LOCUS       NM_023135               1260 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus sulfotransferase family 1E, member 1 (Sult1e1), mRNA.
ACCESSION   NM_023135 XM_976056
VERSION     NM_023135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Wang,J., Zhang,Z., Guan,J., Tung,H.C., Xie,J., Huang,H., Chen,Y.,
            Xu,M., Ren,S., Li,S., Zhang,M., Yang,D. and Xie,W.
  TITLE     Hepatocyte estrogen sulfotransferase inhibition protects female
            mice from concanavalin A-induced T cell-mediated hepatitis
            independent of estrogens
  JOURNAL   J Biol Chem 299 (3), 103026 (2023)
   PUBMED   36796516
  REMARK    GeneRIF: Hepatocyte estrogen sulfotransferase inhibition protects
            female mice from concanavalin A-induced T cell-mediated hepatitis
            independent of estrogens.
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Sato,A., Watanabe,H., Yamazaki,M., Sakurai,E. and Ebina,K.
  TITLE     Estrogen Sulfotransferase is Highly Expressed in Vascular
            Endothelial Cells Overlying Atherosclerotic Plaques
  JOURNAL   Protein J 41 (1), 179-188 (2022)
   PUBMED   35059953
  REMARK    GeneRIF: Estrogen Sulfotransferase is Highly Expressed in Vascular
            Endothelial Cells Overlying Atherosclerotic Plaques.
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Sararols,P., Stevant,I., Neirijnck,Y., Rebourcet,D., Darbey,A.,
            Curley,M.K., Kuhne,F., Dermitzakis,E., Smith,L.B. and Nef,S.
  TITLE     Specific Transcriptomic Signatures and Dual Regulation of
            Steroidogenesis Between Fetal and Adult Mouse Leydig Cells
  JOURNAL   Front Cell Dev Biol 9, 695546 (2021)
   PUBMED   34262907
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Silva Barbosa,A.C., Zhou,D., Xie,Y., Choi,Y.J., Tung,H.C., Chen,X.,
            Xu,M., Gibbs,R.B., Poloyac,S.M., Liu,S., Yu,Y., Luo,J., Liu,Y. and
            Xie,W.
  TITLE     Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates
            Ischemic Acute Kidney Injury in Mice
  JOURNAL   J Am Soc Nephrol 31 (7), 1496-1508 (2020)
   PUBMED   32424001
  REMARK    GeneRIF: Inhibition of Estrogen Sulfotransferase (SULT1E1/EST)
            Ameliorates Ischemic Acute Kidney Injury in Mice.
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Song,W.C., Moore,R., McLachlan,J.A. and Negishi,M.
  TITLE     Molecular characterization of a testis-specific estrogen
            sulfotransferase and aberrant liver expression in obese and
            diabetogenic C57BL/KsJ-db/db mice
  JOURNAL   Endocrinology 136 (6), 2477-2484 (1995)
   PUBMED   7750469
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Leiter,E.H. and Chapman,H.D.
  TITLE     Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces
            aberrant trans-regulation of sex steroid sulfotransferase genes
  JOURNAL   J Clin Invest 93 (5), 2007-2013 (1994)
   PUBMED   8182132
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Tsui,F.W., Tsui,H.W., Mok,S., Mlinaric,I., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Siminovitch,K.A.
  TITLE     Molecular characterization and mapping of murine genes encoding
            three members of the stefin family of cysteine proteinase
            inhibitors
  JOURNAL   Genomics 15 (3), 507-514 (1993)
   PUBMED   8468045
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Leiter,E.H., Chapman,H.D. and Coleman,D.L.
  TITLE     The influence of genetic background on the expression of mutations
            at the diabetes locus in the mouse. V. Interaction between the db
            gene and hepatic sex steroid sulfotransferases correlates with
            gender-dependent susceptibility to hyperglycemia
  JOURNAL   Endocrinology 124 (2), 912-922 (1989)
   PUBMED   2912706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB590464.1, AK015750.1 and AC158917.6.
