LOCUS       NP_666049                372 aa            linear   ROD 14-FEB-2025
DEFINITION  formylglycine-generating enzyme isoform 1 precursor [Mus musculus].
ACCESSION   NP_666049
VERSION     NP_666049.2
DBSOURCE    REFSEQ: accession NM_145937.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Presa,M., Pham,V., Ray,S., Piec,P.A., Ryan,J., Billings,T.,
            Coombs,H., Schlotawa,L., Lund,T., Ahrens-Nicklas,R.C. and Lutz,C.
  TITLE     Bone marrow transplantation increases sulfatase activity in somatic
            tissues in a multiple sulfatase deficiency mouse model
  JOURNAL   Commun Med (Lond) 4 (1), 215 (2024)
   PUBMED   39448727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 372)
  AUTHORS   Sorrentino,N.C., Presa,M., Attanasio,S., Cacace,V., Sofia,M.,
            Zuberi,A., Ryan,J., Ray,S., Petkovic,I., Radhakrishnan,K.,
            Schlotawa,L., Ballabio,A., Lutz,C. and Brunetti-Pierri,N.
  TITLE     New mouse models with hypomorphic SUMF1 variants mimic attenuated
            forms of multiple sulfatase deficiency
  JOURNAL   J Inherit Metab Dis 46 (2), 335-347 (2023)
   PUBMED   36433920
  REMARK    GeneRIF: New mouse models with hypomorphic SUMF1 variants mimic
            attenuated forms of multiple sulfatase deficiency.
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Fraldi,A., Biffi,A., Lombardi,A., Visigalli,I., Pepe,S.,
            Settembre,C., Nusco,E., Auricchio,A., Naldini,L., Ballabio,A. and
            Cosma,M.P.
  TITLE     SUMF1 enhances sulfatase activities in vivo in five sulfatase
            deficiencies
  JOURNAL   Biochem J 403 (2), 305-312 (2007)
   PUBMED   17206939
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17(12):1901. doi:
            10.15252/embr.201570010.. PMID: 27909074]
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Yamashita,M., Ying,S.X., Zhang,G.M., Li,C., Cheng,S.Y., Deng,C.X.
            and Zhang,Y.E.
  TITLE     Ubiquitin ligase Smurf1 controls osteoblast activity and bone
            homeostasis by targeting MEKK2 for degradation
  JOURNAL   Cell 121 (1), 101-113 (2005)
   PUBMED   15820682
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Cosma,M.P., Pepe,S., Annunziata,I., Newbold,R.F., Grompe,M.,
            Parenti,G. and Ballabio,A.
  TITLE     The multiple sulfatase deficiency gene encodes an essential and
            limiting factor for the activity of sulfatases
  JOURNAL   Cell 113 (4), 445-456 (2003)
   PUBMED   12757706
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108919.7.
            
            On Apr 6, 2007 this sequence version replaced NP_666049.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026981.1, AK161203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.71 cM"
     Protein         1..372
                     /product="formylglycine-generating enzyme isoform 1
                     precursor"
                     /EC_number="1.8.3.7"
                     /note="C-alpha-formylglycine-generating enzyme 1"
                     /calculated_mol_wt=37351
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3327
     mat_peptide     32..372
                     /product="formylglycine-generating enzyme isoform 1"
                     /calculated_mol_wt=37351
     Region          61..80
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R0F3.2)"
     Region          86..365
                     /region_name="FGE-sulfatase"
                     /note="Sulfatase-modifying factor enzyme 1; pfam03781"
                     /db_xref="CDD:397722"
     Site            139
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q8R0F3.2)"
     Region          339..358
                     /region_name="Interaction with sulfatases.
                     /evidence=ECO:0000250|UniProtKB:Q8NBK3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R0F3.2)"
     CDS             1..372
                     /gene="Sumf1"
                     /gene_synonym="FGE"
                     /coded_by="NM_145937.4:20..1138"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS51868.1"
                     /db_xref="GeneID:58911"
                     /db_xref="MGI:MGI:1889844"
ORIGIN      
        1 maaparepal rccirlarvf lllvlaceva gsdeaeareg aaslagscgc gtpqragahg
       61 ssaaaqrysr eanapgltsg prplaltkmv pipagvftmg tddpqirqdg eaparrvtvd
      121 gfymdayevs nadfekfvns tgylteaekf gdsfvfegml seqvkthihq avaaapwwlp
      181 vkganwrhpe gpdssilhrs nhpvlhvswn davayctwag krlpteaewe yscrgglqnr
      241 lfpwgnklqp kgqhyaniwq gkfpvsntge dgfqgtapvd afppngygly nivgnvwewt
      301 sdwwtvhhsv eetfnpkgpt sgkdrvkkgg symchksycy ryrcaarsqn tpdssasnlg
      361 frcaadhlpt ad
//
