LOCUS       NM_001025391            4522 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus SUFU negative regulator of hedgehog signaling (Sufu),
            transcript variant 2, mRNA.
ACCESSION   NM_001025391
VERSION     NM_001025391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4522)
  AUTHORS   Havrylov,S., Chrystal,P., van Baarle,S., French,C.R.,
            MacDonald,I.M., Avasarala,J., Rogers,R.C., Berry,F.B., Kume,T.,
            Waskiewicz,A.J. and Lehmann,O.J.
  TITLE     Pleiotropy in FOXC1-attributable phenotypes involves altered
            ciliation and cilia-dependent signaling
  JOURNAL   Sci Rep 14 (1), 20278 (2024)
   PUBMED   39217245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4522)
  AUTHORS   Qin,T., So,K.K.H., Hui,C.C. and Sham,M.H.
  TITLE     Ptch1 is essential for cochlear marginal cell differentiation and
            stria vascularis formation
  JOURNAL   Cell Rep 43 (4), 114083 (2024)
   PUBMED   38602877
REFERENCE   3  (bases 1 to 4522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4522)
  AUTHORS   Han,B., Wang,Y., Yue,S., Zhang,Y.H., Kuang,L., Gao,B.B., Wang,Y.,
            Zhang,Z., Pu,X., Wang,X.F., Hui,C.C., Yu,T.T., Liu,C. and
            Cheng,S.Y.
  TITLE     Increasing Sufu gene dosage reveals its unorthodox role in
            promoting polydactyly and medulloblastoma tumorigenesis
  JOURNAL   JCI Insight 9 (6), e176044 (2024)
   PUBMED   38358805
  REMARK    GeneRIF: Increasing Sufu gene dosage reveals its unorthodox role in
            promoting polydactyly and medulloblastoma tumorigenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4522)
  AUTHORS   Wang,W., Li,F., Wang,J., Liu,Z., Tian,M., Wang,Z., Li,H., Qu,J.,
            Chen,Y. and Hou,L.
  TITLE     Disrupting Hedgehog signaling in melanocytes by SUFU knockout leads
            to ocular melanocytosis and anterior segment malformation
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37577930
  REMARK    GeneRIF: Disrupting Hedgehog signaling in melanocytes by SUFU
            knockout leads to ocular melanocytosis and anterior segment
            malformation.
REFERENCE   6  (bases 1 to 4522)
  AUTHORS   Simon-Chazottes,D., Paces-Fessy,M., Lamour-Isnard,C., Guenet,J.L.
            and Blanchet-Tournier,M.F.
  TITLE     Genomic organization, chromosomal assignment, and expression
            analysis of the mouse suppressor of fused gene (Sufu) coding a Gli
            protein partner
  JOURNAL   Mamm Genome 11 (8), 614-621 (2000)
   PUBMED   10920228
REFERENCE   7  (bases 1 to 4522)
  AUTHORS   Stone,D.M., Murone,M., Luoh,S., Ye,W., Armanini,M.P., Gurney,A.,
            Phillips,H., Brush,J., Goddard,A., de Sauvage,F.J. and Rosenthal,A.
  TITLE     Characterization of the human suppressor of fused, a negative
            regulator of the zinc-finger transcription factor Gli
  JOURNAL   J Cell Sci 112 (Pt 23), 4437-4448 (1999)
   PUBMED   10564661
REFERENCE   8  (bases 1 to 4522)
  AUTHORS   Ding,Q., Fukami,Si., Meng,X., Nishizaki,Y., Zhang,X., Sasaki,H.,
            Dlugosz,A., Nakafuku,M. and Hui,Cc.
  TITLE     Mouse suppressor of fused is a negative regulator of sonic hedgehog
            signaling and alters the subcellular distribution of Gli1
  JOURNAL   Curr Biol 9 (19), 1119-1122 (1999)
   PUBMED   10531011
REFERENCE   9  (bases 1 to 4522)
  AUTHORS   Pearse,R.V. 2nd, Collier,L.S., Scott,M.P. and Tabin,C.J.
  TITLE     Vertebrate homologs of Drosophila suppressor of fused interact with
            the gli family of transcriptional regulators
  JOURNAL   Dev Biol 212 (2), 323-336 (1999)
   PUBMED   10433824
REFERENCE   10 (bases 1 to 4522)
  AUTHORS   Delattre,M., Briand,S., Paces-Fessy,M. and Blanchet-Tournier,M.F.
  TITLE     The Suppressor of fused gene, involved in Hedgehog signal
            transduction in Drosophila, is conserved in mammals
  JOURNAL   Dev Genes Evol 209 (5), 294-300 (1999)
   PUBMED   11252182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114539.8, AK016976.1, AJ308626.1, BC048168.1 and BB732695.1.
