LOCUS       NM_026474               3024 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
            (Sugt1), mRNA.
ACCESSION   NM_026474
VERSION     NM_026474.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Yan,R., Liang,X. and Hu,J.
  TITLE     miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to
            inhibit colonic epithelial cell pyroptosis
  JOURNAL   Autoimmunity 56 (1), 2220988 (2023)
   PUBMED   37317573
  REMARK    GeneRIF: miR-141-3p alleviates ulcerative colitis by targeting
            SUGT1 to inhibit colonic epithelial cell pyroptosis.
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Li,Y., Yuan,J., Chen,F., Zhang,S., Zhao,Y., Chen,X., Lu,L.,
            Zhou,L., Chu,C.Y., Sun,H. and Wang,H.
  TITLE     Long noncoding RNA SAM promotes myoblast proliferation through
            stabilizing Sugt1 and facilitating kinetochore assembly
  JOURNAL   Nat Commun 11 (1), 2725 (2020)
   PUBMED   32483152
  REMARK    GeneRIF: Long noncoding RNA SAM promotes myoblast proliferation
            through stabilizing Sugt1 and facilitating kinetochore assembly.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Ogi,H., Sakuraba,Y., Kitagawa,R., Xiao,L., Shen,C., Cynthia,M.A.,
            Ohta,S., Arnold,M.A., Ramirez,N., Houghton,P.J. and Kitagawa,K.
  TITLE     The oncogenic role of the cochaperone Sgt1
  JOURNAL   Oncogenesis 4 (5), e149 (2015)
   PUBMED   25985210
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Hong,T.J., Kim,S., Wi,A.R., Lee,P., Kang,M., Jeong,J.H. and
            Hahn,J.S.
  TITLE     Dynamic nucleotide-dependent interactions of cysteine- and
            histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1
            and melusin with cochaperones PP5 and Sgt1
  JOURNAL   J Biol Chem 288 (1), 215-222 (2013)
   PUBMED   23184943
  REMARK    GeneRIF: Chp-1 and melusin can interact with cochaperones PP5 and
            Sgt1 and with each other in an ATP-dependent manner
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   Sbroggio,M., Ferretti,R., Percivalle,E., Gutkowska,M., Zylicz,A.,
            Michowski,W., Kuznicki,J., Accornero,F., Pacchioni,B.,
            Lanfranchi,G., Hamm,J., Turco,E., Silengo,L., Tarone,G. and
            Brancaccio,M.
  TITLE     The mammalian CHORD-containing protein melusin is a stress response
            protein interacting with Hsp90 and Sgt1
  JOURNAL   FEBS Lett 582 (13), 1788-1794 (2008)
   PUBMED   18474241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129216.4, AK082328.1 and AK141416.1.
            
            On Apr 17, 2018 this sequence version replaced NM_026474.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141416.1, SRR1660825.3142.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC129216.4         131438-131468
            32-1982             AK082328.1         3-1953
            1983-3024           AK141416.1         1888-2929
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.72 cM"
     gene            1..3024
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /note="SGT1, suppressor of G2 allele of SKP1 (S.
                     cerevisiae)"
                     /db_xref="GeneID:67955"
                     /db_xref="MGI:MGI:1915205"
     exon            1..207
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1180
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /note="suppressor of G2 allele of SKP1 homolog"
                     /codon_start=1
                     /product="protein SGT1 homolog"
                     /protein_id="NP_080750.1"
                     /db_xref="CCDS:CCDS36988.1"
                     /db_xref="GeneID:67955"
                     /db_xref="MGI:MGI:1915205"
                     /translation="MAAAAAGPASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDD
                     AQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETF
                     AEGQKLDSTDTNFDTWIKRCQEIQNGSESEVSASQRTQSKIKYDWYQTESHVIITLMI
                     KSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMK
                     KPEAVRWEKLEGQGDEPTPKQFTADVKNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEG
                     DAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWK
                     QY"
     exon            208..265
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..356
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..426
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..497
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..551
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..568
