LOCUS       NM_019637               4258 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus serine/threonine/tyrosine interaction protein (Styx),
            mRNA.
ACCESSION   NM_019637
VERSION     NM_019637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4258)
  AUTHORS   Liu,J., Zang,Y., Ma,C., Wang,D., Tian,Z., Xu,X., Li,W., Jia,J. and
            Liu,Z.
  TITLE     Pseudophosphatase STYX is induced by Helicobacter pylori and
            promotes gastric cancer progression by inhibiting FBXO31 function
  JOURNAL   Cell Death Dis 13 (3), 268 (2022)
   PUBMED   35338113
  REMARK    GeneRIF: Pseudophosphatase STYX is induced by Helicobacter pylori
            and promotes gastric cancer progression by inhibiting FBXO31
            function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4258)
  AUTHORS   Wishart,M.J. and Dixon,J.E.
  TITLE     The archetype STYX/dead-phosphatase complexes with a spermatid
            mRNA-binding protein and is essential for normal sperm production
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2112-2117 (2002)
   PUBMED   11842224
  REMARK    GeneRIF: We demonstrate that the phosphoserine, -threonine or
            -tyrosine, interaction protein, Styx, complexes with a testicular
            RNA-binding protein and is essential for normal spermiogenesis.
REFERENCE   3  (bases 1 to 4258)
  AUTHORS   Wishart,M.J., Denu,J.M., Williams,J.A. and Dixon,J.E.
  TITLE     A single mutation converts a novel phosphotyrosine binding domain
            into a dual-specificity phosphatase
  JOURNAL   J Biol Chem 270 (45), 26782-26785 (1995)
   PUBMED   7592916
REFERENCE   4  (bases 1 to 4258)
  AUTHORS   Kerr,S.M., Vambrie,S., McKay,S.J. and Cooke,H.J.
  TITLE     Analysis of cDNA sequences from mouse testis
  JOURNAL   Mamm Genome 5 (9), 557-565 (1994)
   PUBMED   8000140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154575.2 and CT025535.14.
            
            On Nov 17, 2006 this sequence version replaced NM_019637.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154136.1, AK046970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AC154575.2         2613-2956           c
            345-377             CT025535.14        20718-20750
            378-431             CT025535.14        22485-22538
            432-529             CT025535.14        25031-25128
            530-590             CT025535.14        32371-32431
            591-627             CT025535.14        33454-33490
            628-667             CT025535.14        34079-34118
            668-718             CT025535.14        34193-34243
            719-791             CT025535.14        36791-36863
            792-885             CT025535.14        38157-38250
            886-4258            CT025535.14        39284-42656
FEATURES             Location/Qualifiers
     source          1..4258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.9 cM"
     gene            1..4258
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /note="serine/threonine/tyrosine interaction protein"
                     /db_xref="GeneID:56291"
                     /db_xref="MGI:MGI:1891150"
     exon            1..344
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..959
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /note="protein tyrosine phosphatase-like unspliced
                     c-terminal product and spliced c-terminal end STYX;
                     protein tyrosine phosphatase-like protein;
