LOCUS       NM_001360784            1271 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus sulfotransferase family, cytosolic, 2B, member 1
            (Sult2b1), transcript variant 2, mRNA.
ACCESSION   NM_001360784 XM_006540997
VERSION     NM_001360784.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Pan,H., Wu,T., Huang,K., Guo,Z., Liang,H., Lyu,P., Huang,H.,
            Feng,X., Wang,Q., Hu,J., He,Y., Guo,Z., Yin,M. and Zhang,Y.
  TITLE     Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with
            SMAD4 to inhibit the macrophage inflammatory response and delay
            atherosclerosis progression
  JOURNAL   Transl Res 268, 13-27 (2024)
   PUBMED   38286358
  REMARK    GeneRIF: Reducing SULT2B1 promotes the interaction of
            LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory
            response and delay atherosclerosis progression.
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Morino,K., Kunimura,K., Sugiura,Y., Izumi,Y., Matsubara,K.,
            Akiyoshi,S., Maeda,R., Hirotani,K., Sakata,D., Mizuno,S.,
            Takahashi,S., Bamba,T., Uruno,T. and Fukui,Y.
  TITLE     Cholesterol sulfate limits neutrophil recruitment and gut
            inflammation during mucosal injury
  JOURNAL   Front Immunol 14, 1131146 (2023)
   PUBMED   37006281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Xu,D., Ma,R., Ju,Y., Song,X., Niu,B., Hong,W., Wang,R., Yang,Q.,
            Zhao,Z., Zhang,Y., Zheng,Y., Bai,Q., Lv,M., Sun,N. and Li,X.
  TITLE     Cholesterol sulfate alleviates ulcerative colitis by promoting
            cholesterol biosynthesis in colonic epithelial cells
  JOURNAL   Nat Commun 13 (1), 4428 (2022)
   PUBMED   35908039
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Wang,Y., Jin,H., Wang,Y., Yao,Y., Yang,C., Meng,J., Tan,X., Nie,Y.,
            Xue,L., Xu,B., Zhao,H. and Wang,F.
  TITLE     Sult2b1 deficiency exacerbates ischemic stroke by promoting
            pro-inflammatory macrophage polarization in mice
  JOURNAL   Theranostics 11 (20), 10074-10090 (2021)
   PUBMED   34815805
  REMARK    GeneRIF: Sult2b1 deficiency exacerbates ischemic stroke by
            promoting pro-inflammatory macrophage polarization in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Falany,C.N. and Rohn-Glowacki,K.J.
  TITLE     SULT2B1: unique properties and characteristics of a hydroxysteroid
            sulfotransferase family
  JOURNAL   Drug Metab Rev 45 (4), 388-400 (2013)
   PUBMED   24020383
  REMARK    Review article
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Kurogi,K., Sakakibara,Y., Kamemoto,Y., Takahashi,S., Yasuda,S.,
            Liu,M.C. and Suiko,M.
  TITLE     Mouse cytosolic sulfotransferase SULT2B1b interacts with
            cytoskeletal proteins via a proline/serine-rich C-terminus
  JOURNAL   FEBS J 277 (18), 3804-3811 (2010)
   PUBMED   20718863
  REMARK    GeneRIF: results suggested that the unique, extended
            proline/serine-rich C-terminus of SULT2B1b is important for its
            interaction with cytoskeletal proteins
REFERENCE   7  (bases 1 to 1271)
  AUTHORS   Korff,S., Schoensiegel,F., Riechert,N., Weichenhan,D., Katus,H.A.
            and Ivandic,B.T.
  TITLE     Fine mapping of Dyscalc1, the major genetic determinant of
            dystrophic cardiac calcification in mice
  JOURNAL   Physiol Genomics 25 (3), 387-392 (2006)
   PUBMED   16705021
REFERENCE   8  (bases 1 to 1271)
  AUTHORS   Shimizu,C., Fuda,H., Yanai,H. and Strott,C.A.
  TITLE     Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene
            structure in the mouse: pre- and postnatal expression, kinetic
            analysis of isoforms, and comparison with prototypical SULT2A1
  JOURNAL   Endocrinology 144 (4), 1186-1193 (2003)
   PUBMED   12639899
  REMARK    GeneRIF: during embryonic development, SULT2B1b is required for
            production of cholesterol sulfate essential for normal skin
            development
REFERENCE   9  (bases 1 to 1271)
  AUTHORS   Falany,J.L., Greer,H., Kovacs,T., Sorscher,E.J. and Falany,C.N.