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..600
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..697
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..805
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..896
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1078
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..3024
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      1204
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /note="major polyA site"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1295
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      1778
                     /gene="Sugt1"
                     /gene_synonym="2410174K12Rik; SGT1"
ORIGIN      
        1 gcccaccctt cgcctccttt tccgcggctg catgctgcgc gaccgctgat tggctacgga
       61 ggacggaagc tcagttgggg tttctttaga agttttccct tcctgggcgg cggcggagct
      121 ggtaaccaag gtagaaacgc tcaggcagaa gctttcttga ctcctaggga tggcggcagc
      181 tgcagcagga cctgcatcgt cccagcggct tttccagagc ttctcagatg ctctgatcga
      241 cggggatccc caggcagcat tagaggagct gaccaaggcc ttggaacaga atccggatga
      301 cgcacagtat tactgtcaga gagcttattg tcacattctt cttgggaaat accgtgatgg
      361 tattgccgat gtaaagaagt ctcttgaact caatccaaat aattgtactg ctcttctgag
      421 gaaagggata tgtgaatacc atgaaaaaga ctacgcttct gccttagaaa catttgcaga
      481 gggacagaaa ttagatagta cagataccaa ttttgacacc tggattaaaa gatgccaaga
      541 aattcagaat ggatcagaat ctgaagtgtc tgcatctcag aggacccagt caaaaatcaa
      601 gtatgactgg tatcaaaccg agtctcacgt aatcatcacc cttatgatca agagcgttca
      661 gaagaatgat gtacgtgtgg gattttcaga gagagagttg tctgctttgg tgaaaattcc
      721 tgctggagaa gactacagtt tgaagctgag gctgctccac cctataatac cagaacagag
      781 tacattcaaa gtactttcaa caaagattga aattaaaatg aaaaagccag aggcggtgag
      841 atgggaaaag ctagagggac aaggagatga gcccacaccg aaacagttca cagcagatgt
      901 aaagaacatg tatccgtcct catctcacta tacccggaac tgggataagt tggttggcga
      961 aatcaaagaa gaagaaaaga acgagaagct ggagggcgac gcagctttaa acaagttatt
     1021 ccagcagatc tactcagacg gttccgatga agtgaaacgt gccatgaaca agtcatttat
     1081 ggagtctggt ggtacagtct tgagtaccaa ctggtctgat gtaggtaaaa ggaaagttga
     1141 aatcaaccct cccgatgata tggaatggaa acagtactaa ataaatcaat ttgctatcac
     1201 tgtattgcgt gtgttcgaga gagcccattg tgtgctttat catattcttg agttttaaac
     1261 agtatctttt gaaagattaa accttcttgc ctctctgtgc tttagaaatg atttttcctg
     1321 caagtattct aaagagtgac aatcacatct tatcatttct gtccttaagg attttgcaca
     1381 tcctgaaact gaatgaaatg ccagttgttc ctagatagat ccgctctgtc tagttatgaa
     1441 gtggagaaat ctttaatagc atcttgggta attgccttat ttttgatgca gtgttctgtc
     1501 aataattgat tagacctggc aactttggtg ggtctaacgt tttcagcttc agtgttgtgt
     1561 ttacttttca gagctgcttt ggaatgagag ctgtgcattt ctctgtgaag gctgctgctt
     1621 tatttacctt cctcttaagt ttttcctggg aactttgaga aattgctgca gagaattccc
     1681 tcatttagtt tttatgagaa gtatttgtaa ctgcagcaag attttggttc taccttctaa
     1741 attctcgaat aaagcataga ttctcgagtt taccagcaca cagatgtaac tgtcaataag
     1801 taatctgagt tggagaccaa gagaatgcca ggcctcctct gccaccatta ctgtggtttc
     1861 agtacttaaa tggagagaga tgcccttagt ttcagagtgt atagtatagc agagagaagg
     1921 ctgacattca ggaaaactta ggaatggctg aatgttgggc tacagaatag ttttaacaaa
     1981 ccaaaaaaaa ttaccccatg atgaattctt tgcagtctat aataatgcat attccactgg
     2041 caactcacag atttgacatc attttatcag cctttgtata gcctagtggc gggtctgtgc
     2101 tctggtaggt gttactgata attttgtggc aagacactcc cttgtatcct cagagctgat
     2161 ggtgaagtga aggagaaaca tgttggaaag catttcagct gcagaaagtg taggagagtt
     2221 catatttaca gtgggctggt cccagaccct ttgctaatag cttgtggaag tgcactggag
     2281 attaggagag gctggctccg aatgaatccc tgatgcccgc ctcaccttcc agtgactgtt
     2341 acgtgctgga taactggcat taccggttca caccaccatg tttggcttaa tctttttgtt
     2401 ggtggtgtcc atgctgaagt tctaactgac cttttgccca cgtaaagctg caaactactg
     2461 tccttgttct tgagcactaa agggaaaggc aaggttgact tcttgctaga gtggagttca
     2521 ggaattcttt cctttgggaa acaagatagt gggttgtggt ctagatgtta aattatctca
     2581 gtgtctttga tcctaagggg aagagaggct tgctacagaa gcaataaagg caggacacct
     2641 ccaccaatgt acaagaattt ccagcccact cactttataa ttttcagcag ttaagcctcc
     2701 ccccacaaga gatatcctta ttgtatgtgt atgtgtgttt gcatgagtgt atgtacaata
     2761 tttgtgtgtg tatacaccca gtgccgcaga agaggccgca ggatgctctg gaaatggagt
     2821 tgcagactct gtgagcctcc tccatgtggg tgctgataac cacgccagat cctctgcaag
     2881 agcaacaagt gcttaatgac agccgtctct ccagccccag tattaagcct gttagattgt
     2941 aattccttta gtaaataata tctagagtct tagaattaaa agattgtgaa tataaataaa
     3001 tcgtattttt actgttcaac cttt
//
