LOCUS       NM_178622               2422 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus suppressor of defective silencing 3 homolog (S.
            cerevisiae) (Suds3), transcript variant 1, mRNA.
ACCESSION   NM_178622
VERSION     NM_178622.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Shen,J., Lai,W., Li,Z., Zhu,W., Bai,X., Yang,Z., Wang,Q. and Ji,J.
  TITLE     SDS3 regulates microglial inflammation by modulating the expression
            of the upstream kinase ASK1 in the p38 MAPK signaling pathway
  JOURNAL   Inflamm Res 73 (9), 1547-1564 (2024)
   PUBMED   39008037
  REMARK    GeneRIF: SDS3 regulates microglial inflammation by modulating the
            expression of the upstream kinase ASK1 in the p38 MAPK signaling
            pathway.
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   3  (bases 1 to 2422)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2422)
  AUTHORS   Zhang,K., Dai,X., Wallingford,M.C. and Mager,J.
  TITLE     Depletion of Suds3 reveals an essential role in early lineage
            specification
  JOURNAL   Dev Biol 373 (2), 359-372 (2013)
   PUBMED   23123966
  REMARK    GeneRIF: These data define a role for Suds3 in activation of
            FGF4/ERK signaling.
REFERENCE   5  (bases 1 to 2422)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
REFERENCE   6  (bases 1 to 2422)
  AUTHORS   David,G., Turner,G.M., Yao,Y., Protopopov,A. and DePinho,R.A.
  TITLE     mSin3-associated protein, mSds3, is essential for pericentric
            heterochromatin formation and chromosome segregation in mammalian
            cells
  JOURNAL   Genes Dev 17 (19), 2396-2405 (2003)
   PUBMED   14522945
  REMARK    GeneRIF: mSds3 and its associated mSin3/HDAC components play a
            central role in initiating the cascade of pericentric
            heterochromatin-specific modifications necessary for the proper
            distribution of chromosomes during cell division in mammalian
            cells.
REFERENCE   7  (bases 1 to 2422)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2422)
  AUTHORS   Alland,L., David,G., Shen-Li,H., Potes,J., Muhle,R., Lee,H.C.,
            Hou,H. Jr., Chen,K. and DePinho,R.A.
  TITLE     Identification of mammalian Sds3 as an integral component of the
            Sin3/histone deacetylase corepressor complex
  JOURNAL   Mol Cell Biol 22 (8), 2743-2750 (2002)
   PUBMED   11909966
REFERENCE   9  (bases 1 to 2422)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 2422)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ094124.1, BC055764.1 and AV338433.1.
            
            On Oct 19, 2013 this sequence version replaced NM_178622.4.
            
            Transcript Variant: This variant (1) differs in the 3' coding
            region and the 3' UTR, compared to variant 2. It encodes isoform a,
            which has a shorter and distinct C-terminus, compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055764.1, AK045475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                CJ094124.1         7-53
            48-2420             BC055764.1         1-2373
            2421-2422           AV338433.1         224-225
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.88 cM"
     gene            1..2422
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /note="suppressor of defective silencing 3 homolog (S.
