LOCUS       NM_133670               1229 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sulfotransferase family 1A, phenol-preferring, member
            1 (Sult1a1), transcript variant 1, mRNA.
ACCESSION   NM_133670
VERSION     NM_133670.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Pagan,C., Benabou,M., Leblond,C., Cliquet,F., Mathieu,A.,
            Lemiere,N., Goubran-Botros,H., Delorme,R., Leboyer,M.,
            Callebert,J., Bourgeron,T. and Launay,J.M.
  TITLE     Decreased phenol sulfotransferase activities associated with
            hyperserotonemia in autism spectrum disorders
  JOURNAL   Transl Psychiatry 11 (1), 23 (2021)
   PUBMED   33414449
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Cen,C., Chen,M., Zhou,J., Zhang,L., Duo,S., Jiang,L., Hou,X. and
            Gao,F.
  TITLE     Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell
            transformation and defect of ovary developmentdagger
  JOURNAL   Biol Reprod 103 (1), 60-69 (2020)
   PUBMED   32301970
REFERENCE   4  (bases 1 to 1229)
  AUTHORS   Monien,B.H., Sachse,B., Meinl,W., Abraham,K., Lampen,A. and
            Glatt,H.
  TITLE     Hemoglobin adducts of furfuryl alcohol in genetically modified
            mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and
            transgenic human sulfotransferases 1A1/1A2
  JOURNAL   Toxicol Lett 295, 173-178 (2018)
   PUBMED   29908303
  REMARK    GeneRIF: Suggest SULT1A1/1A2 play a central role in furfuryl
            alcohol bioactivation and the formation of hemoglobin adducts.
REFERENCE   5  (bases 1 to 1229)
  AUTHORS   Sachse,B., Meinl,W., Sommer,Y., Glatt,H., Seidel,A. and Monien,B.H.
  TITLE     Bioactivation of food genotoxicants 5-hydroxymethylfurfural and
            furfuryl alcohol by sulfotransferases from human, mouse and rat: a
            comparative study
  JOURNAL   Arch Toxicol 90 (1), 137-148 (2016)
   PUBMED   25370010
  REMARK    GeneRIF: SULT1A1 is responsible for bioactivation of food
            genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
REFERENCE   6  (bases 1 to 1229)
  AUTHORS   Warden,C.H., Fisler,J.S., Shoemaker,S.M., Wen,P.Z., Svenson,K.L.,
            Pace,M.J. and Lusis,A.J.
  TITLE     Identification of four chromosomal loci determining obesity in a
            multifactorial mouse model
  JOURNAL   J Clin Invest 95 (4), 1545-1552 (1995)
   PUBMED   7706460
REFERENCE   7  (bases 1 to 1229)
  AUTHORS   Samuelson,L.C., Isakoff,M.S. and Lacourse,K.A.
  TITLE     Localization of the murine cholecystokinin A and B receptor genes
  JOURNAL   Mamm Genome 6 (4), 242-246 (1995)
   PUBMED   7613026
REFERENCE   8  (bases 1 to 1229)
  AUTHORS   Khan,A.S., Taylor,B.R., Filie,J.D., Ringer,D.P. and Kozak,C.A.
  TITLE     Rat phenol-preferring sulfotransferase genes (Stp and Stp2):
            localization to mouse chromosomes 7 and 17
  JOURNAL   Genomics 26 (2), 417-419 (1995)
   PUBMED   7601475
REFERENCE   9  (bases 1 to 1229)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   10 (bases 1 to 1229)
  AUTHORS   Charles,C.H., Abler,A.S. and Lau,L.F.
  TITLE     cDNA sequence of a growth factor-inducible immediate early gene and
            characterization of its encoded protein
  JOURNAL   Oncogene 7 (1), 187-190 (1992)
   PUBMED   1741163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124505.4.