                     phosphoserine/threonine/tyrosine interaction protein;
                     inactive tyrosine-protein phosphatase Styx"
                     /codon_start=1
                     /product="serine/threonine/tyrosine-interacting protein"
                     /protein_id="NP_062611.2"
                     /db_xref="CCDS:CCDS26975.1"
                     /db_xref="GeneID:56291"
                     /db_xref="MGI:MGI:1891150"
                     /translation="MEDVKLEFPSLPQCKDDAEEWTYPMRREMQEVLPGLFLGPYSSA
                     MKSKLPILQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMT
                     KEFIDGSLQNGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPN
                     AGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLAVHSGTTGSVKRTHEEDDDFGNMQVA
                     TAQNG"
     exon            345..377
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            378..431
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            432..529
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            530..590
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            591..627
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            628..667
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            668..718
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            719..791
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            792..885
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..4258
                     /gene="Styx"
                     /gene_synonym="0610039A20Rik; hStyxb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacggtt atgggctcgt gcctgggtcg gatcccggct ctctgagggg cgcggagacc
       61 tgcgggaggg acacggccgc agcatggcgg ccggcagcgc accgccctgc cctccgcctt
      121 cctgtcgcag ccgcttggat cctgtggtcc gcgagtgctt gctgtgagcc tgccgcgcgt
      181 cagccccccc accgctcgcc cgcccgcccg ccctccttcc cttgtcgcct ctgccagccc
      241 ggagggcggc cgggcgcacc gcgcccaccc accggggccc tgggaccatg gaggacgtga
      301 aactggagtt cccctcgctc ccgcagtgca aagacgacgc cgaggagtgg acttacccta
      361 tgagacgaga gatgcaggaa gttttgcctg gattgttctt aggcccatac tcttctgcta
      421 tgaaaagcaa gctacctata cttcagaaac atggcataac tcatataatt tgcatacggc
      481 aaaatattga agcaaacttt attaaaccaa actttcaaca attatttaga tatttagttt
      541 tggatattgc tgataatcca gttgaaaaca taatacgttt tttccctatg actaaagagt
      601 ttattgatgg aagcttacaa aatggaggaa aagttcttgt ccatgggaat gcaggtatct
      661 ctagaagtgc tgcctttgtc attgcataca tcatggagac gtttgggatg aaatacagag
      721 atgcatttgc ttatgtccaa gaaaggagat tttgtattaa tcctaatgct ggatttgtcc
      781 accaacttca ggaatatgaa gccatctact tagcaaaatt aacaatacag atgatgtcac
      841 cactccaaat agaaaggtcc ttagctgttc attctggtac cacaggtagt gtgaagagaa
      901 cacatgagga agatgacgac tttggaaaca tgcaagtggc aaccgcacag aacggctgac
      961 ctgtgaggac tgttacatgg gtgtgagctt ccatctggaa aggagaggat cctagtgatg
     1021 ataatgtgaa atggtaaact cacaaatact ttcttttcaa ttatacattg cttccagaca
     1081 tgtttctctg caacacttta agatgttgga cttatgcagt agatggcact gatgggtgat
     1141 gggtttactt aaaaaaaaga gaaaaaaaga aacaaaaaaa cctttatggt tttattataa
     1201 accaagaatt ttggacttgc aaagaggtat tattgcaata atgcactttt catacttgaa
     1261 atttatttgt atgatataaa gttattactt taaacaaaat acaagttagg gggatttgtt
     1321 tatagatttt ggataattta taacaaaaaa atttcctaat gtttcctaaa aactcatttt
     1381 gtgttatata tattacattt aaggtaattt tacagttcaa ttttatgatg aagcctctta
     1441 caaaaacatt aacaaaatgt agaacttgtc cacatttttt agtataattc agtaacttga
