LOCUS       NM_032400               1571 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus succinate receptor 1 (Sucnr1), mRNA.
ACCESSION   NM_032400
VERSION     NM_032400.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Gerrick,E.R., Zlitni,S., West,P.T., Carter,M.M., Mechler,C.M.,
            Olm,M.R., Caffrey,E.B., Li,J.A., Higginbottom,S.K., Severyn,C.J.,
            Kracke,F., Spormann,A.M., Sonnenburg,J.L., Bhatt,A.S. and
            Howitt,M.R.
  TITLE     Metabolic diversity in commensal protists regulates intestinal
            immunity and trans-kingdom competition
  JOURNAL   Cell 187 (1), 62-78 (2024)
   PUBMED   38096822
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Griepke,S., Trauelsen,M., Nilsson,M.D., Hansen,J., Steffensen,L.B.,
            Schwartz,T.W. and Ketelhuth,D.F.J.
  TITLE     G-Protein-Coupled Receptor 91-Dependent Signalling Does Not
            Influence Vascular Inflammation and Atherosclerosis in
            Hyperlipidaemic Mice
  JOURNAL   Cells 12 (21), 2580 (2023)
   PUBMED   37947659
  REMARK    GeneRIF: G-Protein-Coupled Receptor 91-Dependent Signalling Does
            Not Influence Vascular Inflammation and Atherosclerosis in
            Hyperlipidaemic Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Perniss,A., Boonen,B., Tonack,S., Thiel,M., Poharkar,K.,
            Alnouri,M.W., Keshavarz,M., Papadakis,T., Wiegand,S., Pfeil,U.,
            Richter,K., Althaus,M., Oberwinkler,J., Schutz,B., Boehm,U.,
            Offermanns,S., Leinders-Zufall,T., Zufall,F. and Kummer,W.
  TITLE     A succinate/SUCNR1-brush cell defense program in the tracheal
            epithelium
  JOURNAL   Sci Adv 9 (31), eadg8842 (2023)
   PUBMED   37531421
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Marsal-Beltran,A., Rodriguez-Castellano,A., Astiarraga,B.,
            Calvo,E., Rada,P., Madeira,A., Rodriguez-Pena,M.M., Llaurado,G.,
            Nunez-Roa,C., Gomez-Santos,B., Maymo-Masip,E., Bosch,R.,
            Frutos,M.D., Moreno-Navarrete,J.M., Ramos-Molina,B., Aspichueta,P.,
            Joven,J., Fernandez-Real,J.M., Quer,J.C., Valverde,A.M., Pardo,A.,
            Vendrell,J., Ceperuelo-Mallafre,V. and Fernandez-Veledo,S.
  TITLE     Protective effects of the succinate/SUCNR1 axis on damaged
            hepatocytes in NAFLD
  JOURNAL   Metabolism 145, 155630 (2023)
   PUBMED   37315889
  REMARK    GeneRIF: Protective effects of the succinate/SUCNR1 axis on damaged
            hepatocytes in NAFLD.
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Vargas,S.L., Toma,I., Kang,J.J., Meer,E.J. and Peti-Peterdi,J.
  TITLE     Activation of the succinate receptor GPR91 in macula densa cells
            causes renin release
  JOURNAL   J Am Soc Nephrol 20 (5), 1002-1011 (2009)
   PUBMED   19389848
  REMARK    GeneRIF: Macul densa cells can sense alterations in local tissue
            metabolism via accumulation of tubular succinate and GPR91
            signaling.
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Rubic,T., Lametschwandtner,G., Jost,S., Hinteregger,S., Kund,J.,
            Carballido-Perrig,N., Schwarzler,C., Junt,T., Voshol,H.,
            Meingassner,J.G., Mao,X., Werner,G., Rot,A. and Carballido,J.M.
  TITLE     Triggering the succinate receptor GPR91 on dendritic cells enhances
            immunity
  JOURNAL   Nat Immunol 9 (11), 1261-1269 (2008)
   PUBMED   18820681
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Toma,I., Kang,J.J., Sipos,A., Vargas,S., Bansal,E., Hanner,F.,
            Meer,E. and Peti-Peterdi,J.
  TITLE     Succinate receptor GPR91 provides a direct link between high
            glucose levels and renin release in murine and rabbit kidney
  JOURNAL   J Clin Invest 118 (7), 2526-2534 (2008)
   PUBMED   18535668
  REMARK    GeneRIF: Release of the prohypertensive hormone renin by the
            kidney, triggered by high levels of glucose, is mediated by a
            succinate / GPR91 paracrine signaling cascade in the glomerular
            endothelium.
