggtagg tgccaaagcc atgggcatac
     2761 caagccagag ccccagggat aagctggggg gtcttgtggc ctttaggaca gtgcttagca
     2821 ctgtgcagct gggactgtcc ctggcaagtg cctggtaaag gacaccgagg ctgctgagct
     2881 cttccagcat ggagggtacc atggcccgta ggagcctggg gttcctagca aacgggagga
     2941 aaccagctcc tgtgtgcctc tgacgactgt tgtctgtgcc aacctaagag attcccagtg
     3001 ctgggaccac tgcttttttt cctgatgtgg ggtgagggtc tattctgttt cccattcctg
     3061 ctgcatcctg cctgtgcccc acagcaagct ttccaccccc cagggaggac ccagccctgg
     3121 ctttggggct attctgcagg gttgtctaga ggagtgggga gatgactttg ggggttctcc
     3181 tgattcagtg ccaatagcca cagtgtggct caagatacag gtagaggggc tacactagcc
     3241 caccccattt agagtggtcc tgtctactct acagcaactc tcttgggctc tcagctcttg
     3301 cttacactgc ttcctttctg gcctctatgg tggcagttag atgggggctg ggagagaggg
     3361 agggagggag ggagggaggg aaggagggag ggagacatta acttgtgtgg agaggaggaa
     3421 gaggctttta gactcaacgg ctggccctgc tgtattatat atagaattct caaggtctgt
     3481 tttttgttgt tttgtttttg tttttaactg aaaaagccac aggcttgatt tctagcccca
     3541 ttctgagggg caccagctgt tacccagttt ctagttcctg gctcttgagg ggcttggtcc
     3601 tgcctgctct atggaagggg ccaagaggag ctgcaaggca gcccggttag tgttcgggtg
     3661 aaatggcaag ttgtacagcc ccctcgggct tgttttgtgc tctcctgtca caaatgctgc
     3721 actgttgatt ctttcaaaac aaaacgaaac aaacctctcc agtctctaat ttatgcctat
     3781 gcaaaaaata aaggatgccc aggatcatt
//
