LOCUS       NM_019879               1407 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus succinate-CoA ligase, GDP-forming, alpha subunit
            (Suclg1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019879
VERSION     NM_019879.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1407)
  AUTHORS   Yan,W., Xie,C., Sun,S., Zheng,Q., Wang,J., Wang,Z., Man,C.H.,
            Wang,H., Yang,Y., Wang,T., Shi,L., Zhang,S., Huang,C., Xu,S. and
            Wang,Y.P.
  TITLE     SUCLG1 restricts POLRMT succinylation to enhance mitochondrial
            biogenesis and leukemia progression
  JOURNAL   EMBO J 43 (12), 2337-2367 (2024)
   PUBMED   38649537
  REMARK    GeneRIF: SUCLG1 restricts POLRMT succinylation to enhance
            mitochondrial biogenesis and leukemia progression.
REFERENCE   2  (bases 1 to 1407)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 1407)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1407)
  AUTHORS   Mattebo,A., Sen,T., Jassinskaja,M., Pimkova,K., Prieto
            Gonzalez-Albo,I., Alattar,A.G., Ramakrishnan,R., Lang,S., Jaras,M.,
            Hansson,J., Soneji,S., Singbrant,S., van den Akker,E. and
            Flygare,J.
  TITLE     Yippee like 4 (Ypel4) is essential for normal mouse red blood cell
            membrane integrity
  JOURNAL   Sci Rep 11 (1), 15898 (2021)
   PUBMED   34354145
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1407)
  AUTHORS   Ye,A., Kim,H. and Kim,J.
  TITLE     PEG3 control on the mammalian MSL complex
  JOURNAL   PLoS One 12 (6), e0178363 (2017)
   PUBMED   28609438
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1407)
  AUTHORS   Lambeth,D.O., Tews,K.N., Adkins,S., Frohlich,D. and Milavetz,B.I.
  TITLE     Expression of two succinyl-CoA synthetases with different
            nucleotide specificities in mammalian tissues
  JOURNAL   J Biol Chem 279 (35), 36621-36624 (2004)
   PUBMED   15234968
  REMARK    GeneRIF: ADP and GDP succinyl-CoA synthetases have different
            expression patterns and specificity
REFERENCE   7  (bases 1 to 1407)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1407)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1407)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1407)
  AUTHORS   Johnson,J.D., Mehus,J.G., Tews,K., Milavetz,B.I. and Lambeth,D.O.
  TITLE     Genetic evidence for the expression of ATP- and GTP-specific
            succinyl-CoA synthetases in multicellular eucaryotes
  JOURNAL   J Biol Chem 273 (42), 27580-27586 (1998)
   PUBMED   9765291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY061062.1, AK005080.1 and AI840979.1.
            
            On Aug 14, 2009 this sequence version replaced NM_019879.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream  start codon would result in a
            protein that is 13 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011087.1, AK088888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BY061062.1         2-152
            152-1390            AK005080.1         1-1239
            1391-1407           AI840979.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.4 cM"
     gene            1..1407
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /note="succinate-CoA ligase, GDP-forming, alpha subunit"
                     /db_xref="GeneID:56451"
                     /db_xref="MGI:MGI:1927234"
     exon            1..249
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1193
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /EC_number="6.2.1.4"
                     /EC_number="6.2.1.5"
                     /note="succinyl-CoA ligase [GDP-forming] subunit alpha,
                     mitochondrial; succinyl-CoA synthetase subunit alpha;
                     SCS-alpha; succinyl-CoA ligase [ADP/GDP-forming] subunit
                     alpha, mitochondrial; succinate--CoA ligase
                     [ADP/GDP-forming] subunit alpha, mitochondrial"
                     /codon_start=1
                     /product="succinate--CoA ligase [ADP/GDP-forming] subunit
                     alpha, mitochondrial precursor"
                     /protein_id="NP_063932.2"
                     /db_xref="CCDS:CCDS20246.2"
                     /db_xref="GeneID:56451"
                     /db_xref="MGI:MGI:1927234"
                     /translation="MTATVVAAAATATMVSSSSGLAAARLLSRTFLLQQNGIRHGSYT
                     ASRKHIYIDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQKHLGLPVFN
                     TVKEAKEKTGATASVIYVPPPFAAAAINEAIDAEIPLVVCITEGIPQQDMVRVKHRLT
                     RQGTTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGL
                     GQSLCIGIGGDPFNGTDFIDCLEVFLNDPATEGIILIGEIGGHAEENAAAFLKEHNSG
                     PKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGT
                     TIYKEFEKRKML"
     exon            250..353
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..470
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..683
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..741
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..825
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..977
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1166
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1392
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1369..1374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /note="hexamer: AATAAA"
     polyA_site      1392
                     /gene="Suclg1"
                     /gene_synonym="1500000I01Rik; Sucla1"
                     /note="major polyA site"
ORIGIN      
        1 gtcatccttc ttgttctttt ccacttgtaa cgttcactgt ttgagaagag actccgagga
       61 gcgtaagata ttcaggctac tcctctagac acctttctgc gcgagcctga gcccatgcca
      121 aggtcccggg gtcctgagag tgtcattggg ggatgaccgc aacagtagtt gctgcggctg
      181 ccactgcaac catggtctcc agcagcagcg gcctcgccgc cgcccgcctg ttgtcgcgca
      241 ccttcctcct gcaacagaat gggatacgac acgggtctta cacagcctct cggaaacata
      301 tctatattga taaaaatacg aagattattt gccagggttt cacaggcaaa cagggtacct
      361 ttcacagtca gcaggctttg gagtacggca ccaaactcgt gggaggaacc actccaggga
      421 agggtggcca gaagcacctg ggcttgcccg tctttaatac tgtgaaggaa gccaaagaga
      481 aaacaggagc aacggcttct gtcatctatg tccctcctcc ttttgctgct gctgccatta
      541 atgaagcaat cgacgcggag attcccttgg ttgtgtgcat tacggaaggt attccgcagc
      601 aggatatggt gcgggtcaag cacagactga cacgccaggg aacgacgagg ctaatcgggc
      661 caaactgccc cggcgtcatc aaccctggag aatgcaaaat cggcatcatg cctggccaca
      721 ttcacaagaa gggaagaata ggtatcgtgt ccaggtccgg tactctgact tatgaagcag
      781 ttcaccaaac aacccaagtc ggattggggc agtccttgtg tattggcatt ggaggtgacc
      841 cttttaatgg gactgatttt attgattgcc ttgaagtctt cctgaatgat ccagccacag
      901 aaggcatcat actgattggt gaaattggtg gtcacgctga agaaaatgct gccgcgtttc
      961 tgaaggagca taactcaggt ccaaaggcca agcctgtagt gtccttcatt gctggtataa
     1021 ctgctcctcc tggcagaagg atgggccatg caggggcaat tattgctgga ggaaaaggtg
     1081 gcgctaaaga gaagatctct gctcttcaga gtgctggggt ggttgtcagc atgtcccccg
     1141 cacagctggg aactaccatt tataaggagt ttgaaaagag gaagatgctt tgaaggacac
     1201 aacaagaaat tctttaaagc tgtggaagaa atctagacgt gagggccagt ccaggctgtc
     1261 agcccatgca gctgacactg gttggtctct cagtatgtgg gaaatccagg caagttttag
     1321 aatgtcctaa attgagctat tttcacttac tgtgtaacag agacagataa taaatctatc
     1381 atttgatttg aaaaaaaaaa aaaaaaa
//
