LOCUS       NM_145937               2586 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus sulfatase modifying factor 1 (Sumf1), transcript
            variant 1, mRNA.
ACCESSION   NM_145937
VERSION     NM_145937.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Presa,M., Pham,V., Ray,S., Piec,P.A., Ryan,J., Billings,T.,
            Coombs,H., Schlotawa,L., Lund,T., Ahrens-Nicklas,R.C. and Lutz,C.
  TITLE     Bone marrow transplantation increases sulfatase activity in somatic
            tissues in a multiple sulfatase deficiency mouse model
  JOURNAL   Commun Med (Lond) 4 (1), 215 (2024)
   PUBMED   39448727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Sorrentino,N.C., Presa,M., Attanasio,S., Cacace,V., Sofia,M.,
            Zuberi,A., Ryan,J., Ray,S., Petkovic,I., Radhakrishnan,K.,
            Schlotawa,L., Ballabio,A., Lutz,C. and Brunetti-Pierri,N.
  TITLE     New mouse models with hypomorphic SUMF1 variants mimic attenuated
            forms of multiple sulfatase deficiency
  JOURNAL   J Inherit Metab Dis 46 (2), 335-347 (2023)
   PUBMED   36433920
  REMARK    GeneRIF: New mouse models with hypomorphic SUMF1 variants mimic
            attenuated forms of multiple sulfatase deficiency.
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2586)
  AUTHORS   Fraldi,A., Biffi,A., Lombardi,A., Visigalli,I., Pepe,S.,
            Settembre,C., Nusco,E., Auricchio,A., Naldini,L., Ballabio,A. and
            Cosma,M.P.
  TITLE     SUMF1 enhances sulfatase activities in vivo in five sulfatase
            deficiencies
  JOURNAL   Biochem J 403 (2), 305-312 (2007)
   PUBMED   17206939
REFERENCE   7  (bases 1 to 2586)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17(12):1901. doi:
            10.15252/embr.201570010.. PMID: 27909074]
REFERENCE   8  (bases 1 to 2586)
  AUTHORS   Yamashita,M., Ying,S.X., Zhang,G.M., Li,C., Cheng,S.Y., Deng,C.X.
            and Zhang,Y.E.
  TITLE     Ubiquitin ligase Smurf1 controls osteoblast activity and bone
            homeostasis by targeting MEKK2 for degradation
  JOURNAL   Cell 121 (1), 101-113 (2005)
   PUBMED   15820682
REFERENCE   9  (bases 1 to 2586)
  AUTHORS   Cosma,M.P., Pepe,S., Annunziata,I., Newbold,R.F., Grompe,M.,
            Parenti,G. and Ballabio,A.
  TITLE     The multiple sulfatase deficiency gene encodes an essential and
            limiting factor for the activity of sulfatases
  JOURNAL   Cell 113 (4), 445-456 (2003)
   PUBMED   12757706
REFERENCE   10 (bases 1 to 2586)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108919.7.
            
            On Aug 24, 2022 this sequence version replaced NM_145937.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026981.1, AK161203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC108919.7         19070-19352
            284-457             AC108919.7         28484-28657
            458-532             AC108919.7         31215-31289
            533-615             AC108919.7         49604-49686
            616-738             AC108919.7         51410-51532
            739-853             AC108919.7         52304-52418
            854-967             AC108919.7         59941-60054
            968-1027            AC108919.7         85966-86025
            1028-2586           AC108919.7         96059-97617
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.71 cM"
     gene            1..2586
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /note="sulfatase modifying factor 1"
                     /db_xref="GeneID:58911"
                     /db_xref="MGI:MGI:1889844"
     exon            1..283
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1138
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /EC_number="1.8.3.7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; C-alpha-formylglycine-generating enzyme 1"
                     /codon_start=1
                     /product="formylglycine-generating enzyme isoform 1
                     precursor"
                     /protein_id="NP_666049.2"
                     /db_xref="CCDS:CCDS51868.1"
                     /db_xref="GeneID:58911"
                     /db_xref="MGI:MGI:1889844"
                     /translation="MAAPAREPALRCCIRLARVFLLLVLACEVAGSDEAEAREGAASL
                     AGSCGCGTPQRAGAHGSSAAAQRYSREANAPGLTSGPRPLALTKMVPIPAGVFTMGTD
                     DPQIRQDGEAPARRVTVDGFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGML
