LOCUS       NM_011507               3383 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus succinate-Coenzyme A ligase, GDP-forming, beta subunit
            (Suclg2), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_011507 XM_284754
VERSION     NM_011507.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3383)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   2  (bases 1 to 3383)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3383)
  AUTHORS   Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   4  (bases 1 to 3383)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3383)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3383)
  AUTHORS   Kacso,G., Ravasz,D., Doczi,J., Nemeth,B., Madgar,O., Saada,A.,
            Ilin,P., Miller,C., Ostergaard,E., Iordanov,I., Adams,D.,
            Vargedo,Z., Araki,M., Araki,K., Nakahara,M., Ito,H., Gal,A.,
            Molnar,M.J., Nagy,Z., Patocs,A., Adam-Vizi,V. and Chinopoulos,C.
  TITLE     Two transgenic mouse models for beta-subunit components of
            succinate-CoA ligase yielding pleiotropic metabolic alterations
  JOURNAL   Biochem J 473 (20), 3463-3485 (2016)
   PUBMED   27496549
REFERENCE   7  (bases 1 to 3383)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3383)
  AUTHORS   Inoue,M., Shima,Y., Miyabayashi,K., Tokunaga,K., Sato,T., Baba,T.,
            Ohkawa,Y., Akiyama,H., Suyama,M. and Morohashi,K.
  TITLE     Isolation and Characterization of Fetal Leydig Progenitor Cells of
            Male Mice
  JOURNAL   Endocrinology 157 (3), 1222-1233 (2016)
   PUBMED   26697723
REFERENCE   9  (bases 1 to 3383)
  AUTHORS   Ramirez,A., van der Flier,W.M., Herold,C., Ramonet,D., Heilmann,S.,
            Lewczuk,P., Popp,J., Lacour,A., Drichel,D., Louwersheimer,E.,
            Kummer,M.P., Cruchaga,C., Hoffmann,P., Teunissen,C., Holstege,H.,
            Kornhuber,J., Peters,O., Naj,A.C., Chouraki,V., Bellenguez,C.,
            Gerrish,A., Heun,R., Frolich,L., Hull,M., Buscemi,L., Herms,S.,
            Kolsch,H., Scheltens,P., Breteler,M.M., Ruther,E., Wiltfang,J.,
            Goate,A., Jessen,F., Maier,W., Heneka,M.T., Becker,T. and
            Nothen,M.M.
  CONSRTM   International Genomics of Alzheimer's Project (IGAP); Alzheimer's
            Disease Neuroimaging Initiative (ADNI)
  TITLE     SUCLG2 identified as both a determinator of CSF Abeta1-42 levels
            and an attenuator of cognitive decline in Alzheimer's disease
  JOURNAL   Hum Mol Genet 23 (24), 6644-6658 (2014)
   PUBMED   25027320
REFERENCE   10 (bases 1 to 3383)
  AUTHORS   Johnson,J.D., Mehus,J.G., Tews,K., Milavetz,B.I. and Lambeth,D.O.
  TITLE     Genetic evidence for the expression of ATP- and GTP-specific
            succinyl-CoA synthetases in multicellular eucaryotes
  JOURNAL   J Biol Chem 273 (42), 27580-27586 (1998)
   PUBMED   9765291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121612.2, AC135018.3 and AC125225.4.