            
            On Nov 8, 2013 this sequence version replaced NM_001025391.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056997.1, AJ131692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC114539.8         166560-166581
            23-66               AK016976.1         2-45
            67-2127             AJ308626.1         1-2061
            2128-4517           BC048168.1         2101-4490
            4518-4522           BB732695.1         437-441
FEATURES             Location/Qualifiers
     source          1..4522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.85 cM"
     gene            1..4522
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /note="SUFU negative regulator of hedgehog signaling"
                     /db_xref="GeneID:24069"
                     /db_xref="MGI:MGI:1345643"
     exon            1..389
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1662
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /note="isoform 2 is encoded by transcript variant 2;
                     suppressor of fused homolog"
                     /codon_start=1
                     /product="suppressor of fused homolog isoform 2"
                     /protein_id="NP_001020562.1"
                     /db_xref="CCDS:CCDS29879.1"
                     /db_xref="GeneID:24069"
                     /db_xref="MGI:MGI:1345643"
                     /translation="MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRL
                     YPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDN
                     RVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDH
                     VSWHSPLDNSESRIQHMLLTEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQG
                     ILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWD
                     DLSRPPEDEEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNG
                     LTHDRAPSRKDSLGSDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHG
                     RHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDL
                     TSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH"
     exon            390..524
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            525..661
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            662..804
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            805..890
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            891..963
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1117
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1229
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1364
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1503
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1572
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..4522
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4499..4504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /note="hexamer: ATTAAA"
     polyA_site      4514
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
     polyA_site      4517
                     /gene="Sufu"
                     /gene_synonym="Su(fu)"
                     /note="major polyA site"
ORIGIN      
        1 gagctccccg cggtcccaca gcatcctctg gccgacgtct tgaaggctcc ggcttgggcg
       61 gacggagcct cgtgcgcagg cgcggagtta gacctcgccg tagcccccat cgcctcgggg
      121 agtctcatcc acagtgggtc cgctggccca taggggcgct ttccctcctc taccctcccg
      181 ggttctccgc gcgccctacg cgccccaatg gcggagctgc ggcctagcgt cgcccccggt
      241 cccgccgcgc ccccggcctc tggccctagt gcccctccgg cctttgcttc actctttccc
      301 ccgggactgc acgccatcta cggagagtgt cgccgcctct accctgacca gccgaacccg
      361 ctccaggtta ccgctatcgt caagtactgg ttgggtggtc cggacccctt ggactatgtt
      421 agcatgtaca ggaacatggg gagtccttct gccaacatcc ctgagcactg gcactacatc
      481 agctttggcc tgagtgatct ctatggtgac aacagagtcc atgagtttac aggaacagac
      541 ggaccaagtg gatttggctt tgagttgacg tttcgtctga agagagaaac tggggagtct
      601 gccccaccaa catggccagc agagctgatg cagggcctag cccgatatgt cttccagtca
      661 gagaacacct tctgtagcgg ggaccatgtg tcttggcaca gccctttgga taacagtgag
      721 tcaagaattc agcacatgct gctgacggag gacccacaga tgcagcctgt gcggacaccc
      781 tttggggtag tgactttcct ccagattgtt ggtgtctgca ctgaggagtt acattcagcc
      841 caacagtgga acgggcaggg catcctggaa ctactacgga cagtgcccat tgctggcggt
      901 ccctggctga taactgacat gcggcgggga gaaaccatat ttgagatcga tccgcacctg
      961 caagagagag ttgacaaagg cattgagaca gacggttcta acctgagcgg cgtcagtgcc
