LOCUS       NM_028072               3790 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus sulfatase 2 (Sulf2), transcript variant 2, mRNA.
ACCESSION   NM_028072
VERSION     NM_028072.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3790)
  AUTHORS   Whitehead,A.K., Wang,Z., Boustany,R.J., Vives,R.R., Lazartigues,E.,
            Liu,J., Siggins,R.W. and Yue,X.
  TITLE     Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs
            bone marrow hematopoiesis
  JOURNAL   Matrix Biol 134, 107-118 (2024)
   PUBMED   39368561
REFERENCE   2  (bases 1 to 3790)
  AUTHORS   Swart,M., Redpath,A.N., Ogbechi,J., Cardenas,R., Topping,L.,
            Compeer,E.B., Goddard,M., Chanalaris,A., Williams,R., Brewer,D.S.,
            Smart,N., Monaco,C. and Troeberg,L.
  TITLE     The extracellular heparan sulfatase SULF2 limits myeloid IFNbeta
            signaling and Th17 responses in inflammatory arthritis
  JOURNAL   Cell Mol Life Sci 81 (1), 350 (2024)
   PUBMED   39141086
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3790)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3790)
  AUTHORS   Xin,Y., He,Q., Liang,H., Zhang,K., Guo,J., Zhong,Q., Chen,D.,
            Li,J., Liu,Y. and Chen,S.
  TITLE     m6A epitranscriptomic modification regulates neural
            progenitor-to-glial cell transition in the retina
  JOURNAL   Elife 11, e79994 (2022)
   PUBMED   36459087
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3790)
  AUTHORS   He,R., Shi,J., Xu,D., Yang,J., Shen,Y., Jiang,Y.S., Tao,L.,
            Yang,M., Fu,X., Yang,J.Y., Liu,D., Huo,Y., Shen,X., Lu,P., Niu,N.,
            Sun,Y.W., Xue,J. and Liu,W.
  TITLE     SULF2 enhances GDF15-SMAD axis to facilitate the initiation and
            progression of pancreatic cancer
  JOURNAL   Cancer Lett 538, 215693 (2022)
   PUBMED   35472437
  REMARK    GeneRIF: SULF2 enhances GDF15-SMAD axis to facilitate the
            initiation and progression of pancreatic cancer.
REFERENCE   6  (bases 1 to 3790)
  AUTHORS   Coveney,D., Ross,A.J., Slone,J.D. and Capel,B.
  TITLE     A microarray analysis of the XX Wnt4 mutant gonad targeted at the
            identification of genes involved in testis vascular differentiation
  JOURNAL   Gene Expr Patterns 7 (1-2), 82-92 (2007)
   PUBMED   16844427
  REMARK    Erratum:[Gene Expr Patterns. 2008 Sep;8(7-8):528]
REFERENCE   7  (bases 1 to 3790)
  AUTHORS   Lamanna,W.C., Baldwin,R.J., Padva,M., Kalus,I., Ten Dam,G., van
            Kuppevelt,T.H., Gallagher,J.T., von Figura,K., Dierks,T. and
            Merry,C.L.
  TITLE     Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and
            functional co-operativity
  JOURNAL   Biochem J 400 (1), 63-73 (2006)
   PUBMED   16901266
REFERENCE   8  (bases 1 to 3790)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   9  (bases 1 to 3790)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3790)
  AUTHORS   Morimoto-Tomita,M., Uchimura,K., Werb,Z., Hemmerich,S. and
            Rosen,S.D.
  TITLE     Cloning and characterization of two extracellular heparin-degrading
            endosulfatases in mice and humans
  JOURNAL   J Biol Chem 277 (51), 49175-49185 (2002)
   PUBMED   12368295
  REMARK    GeneRIF: Sulfs are extracellular endosulfatases with strong
            potential for modulating the interactions of heparan sulfate
            proteoglycans in the extracellular microenvironment
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF736722.1, AK036685.1 and AL589873.11.
