LOCUS       NM_019929               2630 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus small ubiquitin-like modifier 3 (Sumo3), transcript
            variant 1, mRNA.
ACCESSION   NM_019929
VERSION     NM_019929.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Zhang,W., Li,F., Hou,J., Cheng,Y., Zhang,W., Liang,X. and Wang,J.
  TITLE     Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is
            linked to the development of diabetic retinopathy in mice
  JOURNAL   Exp Eye Res 237, 109695 (2023)
   PUBMED   37890757
  REMARK    GeneRIF: Aberrant SUMO2/3 modification of RUNX1 upon SENP1
            inhibition is linked to the development of diabetic retinopathy in
            mice.
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Youssef,A., Mohammed,B.K., Prasad,A., Del Aguila,A., Bassi,G.,
            Yang,W. and Ulloa,L.
  TITLE     Splenic SUMO1 controls systemic inflammation in experimental sepsis
  JOURNAL   Front Immunol 14, 1200939 (2023)
   PUBMED   37520526
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Sheban,D., Shani,T., Maor,R., Aguilera-Castrejon,A., Mor,N.,
            Oldak,B., Shmueli,M.D., Eisenberg-Lerner,A., Bayerl,J., Hebert,J.,
            Viukov,S., Chen,G., Kacen,A., Krupalnik,V., Chugaeva,V., Tarazi,S.,
            Rodriguez-delaRosa,A., Zerbib,M., Ulman,A., Masarwi,S.,
            Kupervaser,M., Levin,Y., Shema,E., David,Y., Novershtern,N.,
            Hanna,J.H. and Merbl,Y.
  TITLE     SUMOylation of linker histone H1 drives chromatin condensation and
            restriction of embryonic cell fate identity
  JOURNAL   Mol Cell 82 (1), 106-122 (2022)
   PUBMED   34875212
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Yu,S., Galeffi,F., Rodriguiz,R.M., Wang,Z., Shen,Y., Lyu,J., Li,R.,
            Bernstock,J.D., Johnson,K.R., Liu,S., Sheng,H., Turner,D.A.,
            Wetsel,W.C., Paschen,W. and Yang,W.
  TITLE     Small ubiquitin-like modifier 2 (SUMO2) is critical for memory
            processes in mice
  JOURNAL   FASEB J 34 (11), 14750-14767 (2020)
   PUBMED   32910521
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Sramko,M., Markus,J., Kabat,J., Wolff,L. and Bies,J.
  TITLE     Stress-induced inactivation of the c-Myb transcription factor
            through conjugation of SUMO-2/3 proteins
  JOURNAL   J Biol Chem 281 (52), 40065-40075 (2006)
   PUBMED   17077080
  REMARK    GeneRIF: SUMO-2/3 proteins conjugate to c-Myb transcription factor
            and negatively regulate its activity in cells under stress.
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Li,T., Santockyte,R., Shen,R.F., Tekle,E., Wang,G., Yang,D.C. and
            Chock,P.B.
  TITLE     Expression of SUMO-2/3 induced senescence through p53- and
            pRB-mediated pathways
  JOURNAL   J Biol Chem 281 (47), 36221-36227 (2006)
   PUBMED   17012228
  REMARK    GeneRIF: p53 and pRB can be sumoylated by SUMO-2/3 in vivo, and
            such modification of p53 and pRB may play roles in premature
            senescence and stress response
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Yamaguchi,T., Sharma,P., Athanasiou,M., Kumar,A., Yamada,S. and
            Kuehn,M.R.
  TITLE     Mutation of SENP1/SuPr-2 reveals an essential role for
            desumoylation in mouse development
  JOURNAL   Mol Cell Biol 25 (12), 5171-5182 (2005)
   PUBMED   15923632
REFERENCE   9  (bases 1 to 2630)
  AUTHORS   Gomez-del Arco,P., Koipally,J. and Georgopoulos,K.
  TITLE     Ikaros SUMOylation: switching out of repression
  JOURNAL   Mol Cell Biol 25 (7), 2688-2697 (2005)
   PUBMED   15767674
REFERENCE   10 (bases 1 to 2630)
  AUTHORS   Chen,A., Mannen,H. and Li,S.S.
  TITLE     Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and
            gene/pseudogenes
  JOURNAL   Biochem Mol Biol Int 46 (6), 1161-1174 (1998)
   PUBMED   9891849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153864.5, CJ069985.1 and
            AK148306.1.
            
            On Aug 30, 2014 this sequence version replaced NM_019929.3.