     1021 aagtgtgcct gggatgacct cagccggcct ccggaggatg aagaggatag ccggagcatc
     1081 tgcctcggca cacagcctcg gaggctgtct ggcaaagaca cagagcagat ccgggagacc
     1141 ctgaggcggg gactggagat taacagcaaa cctgtccttc caccaatcaa ttctcagcga
     1201 cagaacggcc tcacccacga cagggctccg agccgcaagg acagtttggg cagcgacagc
     1261 tccacggcca tcatccccca cgagctgatc cgcacacggc agctcgagag cgtgcatcta
     1321 aaatttaacc aagagtcggg agccctcatc cctctctgcc taaggggcag actcctacat
     1381 ggccggcact tcacctacaa gagtatcaca ggcgacatgg ccatcacgtt tgtgtccacg
     1441 ggagtggaag gcgcctttgc cactgaggaa cacccgtatg cagctcacgg accctggtta
     1501 caaattctgt tgacagaaga gtttgtagag aagatgttgg aggacttaga agatctaacc
     1561 tctccagagg aatttaaact tcccaaagag tacagctggc ctgagaagaa actcaaagtg
     1621 tccattctcc ccgacgtggt gttcgacagt ccactgcact agcctgggct gtgccctgca
     1681 ggggccaaga ggagcccagc tgctcctggt gacttccagt gtgacagctt gtaaaggaga
     1741 cacccatgaa taaaagggca agtgtgggga tgactgcaga gtgccacacc catcccaggc
     1801 cccacccacc tcgggcccag gggcctcact cctagcagcc cagcccgagt gaccaggccc
     1861 ctgtcctaca cgccagtgag ggggtgagat gcacctgaaa accctccaca ccgacccgct
     1921 gctgccacag gtctcactgt tgtgctcctg gaacgggaca gccttgccag acagcctggt
     1981 gggtagaaca tgcatgagga cgcactgcct ggtcaacccc agccagcttt ccctcagtca
     2041 ggctgctcca ccctgccgaa tgattgttct ttttcttgtg gaaaccggat ggtattttta
     2101 ttgctcagca aagatggtgc agaagccatg tacatagtga tttttaaata ggactcattc
     2161 ctacctgaac tttattgtcc tttagacaag ggtctggggg ctcccccccc cccacagatc
     2221 ccacatgccc tcttcctgaa aagatgcttg gtgctgcctg tcagctctgg accctggagg
     2281 aggctgggga cagctgacat actccatgca gccctgggta gagattggct gtggcctgga
     2341 aggtgtgcta ttgccttcca agcgaagtaa gtctctacaa ggctctgggg acttcaggga
     2401 ctcaaggaca cgtggcccta gctatgtctt cctaaccagg tctcccaaga agagggtaaa
     2461 gcccactgcc tccccatcct cctgctcagg gcccccagct ctttggtccc cctcccttgg
     2521 agtcccagcc cctgggctgt ctagcttatg aaaaactgag aaccaacctc tctctccaca
     2581 gctctccctt tggttttgct gacactgctc cctgtggccc ttcctctttc tcacatccat
     2641 tctgtcccca tctcccgtcg ctgtctcttc ctgtagcctg gccctcttgt gggtgccatg
     2701 ctgtcacctc caggactgca gagcttcctg cctcccaggg aaggcacctt tgtgagctgc
     2761 agaggagaga gctcccactt ctgacctgga actggcaagt gcctttcctg cattcttgcc
     2821 tgcctgcctc taggtcaatg gtctttgttc attctttaga ttcaaatgtc tccaaaggaa
     2881 agatatgttg tctggcagga accttaaaag agctcctctg ctctgcctgc ctccactgcc
     2941 tacaacgggt gcctccaggg gccttgagaa ctctggctgg ggtcgcaaag aagcagaaat
     3001 tggcctttga aggaatggct cgatctggcc tcatctgcat atcctaggtc taagctcacc
     3061 tagcacttag aggcagaccc ttcaggagca tccgagaggc tggctgcaga cccagccagc
     3121 cagatagaaa gcctgtctgg agcagacacc acactgccct gggaactttc cacaaggaca
     3181 tctccagcca tactcttgtc ttctgaaagt ttatgggcca cgagatgcta tcagccttgc
     3241 ctctgttcct tgccatcacc agtgttgtaa cagccccccc ctccctaatt ctctccggtg
     3301 gtgacccggc tcagggcccc tctgcattct cccctatctc aatttgtctg gcctgggggc
     3361 aggaatgcat gctctgagca ccacatcaca gagttagtgt tggtatgtta gtacatgaga
     3421 gtcctggtca acaacctgcc ctccatctac aaggtctttg cagactggtg gttaccacca
     3481 cctgcttggg tggctccatt cttggggagc agggaatggc aggtaagctc tagatgttca
     3541 caggcccaga ggtctttcct gcttccaccc tgtcaggaac ctcaggaatg tctaaactcc
     3601 tgctgggacc agaccctgtc attcctgtgc aatggctcta ggagagtggc taaactcagc
     3661 ctggtctgac caggcctcct ttccctgggg ctctggtttc ttccagagaa atctcaggga
     3721 aagaggttca ccacatcgga tgaaacaaga ctgcccttac tgtgacatgt gatgggtgct
     3781 ctgtagaggg acccttcctt cccctccctg cagcagctct gtggggttaa cccatcacgg
     3841 ggagggatcc aggagtcttc ctcactggct ccacagactt cctcagcctt tccccaccct
     3901 tcaaccttcc aactccacag gaccagagat tctgaaagga agggacttcg actttctgta
     3961 actaaaactt cctggggcct gtgtgggctg ccgagggtgg cagtgccggc tgccatgctg
     4021 gtgaaacatg ttcctccttt tctaagtgtg acactccagc agggcctgta gaagctctgg
     4081 ggagtctaaa gggctaggat acatacacgc cagaccctgg agccggggct tgggttttga
     4141 gattgagagc tgggagagaa cctgaagatt ggtgccccta tggggcagat cagaaaactc
     4201 cctcagcggt atttttttaa cctggtcttc cctctctggc ttccatgatc ttggtgccag
     4261 gcgaggtgtc tgggtccctg ttacaagtca ggagccctgt caggagaccc acttcttttg
     4321 tacaaagatc tgaatgctgc aatgaacaga cttttgtaca tttttatatc agtttttaat
     4381 gtcagtggcg actcagttcc tggggctaca gctggctcag gatttttgta agaaattttg
     4441 agtgactcac ttagattttg ttcctacttg tccctcttcc tctgtgtaat ctaagtgcat
     4501 taaacatatc tgcagaagtg cc
//