REFERENCE   9  (bases 1 to 1571)
  AUTHORS   He,W., Miao,F.J., Lin,D.C., Schwandner,R.T., Wang,Z., Gao,J.,
            Chen,J.L., Tian,H. and Ling,L.
  TITLE     Citric acid cycle intermediates as ligands for orphan
            G-protein-coupled receptors
  JOURNAL   Nature 429 (6988), 188-193 (2004)
   PUBMED   15141213
  REMARK    GeneRIF: GPR91, a previously orphan G-protein-coupled receptor,
            functions as a receptor for the citric acid cycle intermediate
            succinate
REFERENCE   10 (bases 1 to 1571)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB864882.1, BC096665.1 and AK080866.1.
            
            On Jul 25, 2009 this sequence version replaced NM_032400.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080866.1, AF295367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               BB864882.1         5-400
            397-755             BC096665.1         370-728
            756-1571            AK080866.1         770-1585
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.17 cM"
     gene            1..1571
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /note="succinate receptor 1"
                     /db_xref="GeneID:84112"
                     /db_xref="MGI:MGI:1934135"
     exon            1..60
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /inference="alignment:Splign:2.1.0"
     exon            61..1571
                     /gene="Sucnr1"
                     /gene_synonym="Gpr91"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagctgtc tccagctcct ggcagagttt tctgtcgaga cagaagccga cagcagaatg
       61 gcacagaatt tatcttgtga gaattggttg gcaacagagg ctatcttgaa taagtactac
      121 ctctctgcat tttatgcaat cgagttcatt tttggactgc ttgggaatgt cactgtggtg
      181 tttggctacc tcttctgcat gaagaactgg aacagcagca atgtctatct ttttaacctt
      241 tccatctctg actttgcttt cctgtgcacc cttcccatcc tgataaagag ttatgccaat
      301 gataagggga cctatggaga tgttctctgt ataagcaacc gatatgtgct tcacaccaac
      361 ctctacacca gcatcctctt cctcactttc attagcatgg accgatatct gctcatgaag
      421 taccctttcc gagaacactt tctacaaaag aaggaatttg ccattttaat ctcgctggct
      481 gtctgggcct tagtgacctt agaagttcta cccatgctca ctttcatcaa ttctgtccca
      541 aaagaagagg gcagtaactg catcgactat gcaagttctg gaaaccctga acacaatctc
      601 atttacagcc tctgcctgac tttgttgggc ttcctaattc ctctctctgt gatgtgcttc
      661 ttctactaca agatggtagt cttcttaaag aggaggagcc agcagcaagc aactgccctg
      721 ccactggaca aaccccaacg cctggtggtc ctggcagttg tgatcttctc tatactcttc
      781 acaccctatc atatcatgcg caatttgagg atcgcctcac gcctggatag ttggccacaa
      841 ggatgtacac agaaggccat caaatctata tacacactga cacggcctct ggcctttctg
      901 aacagtgcca tcaatcccat cttctacttc ctcatgggag accattacag agagatgctg
      961 attagtaagt tcagacaata cttcaagtcc cttacatcct tcaggacatg agctgctgga
     1021 tgcaggtctt cactcagcca aaatgagaca cttgataaac agtgctgtgc agttgagttt
     1081 taactaagta aaccaccatt tctaggcttt agctttccac catcctccaa cccccagggc
     1141 tggagtacaa gctgggtcca catgaatcag aaggcagctc tctgttctga ttttaggtta
     1201 tacccagagt atggaaaaaa taaggcatga gaaagcattg acatcttcac ttaagaactg
     1261 aacaaaagag aacaaatatt gtcaatgttt ggacacttag gatctgaaat cttggaaatt
     1321 ttaagacctc tttttctatc agtgtaaaag gaatacaaga tagctagttg caaatgctga
     1381 atgcatttca tcattggtca ggtcgataag cgtgtttctg aaatagtctt atttttattc
     1441 ttgtaatatt aaaatttatg tgaaaaatga atataattca atgtacaaca ttagattttc
     1501 tatttgaaaa ttatatttct tgaaaaaata actgctgtgc ctaaataaat caatataatt
     1561 agtttctctg t
//
