LOCUS       NM_172891               3576 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus serine/threonine/tyrosine kinase 1 (Styk1), transcript
            variant 1, mRNA.
ACCESSION   NM_172891
VERSION     NM_172891.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3576)
  AUTHORS   He,J., He,Y., Biao,R., Wei,Y., Dong,Z. and Du,J.
  TITLE     STYK1 mediates NK cell anti-tumor response through regulating CCR2
            and trafficking
  JOURNAL   J Transl Med 22 (1), 943 (2024)
   PUBMED   39415235
  REMARK    GeneRIF: STYK1 mediates NK cell anti-tumor response through
            regulating CCR2 and trafficking.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3576)
  AUTHORS   Yang,Y., Liu,L. and Tucker,H.O.
  TITLE     Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK
            transgenic mice
  JOURNAL   Biochem Biophys Res Commun 626, 51-57 (2022)
   PUBMED   35970044
REFERENCE   3  (bases 1 to 3576)
  AUTHORS   Wilharm,A., Sandrock,I., Marotel,M., Demera,A., Naumann,R.,
            Walzer,T. and Prinz,I.
  TITLE     Styk1 is specifically expressed in NK1.1+ lymphocytes including NK,
            gammadelta T, and iNKT cells in mice, but is dispensable for their
            ontogeny and function
  JOURNAL   Eur J Immunol 49 (5), 686-693 (2019)
   PUBMED   30758858
  REMARK    GeneRIF: Styk1 expression is specific for NK cells and selected
            NK-like innate T-cell subsets, but dispensable for their
            development and function.
REFERENCE   4  (bases 1 to 3576)
  AUTHORS   Fauteux-Daniel,S., Faure,F., Marotel,M., Geary,C., Daussy,C.,
            Sun,J.C. and Walzer,T.
  TITLE     Styk1 expression is a hallmark of murine NK cells and other NK1.1+
            subsets but is dispensable for NK-cell development and effector
            functions
  JOURNAL   Eur J Immunol 49 (5), 677-685 (2019)
   PUBMED   30690705
  REMARK    GeneRIF: high Styk1 expression is a hallmark of NK cells and that
            Styk1 is not essential for NK cell development, activation and
            antiviral functions.
REFERENCE   5  (bases 1 to 3576)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3576)
  AUTHORS   Chen,Y., Li,Y.H., Chen,X.P., Gong,L.M., Zhang,S.P., Chang,Z.J.,
            Zhang,X.F., Fu,X.Y. and Liu,L.
  TITLE     Point mutation at single tyrosine residue of novel oncogene NOK
            abrogates tumorigenesis in nude mice
  JOURNAL   Cancer Res 65 (23), 10838-10846 (2005)
   PUBMED   16322230
  REMARK    GeneRIF: Point mutations at either Y327 or Y356 dramatically
            blocked cellular transformation by NOK as examined by colony
            formation and cellular DNA synthesis.
REFERENCE   7  (bases 1 to 3576)
  AUTHORS   Liu,L., Yu,X.Z., Li,T.S., Song,L.X., Chen,P.L., Suo,T.L., Li,Y.H.,
            Wang,S.D., Chen,Y., Ren,Y.M., Zhang,S.P., Chang,Z.J. and Fu,X.Y.
  TITLE     A novel protein tyrosine kinase NOK that shares homology with
            platelet- derived growth factor/fibroblast growth factor receptors
            induces tumorigenesis and metastasis in nude mice
  JOURNAL   Cancer Res 64 (10), 3491-3499 (2004)
   PUBMED   15150103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122191.4 and AC148326.2.
            
            On Aug 31, 2022 this sequence version replaced NM_172891.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033606.1, BC150724.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1105              AC122191.4         127289-128393       c
            1106-1240           AC122191.4         126821-126955       c
            1241-1507           AC122191.4         125303-125569       c
            1508-1689           AC122191.4         124253-124434       c
            1690-1773           AC122191.4         121441-121524       c
            1774-1988           AC122191.4         119077-119291       c
            1989-2029           AC122191.4         116693-116733       c
            2030-2126           AC122191.4         115995-116091       c
            2127-2432           AC122191.4         114656-114961       c
            2433-3576           AC148326.2         1-1144
FEATURES             Location/Qualifiers
     source          1..3576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..3576
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /note="serine/threonine/tyrosine kinase 1"
                     /db_xref="GeneID:243659"
                     /db_xref="MGI:MGI:2141396"
     exon            1..1105
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1240
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1507
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1689
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1773
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1988
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2029
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2126
