LOCUS       NM_027481               2707 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus SURP and G patch domain containing 1 (Sugp1),
            transcript variant 1, mRNA.
ACCESSION   NM_027481
VERSION     NM_027481.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2707)
  AUTHORS   Benbarche,S., Pineda,J.M.B., Galvis,L.B., Biswas,J., Liu,B.,
            Wang,E., Zhang,Q., Hogg,S.J., Lyttle,K., Dahi,A., Lewis,A.M.,
            Sarchi,M., Rahman,J., Fox,N., Ai,Y., Mehta,S., Garippa,R.,
            Ortiz-Pacheco,J., Li,Z., Monetti,M., Stanley,R.F., Doulatov,S.,
            Bradley,R.K. and Abdel-Wahab,O.
  TITLE     GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in
            hematologic malignancies
  JOURNAL   Mol Cell 84 (10), 1886-1903 (2024)
   PUBMED   38688280
REFERENCE   2  (bases 1 to 2707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2707)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2707)
  AUTHORS   Kim,M.J., Yu,C.Y., Theusch,E., Naidoo,D., Stevens,K., Kuang,Y.L.,
            Schuetz,E., Chaudhry,A.S. and Medina,M.W.
  TITLE     SUGP1 is a novel regulator of cholesterol metabolism
  JOURNAL   Hum Mol Genet 25 (14), 3106-3116 (2016)
   PUBMED   27206982
  REMARK    GeneRIF: Our results strongly support a role for SUGP1 as a novel
            regulator of cholesterol metabolism and suggest that it contributes
            to the relationship between rs10401969 and plasma cholesterol
REFERENCE   5  (bases 1 to 2707)
  AUTHORS   Sampson,N.D. and Hewitt,J.E.
  TITLE     SF4 and SFRS14, two related putative splicing factors on human
            chromosome 19p13.11
  JOURNAL   Gene 305 (1), 91-100 (2003)
   PUBMED   12594045
REFERENCE   6  (bases 1 to 2707)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167132.12.
            
            On Feb 9, 2019 this sequence version replaced NM_027481.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017736.1, AF521129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC167132.12        102862-103155
            295-466             AC167132.12        108584-108755
            467-567             AC167132.12        112666-112766
            568-786             AC167132.12        116461-116679
            787-910             AC167132.12        119357-119480
            911-1011            AC167132.12        119828-119928
            1012-1135           AC167132.12        120611-120734
            1136-1497           AC167132.12        124912-125273
            1498-1604           AC167132.12        129527-129633
            1605-1782           AC167132.12        130071-130248
            1783-1889           AC167132.12        130406-130512
            1890-2035           AC167132.12        131189-131334
            2036-2165           AC167132.12        131597-131726
            2166-2707           AC167132.12        131881-132422
FEATURES             Location/Qualifiers
     source          1..2707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..2707
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /note="SURP and G patch domain containing 1"
                     /db_xref="GeneID:70616"
                     /db_xref="MGI:MGI:1917866"
     exon            1..294
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2192
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /note="splicing factor 4"
                     /codon_start=1
                     /product="SURP and G-patch domain-containing protein 1"
                     /protein_id="NP_081757.1"
                     /db_xref="CCDS:CCDS22356.1"
                     /db_xref="GeneID:70616"
                     /db_xref="MGI:MGI:1917866"
                     /translation="MSLKMDNRDVAGKANRWFGMAQPKSGKMNMNILHQEELIAQKKR
                     EIEARMEQKARQSHVPSPQPPHPGEIADAHNSCISNKFANDGSFLQQFLKLQKAQTST
                     DSAPRAPPSMPTPSSLKKPLVLSKRTGLGLSSPTGPVKNYSHAKQLPVAHRPSVFQSP
                     DDDEEEDYEQWLEIKVSPPEGAETRRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTF
                     LHDKNSREFLYYRRKVAEIRKEAQKPQAATQKVSPPEDEEAKNLAEKLARFIADGGPE
                     VETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEFRKAKAGSTGSFPAPAPNPSLRR
                     KSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKV
                     ELPPAELAQRDIDASPSPLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQ
                     QMYDMIMQHKRAMQDMQLLWEKALQQHQHGYDSDEEVDSELGTWEHQLRRMEMDKTRE
                     WAEQLTQMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVENIGYQ
                     MLMKMGWKEGEGLGTEGQGIKNPVNKGATTIDGAGFGIDRPAELSKEDDEYEAFRKRM
                     MLAYRFRPNPLNNPRRPYY"
     exon            295..466