            
            On Sep 1, 2009 this sequence version replaced NM_023135.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034891.1, AK015750.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BB590464.1         2-18
            18-1157             AK015750.1         2-1141
            1158-1260           AC158917.6         6017-6119
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1260
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /note="sulfotransferase family 1E, member 1"
                     /db_xref="GeneID:20860"
                     /db_xref="MGI:MGI:98431"
     exon            1..118
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     exon            119..279
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1019
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /EC_number="2.8.2.4"
                     /note="sulfotransferase, estrogen preferring"
                     /codon_start=1
                     /product="sulfotransferase 1E1"
                     /protein_id="NP_075624.2"
                     /db_xref="CCDS:CCDS19392.1"
                     /db_xref="GeneID:20860"
                     /db_xref="MGI:MGI:98431"
                     /translation="METSMPEYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIA
                     TYPKSGTTWISEVVYMIYKEGDVEKCKEDAIFNRIPYLECRNEDLINGIKQLKEKESP
                     RIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVE
                     KFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAE
                     LVDRIVQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERF
                     DEHYKQQMKDCTVKFRMEL"
     exon            280..405
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     exon            406..503
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     exon            504..630
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     exon            631..725
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     exon            726..906
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1260
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1236..1241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /note="hexamer: AATAAA"
     polyA_site      1259
                     /gene="Sult1e1"
                     /gene_synonym="EST; ST1E1; Ste"
                     /note="major polyA site"
ORIGIN      
        1 agaaactttc caagtgtaca accagttctc atttttattc agagctgaag aatcgtgctg
       61 ccattcgaag agaactaaac cggatcattt cacttcttcc acgggaacat ctggacagta
      121 caccatttga gatggagact tctatgcctg agtattatga agtttttgga gagttccgtg
      181 gagttctaat ggacaaacgg ttcaccaaat attgggaaga tgttgaaatg ttcttggcaa
      241 ggccagatga ccttgtcatt gctacatatc ctaaatctgg taccacctgg attagtgaag
      301 ttgtgtatat gatctataaa gaaggtgatg tggaaaaatg caaggaggat gcaattttta
      361 acagaatacc ttatttggag tgcagaaacg aagacctaat aaatggaata aaacaattaa
      421 aagagaagga atctcccaga atagtaaaaa ctcacctgcc acccaagctc cttccagcat
      481 cattttggga aaagaattgc aagatgatct atctttgccg gaacgccaaa gatgtcgccg
      541 tttcttatta ctactttttg ctaatgataa ctagttatcc aaatcctaaa tctttttctg
      601 aatttgtgga gaaatttatg caagggcaag ttccgtatgg ttcctggtat gatcatgtga
      661 aagcttggtg ggaaaagagt aagaattcac gtgttttatt tatgttctat gaagacatga
      721 aagaggatat cagaagagaa gttgtaaagc taatagagtt cctggagaga aagccctcgg
      781 cagagcttgt ggacagaatc gttcaacaca cttccttcca ggagatgaag aacaatccat
      841 ccaccaatta tacaatgatg ccagaggaaa tgatgaatca aaaagtatca ccattcatgc
      901 gaaagggaat tataggagac tggaagaacc acttcccaga agccctgagg gagagatttg
      961 atgagcacta caagcagcag atgaaggatt gcactgtgaa gtttagaatg gagctctgag
     1021 ccacttcctt gtgtctgaaa ttagagtagt ctgaaattta tccttcagtt tctcttgtga
     1081 attcagtaga agtagaagtc ttttgaagtc tgatggttta aattcatttt tttctaactt
     1141 ttatgtcaat gtaatttcta aatgtttgac agcaaaatca catttttctt atatataaca
     1201 taagcattgt cctctaacag tgttcaaaga tttctaataa aaataatttg atgcctgcat
//