            
            On Nov 19, 2011 this sequence version replaced NM_028072.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133336.1, AK036685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CF736722.1         1-67
            68-3768             AK036685.1         4-3704
            3769-3790           AL589873.11        33668-33689         c
FEATURES             Location/Qualifiers
     source          1..3790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 86.31 cM"
     gene            1..3790
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /note="sulfatase 2"
                     /db_xref="GeneID:72043"
                     /db_xref="MGI:MGI:1919293"
     exon            1..181
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..448
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2901
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /EC_number="3.1.6.1"
                     /EC_number="3.1.6.14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; extracellular sulfatase Sulf-2; arylsulfatase;
                     N-acetylglucosamine-6-sulfatase"
                     /codon_start=1
                     /product="extracellular sulfatase Sulf-2 isoform 1
                     precursor"
                     /protein_id="NP_082348.2"
                     /db_xref="CCDS:CCDS17086.1"
                     /db_xref="GeneID:72043"
                     /db_xref="MGI:MGI:1919293"
                     /translation="MAPPGLPLWLLSTALLSLLAGSSAFLSHPRLKGRFQRDRRNIRP
                     NIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVH
                     NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEW
                     VGLLKNSRFYNYTLCRNGVKEKHGSDYSTDYLTDLITNDSVSFFRTSKKMYPHRPVLM
                     VISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFT
                     NMLQRKRLQTLMSVDDSMETIYDMLVETGELDNTYILYTADHGYHIGQFGLVKGKSMP
                     YEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDS
                     ERPVNRFHLKKKLRVWRDSFLVERGKLLHKREGDKVNAQEENFLPKYQRVKDLCQRAE
                     YQTACEQLGQKWQCVEDASGTLKLHKCKGPMRFGGGGGSRALSNLVPKYDGQSSEACS
                     CDSGGGGDYKLGLAGRRKLFKKKYKTSYARNRSIRSVAIEVDGEIYHVGLDTVPQPRN
                     LSKPHWPGAPEDQDDKDGGSFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLDLYK
                     SLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHRISYHSQHKGRLKH
                     KGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNHHW
                     QTAPLWTLGPFCACTSANNNTYWCLRTINETHNFLFCEFATGFIEYFDLSTDPYQLMN
                     AVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLRDGGSYEQYRQFQRRKWP
                     EMKRPSSKSLGQLWEGWEG"
     exon            449..688
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..840
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1010
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1161
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1337
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1466
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1523
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1653
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1864
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2093
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2190
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2285
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2345
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2515
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2658
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2782
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2816
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2870
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3790
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3514..3519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /note="hexamer: AATAAA"
     polyA_site      3543
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /note="major polyA site"
     polyA_site      3778
                     /gene="Sulf2"
                     /gene_synonym="2010004N24Rik; mKIAA1247; MSulf-2"
                     /note="major polyA site"
ORIGIN      
        1 agggaaccgg cctccccttt ctttcccatt cccggcccat gtctgggcaa cgcttctgct
       61 ttcgcttgag ctcaacttaa tttctcagag agcttcggag acgcgtggga aggtcccagg
      121 cgcgtgggca gttcctcccg cgatctagct tggggatcgg cccgagccgg cgtctccaat
      181 gatcctgagg gaagagggga aggaatccca tcctcacgac accacctcgg cctctgcatc
