LOCUS       NM_001111296            1021 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sulfotransferase family 2A, dehydroepiandrosterone
            (DHEA)-preferring, member 1 (Sult2a1), mRNA.
ACCESSION   NM_001111296 XM_001471625 XM_001477229
VERSION     NM_001111296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Butali,A., Mossey,P.A., Adeyemo,W.L., Eshete,M.A., Gowans,L.J.J.,
            Busch,T.D., Jain,D., Yu,W., Huan,L., Laurie,C.A., Laurie,C.C.,
            Nelson,S., Li,M., Sanchez-Lara,P.A., Magee,W.P., Magee,K.S.,
            Auslander,A., Brindopke,F., Kay,D.M., Caggana,M., Romitti,P.A.,
            Mills,J.L., Audu,R., Onwuamah,C., Oseni,G.O., Owais,A., James,O.,
            Olaitan,P.B., Aregbesola,B.S., Braimah,R.O., Oginni,F.O.,
            Oladele,A.O., Bello,S.A., Rhodes,J., Shiang,R., Donkor,P.,
            Obiri-Yeboah,S., Arthur,F.K.N., Twumasi,P., Agbenorku,P.,
            Plange-Rhule,G., Oti,A.A., Ogunlewe,O.M., Oladega,A.A.,
            Adekunle,A.A., Erinoso,A.O., Adamson,O.O., Elufowoju,A.A.,
            Ayelomi,O.I., Hailu,T., Hailu,A., Demissie,Y., Derebew,M.,
            Eliason,S., Romero-Bustillous,M., Lo,C., Park,J., Desai,S.,
            Mohammed,M., Abate,F., Abdur-Rahman,L.O., Anand,D., Saadi,I.,
            Oladugba,A.V., Lachke,S.A., Amendt,B.A., Rotimi,C.N.,
            Marazita,M.L., Cornell,R.A., Murray,J.C. and Adeyemo,A.A.
  TITLE     Genomic analyses in African populations identify novel risk loci
            for cleft palate
  JOURNAL   Hum Mol Genet 28 (6), 1038-1051 (2019)
   PUBMED   30452639
  REMARK    Erratum:[Hum Mol Genet. 2023 Jun 5;32(12):2117. doi:
            10.1093/hmg/ddad027.. PMID: 36822579]
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Barrett,K.G., Fang,H., Gargano,M.D., Markovich,D., Kocarek,T.A. and
            Runge-Morris,M.
  TITLE     Regulation of murine hepatic hydroxysteroid sulfotransferase
            expression in hyposulfatemic mice and in a cell model of
            3'-phosphoadenosine-5'-phosphosulfate deficiency
  JOURNAL   Drug Metab Dispos 41 (8), 1505-1513 (2013)
   PUBMED   23674610
  REMARK    GeneRIF: hyposulfatemia leads to hepatic
            phosphoadenosine-5'-phosphosulfate depletion, which causes loss of
            SULT2A1 activity and results in accumulation of nonsulfated bile
            acids and activated farnesoid X receptor activation.
REFERENCE   3  (bases 1 to 1021)
  AUTHORS   Senggunprai,L., Yoshinari,K. and Yamazoe,Y.
  TITLE     Inhibitory effects of kynurenic acid, a tryptophan metabolite, and
            its derivatives on cytosolic sulfotransferases
  JOURNAL   Biochem J 422 (3), 455-462 (2009)
   PUBMED   19548878
  REMARK    Erratum:[Biochem J. 2009 Nov 1;423(3):442]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1021)
  AUTHORS   Kocarek,T.A., Duanmu,Z., Fang,H.L. and Runge-Morris,M.
  TITLE     Age- and sex-dependent expression of multiple murine hepatic
            hydroxysteroid sulfotransferase (SULT2A) genes
  JOURNAL   Biochem Pharmacol 76 (8), 1036-1046 (2008)
   PUBMED   18725207
REFERENCE   5  (bases 1 to 1021)
  AUTHORS   Shimizu,C., Fuda,H., Yanai,H. and Strott,C.A.
  TITLE     Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene
            structure in the mouse: pre- and postnatal expression, kinetic
            analysis of isoforms, and comparison with prototypical SULT2A1
  JOURNAL   Endocrinology 144 (4), 1186-1193 (2003)
   PUBMED   12639899
  REMARK    GeneRIF: during embryonic development, SULT2B1a produces
            pregnenolone sulfate, an essential neurosteroid during development
            of the central nervous system.
REFERENCE   6  (bases 1 to 1021)
  AUTHORS   Nagai,F., Satoh,H., Hirota,M., Ogawa,K., Homma,H. and Matsui,M.
