LOCUS       NM_001199306            2097 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus sulfotransferase family 2A, dehydroepiandrosterone
            (DHEA)-preferring, member 8 (Sult2a8), transcript variant 2, mRNA.
ACCESSION   NM_001199306
VERSION     NM_001199306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Teramoto,T., Nishio,T., Kurogi,K., Sakakibara,Y. and Kakuta,Y.
  TITLE     The crystal structure of mouse SULT2A8 reveals the mechanism of
            7alpha-hydroxyl, bile acid sulfation
  JOURNAL   Biochem Biophys Res Commun 562, 15-20 (2021)
   PUBMED   34030040
  REMARK    GeneRIF: The crystal structure of mouse SULT2A8 reveals the
            mechanism of 7alpha-hydroxyl, bile acid sulfation.
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Wang,K., Chan,Y.C., So,P.K., Liu,X., Feng,L., Cheung,W.T., Lee,S.S.
            and Au,S.W.
  TITLE     Structure of mouse cytosolic sulfotransferase SULT2A8 provides
            insight into sulfonation of 7alpha-hydroxyl bile acids
  JOURNAL   J Lipid Res 62, 100074 (2021)
   PUBMED   33872606
  REMARK    GeneRIF: Structure of mouse cytosolic sulfotransferase SULT2A8
            provides insight into sulfonation of 7alpha-hydroxyl bile acids.
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Wang,K., Chan,M.Y., Xu,J., Li,P.S., Liu,X., Lee,A.Y., Lee,S.S. and
            Cheung,W.T.
  TITLE     Male-biased fasting-induced changes in hepatic tauro-cholic acid
            and plasma cholesterol in Sult2a8-haplodeficient mice
  JOURNAL   Transgenic Res 29 (5-6), 499-510 (2020)
   PUBMED   33029720
  REMARK    GeneRIF: Male-biased fasting-induced changes in hepatic
            tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient
            mice.
REFERENCE   5  (bases 1 to 2097)
  AUTHORS   Shimohira,T., Kurogi,K., Liu,M.C., Suiko,M. and Sakakibara,Y.
  TITLE     The critical role of His48 in mouse cytosolic sulfotransferase
            SULT2A8 for the 7alpha-hydroxyl sulfation of bile acids
  JOURNAL   Biosci Biotechnol Biochem 82 (8), 1359-1365 (2018)
   PUBMED   29685090
  REMARK    GeneRIF: findings suggested that substitutions of two amino acids,
            which might have occurred during the evolution of the mouse SULT2A8
            gene, endowed mouse SULT2A8 the capacity to catalyze the
            7-O-sulfation of bile acids
REFERENCE   6  (bases 1 to 2097)
  AUTHORS   Feng,L., Yuen,Y.L., Xu,J., Liu,X., Chan,M.Y., Wang,K., Fong,W.P.,
            Cheung,W.T. and Lee,S.S.
  TITLE     Identification and characterization of a novel PPARalpha-regulated
            and 7alpha-hydroxyl bile acid-preferring cytosolic sulfotransferase
            mL-STL (Sult2a8)
  JOURNAL   J Lipid Res 58 (6), 1114-1131 (2017)
   PUBMED   28442498
  REMARK    GeneRIF: a novel PPARalpha-dependent gene
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110880.10 and AK050422.1.
