LOCUS       NM_001403131            1140 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sulfotransferase family 1A, phenol-preferring, member
            1 (Sult1a1), transcript variant 2, mRNA.
ACCESSION   NM_001403131 XM_017322084
VERSION     NM_001403131.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Pagan,C., Benabou,M., Leblond,C., Cliquet,F., Mathieu,A.,
            Lemiere,N., Goubran-Botros,H., Delorme,R., Leboyer,M.,
            Callebert,J., Bourgeron,T. and Launay,J.M.
  TITLE     Decreased phenol sulfotransferase activities associated with
            hyperserotonemia in autism spectrum disorders
  JOURNAL   Transl Psychiatry 11 (1), 23 (2021)
   PUBMED   33414449
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Cen,C., Chen,M., Zhou,J., Zhang,L., Duo,S., Jiang,L., Hou,X. and
            Gao,F.
  TITLE     Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell
            transformation and defect of ovary developmentdagger
  JOURNAL   Biol Reprod 103 (1), 60-69 (2020)
   PUBMED   32301970
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Monien,B.H., Sachse,B., Meinl,W., Abraham,K., Lampen,A. and
            Glatt,H.
  TITLE     Hemoglobin adducts of furfuryl alcohol in genetically modified
            mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and
            transgenic human sulfotransferases 1A1/1A2
  JOURNAL   Toxicol Lett 295, 173-178 (2018)
   PUBMED   29908303
  REMARK    GeneRIF: Suggest SULT1A1/1A2 play a central role in furfuryl
            alcohol bioactivation and the formation of hemoglobin adducts.
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Sachse,B., Meinl,W., Sommer,Y., Glatt,H., Seidel,A. and Monien,B.H.
  TITLE     Bioactivation of food genotoxicants 5-hydroxymethylfurfural and
            furfuryl alcohol by sulfotransferases from human, mouse and rat: a
            comparative study
  JOURNAL   Arch Toxicol 90 (1), 137-148 (2016)
   PUBMED   25370010
  REMARK    GeneRIF: SULT1A1 is responsible for bioactivation of food
            genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Warden,C.H., Fisler,J.S., Shoemaker,S.M., Wen,P.Z., Svenson,K.L.,
            Pace,M.J. and Lusis,A.J.
  TITLE     Identification of four chromosomal loci determining obesity in a
            multifactorial mouse model
  JOURNAL   J Clin Invest 95 (4), 1545-1552 (1995)
   PUBMED   7706460
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Samuelson,L.C., Isakoff,M.S. and Lacourse,K.A.
  TITLE     Localization of the murine cholecystokinin A and B receptor genes
  JOURNAL   Mamm Genome 6 (4), 242-246 (1995)
   PUBMED   7613026
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Khan,A.S., Taylor,B.R., Filie,J.D., Ringer,D.P. and Kozak,C.A.
  TITLE     Rat phenol-preferring sulfotransferase genes (Stp and Stp2):
            localization to mouse chromosomes 7 and 17
  JOURNAL   Genomics 26 (2), 417-419 (1995)
   PUBMED   7601475
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Charles,C.H., Abler,A.S. and Lau,L.F.
  TITLE     cDNA sequence of a growth factor-inducible immediate early gene and
            characterization of its encoded protein
  JOURNAL   Oncogene 7 (1), 187-190 (1992)
   PUBMED   1741163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124505.4.
            
            On Mar 28, 2022 this sequence version replaced XM_017322084.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4425268.1,
                                           ERR3363660.1214429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124505.4         17070-17145         c
            77-253              AC124505.4         16175-16351         c
            254-351             AC124505.4         15817-15914         c
            352-478             AC124505.4         15039-15165         c
            479-573             AC124505.4         14855-14949         c
            574-754             AC124505.4         14185-14365         c
            755-1140            AC124505.4         13638-14023         c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1140
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /note="sulfotransferase family 1A, phenol-preferring,
                     member 1"
                     /db_xref="GeneID:20887"
                     /db_xref="MGI:MGI:102896"
     exon            1..76
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..253
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..867
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /EC_number="2.8.2.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sulfotransferase 1A1; arylsulfotransferase ST1A4;
                     sulfokinase; aryl sulfotransferase; phenol
                     sulfotransferase; phenol/aryl sulfotransferase;
                     sulfotransferase, phenol preferring 1"
                     /codon_start=1
                     /product="sulfotransferase 1A1 isoform 2"
                     /protein_id="NP_001390060.1"
                     /db_xref="GeneID:20887"
                     /db_xref="MGI:MGI:102896"
                     /translation="MMCSSARTQSLVSEQWSPPHTHFGLETLKETPAPRIIKTHLPLS
                     LLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYG
                     SWYQHVKEWWELRRTHPVLYLFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTS
                     FKKMKENPMANYTTIPTEVMDHTISPFMRKGTIGDWKNTFTVAQSEHFDAHYAKIMTG
                     CDFTFRCQI"
     exon            254..351
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..478
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..754
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1140
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1119..1124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /note="hexamer: AATAAA"
     polyA_site      1140
                     /gene="Sult1a1"
                     /gene_synonym="mSTp1; PST; ST1A1; ST1A4; Stp; Stp1"
                     /note="major polyA site"
ORIGIN      
        1 gcattcccca cattgcaaag cctacacaaa gatccctacc actgagcacc gagggaggca
       61 tggctcagaa ccccagcaac atggagccct tgcgtaaacc actggtgcct gtgaagggaa
      121 tcccactcat caaatacttt gcggagacaa tggagcaact gcagaacttc acagcctggc
      181 ctgatgatgt gctcatcagc acgtacccaa agtctggtga gcgagcagtg gtccccacca
      241 cacacacact ttggtcttga aactctgaaa gagacaccag ccccacggat cattaagaca
      301 catctgccct tgtccttact ccctcagagt ctgctggatc aaaagatcaa ggtgatctac
      361 gttgcccgaa atgcaaagga tgtggttgtc tcctattata acttctacaa aatggccaag
      421 ctgcaccctg acccaggcac ctgggaaagc ttcttggaga acttcatgga tgggaaagtg
      481 tcctatgggt cgtggtacca gcacgtgaag gagtggtggg agctgagacg cactcaccct
      541 gttctctatc tcttctatga agacatgaag gagaatccca aaagggagat caagaagatt
      601 ctagagtttc tggggcgctc tctacctgag gagactgtgg atttaattgt tcaccacaca
      661 tccttcaaga aaatgaagga gaaccccatg gctaactaca caaccatccc aactgaagtt
      721 atggaccaca ctatttctcc cttcatgagg aaaggtacca ttggggactg gaaaaatacc
      781 ttcactgtag cccagagtga gcactttgat gcccactatg ccaagataat gacaggttgt
      841 gacttcacgt tccgctgtca aatatgagtg gatatggcta tactgggaac caaggcaagc
      901 tgacacagcc catcatgatc tcaagagaaa aatgtgatgt gttcaattta tttgttgtat
      961 gcctaaagga aatctgagct aagagaatag gactggggat gtagctgagg cagagggtct
     1021 tatcaacatg tcaggaaagc catcagtcct aacactgaaa aagaacctaa agtacaaaca
     1081 tgcaaaaata gtaagataaa ctgtatttta cctgaacaaa taaatgccac tgggagctga
//