  TITLE     Assignment of two hydroxysteroid sulfotransferase genes (St1 and
            St2) to rat chromosome bands 1q21.3-->q22.1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 111-112 (1996)
   PUBMED   8893814
REFERENCE   7  (bases 1 to 1021)
  AUTHORS   Kong,A.N. and Fei,P.
  TITLE     Molecular cloning of three sulfotransferase cDNAs from mouse liver
  JOURNAL   Chem Biol Interact 92 (1-3), 161-168 (1994)
   PUBMED   8033251
REFERENCE   8  (bases 1 to 1021)
  AUTHORS   Kong,A.N., Tao,D., Ma,M. and Yang,L.
  TITLE     Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of
            sulfotransferase from mouse liver
  JOURNAL   Pharm Res 10 (4), 627-630 (1993)
   PUBMED   8483851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157361.8.
            
            On May 27, 2010 this sequence version replaced NM_001111296.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145167.1, SRR5189685.63822.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC157361.8         177504-177693       c
            191-399             AC157361.8         176244-176452       c
            400-526             AC157361.8         172860-172986       c
            527-621             AC157361.8         144313-144407       c
            622-799             AC157361.8         141665-141842       c
            800-1021            AC157361.8         136529-136750       c
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.02 cM"
     gene            1..1021
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /note="sulfotransferase family 2A, dehydroepiandrosterone
                     (DHEA)-preferring, member 1"
                     /db_xref="GeneID:20859"
                     /db_xref="MGI:MGI:98430"
     exon            1..190
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..912
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /EC_number="2.8.2.2"
                     /EC_number="2.8.2.14"
                     /note="bile salt sulfotransferase 1; ST; hydroxysteroid
                     sulfotransferase; sulfotransferase, hydroxysteroid
                     preferring 1; sulfotransferase, DHEA preferring"
                     /codon_start=1
                     /product="sulfotransferase 2A1"
                     /protein_id="NP_001104766.1"
                     /db_xref="CCDS:CCDS52031.1"
                     /db_xref="GeneID:20859"
                     /db_xref="MGI:MGI:98430"
                     /translation="MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPK
                     SGTNWLIEIVCLIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLITSHLPI
                     HLFSKSFFSSKAKAIYLVRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLKGNVLF
                     GSWFEHVRGWLSMREWDNFLVLYYEDIKKDTKGTIKKICDFLGKNLGPDELDLVLKYS
                     SFQAMKENNMSNFSLIKEDQVTNGLKLMRKGTIGDWKNHFTVAQAEAFDKVFQEKMAG
                     FPPGIFPWE"
     exon            191..399
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..526
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..621
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..799
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1021
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      997..1002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /note="hexamer: AATAAA"
     polyA_site      1021
                     /gene="Sult2a1"
                     /gene_synonym="mSTa1; ST2A1; Std; Sth1"
                     /note="major polyA site"
ORIGIN      
        1 agttgaatag gtgtcctcgg ctggaatcct aagagaacct acaaggagtt attcatgatg
       61 tcagactata attggtttga aggcatacct tttcctgcca tatcatatca aagagaaatt
      121 ttggaagata ttcgtaataa gtttgtggtg aaagaagaag acttgttgat attaacttac
      181 cccaagtcag gaacgaactg gctgattgag attgtatgct tgattcagac caagggagat
      241 ccgaagtgga tccaaactgt gcccatttgg aaccgctcac cctggataga gactgatata
      301 ggatattctg cattaatcaa taaggaagga ccacgactca taacctccca tcttcccatc
      361 catctcttct ccaagtcttt cttcagttcc aaggccaagg cgatctatct cgtgagaaat
      421 cccagagata ttcttgtgtc tggttacttt ttctggggta acacaaacct tgtgaagaat
      481 ccagggtcac tcggaactta ttttgaatgg ttcctcaaag gaaatgttct attcggatca
      541 tggtttgagc atgttcgtgg ctggctgtcc atgagagaat gggacaactt tttggtactg
      601 tactatgaag acataaaaaa ggatacaaag ggaaccataa agaagatctg tgacttccta
      661 gggaaaaatt tagggccaga tgagctggat ctcgtcctca agtacagctc tttccaagcc
      721 atgaaagaaa acaacatgtc caattttagt ctcattaagg aagatcaggt tactaatggc
      781 ttgaagctca tgagaaaagg cacaattggg gactggaaga atcacttcac agtagcccaa
      841 gctgaagcct tcgataaagt tttccaggag aaaatggctg gattcccccc agggattttc
      901 ccatgggaat aattttcaaa gcttttgaat attatatgaa cactgatgtt tatgttcctg
      961 ttgttgtgta tcttgaatac ctagatgtgg tcatagaata aaacctgttg tggaattgtg
     1021 a
//
