LOCUS       NM_001256115            4022 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Sad1 and UNC84 domain containing 1 (Sun1), transcript
            variant 2, mRNA.
ACCESSION   NM_001256115
VERSION     NM_001256115.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4022)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4022)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4022)
  AUTHORS   Jiao,S., Li,C., Guo,F., Zhang,J., Zhang,H., Cao,Z., Wang,W., Bu,W.,
            Lin,M., Lu,J. and Zhou,Z.
  TITLE     SUN1/2 controls macrophage polarization via modulating nuclear size
            and stiffness
  JOURNAL   Nat Commun 14 (1), 6416 (2023)
   PUBMED   37828059
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4022)
  AUTHORS   Ross,J.A., Arcos-Villacis,N., Battey,E., Boogerd,C., Orellana,C.A.,
            Marhuenda,E., Swiatlowska,P., Hodzic,D., Prin,F., Mohun,T.,
            Catibog,N., Tapia,O., Gerace,L., Iskratsch,T., Shah,A.M. and
            Stroud,M.J.
  TITLE     Lem2 is essential for cardiac development by maintaining nuclear
            integrity
  JOURNAL   Cardiovasc Res 119 (11), 2074-2088 (2023)
   PUBMED   37067297
REFERENCE   5  (bases 1 to 4022)
  AUTHORS   Buglak,D.B., Bougaran,P., Kulikauskas,M.R., Liu,Z.,
            Monaghan-Benson,E., Gold,A.L., Marvin,A.P., Burciu,A., Tanke,N.T.,
            Oatley,M., Ricketts,S.N., Kinghorn,K., Johnson,B.N., Shiau,C.E.,
            Rogers,S., Guilluy,C. and Bautch,V.L.
  TITLE     Nuclear SUN1 stabilizes endothelial cell junctions via microtubules
            to regulate blood vessel formation
  JOURNAL   Elife 12, e83652 (2023)
   PUBMED   36989130
  REMARK    GeneRIF: Nuclear SUN1 stabilizes endothelial cell junctions via
            microtubules to regulate blood vessel formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4022)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4022)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 4022)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   9  (bases 1 to 4022)
  AUTHORS   Dreger,M., Bengtsson,L., Schoneberg,T., Otto,H. and Hucho,F.
  TITLE     Nuclear envelope proteomics: novel integral membrane proteins of
            the inner nuclear membrane
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11943-11948 (2001)
   PUBMED   11593002
REFERENCE   10 (bases 1 to 4022)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK389844.1, AK036187.1 and AV239459.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The resulting isoform (2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036187.1, SRR6116558.24704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CK389844.1         1-23
            24-3978             AK036187.1         1-3955
            3979-4022           AV239459.1         259-302
FEATURES             Location/Qualifiers
     source          1..4022
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.12 cM"
     gene            1..4022
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /note="Sad1 and UNC84 domain containing 1"
                     /db_xref="GeneID:77053"
                     /db_xref="MGI:MGI:1924303"
     exon            1..63
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            64..160
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2714
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein unc-84 homolog A; SUN domain-containing protein 1;
                     sad1/unc-84 protein-like 1"
                     /codon_start=1
                     /product="SUN domain-containing protein 1 isoform 2"
                     /protein_id="NP_001243044.1"
                     /db_xref="CCDS:CCDS57395.1"
                     /db_xref="GeneID:77053"
                     /db_xref="MGI:MGI:1924303"
                     /translation="MDFSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHKLEP
                     VFDSPRMSRRSLRLVTTASYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPA
                     FSINHLSGKGLSSSTSHDSSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLK
                     GGNKAATQGNGELAAEVASSNGYTCRDCRMLSARTDALTAHSAIHGTTSRVYSRDRTL
                     KPRGVSFYLDRTLWLAKSTSSSFASFIVQLFQVVLMKLNFETYKLKGYESRAYESQSY
                     ETKSHESEAHLGHCGRMTAGELSRVDGESLCDLLVQALRRTRAAGWSVAEAVWSVLWL
                     AVSAPGKAASGTFWWLGSGWYQFVTLISWLNVFLLTRCLRNICKVFVLLLPLLLLLGA
                     GVSLWGQGNFFSLLPVLNWTAMQPTQRVDDSKGMHRPGPLPPSPPPKVDHKASQWPQE
                     SDMGQKVASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGREGLSLWVKNVVGQHLQ
                     EMGTIEPPDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDE
                     EQPLLDRVQHLELELNLLKSQLSDWQHLKTSCEQAGARIQETVQLMFSEDQQGGSLEW
                     LLEKLSSRFVSKDELQVLLHDLELKLLQNITHHITVTGQAPTSEAIVSAVNQAGISGI
                     TEAQAHIIVNNALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALLSLFGVPL
                     WYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLSPTGNI
                     SSAPKDFAVYGLETEYQEEGQPLGRFTYDQEGDSLQMFHTLERPDQAFQIVELRVLSN
                     WGHPEYTCLYRFRVHGEPIQ"
     exon            161..352
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            353..537
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            538..564
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            565..744
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            745..936
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1002
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1101
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1195
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1254
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1400
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1640
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1727
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1771
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1883
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2138
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2223
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2339
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2507
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2600
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..4022
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3953..3958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /note="hexamer: AATAAA"
     polyA_site      3978
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /note="major polyA site"
     regulatory      4000..4005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
                     /note="hexamer: AATAAA"
     polyA_site      4022
                     /gene="Sun1"
                     /gene_synonym="4632417G13Rik; 5730434D03Rik; mKIAA0810;
                     Unc84a"
ORIGIN      
        1 ggggagtctt cggtcccggg cctgggcggt gcggacgagg cctgaggcgg cggcgcgagg
       61 cagcatggtc tgagacggtg aacatggact tttctcggct gcacacgtac accccacccc
      121 agtgtgtgcc ggagaacact ggctacactt acgcactcag ttctagttac tcgtcggatg
      181 ctctggattt tgaaactgag cacaagttgg aacctgtatt tgactctcca aggatgtccc
      241 gccgcagctt gcgtctggtc acaacagctt cgtacagcag tggggacagc caggctattg
      301 attcgcacat tagcaccagc agggccaccc ccgccaaggg gagagaaacc aggacagtca
      361 aacagagaag aagtgcaagc aagccagctt ttagtatcaa ccacctgtca gggaagggct
      421 tgtcctcgag cacaagccat gacagctctt gcagcctgcg gagtgccacg gtgctgcggc
      481 accctgtgct agatgagtcc ctgattcgtg agcagaccaa agtggaccac ttctggggtc
      541 tcgatgatga tggtgacctt aaaggtggaa ataaagctgc cactcaggga aatggtgaac
      601 tggcagcaga ggtggcgagc agcaatggat acacttgccg tgactgcagg atgctctcag
      661 cgcgcactga cgcactcaca gcccactctg ccatccacgg gaccacctcc agggtgtact
      721 ccagagacag gactctcaaa ccacgcggag tgtcctttta cctggatagg actctgtggc
      781 tggccaagtc cacctcctca tcctttgcat catttatagt tcaacttttc caagtggttt
      841 taatgaagct caattttgaa acttacaaat tgaaaggcta tgaatccaga gcttatgaat