      241 caggaagaag caaaggacca gcaagccacg ccaatggcac cccctggcct gccactatgg
      301 ctgctgtcca ccgctctcct ctccctgctg gctggcagct cggccttcct ctcccatccc
      361 cgcctgaagg gacgcttcca gagggaccgc aggaacatcc ggcccaacat catcttggtg
      421 cttacggatg accaggatgt ggagctgggc tccatgcaag tgatgaacaa gacaaggcgt
      481 atcatggagc agggcggggc gcacttcatc aatgccttcg tgactacacc aatgtgctgt
      541 ccgtctcgct cctccattct caccggcaag tacgtccaca accacaacac ctacaccaac
      601 aatgagaatt gttcctcgcc ctcctggcag gcccagcacg agagccgcac cttcgccgtg
      661 tatctcaaca gcacaggcta ccggacagct ttcttcggaa aatacctcaa tgagtacaac
      721 ggctcatacg tgccgcccgg ctggaaggag tgggtcggcc tacttaagaa ctcccgcttt
      781 tataactaca cactctgccg gaatggggtg aaggagaaac atggctcaga ctactccacg
      841 gattacctca cggatctcat caccaatgac agtgtgagct tcttccgaac atccaagaag
      901 atgtacccac acaggcccgt gctcatggtc atcagccacg cggctcccca tggccccgag
      961 gactcagcac cccagtactc acggctcttc cccaatgcgt cccagcacat cacaccgagt
     1021 tacaactatg cacccaaccc agacaagcat tggatcatgc gctacacggg acccatgaag
     1081 cccattcaca tggaattcac caacatgcta caacgaaaac gcctacagac cctcatgtct
     1141 gtggatgact ccatggagac gatctatgac atgctggtgg agacggggga gctggacaac
     1201 acgtacatcc tgtacaccgc cgaccacggc taccacattg gccagtttgg gctggtgaag
     1261 ggcaagtcta tgccgtatga attcgacatc agagtcccgt tctacgtgag gggccccaac
     1321 gtggaagctg gctctctgaa cccccacatt gtcctcaaca ttgacctggc ccccaccata
     1381 ctggatatcg ctggactgga catccctgca gacatggacg ggaagtctat tctcaaacta
     1441 ctggactcag agcggccagt gaaccggttc cacttgaaaa agaagctgag ggtctggcga
     1501 gactccttcc tggtggagag aggcaaactg ctccacaaga gggagggtga caaagtgaat
     1561 gcccaggagg agaacttcct gcccaagtac cagcgcgtga aggacctgtg tcagcgagct
     1621 gagtaccaga cagcatgcga acagctgggg cagaagtggc agtgtgtgga ggacgcttct
     1681 gggacgctga agctgcacaa atgtaaaggc cccatgcggt ttggtggcgg cggtggcagc
     1741 agagccctct ccaacctggt gcccaagtat gacggccaga gcagcgaggc ctgcagctgt
     1801 gacagtggcg gtggagggga ctacaaactg ggcctggctg gacgccgtaa gctctttaag
     1861 aaaaagtata agaccagcta tgcccggaac cgctccatcc gttccgtggc catcgaggtg
     1921 gacggtgaga tataccacgt aggcttggat actgtgcctc agccccgcaa ccttagcaag
     1981 ccgcactggc caggggcccc tgaagaccaa gatgacaagg atggtggcag tttcagtggt
     2041 actggtggcc ttccagatta ttctgccccc aatcccatca aagtgaccca tcggtgctac
     2101 atccttgaga atgacacagt ccagtgcgac ttggacctgt acaagtccct gcaggcttgg
     2161 aaagaccaca agctgcacat cgaccatgag atcgaaaccc tgcagaacaa aattaagaac
     2221 cttcgagaag tcaggggtca cctgaagaag aagcgaccgg aagaatgtga ctgccataga
     2281 atcagttacc acagccaaca caaaggccgt ctcaagcaca aaggctccag cctgcaccct
     2341 ttcaggaagg gtctgcagga gaaggacaag gtgtggctgc tgcgggagca gaaacgcaag
     2401 aagaaactgc gcaagctgct caaacggctg cagaacaacg atacgtgcag catgcccggc
     2461 ctcacgtgct ttacccacga caaccaccac tggcagacgg cgccactctg gacgctgggg
     2521 ccgttctgcg cctgcaccag cgccaacaac aacacgtact ggtgcttgag gaccataaat
     2581 gagacccaca acttcctctt ctgcgaattt gcaaccggct tcatagaata ctttgacctc
     2641 agtacagacc cctaccagct gatgaacgcg gtgaacacac tggacaggga cgtccttaac
     2701 caactgcacg tgcagctcat ggagctaagg agctgtaaag gctacaagca gtgcaacccc
     2761 cggacccgca acatggacct ggggcttaga gacggaggaa gctatgaaca atacaggcag
     2821 tttcagcgtc gaaaatggcc agaaatgaag agaccttctt ccaaatcact gggacagcta
     2881 tgggaaggtt gggaaggcta agcggccata gagagaggaa cctccaaaac caggggcctc
     2941 gtgtggctgc ccaggccatg caaaaaacac ccgattccca gaagatgaat gttggaactg
     3001 ggagacctga cagaaggcag ggcctgctct tgggacagga aatcctggag gacagcgcct
     3061 ggactttccg atgctcagtt tctttgccct gctttgctct ggatcaaacc tcactggctg
     3121 ctctgggatg cgtgctcaca cctggagtct ctgctcaccc tttcagaggc tcacaaagac
     3181 aaaggaacta atttccatgg acacttcctc cagagatgga aattgctggg attcgcccac
     3241 tcctcccctg cacccctccc ccagtcatct agggaagcaa gcttgtttta accttcttac
     3301 tctttggaga aagcacggac atcccaggtg ctgtcaacct cacagtcttg acaaagtcta
     3361 tagcacaaaa cagtaccatt caccaggctg gttgacctgg ctggctcaga agctgccttc
     3421 accacataca tgaccgctca cacgtaacca acacagggaa ttgtagggga atctcactaa
     3481 tatgaaatcc cgcttttcaa gagtcgcggt gtcaataaac gctgtggcta ggatcaagga
     3541 taatcccttg agctttcaga catttattcc tgcccgggat tcgttccttt gttatccatc
     3601 ccagaactga tgtttttcta aggtaccgaa accccaagtt gatgtgtgtc ctgtgtttta
     3661 atgacattgt atttgtaaag ttttgtagta taagtaccat cttacagtgt tcctgccccc
     3721 agccaatgtc tagctattgg tatgaaaaaa aaaatctttg aatttttgta aaaggctatc
     3781 ttgggacttt
//
