LOCUS       NM_001411715            3326 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus SUB1 homolog, transcriptional regulator (Sub1),
            transcript variant 2, mRNA.
ACCESSION   NM_001411715 XM_006520042
VERSION     NM_001411715.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3326)
  AUTHORS   Yan,B., Luo,P., Qiu,H., Wang,J., Xiong,Q., Hu,W., Wang,F., Liu,G.,
            Zhi,Y., Fang,Q., Shi,C. and Li,W.
  TITLE     PC4 promotes bladder cancer progression and stemness by directly
            interacting with Sp1 to transcriptionally activate the
            Wnt5a/beta-catenin pathway
  JOURNAL   Pathol Res Pract 259, 155369 (2024)
   PUBMED   38820928
  REMARK    GeneRIF: PC4 promotes bladder cancer progression and stemness by
            directly interacting with Sp1 to transcriptionally activate the
            Wnt5a/beta-catenin pathway.
REFERENCE   2  (bases 1 to 3326)
  AUTHORS   Ochiai,K., Yamaoka,M., Swaminathan,A., Shima,H., Hiura,H.,
            Matsumoto,M., Kurotaki,D., Nakabayashi,J., Funayama,R.,
            Nakayama,K., Arima,T., Ikawa,T., Tamura,T., Sciammas,R., Bouvet,P.,
            Kundu,T.K. and Igarashi,K.
  TITLE     Chromatin Protein PC4 Orchestrates B Cell Differentiation by
            Collaborating with IKAROS and IRF4
  JOURNAL   Cell Rep 33 (12), 108517 (2020)
   PUBMED   33357426
REFERENCE   3  (bases 1 to 3326)
  AUTHORS   Swaminathan,A., Delage,H., Chatterjee,S., Belgarbi-Dutron,L.,
            Cassel,R., Martinez,N., Cosquer,B., Kumari,S., Mongelard,F.,
            Lannes,B., Cassel,J.C., Boutillier,A.L., Bouvet,P. and Kundu,T.K.
  TITLE     Transcriptional Coactivator and Chromatin Protein PC4 Is Involved
            in Hippocampal Neurogenesis and Spatial Memory Extinction
  JOURNAL   J Biol Chem 291 (39), 20303-20314 (2016)
   PUBMED   27471272
  REMARK    GeneRIF: These observations indicate that non-histone
            chromatin-associated proteins like PC4 play a significant role in
            neuronal plasticity.
REFERENCE   4  (bases 1 to 3326)
  AUTHORS   Jo,J., Hwang,S., Kim,H.J., Hong,S., Lee,J.E., Lee,S.G., Baek,A.,
            Han,H., Lee,J.I., Lee,I. and Lee,D.R.
  TITLE     An integrated systems biology approach identifies positive cofactor
            4 as a factor that increases reprogramming efficiency
  JOURNAL   Nucleic Acids Res 44 (3), 1203-1215 (2016)
   PUBMED   26740582
  REMARK    GeneRIF: Results suggest that positive cofactor 4 (Pc4) has an
            important role in inducing spontaneous somatic cell reprogramming
            via up-regulation of key pluripotency genes.
REFERENCE   5  (bases 1 to 3326)
  AUTHORS   Redshaw,N., Camps,C., Sharma,V., Motallebipour,M., Guzman-Ayala,M.,
            Oikonomopoulos,S., Thymiakou,E., Ragoussis,J. and Episkopou,V.
  TITLE     TGF-beta/Smad2/3 signaling directly regulates several miRNAs in
            mouse ES cells and early embryos
  JOURNAL   PLoS One 8 (1), e55186 (2013)
   PUBMED   23390484
REFERENCE   6  (bases 1 to 3326)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3326)
  AUTHORS   Marroquin,C.E., Wai,P.Y., Kuo,P.C. and Guo,H.
  TITLE     Redox-mediated upregulation of hepatocyte iNOS transcription
            requires coactivator PC4
  JOURNAL   Surgery 138 (1), 93-99 (2005)
   PUBMED   16003322
  REMARK    GeneRIF: Redox-mediated upregulation of hepatocyte iNOS
            transcription requires an HNF-4alpha-PC4 transcriptional complex
REFERENCE   8  (bases 1 to 3326)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3326)
  AUTHORS   Nishiguchi,S., Joh,T., Horie,K., Zou,Z., Yasunaga,T. and Shimada,K.
