LOCUS       NM_013873               2446 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus sulfotransferase family 4A, member 1 (Sult4a1),
            transcript variant 1, mRNA.
ACCESSION   NM_013873 XM_001002084
VERSION     NM_013873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Culotta,L., Scalmani,P., Vinci,E., Terragni,B., Sessa,A.,
            Broccoli,V., Mantegazza,M., Boeckers,T. and Verpelli,C.
  TITLE     SULT4A1 Modulates Synaptic Development and Function by Promoting
            the Formation of PSD-95/NMDAR Complex
  JOURNAL   J Neurosci 40 (37), 7013-7026 (2020)
   PUBMED   32801157
  REMARK    GeneRIF: SULT4A1 Modulates Synaptic Development and Function by
            Promoting the Formation of PSD-95/NMDAR Complex.
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Hossain,M.I., Marcus,J.M., Lee,J.H., Garcia,P.L., Gagne,J.P.,
            Poirier,G.G., Falany,C.N. and Andrabi,S.A.
  TITLE     SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial
            Dysfunction in Neuronal Cells
  JOURNAL   Drug Metab Dispos 47 (9), 949-953 (2019)
   PUBMED   31266751
  REMARK    GeneRIF: Study in SULT4A1 knockout mice demonstrates that depletion
            of SULT4A1 induces oxidative stress in neurons and expression of
            SULT4A1 in human SH-SY5Y cells protects against
            oxidative-stress-induced mitochondrial dysfunction and cell death.
            Results suggest that SULT4A1 may have a crucial protective function
            against mitochondrial dysfunction and oxidative stress.
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Idris,M., Butcher,N.J. and Minchin,R.F.
  TITLE     The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase
            4A1 Protein Expression during Cell Differentiation
  JOURNAL   Drug Metab Dispos 47 (3), 314-319 (2019)
   PUBMED   30606728
  REMARK    GeneRIF: Study using SH-SY5Y cells, human induced pluripotent stem
            cells, and mouse embryonic tissue revealed time-dependent changes
            in SULT4A1 protein and MBNL/CELF protein during differentiation
            supported their role in correctly splicing the SULT4A1 mRNA.
            Furthermore, ectopic expression of each factor produced efficient
            splicing in the minigene assay as well as correct splicing of the
            endogenous SULT4A1 mRNA.
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Garcia,P.L., Hossain,M.I., Andrabi,S.A. and Falany,C.N.
  TITLE     Generation and Characterization of SULT4A1 Mutant Mouse Models
  JOURNAL   Drug Metab Dispos 46 (1), 41-45 (2018)
   PUBMED   29109113
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Sakakibara,Y., Suiko,M., Pai,T.G., Nakayama,T., Takami,Y.,
            Katafuchi,J. and Liu,M.C.
  TITLE     Highly conserved mouse and human brain sulfotransferases: molecular
            cloning, expression, and functional characterization
  JOURNAL   Gene 285 (1-2), 39-47 (2002)
   PUBMED   12039030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054757.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001002084.1, NM_013873.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054757.1, AK032195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.73 cM"
     gene            1..2446
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /note="sulfotransferase family 4A, member 1"
                     /db_xref="GeneID:29859"
                     /db_xref="MGI:MGI:1888971"
     exon            1..324
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1010
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /EC_number="2.8.2.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfotransferase 4A1; nervous system sulfotransferase;
                     brain sulfotransferase-like protein;
                     sulfotransferase-related protein"
                     /codon_start=1
                     /product="sulfotransferase 4A1 isoform 1"
                     /protein_id="NP_038901.3"
                     /db_xref="CCDS:CCDS27708.1"
                     /db_xref="GeneID:29859"
                     /db_xref="MGI:MGI:1888971"
                     /translation="MAESEAETPGTPGEFESKYFEFHGVRLPPFCRGKMEDIADFPVR
                     PSDVWIVTYPKSGTSLLQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKEL
                     TSPRLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQE
                     FCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLFLKYEDMHRDLVTMVEQLARFLGVSC
                     DKAQLESLIEHCHQLVDQCCNAEALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKC
                     DLTFDFYL"
     exon            325..455
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..536
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     exon            537..663
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..758
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     exon            759..897
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     exon            898..2383
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /note="hexamer: AATAAA"
     polyA_site      2383
                     /gene="Sult4a1"
                     /gene_synonym="2400007A17Rik; BR-STL; BR-STL-1; mBR-STL;
                     NST; ST4A1; Sultx3"
                     /note="major polyA site"
ORIGIN      
        1 cggacccgac gcacctttgc ggcaggcgcg gggcctcggc aaccgacgtc aggggcgcgg
       61 cgtgcgtggg tgcggccatg acgtcatgcc cgcggagccc cgcgccggcg ccgtgacgtc
      121 acgccctgga gctgcgggcc gggccgggcg gcggcatggc ggagagcgaa gcggagaccc
      181 cgggcacccc gggcgagttc gagagcaagt acttcgagtt ccatggcgtg cggctgccgc
      241 ccttctgccg cgggaagatg gaggatatcg ccgacttccc cgtgcggccc agcgacgtgt
      301 ggatcgtcac ctaccccaag tcaggtacaa gcttgctgca agaggtggtc tacttggtga
      361 gccagggtgc cgaccctgat gaaatcggcc tgatgaacat tgacgagcag ctgccggtgc
      421 tggagtaccc acagccgggg ctggacatca tcaaggaact gacatctccc cgcctcatca
      481 agagccacct cccgtaccgc ttcctgccct ctgacctcca caatggggac tccaaggtca
      541 tctacatggc tcgcaacccc aaggacttgg tggtatctta ctatcagttc caccgctcgc
      601 tgcggaccat gagctaccga ggcaccttcc aggagttctg tcggaggttc atgaatgaca
      661 aactgggcta cggctcctgg tttgagcatg ttcaggaatt ctgggaacat cgaatggatg
      721 ccaacgtgct tttccttaag tatgaagaca tgcaccggga cctggtgacc atggtggagc
      781 agctggccag attcctgggt gtgtcctgtg ataaggccca gctggagtcc ttgatcgagc
      841 actgtcacca gctggtggat cagtgctgca atgccgaggc cctgcctgtg ggtcggggaa
      901 gagttgggct gtggaaggac atcttcaccg tctccatgaa cgagaagttt gatctagtgt
      961 acaaacagaa gatggggaag tgtgacctca cgtttgactt ttatctataa taccagaatc
     1021 cgagaacttg catgctcacg gtccccggac gctctactag ctaaaagtcc tgtttgcgtt
     1081 cttttattcc tcgctggaca cacttccgga agctgcttgg aaacagcagg gggcgagcct
     1141 ggtggagaga gccgaggagg agtgagagga tgctgtctac agcagccgcc tggcctggcc
     1201 catagtgttt tgagtctcca catggtggcc aataccacac gcacgggcag tgcaaatgtc
     1261 tgccccacac cccgtgttat tcactatttt atagcgcttt tcactgaaag cggaaataaa
     1321 tatctgtcag ccaaatacaa gtgcatttcc aggggggagc aggagcgtgc tgtgccggga
     1381 tgctaggaag ctctcagggg tcactgtaat ttttgtagtc ttttctctag gcacagccat
     1441 cctaccttgt tcggagatca aagaacgggt ttggggggtg gggtgagctg gagaggttgg
     1501 tgtcgcctgt ggagttcagt cttttggaac catcctgata ccaagccagg acctgtccca
     1561 ggccgttttc agaaacacct ctaagcgcgc atctctctca gccccagcac agaagagccc
     1621 aaggaatgtt tcggcaggga agctggcccg aggctgcggg tggcatctga aggcactggt
     1681 aggtgtggaa gaggccccac agatgccaga ctgcaccaag aattagtatc tttcacagcc
     1741 ttcacgtgct ccccaaggca gcgactgaca cactcctgct ggcaagagat acaggacata
     1801 gcatggttct aaagtcccta gtcgctgtcc catctgctcc acctgtgcca agcgaggctc
     1861 tcacccagga gacccagtct gcaggttgac cgtcctccgt gcagatagga ttggcaagcc
     1921 cacctgtgtg agtggggcac cttagacctc aagagtgtct ggggggagcc atgatcctgt
     1981 gtgctgccca cccccacacc tatgggcttg aatttgacca gatgagcggt ggaccaggag
     2041 atcgctgctt gtggggaccg acttgttctg ttactcacca ggctgggaag aacgtggtag
     2101 tgggaggctg aggctgtgga aggggcctgc tctgggccgt ctctgaagcg ggtctggttg
     2161 tcgtggcatt acctctgtcc agagagaagc ttgtgtaggt ctggtgcatg gttctctggg
     2221 gtgggcatgg cggcagcgcc tttcctgtgt gtctggggag gaaggctgct ttctgtgaaa
     2281 ttttctttct atttttctat ttttagtact gtacggatgt tctggaacca cacatggtaa
     2341 tctctgcttg cctgcatctt taataaaaga cacctcccct gttaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