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            467..567
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            568..786
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            787..910
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1011
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1135
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1497
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1604
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1782
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1889
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2035
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2165
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2707
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2295..2300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /note="hexamer: ATTAAA"
     polyA_site      2317
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /note="major polyA site"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
                     /note="hexamer: GATAAA"
     polyA_site      2707
                     /gene="Sugp1"
                     /gene_synonym="5730496N02Rik; Sf4"
ORIGIN      
        1 acttctgggt cttatggtgt gtgttcgaag tggctccgac tgaggaagac tctgaggaga
       61 ggatgatacc tctgcatcat cgtaactgag agtaatacac gttcgtgaac tgacgccggc
      121 gtttctgtgg agaagacgcc cggtgtccta gaagggggtt ggacgagatt gtcggagaag
      181 gactacattt accatcagac caagcgcact ataacagagc ctccctcttc tcaggtggcg
      241 ccggagcatt gtgggattgg atgagtctca agatggacaa ccgggatgtt gcaggaaagg
      301 ccaatcggtg gtttgggatg gcacaaccca agtctggaaa gatgaatatg aacatcctcc
      361 accaggaaga gcttattgct cagaagaagc gggagattga ggccagaatg gaacaaaagg
      421 ccagacagag tcatgtgccc agtccacagc cccctcatcc tggagaaatt gctgatgcac
      481 ataactcctg catctccaac aagtttgcca atgatggcag cttcctgcag cagtttctga
      541 agttacagaa ggcacagaca agcacagatt cagcccccag ggcccctccc agcatgccaa
      601 cacccagctc cttgaagaaa ccccttgtgc tcagcaagcg aacaggcctg ggactgagta
      661 gcccaacggg tcctgtgaag aactactcac atgccaaaca gctgcctgtt gcacaccgcc
      721 cgagtgtctt ccagtcccct gatgatgatg aggaggagga ctatgagcag tggctggaaa
      781 tcaaagtttc acccccagag ggagccgaga ctcggagagt gatagagaag ctggcccgtt
      841 ttgtggcaga aggaggcccc gagctagaga aagtagctat ggaggactac aaggataacc
      901 cggccttcac atttttacat gataagaata gcagggaatt cctgtactac agaaggaagg
      961 tagccgagat caggaaagaa gcccaaaagc cacaggcagc cacccagaaa gtttcacccc
     1021 cagaggatga agaggccaag aaccttgcag aaaagttggc caggttcata gcagacgggg
     1081 gtccagaagt ggagaccatc gccctccaga acaaccgtga gaatcaggcc ttcagttttc
     1141 tctatgatcc caacagccaa gggtacagat actacaggca aaagctagat gagttccgga
     1201 aagccaaggc gggctccaca ggctccttcc ctgctcctgc tcccaacccc agcctgcggc
     1261 gaaagtctgc cccagaagcc ctgtcagggg ctgtgccccc catcactgcc tgccccactc
     1321 cagtggcccc agcacctgct gtcaacccca ctccatccat ccctgggaag cccaccgcca
     1381 cagccgctgt gaagaggaag cggaagagcc ggtgggggcc tgaagaggac aaagtggagc
     1441 ttccacctgc tgaactggca cagagggaca tagatgcctc accttcacct ctttcagttc
     1501 aggatctcaa agggcttggc tatgagaagg ggaaacctgt gggcctggtg ggtgtcacag
     1561 agctgtctga tgcacaaaag aagcagctga aggagcagca ggagatgcag cagatgtatg
     1621 acatgattat gcagcacaag cgcgccatgc aagacatgca gcttctgtgg gagaaggcgc
     1681 tgcagcaaca ccagcatggc tatgacagtg atgaggaggt agacagtgaa ctgggcacct
     1741 gggagcacca gctgcgacgc atggagatgg acaagacacg ggagtgggca gagcagctga
     1801 cacagatggg tcggggcaag cacttcatcg gtgactttct gccccctgat gagctggaga
     1861 agttcatgga gaccttcaag gccctgaagg agggcagaga gccagactac tcagaatata
     1921 aggagtttaa gctgacggtg gaaaacattg gctaccagat gctcatgaag atgggctgga
     1981 aagagggcga ggggctgggc actgagggcc agggcatcaa gaacccagtg aacaagggtg
     2041 ccaccacaat agatggagct ggctttggca tcgaccggcc agctgaactc tccaaggagg
     2101 atgatgagta cgaggccttc cgcaagagga tgatgctggc ctaccgattc cggcccaacc
     2161 cgctgaacaa ccccagacgg ccctactact gaatattctg gaaacacaaa gtctacattc
     2221 agatcggcca tccttggact atgaaatgtt ctggcatcca tctctatcct gtggtcacaa
     2281 gtgttgtgct gtgtattaaa gtcccaatgc tcacctgtcc agcattccag ttcctgctgt
     2341 tgccagaaac ctcttttgtc cctcctccag tcccactgag gctcattgag ttcacagtaa
     2401 ctggagacca gccagttgat tcagacttta ccccaggcag aggaaaaaga ggcttccaaa
     2461 cacttcatga tatgtgcatg ggctggtgtg gactgggcac agctggagta tgggtagggc
     2521 ctgtctagag gcagaggcct gggctgtctc atgtattgct cactgcatag ctgcaagagc
     2581 ccagctggag cccgtgatgg tcaatctttg cagcttcatc ccatttgtgc tgccctggat
     2641 cctccccaga cctctccagc tagtcaaagt cctcaagaga ataagaatga taaatctgag
     2701 tactcca
//