                     SEQVKTHIHQAVAAAPWWLPVKGANWRHPEGPDSSILHRSNHPVLHVSWNDAVAYCTW
                     AGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGKFPVSNTGEDGFQGT
                     APVDAFPPNGYGLYNIVGNVWEWTSDWWTVHHSVEETFNPKGPTSGKDRVKKGGSYMC
                     HKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAD"
     exon            284..457
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            458..532
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            533..615
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            616..738
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            739..853
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            854..967
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1027
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..2586
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /note="hexamer: AATAAA"
     polyA_site      2586
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /note="major polyA site"
ORIGIN      
        1 acatgactcc gggaacaaca tggctgcgcc cgcgcgagag ccggctctcc gctgctgcat
       61 cagactggcg cgagtcttct tgctgctggt gttggcgtgc gaggtggcgg gaagcgatga
      121 ggccgaggcc agggaaggtg cggcgtccct tgcgggctcg tgcggctgcg gaacgcccca
      181 gagggccggg gcccatggca gctcggcggc ggcgcagcgc tactcccggg aggcgaacgc
      241 cccgggcctg acctcaggcc cgcgaccgct cgcgctcacc aagatggtcc ccattcctgc
      301 tggagtattc acaatgggca ctgatgatcc tcagatcagg caggatggag aagcccctgc
      361 caggagagtc actgttgatg gcttttacat ggacgcctat gaagtcagca atgcggattt
      421 tgagaagttt gtgaactcga ctggctattt gacagaggct gagaagtttg gagactcttt
      481 cgtctttgaa ggcatgttga gcgagcaagt gaaaacgcat atccaccagg cagttgcagc
      541 tgctccatgg tggttgcctg tcaagggagc taattggaga cacccagagg gtccggactc
      601 cagtattctg cacaggtcaa atcatccggt tctccatgtt tcctggaacg atgctgttgc
      661 ctactgcaca tgggcgggca agaggttgcc tactgaggca gagtgggaat acagctgtag
      721 aggaggcctg cagaacaggc ttttcccctg gggcaacaaa ctgcagccca aaggacagca
      781 ttatgccaac atctggcagg gcaagtttcc tgtgagcaac actggcgagg atggcttcca
      841 aggaactgcc cccgttgatg cctttcctcc caatggctat ggcttataca acatagtggg
      901 gaatgtgtgg gagtggacct cagactggtg gactgttcac cattctgttg aggaaacgtt
      961 caacccaaag ggtcccactt ctgggaaaga ccgagtgaag aagggtggat cctacatgtg
     1021 ccataagtcc tattgctata ggtaccgctg tgcagctcga agccagaaca caccagatag
     1081 ctctgcatcc aacctgggat tccgatgtgc agccgaccac ctgcccaccg cagactgaca
     1141 gccaagagga gcttttccag attcaagaag gcgtttctta ctcgcagctg gcctcccctg
     1201 gaaatctgaa ctgatctcat gtaaagtatt cccatctacg gaggattcca tgtccaccca
     1261 gtggccaaag gaactgtctc gcgtgaccaa atggctggcg agtgtcagca cgtgtgcttt
     1321 attgtgtggt gtatctttgg ggatcatcgc catgttttac tttgaaagcc ttttgaagag
     1381 gagagagccg agaaccagga agtcctggcc agactctgcc acagggtcag accctggagt
     1441 ccagcacctt gtctgccttg acctctgtct cctcatgaaa tgagggatgg tcaacgtgat
     1501 ctttgaggct ctctccaact ctatttgaac tagcagattc tattcgaact agcagagtgt
     1561 attgtgattg catagtgaga atttatgaca gattattttt tagctatttt tttgccatgt
     1621 gtgaatcttg agtaatacta atcatataag gcgagagtta tcttacatat tattttcaga
     1681 aaagggtggg gtttgagtct tttatattca tactgcactt tgttctttca aggaaatcag
     1741 tgtcttttac attgttgtga caaatcccat tgggacagcg aggggacact taagtttgga
     1801 gttctgaaca cacaggaatg cctgtggagt gactctactg tcctttttct tttgacatta
     1861 agtgcctttg gctcagaggg acagtttgaa gccttgtttc ccctttgccc ccaagccttc
     1921 aaagaatgtg aaatatgtac taattaggga aaccatttaa ttctaggtct ttgggtgttg
     1981 aggttttgtc agatggtatg aattgtattg taatgctaaa tctggtacct gaaggtctag
     2041 gcctgtgagt gaattctcac atttacaaga ttttgttgtg caaaccttgt tccttaattt
     2101 aaaactattg gttaaataaa attggctaca gccaattact ggagggatta gaggtaggtg
     2161 ggttttgagt gtggttgggt atggagagag agaggagaga tcaaggagag aagcaggaag
     2221 aagaggatag gaggagctgc catgaagaag atggaccata agcctttgtc cagaggaaac
     2281 tcccaagtat ctgggaacac cgctgtgagg caaccaggcc agcagttaga aaagtagatt
     2341 aggggctacc cccagtaatt gtcaaagcca aataaaatat ccatagtctg agtctcattt
     2401 atttgtaagc cagttgggga taagcttata ttggtaccac atgggagaaa aagaaccagg
     2461 accttgaata gactccattc agggtgtgtg atatattaca ccagagagat acgagaaatc
     2521 tggttgattt tgcgatatca gatgctttga atcatgtact atgtcaaata aactagtacc
     2581 tcccga
//