  TITLE     A survey of genes expressed in undifferentiated mouse embryonal
            carcinoma F9 cells: characterization of low-abundance mRNAs
  JOURNAL   J Biochem 116 (1), 128-139 (1994)
   PUBMED   7798170
REFERENCE   10 (bases 1 to 3326)
  AUTHORS   Ballard,D.W., Philbrick,W.M. and Bothwell,A.L.
  TITLE     Identification of a novel 9-kDa polypeptide from nuclear extracts.
            DNA binding properties, primary structure, and in vitro expression
  JOURNAL   J Biol Chem 263 (17), 8450-8457 (1988)
   PUBMED   3372536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121860.4.
            
            On Aug 31, 2022 this sequence version replaced XM_006520042.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.296779.1,
                                           SRR17253013.2785316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC121860.4         87770-87828
            60-132              AC121860.4         89914-89986
            133-255             AC121860.4         92694-92816
            256-364             AC121860.4         97211-97319
            365-3326            AC121860.4         99478-102439
FEATURES             Location/Qualifiers
     source          1..3326
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.9 cM"
     gene            1..3326
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /note="SUB1 homolog, transcriptional regulator"
                     /db_xref="GeneID:20024"
                     /db_xref="MGI:MGI:104811"
     exon            1..59
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..132
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..444
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /note="p14; positive cofactor 4; single-stranded
                     DNA-binding protein p9; RNA polymerase II transcriptional
                     coactivator"
                     /codon_start=1
                     /product="activated RNA polymerase II transcriptional
                     coactivator p15"
                     /protein_id="NP_001398644.1"
                     /db_xref="GeneID:20024"
                     /db_xref="MGI:MGI:104811"
                     /translation="MPKSKELVSSSSSGSDSDSEVEKKLKRKKQAVPEKPVKKQKPGE
                     TSRALASSKQSSSSRDDNMFQIGKMRYVSVRDFKGKILIDIREYWMDSEGEMKPGRKG
                     ISLNMEQWSQLKEQISDIDDAVRKL"
     exon            133..255
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..364
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..3326
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      585..590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /note="hexamer: ATTAAA"
     polyA_site      604
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /note="hexamer: AATAAA"
     polyA_site      687
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /note="major polyA site"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
                     /note="hexamer: AATAAA"
     polyA_site      3326
                     /gene="Sub1"
                     /gene_synonym="P15; P9; Pc4; Rpo2tc1"
ORIGIN      
        1 agtccggagt aggcgagcga gcgaggcaga ggtttttggt cggccggagc ggagcgtgaa
       61 atgcctaaat caaaggaact tgtttcttca agctcttcag gcagtgattc ggacagcgaa
      121 gttgaaaaaa agttaaagag gaaaaagcaa gcggttccag agaagcccgt gaagaagcag
      181 aagcctggtg agacttctag agcactggca tcctccaagc agagcagcag cagcagagat
      241 gacaacatgt tccagattgg aaagatgaga tatgtcagtg ttcgggactt caaaggaaaa
      301 attctaattg atattagaga atattggatg gattcagaag gtgaaatgaa accaggaaga
      361 aaaggtattt ctttaaacat ggaacaatgg agccagctga aggaacagat ctctgatata