     1501 ttaccatttt tttaaacttc ttggtcccgt atctttaaat catgacttta gccaactagc
     1561 ctactttaca atttaataca gttaatactt cctttctaat tgcctccctt attctaaatg
     1621 agaaaagttg aaatgattaa agaaagaggt cttactttct aaaaccagat actccaaaaa
     1681 ataaggatag tgttatattt tccacatgac ttttttctct ttgctgttta agccaaatgt
     1741 agacttggtc ttttcagagt tgctgagctc ttctaacttt tgtccaaaat ggttcaaagt
     1801 agaccaaacc aatgtagcac tgtttcttca atatgaaacc cccaaaagaa aagtgccttg
     1861 catcaacaaa caagcaaatc ctcatgactt ctaaattagt atataaagca gtgaacagct
     1921 attaacgttt ttctgtaatt tcttgtttta aaatcataaa ttaaatctga tgcttgaaga
     1981 aagtaaatta tttggaatga gacacttcct tctattttct gttaattatt tctctgaggt
     2041 tcagctgaca gctttgcttt gaagatgtat ccattgggga aagcaatttg tgggtggctt
     2101 cagtgtattg tagattactg ttttaacttg ttcctaaatt aattcaaatt tgtaccataa
     2161 tttgcattag caaaatcatt ttatggctct ttagttttcc atgtttttat ctatatgtat
     2221 aaaagttgtt ctacaaaaaa cattttacta ctgtaaatgt gatgtgcaga agagagaagt
     2281 gtttttaact tttgtacatg atgactttag ggtagcacaa acacagctcc tttatatata
     2341 tatagctcac gtgtctcagc cctctttcga ggtgctttac ggttgggaat gatgcccgca
     2401 cactcccagg gtaccatgag gcactgtgta aggtaacagg ttgcacttaa gttccttgct
     2461 ttgctcacca ccctatgaca tcaacagtat agaaaggttc tttgtccttc acagtaggag
     2521 cctgaatata aaccagaatt actgttacct tgatttctag cctcttctgg tttcccatcc
     2581 catctcctat ctttcagctc tgaaaaaaag cattgctttt aattctgttg tgtcacaggc
     2641 atggtggtct agcagagcca agattacatt gggtattcaa aaatccctgt atacatacag
     2701 gccaacaaag atctctcttg gagtcaaccc ataatccatg gctcactgaa cagaaattgt
     2761 gattaaagca atctctattt taaaaaaatt ggattttcaa gatgagacat gtgaagtaac
     2821 tttttaaaat aagttttata aaaatacatg ttcctcttta aataggagtc tgtccaaaaa
     2881 cagaggttat tgacattcat ttgtagctgg taattttcca tttttctatc cactgtcatt
     2941 tttttcttct cacataaagt gcctatccag cacgatatac tggagacagt ctcagacact
     3001 agggactgcc accatgttga gcacagttga tgtggacaga tgaagtttgt cctttcataa
     3061 gaagcctcca agtttctttt cttcctctgt atttactgtc agtagctgtc ttaggttcca
     3121 tttctagtga tgttttgtaa gttaactatg ataaatttat ccaatcatga tttattctct
     3181 agacaacttg aataatgtat gaatgtccac ccagtttcag tattaaatat gaaagctggg
     3241 ttcataatta aaactataca ttttcttatc aaaacttagg gaacttcatt actccccatt
     3301 tgaaagtttg agacagctcc tggaaactgg agtggagaag ggagtcttct cctagtttaa
     3361 ctgattcatg ctagtttctt gtctattaga tgttatacca actctatagt aggaatgttc
     3421 aagtgtgata actttgctac caactttcaa ccgcttgtag aacagaatat tcatttgaag
     3481 gggtgtaggg ctgtacttaa tctacttaat ctgagtctag aagtaatgtc agaaaatgct
     3541 aagcatgtcc tttgtaataa aacataaggt tcttaattgt ttaactgcta tggaattcac
     3601 atgaattaga agtatttaag tgcaatcttg aattatgaag ttggatgtat atattaggat
     3661 gtcaacttga tgtaaagtaa atgagcagtt acctgatgga tctttttaaa taaccggttt
     3721 aattcacaat cctaaagcat aacttcacgt cagtatttac agtatctttg tccattcaac
     3781 aacactccaa tgagcaaata gtaggaaata gctgagaatt actcaaggat tttgtttatt
     3841 tatttttatt aggaaaataa gtttctagag tcttgagtgc tggataattc ttttgtcttt
     3901 cccatccatg gcagctaaaa aaaaaatcac tcaaaatatt caggtttaca tgttctgctc
     3961 tcttacaggg agctaccata cctcacagtt caaagtgttt tctcaatcag taacatgata
     4021 ctgacatgta attgcaattt actatgcagc aaaaatgact caagaacagt aacatatgtg
     4081 tctctttacc tctgtatagg caattgctta cgttattcta cttttaacat ttgtactcag
     4141 ataaaatgct tatgtatgta taggaatgtc acagtgcaag atgctgctag cctgggcaca
     4201 aagtattaaa attattttgt gaagactggt ggttgtatta aaactcttgt gccattgt
//
