LOCUS       NM_009460               1230 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus small ubiquitin-like modifier 1 (Sumo1), mRNA.
ACCESSION   NM_009460
VERSION     NM_009460.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1230)
  AUTHORS   Wang,Y., Wang,J.M., Xiao,Y., Hu,X.B., Zheng,S.Y., Fu,J.L.,
            Zhang,L., Gan,Y.W., Liang,X.M. and Li,D.W.
  TITLE     SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells
  JOURNAL   Aging (Albany NY) 15 (17), 8812-8832 (2023)
   PUBMED   37683133
  REMARK    GeneRIF: SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells.
REFERENCE   3  (bases 1 to 1230)
  AUTHORS   Youssef,A., Mohammed,B.K., Prasad,A., Del Aguila,A., Bassi,G.,
            Yang,W. and Ulloa,L.
  TITLE     Splenic SUMO1 controls systemic inflammation in experimental sepsis
  JOURNAL   Front Immunol 14, 1200939 (2023)
   PUBMED   37520526
  REMARK    GeneRIF: Splenic SUMO1 controls systemic inflammation in
            experimental sepsis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1230)
  AUTHORS   Rossitto,M., Dejardin,S., Rands,C.M., Le Gras,S., Migale,R.,
            Rafiee,M.R., Neirijnck,Y., Pruvost,A., Nguyen,A.L., Bossis,G.,
            Cammas,F., Le Gallic,L., Wilhelm,D., Lovell-Badge,R.,
            Boizet-Bonhoure,B., Nef,S. and Poulat,F.
  TITLE     TRIM28-dependent SUMOylation protects the adult ovary from
            activation of the testicular pathway
  JOURNAL   Nat Commun 13 (1), 4412 (2022)
   PUBMED   35906245
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1230)
  AUTHORS   Ramirez-Jarquin,U.N., Sharma,M., Zhou,W., Shahani,N. and
            Subramaniam,S.
  TITLE     Deletion of SUMO1 attenuates behavioral and anatomical deficits by
            regulating autophagic activities in Huntington disease
  JOURNAL   Proc Natl Acad Sci U S A 119 (5) (2022)
   PUBMED   35086928
REFERENCE   6  (bases 1 to 1230)
  AUTHORS   Chen,A., Mannen,H. and Li,S.S.
  TITLE     Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and
            gene/pseudogenes
  JOURNAL   Biochem Mol Biol Int 46 (6), 1161-1174 (1998)
   PUBMED   9891849
REFERENCE   7  (bases 1 to 1230)
  AUTHORS   Tsytsykova,A.V., Tsitsikov,E.N., Wright,D.A., Futcher,B. and
            Geha,R.S.
  TITLE     The mouse genome contains two expressed intronless retroposed
            pseudogenes for the sentrin/sumo-1/PIC1 conjugating enzyme Ubc9
  JOURNAL   Mol Immunol 35 (16), 1057-1067 (1998)
   PUBMED   10068040
REFERENCE   8  (bases 1 to 1230)
  AUTHORS   Yoshiba,K., Yoshiba,N., Aberdam,D., Meneguzzi,G.,
            Perrin-Schmitt,F., Stoetzel,C., Ruch,J.V. and Lesot,H.
  TITLE     Expression and localization of laminin-5 subunits during mouse
            tooth development
  JOURNAL   Dev Dyn 211 (2), 164-176 (1998)
   PUBMED   9489770
REFERENCE   9  (bases 1 to 1230)
  AUTHORS   Howe,K., Williamson,J., Boddy,N., Sheer,D., Freemont,P. and
            Solomon,E.
  TITLE     The ubiquitin-homology gene PIC1: characterization of mouse (Pic1)
            and human (UBL1) genes and pseudogenes
  JOURNAL   Genomics 47 (1), 92-100 (1998)
   PUBMED   9465300
REFERENCE   10 (bases 1 to 1230)
  AUTHORS   Shen,Z., Pardington-Purtymun,P.E., Comeaux,J.C., Moyzis,R.K. and
            Chen,D.J.