            
            On Mar 29, 2022 this sequence version replaced NM_133670.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02331.1, AK002700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124505.4         17070-17145         c
            77-216              AC124505.4         16212-16351         c
            217-342             AC124505.4         15996-16121         c
            343-440             AC124505.4         15817-15914         c
            441-567             AC124505.4         15039-15165         c
            568-662             AC124505.4         14855-14949         c
            663-843             AC124505.4         14185-14365         c
            844-1229            AC124505.4         13638-14023         c
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1229
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /note="sulfotransferase family 1A, phenol-preferring,
                     member 1"
                     /db_xref="GeneID:20887"
                     /db_xref="MGI:MGI:102896"
     exon            1..76
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..956
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /EC_number="2.8.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfotransferase 1A1; arylsulfotransferase ST1A4;
                     sulfokinase; aryl sulfotransferase; phenol
                     sulfotransferase; phenol/aryl sulfotransferase;
                     sulfotransferase, phenol preferring 1"
                     /codon_start=1
                     /product="sulfotransferase 1A1 isoform 1"
                     /protein_id="NP_598431.2"
                     /db_xref="CCDS:CCDS40128.2"
                     /db_xref="GeneID:20887"
                     /db_xref="MGI:MGI:102896"
                     /translation="MAQNPSNMEPLRKPLVPVKGIPLIKYFAETMEQLQNFTAWPDDV
                     LISTYPKSGTTWMSEIMDMIYQGGKLDKCGRAPVYARIPFLEFSCPGVPPGLETLKET
                     PAPRIIKTHLPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWES
                     FLENFMDGKVSYGSWYQHVKEWWELRRTHPVLYLFYEDMKENPKREIKKILEFLGRSL
                     PEETVDLIVHHTSFKKMKENPMANYTTIPTEVMDHTISPFMRKGTIGDWKNTFTVAQS
                     EHFDAHYAKIMTGCDFTFRCQI"
     exon            77..216
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            217..342
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..440
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..567
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..662
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..843
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1229
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1208..1213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /note="hexamer: AATAAA"
     polyA_site      1229
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /note="major polyA site"
ORIGIN      
        1 gcattcccca cattgcaaag cctacacaaa gatccctacc actgagcacc gagggaggca
       61 tggctcagaa ccccagcaac atggagccct tgcgtaaacc actggtgcct gtgaagggaa
      121 tcccactcat caaatacttt gcggagacaa tggagcaact gcagaacttc acagcctggc
      181 ctgatgatgt gctcatcagc acgtacccaa agtctggtac tacctggatg agtgagatca
      241 tggatatgat ctatcagggt ggcaagctag ataagtgtgg ccgggccccc gtctatgccc
      301 ggataccctt ccttgagttc agctgcccag gggtcccccc aggtcttgaa actctgaaag
      361 agacaccagc cccacggatc attaagacac atctgccctt gtccttactc cctcagagtc
      421 tgctggatca aaagatcaag gtgatctacg ttgcccgaaa tgcaaaggat gtggttgtct
      481 cctattataa cttctacaaa atggccaagc tgcaccctga cccaggcacc tgggaaagct
      541 tcttggagaa cttcatggat gggaaagtgt cctatgggtc gtggtaccag cacgtgaagg
      601 agtggtggga gctgagacgc actcaccctg ttctctatct cttctatgaa gacatgaagg
      661 agaatcccaa aagggagatc aagaagattc tagagtttct ggggcgctct ctacctgagg
      721 agactgtgga tttaattgtt caccacacat ccttcaagaa aatgaaggag aaccccatgg
      781 ctaactacac aaccatccca actgaagtta tggaccacac tatttctccc ttcatgagga
      841 aaggtaccat tggggactgg aaaaatacct tcactgtagc ccagagtgag cactttgatg
      901 cccactatgc caagataatg acaggttgtg acttcacgtt ccgctgtcaa atatgagtgg
      961 atatggctat actgggaacc aaggcaagct gacacagccc atcatgatct caagagaaaa
     1021 atgtgatgtg ttcaatttat ttgttgtatg cctaaaggaa atctgagcta agagaatagg
     1081 actggggatg tagctgaggc agagggtctt atcaacatgt caggaaagcc atcagtccta
     1141 acactgaaaa agaacctaaa gtacaaacat gcaaaaatag taagataaac tgtattttac
     1201 ctgaacaaat aaatgccact gggagctga
//