            
            On Aug 7, 2022 this sequence version replaced NM_011507.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045176.1, AK167136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC121612.2         44325-44454         c
            131-272             AC135018.3         35951-36092
            273-372             AC135018.3         95797-95896
            373-463             AC135018.3         96800-96890
            464-616             AC135018.3         102460-102612
            617-706             AC135018.3         104521-104610
            707-803             AC135018.3         112315-112411
            804-965             AC135018.3         121817-121978
            966-1108            AC135018.3         125024-125166
            1109-1229           AC125225.4         6186-6306
            1230-3383           AC125225.4         28739-30892
FEATURES             Location/Qualifiers
     source          1..3383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.63 cM"
     gene            1..3383
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /note="succinate-Coenzyme A ligase, GDP-forming, beta
                     subunit"
                     /db_xref="GeneID:20917"
                     /db_xref="MGI:MGI:1306824"
     exon            1..130
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1345
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /EC_number="6.2.1.4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; succinyl-CoA ligase [GDP-forming] subunit beta,
                     mitochondrial; succinyl-CoA synthetase beta-G chain;
                     GTP-specific succinyl-CoA synthetase beta subunit;
                     succinate--CoA ligase [GDP-forming] subunit beta,
                     mitochondrial"
                     /codon_start=1
                     /product="succinate--CoA ligase [GDP-forming] subunit
                     beta, mitochondrial isoform 1 precursor"
                     /protein_id="NP_035637.2"
                     /db_xref="CCDS:CCDS20381.1"
                     /db_xref="GeneID:20917"
                     /db_xref="MGI:MGI:1306824"
                     /translation="MASPVAIAAQAGKLLRERALRPLLAVRSQAGHLTPRRWLNLQEY
                     QSKKLMSEHGVRVQRFFVANTAKEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLK
                     GGVHLTKDPKVVGELAQQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMD
                     RSHNGPVIVGSPQGGVDIEEVAASSPELIFKEQIDIFEGIKDSQAQRMAENLGFLGSL
                     KNQAADQITKLYHLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFA
                     MDDKSENEPIENEAARYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDL
                     GGGVKEAQVYEAFKLLTSDPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVV
                     RLEGTNVQEAQNILKSSGLPITSAVDLEDAAKKAVASVAKK"
     exon            131..272
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            273..372
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            373..463
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            464..616
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            617..706
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            707..803
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            804..965
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1108
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1229
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..3383
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /note="hexamer: AATAAA"
     polyA_site      2248
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /note="major polyA site"
     regulatory      2651..2656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /note="hexamer: AAGAAA"
     polyA_site      2672
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
                     /note="hexamer: ATTAAA"
     polyA_site      3383
                     /gene="Suclg2"
                     /gene_synonym="D6Wsu120e; G-SCS; GTPSCS; SCS-betaG"
ORIGIN      
        1 ccctccctcc ccctcgccgc ctctcttcag gttcctggtt aagatggcgt ccccggtggc
       61 catcgcggcg caggctggga agcttctgcg agagcgagcg ctgcggccgc tcctggcggt