                     cerevisiae)"
                     /db_xref="GeneID:71954"
                     /db_xref="MGI:MGI:1919204"
     exon            1..322
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..392
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..448
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..520
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..540
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..697
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..793
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..855
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            856..877
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..983
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1068
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..2422
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1644..1649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /note="hexamer: AATAAA"
     polyA_site      1663
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /note="hexamer: GATAAA"
     polyA_site      2420
                     /gene="Suds3"
                     /gene_synonym="2400003N08Rik; 2410008L21Rik; mSds3"
                     /note="major polyA site"
ORIGIN      
        1 cgcgaggccc ccgttgccca gcgcgggcgc cggggtgcgg ggtggggggc ggagctcgga
       61 gccgagggga gtcccggtgc ccgcggctcg gaaccgcgcg aggttgcggg gctccgggga
      121 cgcagccagg cggccgcgat ctccgcggga ccggctccgc cgcggccccg aggcggcgac
      181 atgagcgccg cggggctgct ggctccggcg ccggctccgg ctgcagcgcc ggccgccccg
      241 gagtactacc cggaggacga ggaggagttg gagagcgccg aggacgacga gcgcagctgc
      301 cggggccgag agtccgacga agacaccgag gatgccagcg agactgacct ggcgaagcac
      361 gatgaggaag actacgtgga gatgaaggaa cagatgtatc aggacaaact ggcatctttg
      421 aagaggcagc tgcaacagct tcaggaaggt acgctccagg aatatcagaa acggatgaag
      481 aaactggacc agcagtaccg agagcggatc cggaatgcag agctcttcct ccagctggaa
      541 acggaacagg tggagaggaa ttacattaaa gagaagaagg cggccgtgaa ggagtttgaa
      601 gacaagaagg tggagctgaa ggagaacctg attgccgagc tggaggagaa gaagaagatg
      661 atcgagaacg agaaactcac catggagctg actggagatt ctatggaagt gaaacccatc
      721 atgaccagaa aattgcggag gcgaccaaac gatcctgtcc ccattccaga caagaggaga
      781 aaaccggctc ctgctcagct gaactacttg ctaacagacg agcagatcat ggaggacctg
      841 aggacgctga acaagcttaa gtcacccaag agaccagctt ccccatcctc tcctgaacac
      901 ttgcctgcca cacctgcaga gtctccagcc cagaggtttg aggctcggat agaagatggc
      961 aaactgtact atgataagag atggtaccac aagagccagg ccatctacct ggaatctaag
     1021 gacaaccaga agctgagctg tgtgatcagc tcagtgggag ccaacgagat ctgggtgagg
     1081 aagaccagcg acagcaccaa gatgcggatc tacgtgggcc agctgcagcg tgggctcttc
     1141 gtgatccgcc ggcggtcagc ggcttgactt tctacgagct tcctcctccc ttgacccctt
     1201 ctctggagtg gtttttattt ttgttttgtt ttcttcttaa tagaaaattc ttaacttacc
     1261 gggactagct ccttggcctg ggacatgggg agcactgtgg agtcttcagg gcgctcacat
     1321 ggccgccacc tccatctctg tgccgctctc tcctgcctcg gcctcttcca gaactcagtc
     1381 accagagaga ctcttgcttt cggagtagag gggttcaccc accttccttg aattcctctc
     1441 ttgtctcgtt ttgtttatac ttgatccttt tttcagacct cctttgagtt tgaagggaag
     1501 ctcgttttaa caattatctt taggcctttg aagagcagca ggtatgcttt cccgcctaat
     1561 ctgctgggca gattgtgtgc ctgcctgccg agttgggccc ggaagcatgg ggcagggttc
     1621 tcctggctcc actttcttgg agaaataaat gatatagaac atctatctgc cttgggcttc
     1681 tactccaatg actgcgtgag tgtcttcacc ctggacactg cagccaacgg atggggctgg
     1741 gggtggggga gaggggtggc atgtccctaa catgctaagt cactgctctg agcagtttcc
     1801 agcgaacacg attcatttag gtatgcccgt ccttgttcag ggtggaagaa gtgggaattc
     1861 cagaggtctc cgtctgtaac tcctctggct cccagtggct acaaggatct catcacgtgc
     1921 cctactgtga tgtgggttct cccttcccca tagctgcggt ggcaaggtgg gtgcctcgct
     1981 cttgcagctg gacccactgc agtactggac cgctcaatat cgaagaacct ccagcctccc
     2041 ccgaggtttg tcccacgtta gtgacaagga gagctctgtc atgctgcagc tgccaagtct
     2101 gcgtgctgct tgagccccag cgaagccacc tgccatggcc ctcttgctcc ctgggcctct
     2161 tattggagaa atgactggtg tggctgagca ggagattcct tctgctctag ccgccacagg
     2221 ccacgagaga agaagcggat ccgagcgact gtcaccatct cggggcaatc agtaggctgt
     2281 ccacaccttg ttttgctgtg ggtgtgggga gccacaggaa gtcgtgtgcc tccacggaag
     2341 actgtacaga atcactttgt ttatggccgc tctcccattg gattcttaag aaaacaggat
     2401 aaacaatgtt tattcactaa gt
//