      901 cacagagcta tgagacaaag agccatgagt cagaagccca tctcggtcac tgtgggagga
      961 tgactgccgg agaactttcc agagtggacg gggagtccct gtgtgacctc ttggttcaag
     1021 cactgcgaag gactagagct gccgggtggt ctgtggccga ggccgtgtgg tcggtgctct
     1081 ggctggctgt ctctgctcca gggaaggcag cctcgggaac cttctggtgg ctagggagcg
     1141 gctggtacca atttgttact ttgatttctt ggctgaatgt ctttcttctt accaggtgcc
     1201 ttcgaaatat ttgcaaggtt tttgtcttgc tcctcccact cctactttta ctaggtgctg
     1261 gtgtctccct gtggggccag ggaaacttct tctcactcct accagtgctg aactggacgg
     1321 ccatgcagcc aacacagagg gtggacgatt ccaagggcat gcatagacct ggccctcttc
     1381 ccccgagccc acctccaaag gttgatcaca aggcttccca gtggcctcag gagagtgaca
     1441 tggggcagaa ggtagcttct ttgagtgcgc agtgccacaa ccatgatgag agacttgcag
     1501 agctgacagt cctgcttcag aaactacaga tacgggtaga ccaagtggat gacggcaggg
     1561 aagggctgtc actgtgggtc aagaatgtgg ttggacagca cctgcaggag atgggcacca
     1621 tagaaccacc tgatgctaag actgacttca tgactttcca ccatgaccat gaagtgcgtc
     1681 tctccaactt ggaagatgtt cttagaaaac tgacagaaaa atctgaggct atccagaagg
     1741 agctggaaga aaccaagctg aaagcaggca gcagggatga agagcagccc ctccttgacc
     1801 gtgtgcagca cctagaactg gaactgaacc tgttgaagtc acagctgtca gactggcagc
     1861 atctgaagac cagctgtgag caggctgggg cccgcatcca ggagactgtg cagctcatgt
     1921 tctctgagga tcagcagggc ggttccctcg agtggctatt agagaagctt tcttctcggt
     1981 tcgtgagcaa ggatgagctg caggtgctct tacatgacct tgagctgaaa ctgctgcaga
     2041 atatcacaca ccacatcacc gtgacaggac aggccccgac atccgaggct attgtgtctg
     2101 ccgtgaatca ggcagggatt tcaggaatca cagaagcgca agcacatatc attgtgaaca
     2161 atgctctgaa gctgtactcc caagacaaga cggggatggt ggactttgct ctggagtctg
     2221 gaggtggcag catcctaagc actcggtgct ctgagaccta tgagaccaag acggcactgc
     2281 tgagcctgtt tggggtccca ctgtggtact tctcacagtc acctcgagtg gtgatccagc
     2341 ccgacatcta cccagggaat tgctgggcgt tcaaaggttc ccaggggtac ctggtggtgc
     2401 ggttgtccat gaagatctac ccaaccacat tcaccatgga acacattcca aagacactat
     2461 cacccactgg taacatctcc agtgccccca aagactttgc agtctatgga ctggaaacgg
     2521 agtatcaaga agaggggcag cctctgggac ggttcaccta tgaccaggaa ggagactcac
     2581 tccagatgtt ccacacactg gaaagacctg accaagcctt ccagatagta gagctccggg
     2641 tcctgtccaa ctggggccac cctgagtaca cttgcctcta ccggttccga gtccacggag
     2701 agcccatcca gtagagcact ccagccatgt acatgtctgt atataccaag acgccataac
     2761 actggaactc attgagaaag agagcacgtg agcataggaa cttgtcagcc acccttcaat
     2821 aaatgtgctg tggtcctgag gacgtgctga gtcctctgag gctgtgcgtg tgttctcaaa
     2881 gcccaaaagc cggggaggct tttttaattc atttgaatgt atgattctcg gacactcctt
     2941 ttgacttagg gatttgcttg aatgcataaa gtcaagaagc agataggctg gcaggtttcc
     3001 aggctcctga cataaaggct gagagctctg cattggccat cctctggatg tcaagaaggc
     3061 aaagtcccat ctgctaaacc cacgtttctt tcagggaaaa ctgttgctct gtcttcagtc
     3121 tgaccccttc caggttccct ggtggggaga ggctatgtca tagactgtct gctttgagct
     3181 gggactcctc tgattcccca ggggagtaga tcgggctttg cagaagagca gtggggtgtg
     3241 cacaccatga atggtgctct tgggtctcag ccaggccgtt cctggcagat cacagaatgg
     3301 acaggaacct tgagaaggga tgctctgctg tccttgagct atgagtctct gctgaagggg
     3361 gaacactaag gtggtgctag tggctgccac tcttggtctt tatcacagca gcattctgtg
     3421 ctgcccttgg gtttgcctct acaccattat cagcccttct cactgattca aatttgggta
     3481 tatttaatat ttagactttt gtgagtagac tttataactg atacatcatc tggacactta
     3541 aaagtgttta gatgtcttac ctaaagaatt gttaagtttc attggttaga cagccttggc
     3601 agaatacaaa gctcacctgc tggggctcag agttctggga tttctcgcat gttgcaagca
     3661 gcccttaaga cagtggccca aagcacatcc cactccatag ggttagagcc actgcctgtg
     3721 tggccaggtt gtgtgggatg cacacatttt gcatactcaa ggttacatgc agaagtcaga
     3781 atttcctata ttaaactaaa ttggggaatt gggggtggag atatttcaaa tatttatttt
     3841 taaagatgca agataggact ttgtgcaatg tatttttgta aatgcttttc aaaacacttg
     3901 tctttggtag tgcttctact gccactaaat taagatgcta ttgagatgtt taaataaaag
     3961 agttaatttt taaaagtgca tgtgcgattt caagtgatta ataaaagtgt gtatttcttt
     4021 tc
//