      121 caggtcccag gccggtcact taaccccccg aagatggctg aacctgcagg agtaccagag
      181 caagaagctc atgtcagagc acggagtgag agtgcagagg ttctttgttg ccaacactgc
      241 taaagaggct ctggaggcag ccaagagatt gaatgcaaaa gaaattgttt taaaagccca
      301 gatcttagct ggaggaagag gaaaaggtgt cttcaatagc ggtttgaaag gaggtgttca
      361 tttaacaaaa gaccctaaag tagtgggaga gttggctcaa cagatgattg gttataatct
      421 agcaacgaaa caaactccaa aagaaggtgt gaaagttaac aaggtgatgg ttgctgaagc
      481 cctggatatt tctagagaaa catacttggc cattctaatg gaccggtccc ataatggccc
      541 tgtgatagtg ggcagtcctc aggggggcgt tgatattgag gaagtggcag cttccagtcc
      601 agaactcatc tttaaggagc agattgacat ctttgaaggg ataaaggata gccaggccca
      661 gcgcatggca gaaaatctgg gcttccttgg gtctctgaaa aaccaggctg cagatcagat
      721 tacaaagctg taccatctct tcctgaagat tgatgccact caggtggaag tgaacccctt
      781 cggtgaaact ccagaaggac aagttgtctg ttttgatgcc aagataaact ttgatgacaa
      841 tgctgagttc cgacaaaagg acatatttgc tatggacgac aaatccgaga atgagcccat
      901 tgaaaatgaa gctgccagat acgatctcaa gtatatagga ctggacggga acattgcctg
      961 cttcgtgaat ggtgctgggc tggccatggc tacctgcgac atcatcttcc tgaacggagg
     1021 gaagccagcg aacttcttgg accttggagg tggtgtaaag gaagcccaag tctatgaagc
     1081 attcaaactg ctcacgtctg accccaaggt ggaagccatt ctcgtcaata tctttggtgg
     1141 gatcgtcaac tgtgccatca ttgccaacgg aatcaccaaa gcctgccggg agctggagct
     1201 caaggtgcca ctggtagtcc ggcttgaagg aactaatgtg caggaggctc agaatatcct
     1261 caagagcagc ggactcccca tcacgtcagc tgtggacctg gaggatgcag ccaagaaagc
     1321 tgttgccagt gtggcaaaga agtgatgctc tccctggctc ccatgaagaa gggcatgtcc
     1381 ctgactactg tgaaagcaat tgttttctca ctgggaaggg acacacacaa ggatcatcat
     1441 gtgaaaaata ttaactctga actttctcaa atacgttatc cagagtgcct aaagctgaat
     1501 ttatactgta gtcattgttt aaaaaaaaaa atcactcctt acaatttcac atcttctctt
     1561 gcccattcag tagcagggtc taccagctct gggccacagt cagtttagcc aaatagtgtg
     1621 catacataca gtatttaaag ccagatctag gttcattcac aagggcattt attctacatt
     1681 agaaaatttt acaggaccct caagttcaga caggctgata tttaacatag tggcttccag
     1741 aagggtacag ctaagacacc tgagcttctg tgaccagtgg cctccactgg cccctaattc
     1801 cagtacatta agaaagccca tgaacatttc taaagtgtgg cttatattgg gcatcccgtg
     1861 ttgatatatg tacattgcac acattttacc ctgtgcctta atgttgaatc tactgtttgc
     1921 ctcacactaa gttactacca gaagccttag tcatgggtgt gaggtggaag gtttcatttt
     1981 gtgtcagagt tgctgaatgt taatctattt cataaagagt cacactaatg atctagctgc
     2041 tggtagcggc caggcttttc cctcttgtcc cctccacctc acatctatca gtttgccaca
     2101 gaaagatgag agatgccatt ggacagaatg tgaccttcct aatgatgtcc ttttttgtga
     2161 caggaatttt cttaacttga tttttttgat ttaattttga taaatttata gtcctataca
     2221 ttttaaataa aattgttttt cagtgctact tagcctcaca gttcttgttt ctgtctgtta
     2281 tctgttcttg tgaagacact agcctctgtg ccagaggcct agctctagtt aagaaactgc
     2341 agttgacccg gattgttcca gcgccacagt gccttgccat gtgaccattt ctgtggtggt
     2401 gattcagtga agggctaaca tgtacacatt agacacaagc ccaggaatct gtccctgacg
     2461 gtggtcaggg tggtgtggtg cagtcacgca ctgtgccgtg tagcaggggc cacgtcggtg
     2521 taacagtctt cccatccgta cgccccggca cagcgagcca cactttattt catgttagcc
     2581 tcacacagtt cacagattga taaaataaaa agtcttcact tgataaatcc acatgtgccg
     2641 tggagaaata aagaaacatc gactagatca aatcctgcgt cttttctcaa acatgacaag
     2701 gagtgaagac tattgacaag gtctttttaa atctcctgtt ttctgatagc tgactaacta
     2761 gtttgcacag ttaaatagaa gtaaatgtgc atttcctcag ttagcaaaca ataaaggaac
     2821 tgtgtctatc ttgtatattg atgtttctaa tcaaccagtt tggaggggaa agaaacgaaa
     2881 gcatacgtgt agttatttta tagaagggtt aatattagtt aataataggc aaatagtttt
     2941 tctcttcaaa tgagcttcct tttctctctc ttcctttctt tctttctctc tttctttcct
     3001 tctttctttc tttctttctt tctttctttc tctctttctc tttttctctc tttctctctc
     3061 tctttttctt tatttctctt tctttctctc tgtctttctt tctgtctgtc tgtctgtctg
     3121 tctttctgtc tttcctcctt tctttctttc tgaagtgcca attgtgtgtg tttggattgc
     3181 tcaaatcccc gatgttgtac cagtatcatg cctgtatcct gaagtgtgtg gaacggaccc
     3241 tgcaatactt agtcatagag aatctgctgc agctatgctg ttggttccta agtcccccta
     3301 tgtgccctac tctggtgtgt cccatgtctt gaatttctta acagcctgta actatataaa
     3361 aatattaaaa tagttacctt tca
//