  TITLE     UBL1, a human ubiquitin-like protein associating with human
            RAD51/RAD52 proteins
  JOURNAL   Genomics 36 (2), 271-279 (1996)
   PUBMED   8812453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY242724.1, AK159366.1, BC082566.1 and BE691755.1.
            
            On Jan 26, 2007 this sequence version replaced NM_009460.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082566.1, AF033353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               BY242724.1         2-226
            226-693             AK159366.1         197-664
            694-1212            BC082566.1         669-1187
            1213-1230           BE691755.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.32 cM"
     gene            1..1230
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /note="small ubiquitin-like modifier 1"
                     /db_xref="GeneID:22218"
                     /db_xref="MGI:MGI:1197010"
     exon            1..155
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..449
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /note="ubiquitin-like 1; SMT3 suppressor of mif two 3
                     homolog 1; SMT3 homolog 3; ubiquitin-like protein SMT3C;
                     ubiquitin-homology domain protein PIC1; SUMO-1 related
                     peptidase"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 1"
                     /protein_id="NP_033486.1"
                     /db_xref="CCDS:CCDS35586.1"
                     /db_xref="GeneID:22218"
                     /db_xref="MGI:MGI:1197010"
                     /translation="MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHL
                     KKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV"
     exon            156..230
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /inference="alignment:Splign:2.1.0"
     exon            231..308
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..380
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1215
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1190..1195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /note="hexamer: AATAAA"
     polyA_site      1212
                     /gene="Sumo1"
                     /gene_synonym="GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3;
                     SMTP3; SUMO-1; Ubl1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgacg caagacgtag aggaagtccc tgcagccgcg gtgttgtgct gtagagaagg
       61 gacggatttg taaacctcag agtgaggttc tgcctgccgg aggccgcagt ggtgcggaga
      121 cccccgggtg aatccacgtc accatgtctg accaggaggc aaaaccttca actgaggact
      181 taggcgataa gaaggaagga gaatacatta aactcaaagt tattggacag gatagcagtg
      241 agatacattt caaagtgaaa atgacaacac atctcaagaa actcaaagaa tcatactgtc
      301 aaagacaggg agttccaatg aattcactca ggtttctctt tgaaggtcag agaattgctg
      361 ataatcatac tccgaaagaa ctgggaatgg aggaagaaga tgtgattgaa gtttatcagg
      421 aacaaacggg gggtcactcg acggtttaga taattctttt tattttttat ttttcctttc
      481 cctcaatcct tttttatttt taaaaatagt tcttttgtaa tgtggtgttc aaaatgaaaa
      541 ttgaatactg gcactccatc tcttagaaca tatgaattct agtgttcaat attcattatt
      601 ggttgttttt gttgtgctga tttttggtga tcagacctca gctcccttaa tactgccctt
      661 tttcctttaa gagatttcat gtgtgcacag agaggccacc cttttcagga ctgtgcattt
      721 tcaggtttgt gatgataaaa agatcgacca atgggagctt tcctatgacc tttcaattgg
      781 ctctgaagtt ccagcatgtg gttgcttcac tcctggactg tgattttcag tgggagatgg
      841 aaatttttca gagaactgaa ctgtggaaaa tgacctttcc tcagcttgaa gctactttta
      901 aaatctgcgg gtctggacca aaagaagaac atcatgtttg tagtcaagat gacagataca
      961 gtgagagcaa cagctaactc caaaggtggc ttcactggag agaaagaaag tgtcttgagc
     1021 aagacagtat tgtcagaaga tcccaggaaa gttctaatgt tcatcagcag ttattaataa
     1081 agttactcat acagaagtgt acgcaacaga cactgctttt gattctgttt gtactttttg
     1141 gcctgggaca tgggttttca agggacatcg tctgtaccag cttcattaaa ataaacaata
     1201 tttgtaaaaa cattaaaaaa aaaaaaaaaa
//