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..3576
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3549..3554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /note="hexamer: AATAAA"
     polyA_site      3576
                     /gene="Styk1"
                     /gene_synonym="9130025L13; Nok"
                     /note="major polyA site"
ORIGIN      
        1 aggagacagt gctagctaga gcttgagaca gagcagttat gctggggtat acagagatca
       61 cacacatact aaggtagaca gggaacttac taggtagcca caggctggct tctaacttgc
      121 catcttgctg tctttgtctc tagagtgctg tttttgcagg tgtgagttgc cttgttttgg
      181 tattgcatag ttacattaat atgtggtcat tgggggaact gggtgaggga tacagagaaa
      241 gaggacacat ctgttgtgta cttgtaactt tacatgaaac tctgctttaa aattaaaggg
      301 aagcagaggc aggtagatct ctggagttca aggccagcct ggtctacaca gtgagttcta
      361 agataaccag ggctacacag agaaactctg tctccatcca gcccccacaa agtcccactg
      421 aacttattgg aaattgttcc tacattatat ttcagttggt tgatgtaaaa taaaatattt
      481 atatgttgta tgtaaaaaaa gcataaatca tctcttggca tttgccatat atatttattc
      541 agacaatggt ttggataaag gtggaatgaa atgttatgta caaaaatgtg acatgcagct
      601 gaaatgaatt taacatgctt caagattgta gcaggggtag atatttatca gcagtcagga
      661 tggttcggcg ggtccctact tcagcatgat cacataagtc tagggtgcct ttacaatact
      721 ttcaataaca atgaaaaaag gagcaaggct ggaaagttgc aaaagagaga aagtaaaatg
      781 cattgggggg aaatgaatgt ttttcagact gaattttaga aaaaagagca gagaggagtg
      841 ggtggctcag aaaagacact atgtgcttag taactagagt gtcataggta tatttaaatt
      901 ttctacatgt gctgtttttt gttttatgtt ttttgttttt tttccctaga ataataacga
      961 agtctttgga aatactgcac cactgccgct gtgctccgtg catcctctgt gcgcctaaca
     1021 gaggaggttg gccctgtggc catgggagag aagggtcacc tgagccgggt gttgttggaa
     1081 tgcagtctca gtgacaagct gtgtgttgtc cgagagaagc agtatgaagt aatcattgtt
     1141 ccggctctcc tggttggcgg ctttctcatc cttcttgcaa tcatcctgtg gctttttatc
     1201 agaggacaga gatcccaaag gcagagccct ggaccccgag gcactgcctc tgtacctgca
     1261 tctaggggca gaagccagga ggcagcagga catggagaaa aagtacttct gcctcttaag
     1321 gagacctcag tggagggctt tctgcgagcg gccacacccc gcctggctaa gctgcaggtg
     1381 cccagggaac agctcttgga ggttctggag caaatccaca gtggtagttg tgggaccctc
     1441 tatcatgcaa caatgaccac caaggatcac cctaagccaa aaagtgtggt ccttaaggct
     1501 ttagaagatc cagttggact ccaggaggtc caggatttta taggacgaat ccaattctat
     1561 cagtacctgg ggaaacacaa gaacctggta cagctggagg gctgctgtac agaaaggctg
     1621 ccactctata tgatgctgga ggatgtggtc ccaggggacc tgctcagctt tctttggacc
     1681 tgtcgaaggg atgtgatgac catggatggc ctgctctatg atctcacaga aaaacaaata
     1741 tatcacattg gaaagcagat ccttttggcc ctggaattcc tgcaggagaa gcacctgttt
     1801 catggggatg tggctgccag gaacatcctg atccaaagtg acctgactcc caaactttgt
     1861 catctgggcc tggcttatga agttcatgcc catggggcca tctcctctgc tcgatccagc
     1921 accatccctc tcaagtggct tgctccagaa aggcttctcc tgagacctgc aagcatcagg
     1981 ggagatattt ggtcctttgg gatcctgctt tatgagatgg tgactctagg agcaccacca
     2041 taccctgaag tccctcccac cagcatccta caatatcttc agagaaagaa aatcatgaag
     2101 agacccagca gctgctcaca tgccatgtac aacatcatga agtgctgttg gcgctggagt
     2161 gaggacagcc gccccttact tggtcagctg ctccagcgcc tagaagctgc ttctagatct
     2221 gccgatgaca aggctgtgtt gcaagtgcca gagttggtgg tgcctgaact gtatgcagat
     2281 gtggctggca tcagggcaga aagcatttcc tatagcttca gtgtcctttg aagatggtcc
     2341 tagacaaatg actatatatg ggtggaatta gttccttcaa gaacagagag aaggaacttt
     2401 ctgtggccca ccaagggaga aaaaaggaca tggatcttgc atctttccct aaacattttc
     2461 ctagacatct gaaatgctgc tggatgaagc tctacctcta cataccatgt actcttgagc
     2521 taagaatcac catcaattgt agtttgcttt ccagtcccaa gggctgaagt ataagtggtg
     2581 gaccgtgtca ttctaaagga ggtttttaaa atctgcaatg attgtaaggg aattaggcaa
     2641 aagggctggt cccactcact ccaggctggt ttactactga aactagtttt tcttttcttt
     2701 tttttttaag ttaaactatt acagagtaaa aataaaccag atgggcatga atgaacacct
     2761 tctaattttt aaccatgaat tgaatattgg aattcatgag aaagaaaatt ctaggttctt
     2821 tttgctaaga ggtgttaagg tgagtcaata tatccttcaa ggaaaggctt tgtctcatct
     2881 atgttgacgg gacgtaaaag tcctcgtccc gttatgaaga gctgaagaag atctataaga
     2941 aacaatactg agcctttcct tgactataga tagaagagca tcctttcatt gaactctgag
     3001 gcaggtggac catgcatgat actaagttta attagaagca ggaggagtca tttcatgatt
     3061 aggaacattg ttcatcccat ttgtttgcca gttcctgtaa gactaaggag aatcagccta
     3121 tagagccaaa gctagaacca gggataaaaa gtgtgtgtgt gtataacaaa taggaagcat
     3181 gaaagtcgag caagaagact tagtaaccca ggtggtcatt aagaggtaca gagaagaagt
     3241 aatcttatag gaatggatgg tagcttctaa tttttaacca ttcattgaaa taactgtgaa
     3301 gcaactcatt aaactagtat ttattgacca aaagtagact tttcaggtgt atagctgcca
     3361 aaatctctat aataaagagg ctaaaagaaa ataaatggga gttattttac taggaaaatt
     3421 agagaaccta tagtttccaa aaagagattc tttatgtgca aaatgagata actctctacc
     3481 tcacagggtt ggtgtgagga acaatgagaa tatgtatttg tgtattatgt agaatataat
     3541 atattctcaa taaatactag tttttcccct ttctaa
//