            
            Summary: This gene encodes a member of the small ubiquitin-like
            modifier family. The encoded protein may regulate a variety of
            proteins in many pathways via a post-translational modification,
            known as SUMOylation. This activity may play a role in a wide
            variety of cellular processes, including nuclear transport, DNA
            replication and repair, mitosis, transcriptional regulation, and
            signal transduction. Disruption of some of these processes has been
            associated with cerebral ischemia, neural dysfunction, and heart
            disease. A pseudogene of this gene has been defined on the X
            chromosome. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148306.1, AK162035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC153864.5         77058-77155
            99-137              CJ069985.1         1-39
            138-2630            AK148306.1         2-2494
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2630
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /note="small ubiquitin-like modifier 3"
                     /db_xref="GeneID:20610"
                     /db_xref="MGI:MGI:1336201"
     exon            1..245
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..557
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; small ubiquitin-related modifier 3;
                     ubiquitin-like protein SMT3A; SMT3 suppressor of mif two 3
                     homolog 3"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 3 isoform 1
                     precursor"
                     /protein_id="NP_064313.1"
                     /db_xref="CCDS:CCDS23958.1"
                     /db_xref="GeneID:20610"
                     /db_xref="MGI:MGI:1336201"
                     /translation="MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMK
                     AYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSASRGSVPTP
                     NRCPDLCY"
     exon            246..374
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..446
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..2630
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /note="hexamer: AATATA"
     polyA_site      1716
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /note="major polyA site"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
                     /note="hexamer: AATAAA"
     polyA_site      2629
                     /gene="Sumo3"
                     /gene_synonym="2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1;
                     SUMO-3"
ORIGIN      
        1 tcctgaatcg cggctggcca gcgcgcaccc gcggcgcggg gcgcgcgcct cgtgcacgcg
       61 cccgaccacg tgactccgcg cgaccaacca gcgcgccggg atttagggat aaagcgcggc
      121 cccgcgacag ttgcggcggg agagcggcgg ggcagagagc gtgactcgcc cgctccagtg
      181 ccaccggttc ccgctgcgct tgccgccgcc gtcgctgcgc aaccatgtcg gaagagaagc
      241 ccaaggaggg tgtgaagaca gagaatgacc acatcaacct gaaagtggcg gggcaggatg
      301 gctcggtggt acagttcaag atcaagaggc acaccccact gagcaagctg atgaaggcct
      361 actgtgagag gcagggcttg tcaatgaggc agattcgatt ccggtttgat ggacaaccaa
      421 tcaatgaaac agacactcca gcccagctgg agatggagga tgaggacacc attgatgtat
      481 tccagcagca gacaggagga tcagcctccc gagggagcgt ccccacaccc aaccgttgtc
      541 ctgacctgtg ctattgagca gtgaccatgc agccacaccc aatcacacaa gagtcagcag
      601 aagccagagt caccgaagga ttctcctttt ccgacgcgct tggagtgaac tacacataga
      661 ccacactgcg gggcgagagc attacataac atggccacta ggagggtttg gtttggggga
      721 aatgaggtgt gaggctttgg ggtttgtttt tgttttcatt tttgttccct cccatcccta
      781 acattttttt ccccaaactt gggtctggat gtagattctc accctatggc ctgagtccaa
      841 tccctagaac tgtggtttcc tccagtgtga cttgtcctga tcaggtagag agagcttgtg
      901 gtcatattcc ccaatgggca tgcctgtggg atgtggggag gggcagagag gcagaattcc
      961 acctgttcgt tgtaggcata gaatattaaa aaatgtgaga tactgtaaat ttgagctttg
     1021 tcaaacatat ggtaagttaa aggggaagac cagtgcttct taagacagtg aggggtcttc
     1081 ctcctgtggc caggcgctcc tgcacgtgcc cacttcctgc tcggtactgg tactgggtac
     1141 atgggtaagg gtggtacagt gaaacccact ctctcccctt tttataatgt agaagaaagt
     1201 aattgtcctg tctcatttgg gaattgaatg tggcctcaga tttcttctag tacttgtttt
     1261 cgatacataa ttatggtttc tgtataagaa ggtattggtt aagtatcacg ttttcagcca
     1321 tgttgtgtaa gagacctgct ttcaagtgtg gttgtaaaag caagcccagg aaaggtgacc
     1381 tcattctcac ggactgtgct gtgcagcttt ccaagtgtgt attaaagtga cgcatcagtg
     1441 ggtagcttgg gttccgcatt gtggggtcag ttcaatgtcc atagttcctg cctgccatcc
     1501 ttctgtgagg gtccattgct gcttgatggc catctctgcc ttttatagtc acctgacact
     1561 gacctacatc tctcgcttgc ttaaagtctt gaggaaaatg ttcctgtttg ctgcgtgggc
     1621 ctgggtggga tgtctgttgg ctctgttgtg tttactcacc ggtttgtaca ttatctgttg
     1681 tcctttacta ctgtaaacag taaatatagt ttggtattct gtctcttggc ctatgttaaa
     1741 cactgtattt ggagacgggt catatgtcac agcccactgt tgacagtctg tccagtgagg
     1801 ccacttagat ggacagacaa ggcagttgct tagcttgctc tgtaccatgt gccccacact
     1861 ggtccagctg cctgcctgct ggtcctgact ttgcacatac cacttggctc tcctccccta
     1921 ggtgtgtgaa gataaggtgg gctttagagg cagggtgtag tgtgaagtat cagtcagttc
     1981 atgacctact tactaatctg ctttgacatg aattgatgct aatttggctg tgaggggttt
     2041 cagtacttag gttagataaa acccagggtt gtcattgcct gagccatgtt agtctatcag
     2101 tcgagcacaa gctccaagca cctaattcat ccagcaggaa tgtgtgcatt aaaatagagg
     2161 acagagctct agccattttc taggtctctc agaagtatta gttactttct cagtgctgtc
     2221 acagaatatg tggcaagcag cctagaggag caggagttta tgttggctta tggtttgagg
     2281 gtgctccatc aggacatggg agacaaaggt aactggagca ttaggctgct tgttgagggg
     2341 tttgggaatc aggaagcagt taatcctgtc aggaaaaggc ccttagggga tactcaaagg
     2401 tgaactttat taacactcca ggcatttaat tgacttaagt ttcttatcgg cctgacaccc
     2461 aagtacatca ttgtagaacc aacttgcctt ttaagatcgt gtgttgcata gtacaaaaca
     2521 catttagtct gtctctgaga gctcactcta aagttcaaag tctgctctga gactcaagat
     2581 aggttttgaa tggtgagccc ctgtaaaata aacaagttac tctgacatac
//