  TITLE     Elevation of hepatic sulphotransferase activities in mice with
            resistance to cystic fibrosis
  JOURNAL   Biochem J 364 (Pt 1), 115-120 (2002)
   PUBMED   11988083
  REMARK    GeneRIF: Elevation of hepatic sulphotransferase activities in mice
            with resistance to cystic fibrosis
REFERENCE   10 (bases 1 to 1271)
  AUTHORS   Sakakibara,Y., Yanagisawa,K., Takami,Y., Nakayama,T., Suiko,M. and
            Liu,M.C.
  TITLE     Molecular cloning, expression, and functional characterization of
            novel mouse sulfotransferases
  JOURNAL   Biochem Biophys Res Commun 247 (3), 681-686 (1998)
   PUBMED   9647753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167242.4 and BM899747.1.
            
            On Feb 14, 2018 this sequence version replaced XM_006540997.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF478566.1, SRR5189673.40563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AC167242.4         142714-143138       c
            426-634             AC167242.4         135795-136003       c
            635-761             AC167242.4         134647-134773       c
            762-856             AC167242.4         134279-134373       c
            857-1037            AC167242.4         131898-132078       c
            1038-1253           AC167242.4         130644-130859       c
            1254-1271           BM899747.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.47 cM"
     gene            1..1271
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /note="sulfotransferase family, cytosolic, 2B, member 1"
                     /db_xref="GeneID:54200"
                     /db_xref="MGI:MGI:1926342"
     exon            1..425
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            426..634
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            635..761
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            762..856
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1037
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1254
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /note="hexamer: AATAAA"
     polyA_site      1254
                     /gene="Sult2b1"
                     /gene_synonym="ST2B1; SULT2B"
                     /note="major polyA site"
ORIGIN      
        1 acttagctcc actttgcaga catgaagtac ccttcctcct accagaagcg tagctttggg
       61 cgagtcactc ccaccctcca cgctcagctt tctacaccca tagtgtgggg gcgacagtat
      121 gacatcacgg gactgctgtg gtggagttga agtggatcta ctcctcaggt ggacacacgg
      181 ggctcagaga aaggacactc ctcactggcg tgtgaatgga gggccctgcg actcttgccc
      241 acctccttgg tcttctttac acgtgccctt cccctctttc agctggaatt ttggaggtga
      301 atacttcaga tacaaaggta tcccttttcc tgtcggcatg tactcaccgg agagcctcag
      361 tctggctgag aacactagca acgtgcggga cgacgacatc ttcattgtca cctaccccaa
      421 atcaggtacc aactggatga ttgagatcgt ctgcttaatc ctgaaagatg gggatccctc
      481 gtggatccga tcggagccca tctggcaacg tgcgccctgg tgcgagacca tcataagcgc
      541 cttcaatgtc ttagaccggc ccagcccccg cattatgagc tctcacctcc ctattgaact
      601 cttcacgaag gcattcttca gctccaaggc taaggtgatt tacgtgggcc ggaacccccg
      661 cgatgtcgtg gtctccctct attattattc taagattgct gggcaattaa aggaccctgg
      721 tacacccgac cagttccttc aaaatttcct caaaggagaa gtgcagtttg gctcctggtt
      781 tgaccacatc aagggctgga tccggatgca gaaccaagag aacttcctgt ttatcaccta
      841 tgaggagctg cagcaggacc tgcgaggctc cgtgcaacgc atctgtgagt tcctgggccg
      901 gccactgggt gaagaggccc tgagctctgt ggtggcccac tcagcctttg ctgccatgaa
      961 ggccaatacc atgtccaact actcgctgct gccggccagc ctgctggacc accgccaggg
     1021 ggagttcctg cgcaaaggga tcagtggcga ctggaagaac cacttcactg tggcccagag
     1081 tgaggctttt gacagtgttt accgagagca aatgcacggg gtgcagaggt tcccctggga
     1141 cacgtctgaa gaggatagca gccctgatgg ccagcctgac cctgagccca gccccagccc
     1201 agcttctgat gaccccaacc caggatcctc acaataaact tatcactcca accaaaaaaa
     1261 aaaaaaaaaa a
//