            
            Transcript Variant: This variant (2) contains a different segment
            for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the
            same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031851.1, AK050422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC110880.10        151795-151797       c
            4-1466              AK050422.1         2-1464
            1467-2097           AC110880.10        123932-124562       c
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.2 cM"
     gene            1..2097
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /note="sulfotransferase family 2A, dehydroepiandrosterone
                     (DHEA)-preferring, member 8"
                     /db_xref="GeneID:76971"
                     /db_xref="MGI:MGI:1924221"
     exon            1..96
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     exon            97..363
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1076
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /EC_number="2.8.2.34"
                     /note="sulfotransferase-like protein 1; liver
                     sulfotransferase-like protein; glycochenodeoxycholate
                     sulfotransferase 2A8"
                     /codon_start=1
                     /product="sulfotransferase 2A8"
                     /protein_id="NP_001186235.1"
                     /db_xref="CCDS:CCDS20833.1"
                     /db_xref="GeneID:76971"
                     /db_xref="MGI:MGI:1924221"
                     /translation="MTDEFLWIEGIPFPTVYYSQEIIREVRDRFVVRDEDTIIVTYPK
                     SGTHWLNEIVCLILTKGDPTWVQSTIANERTPWIEFENNYRILNSKEGPRLMASLLPI
                     QLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGKSYF
                     GSWFEHACGWISLRKRENILVLSYEQLKKDTRNTIKKICEFLGENLESGELELVLKNI
                     SFQIMKERMISQSCLSNIEKHEFIMRKGITGDWKNHFTVAQAEAFDKAFQEKAADFPQ
                     ELFSWE"
     exon            364..572
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     exon            573..699
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     exon            700..794
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     exon            795..963
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     exon            964..2097
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /note="hexamer: AGTAAA"
     polyA_site      1470
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /note="major polyA site"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
                     /note="hexamer: ATTAAA"
     polyA_site      2094
                     /gene="Sult2a8"
                     /gene_synonym="2810007J24Rik; L-STL; mL-STL"
ORIGIN      
        1 agtaagtagt tcaagttcac cctgagttac acagtgagtt tgtgttcagc catggtcaca
       61 taaaaacctg caaaagcaaa atctatatag gcaattcaac ttgatttctt aaccaatgag
      121 gcagaaacac tgatcattgt gtcctcacta taaaattgag actcaaagca cctgtgtgca
      181 tctccaacag aagaggtcaa acagataaat tcccaaagct cacgatcatg acagatgaat
      241 ttctgtggat agaagggata ccattcccta cagtttacta ctcacaagaa atcataagag
      301 aagtacgtga caggtttgtg gtaagggatg aagacacgat catagtgact tatccaaaat
      361 caggaaccca ctggttgaat gaaattgtct gcttgattct gaccaaggga gatcccacat
      421 gggtccaatc tacaattgcc aatgagcgca caccatggat agaatttgaa aataactata
      481 gaatactaaa cagcaaggag ggtccacgtc tcatggcctc tctccttccc atccaactat
      541 ttccaaagtc tttcttcagt tctaaggcaa aggtgattta tctcatcaga aatcccagag
      601 atgttcttgt gtcaggctat cactacttca atgctctaaa acagggaaag gaacaagtgc
      661 catggaaaat atattttgag aactttttgc aaggaaaatc atattttgga tcatggttcg
      721 aacatgcatg tggctggata tccctgagga aaagagaaaa cattctagtg ttaagttatg
      781 aacagctgaa aaaggataca agaaatacca tcaagaagat ctgtgaattc ctgggagaga
      841 atttggaatc aggggaactg gagttagttt tgaagaacat ttcttttcag atcatgaaag
      901 aaaggatgat atctcagtca tgtctctcaa atatagaaaa acatgaattc attatgagaa
      961 aaggcatcac aggggactgg aagaatcact ttacagtagc ccaggctgaa gcctttgata
     1021 aagcatttca ggagaaagca gctgattttc ctcaagagct cttttcatgg gaataatcaa
     1081 cactgtggat cttattggaa tactctctat gatttgtttt ccttgtactt gtttttgatt
     1141 taaggatgtg gcatataaat tgctaattaa tctcacatac tgtagtaatc aagtattgtg
     1201 ctagagaagt gactccaagg ataaagaatc ttgttaacga ccatgaggat ctgagttcaa
     1261 tcctggcacc aacatagttg aaggaaagaa gtagttcctg aaattattct tagacttcca
     1321 caaatgcacc atgatggctc cacccataaa atttctgtaa ttaaaatatt tcttgatgtc
     1381 aaatccttaa ataatgaaat aattatacaa atttgatttc tgagtgtttc agacatttta
     1441 aagaaaagta aaattcagaa acaatcataa ctctgctctt ggaccacttc tgtacacctc
     1501 tatgtctggc cctgtgggtc acaggtgact ttcaaatctt agtaaggatt ttcctaaaat
     1561 atgaccagct gttgaaaatc caggtcatga gcctactcag tttttatggt tctctactta
     1621 tggaagtaga aatttgtaca gtttgataag aaagagattc agctgttttt gatgtttctt
     1681 aacttctccc acccctttcc agggaagctt catgcctgga caagccatga agcagtagag
     1741 tgctcctcat acctttgaag tagaaaagat gcctgcctgt ttgtgtaaca ggctggggaa
     1801 gattccaata cagagctaat cagattggcc tcagaaaaaa tactaactta ttcgttttgt
     1861 tcctgtcttt cagtgtagaa gacttctgta ttttttaaaa tacaatttta tttctttcaa
     1921 cgaatttaaa aaaaaacacc tttggaacaa caagaacaac aaaagtataa ttacttcttc
     1981 tattgcttgc attgaagaaa tgctttaaag tatcatcata tttaatattt ctccatcatt
     2041 tcacttataa tcaataatgt cggtaaacaa aaattaaaaa aaaaacaatc atgacta
//