      421 gatgacgcag taagaaagct gtaaaatctg agccatatca aacctgtact gttgtagttg
      481 tctttttaca ttggcttttg ttttctaaat gttgttttcc aagctgttgt atatttggat
      541 tgcagaacaa tttgtaagac aaatactttt ttttaatgtg cattattaaa atgttctaag
      601 tgaagctaat tgtcaagttt attaaagagg attgctttgt gccccctacc tagtgtgtaa
      661 aataaagtca gatcattaca atcttaactg tggtaccctt ttttgatcaa aaaaacctag
      721 ttactgttta aggccaaaag aacaactagg cacactgttg agtcagctta cattcagaag
      781 gatttgtatt acattgagtt tcttagattg ctttgtgaaa tgtatactca gcctttttct
      841 ttccaaccag atttactgcg ttttcctctc caggacttct ccctaccaca ataacttatc
      901 ttttcttcag ttctcttagt gctcaagttt aaatcactct ttactcagat agattacgct
      961 tatttagaaa gtcaaactgt cagttttgtt gcctcctaag tctactgtgc taattactag
     1021 tatctgtttg gcaacatgac ttatatgaga actccaagca agtgtatgtc attattcata
     1081 gtgctctgtg tagatgttgc ttagtttaca gaacatagtg actttgatgt ctgatgagct
     1141 gtcactcagt aaacatttgt gctagggtga tggttataaa gtcagatatt aaactagatt
     1201 agacttgtaa aaagtgtgaa acttactggc ctactgttat attctaataa tgtgtggatt
     1261 ctatgtagtc agatgtggca ctgagctcaa ctgtggtagg ttctgtgggc agttttagag
     1321 ttgactgttc tacagttaat ctggacaagt gacttccaga cttgatgtta actaggtttg
     1381 atagacattt ccattggttt tcatttcaat tgtgatgatt aagcaagcag acaggcacat
     1441 gttttaggga cattgctcca atgaaaaggg catagtgttc tgagggaaaa tgtttgcaaa
     1501 ggaaagtcac cacactgaag ggagctagcc tgtgatgaga aaggaacttt cttgaaacta
     1561 aatgttgtgc acatgatatg ttggtgataa cattaagatg ggtcttcgta gaataatagc
     1621 taacaaggac aatttataga tgtgaaaaaa tgctgccact aagggctgcc atatcagaat
     1681 tgcactgtca tactgagtcc caccgtctaa gcattttata gaactgttaa ggattaaatt
     1741 taaaaaacag tctgccaggc ctcatgtggt taactgtcct ccccacagat actctttagg
     1801 taacttttta gtgtgttact ccaaattgat acatatatat caaagggttt aagatatata
     1861 ccatagctca ttcttgaggg atgatcctct tataatgtgt tgcatttcat tgattttata
     1921 aagtattcct tatttgtcat gtaaagaaag gatagttaga acataagact ggtttggtgc
     1981 agatgagggg agaataacag gtaaattcct gaggccatgt gttatatgta catttcagct
     2041 gtccgattgc agagatctgc cgtctgctac ctaggcattg ctagctgctt agcataaaat
     2101 tccatgtgga aagctttctc gggcataatt tgttaggttg atagctaaat acattcacta
     2161 atgttatacc agagttgttg ttatttttct ttgtgtgttg aaaaggaaaa ttgagttaaa
     2221 agaagaggaa ggacttttca gatggaaaag aaagggtaca gtccttctat tttgcgttca
     2281 gatgcctttc tcctcagtgt cttagtttct tttctgttgc tgtggtgaag tgccctgaca
     2341 gaagcagcca agggagaaag ggtttatcct gactcacagt tccatgttcc agtccgttgt
     2401 cgcattgtca cagtggcagg aactccagac atctggccac atggctccat agccaggaag
     2461 ctgagagctg tgattgcatg ctcagttcct ttttgtctca ttaacctgag cccaggagct
     2521 ggagttggcc acagcaggca agatgattct ccagacatca tgcctagagg cctatctttt
     2581 gggtagttct agattctgtt gaactaataa ccatcatagt aagttttctc ccaggaagaa
     2641 ggcttgacat tttaaggcat aatatcttat tttgtaacac taaaataatt agatctgctg
     2701 ccaggttttg ccctttaata tgctccatag taaggcttcc aaatgggttt tcctcttagg
     2761 gtaaaaagcc tttggccaat ttccacaatc actgaaaaag aaaaactcag attttctttt
     2821 gtttgcttca caaatgccta aaatcttgag aaatactacc tccttaccta gtcaagacgc
     2881 tgtgataacc agtctgtgct gcgtagtgtt ggagtcagca gcgtggggaa aaccgtgggg
     2941 aaagagcatc ctggtctggc tgcaaaggga ggaagggatt gaacagttat gtaagcgttc
     3001 ctgacaggaa cgctagcaca gagcttgcca tagagcctgt gaacgtcttc agaaccgttg
     3061 agttatattt aggtatcttt tctgaatttc tttgtggttc actttttata gaaattaatg
     3121 tagtgaaaca ctaaagattt ttttcttaag aaaggtattt ttttccagat aaactataat
     3181 gtaaacatgc atctagtgag aagtatgtga ctctgtaatt gtggaatgac tgtatgcttt
     3241 gtttagtaca tcttccgtgg aggtgtcaat gaacctatta ttccacctgt gaatatttta
     3301 aatgttgaat aaaaacaaga aacaca
//
